Imiyalo yokusebenzisa umuthi i-Glyurenorm

Isifo sikashukela sohlobo 2 sibhekwa njengesifo se-metabolic esibonakaliswa ukuthuthukiswa kwe-hyperglycemia engapheli ngenxa yokuhlangana okungatheni kwamangqamuzana omzimba nge-insulin.

Ukulungisa izinga le-glucose ejwayelekile egazini, ezinye iziguli, kanye nokudla kokudla, zidinga umuthi owengeziwe.

Omunye wale mithi yi-glurenorm.

Imininingwane ejwayelekile, ukwakheka kanye nendlela yokukhululwa

I-Glurenorm imele ama-sulfonylureas. Lezi zimali zenzelwe ukwehlisa amazinga kashukela egazi.

Umuthi ukhuthaza ukukhululeka okusebenzayo kwe-insulin ngamangqamuzana pancreas, asiza ukumunca ushukela owedlulele.

Umuthi ubekelwe iziguli ezimweni lapho ukudla kunganikeli khona umphumela ofunekayo, futhi izinyathelo ezengeziwe ziyadingeka ukwenza inkomba yeglucose ejwayelekile.

Amathebhulethi amhlophe ngombala, abe nombhalo oqoshiwe "57C" kanye nelogo ehambisanayo yomenzi.

Ukwakheka:

• I-Glycvidone - isakhi esiyinhloko esisebenzayo - 30 mg;
• isitashi sommbila (omisiwe futhi unyibilikisiwe) - 75 mg;
• i-lactose (134.6 mg);
• i-magnesium stearate (0.4 mg).

Iphakethe lezidakamizwa lingaqukatha amaphilisi angama-30, 60, noma angama-120.

I-Pharmacology ne-pharmacokinetics

Ukuthatha umuthi kubangela izinqubo ezilandelayo ze-metabolic emzimbeni:

• kumaseli we-beta umkhawulo wokungabekezeleleki nge-glucose uyancipha, obangela ukukhiqizwa okwandayo kwe-insulin;
• ukuzwela kwamangqamuzana aphathelene ne-hormone kukhuphuka;
• impahla ye-insulin yanda ukuthonya inqubo yokufakwa emzimbeni yisibindi nezicubu zeglucose;
• i-lipolysis eyenzeka kwezicubu ze-adipose yehlisa ijubane;
• i-glucagon egazini iyancipha.

I-Pharmacokinetics:

1. Isenzo sezingxenye zomenzeli siqala ngemuva kwamahora angaba ngu-1 noma 1.5 ukusuka esikhathini sokufakwa kwaso. Umsebenzi ophakeme wezinto ezifakiwe kulungiselelo ufinyelelwa ngemuva kwamahora ama-3, bese kusele amanye amahora ayi-12.
2. I-metabolism yezakhi ezisebenzayo zomuthi zenzeka ikakhulu esibindini.
3. Ukwembiwa kwezakhi zesidakamizwa kwenziwa ngamathumbu nezinso. Isigamu sempilo singamahora amabili.

Amapharamitha we-kinetic wesidakamizwa awashintshi lapho asetshenziswa asebekhulile, kanye neziguli ezinokuphazamiseka kwe-pathological ezinso.

Izinkomba kanye ne-contraindication

I-Glurenorm isetshenziswa njengomuthi oyinhloko osetshenziswa ekwelapheni isifo sikashukela sohlobo 2. Imvamisa, umuthi ubekelwe iziguli ngemuva kokufika eminyakeni ephakathi noma esekhulile, lapho i-glycemia ingenakujwayelekile ngosizo lokwelashwa kokudla.

Contraindication:

• ukuba khona kwesifo sikashukela sohlobo 1;
• isikhathi sokutakula ngemuva kokuvuselelwa kabusha kwe-pancreatic;
• ukwehluleka kwezinso;
• ukuphazamiseka kwesibindi;
• i-acidosis eyenziwe ngemuva kwesifo sikashukela;
• ketoacidosis;
• i-coma (okubangelwa isifo sikashukela);
• galactosemia;
• ukungabekezelelani kwe-lactose;
• izinqubo ze-pathological ezithathelwanayo ezenzeka emzimbeni;
• ukungenelela kokuhlinzwa;
• ukukhulelwa
• izingane ezingaphansi kweminyaka yobudala obuningi;
• ukungabekezeleli izingxenye zomuthi;
• isikhathi sokuncelisa;
• isifo se-yegilo;
• utshwala;
• i-porphyria eyingozi.

Imiyalo yokusebenzisa

I-Glurenorm ithathwa ngomlomo. Umthamo wesidakamizwa ubekwa udokotela ngemuva kokuhlola isimo esivamile sesiguli, ukuba khona kwezifo ezihambisanayo kanye nezinqubo ezisebenzayo zokuvuvukala.

Ngesikhathi sokuthatha amaphilisi, kufanele uhambisane nohlelo lokudla okunempilo olunqunywe yi-endocrinologist kanye nohlu olusunguliwe.

Udinga ukuqala ukwelashwa ngomthamo okungenani wamathebhulethi ayi-0.5. Umuthi wokuqala uthathwa ngesikhathi sebhulakufesi.

Uma kungabikho mphumela kusuka ekuthatheni uhhafu wethebhulethi, kufanele uthintane nodokotela wakho, njengoba kungadingeka umthamo wokukhulisa umthamo. Awekho amaphilisi angaphezu kuka-2 avunyelwe ngosuku. Uma kungekho umphumela we-hypoglycemic, iziguli azidingi ukwandisa umthamo we-Glyurenorm, kepha thatha iMetformin ngokungeziwe ngemuva kwesivumelwano nodokotela oya khona.

Imiyalo ekhethekile

Ukwelashwa kwesifo sikashukela kufanele kwenziwe kuphela ngaphansi kokuqondisa udokotela.

Iziguli akufanele ziguqule umthamo wezidakamizwa, futhi zikhansele ukwelashwa noma zishintshe ukuthatha ezinye izidakamizwa ze-hypoglycemic ngaphandle kokuxhumana kwangaphambili ne-endocrinologist.

Imithetho ekhethekile yokwamukelwa okufanele ihlonishwe:

• lawula isisindo somzimba;
• musa ukweqa ukudla;
• phuza amaphilisi kuphela ekuqaleni kwesidlo sasekuseni, hhayi esiswini esingenalutho;
• hlela umsebenzi wokuzivocavoca kwangaphambili;
• ngaphandle kokusetshenziswa kwamathebulethi ngokugula okutholakele kwe-glucose-6-phosphate dehydrogenase;
• naka ithonya lezimo ezicindezelayo ekugxileni kwe-glucose, kanye nasekuphuzeni utshwala.

Iziguli ezinokwehluleka kwezinso kanye nezifo zesibindi kufanele zibe ngaphansi kokuqashwa kochwepheshe ngesikhathi sokwelashwa kwezidakamizwa, yize iqiniso lokuthi ukulungiswa komthamo ngenxa yokuphazamiseka okunjalo akudingeki. Izindlela ezinamandla zokuhluleka kwesibindi zibhekwa njengokuphikisana nokusetshenziswa kweGlyurenorm ngenxa yokuthi izingxenye zayo zakhiwe emzimbeni walesi sitho.

Ukuhambisana nalezi zincomo kuzovumela isiguli ukuthi sigweme ukuthuthukiswa kwe-hypoglycemia. Ukubonakala kwalesi simo kubhekwa njengokuyingozi kakhulu ngesikhathi sokushayela, lapho kunzima ukuthatha izinyathelo zokuqeda izimpawu. Iziguli ezisebenzisa i-Glurenorm kufanele zizame ukugwema ukushayela, kanye nezinqubo ezahlukahlukene.

Ngesikhathi sokukhulelwa, kanye nokuncelisa, abesifazane kufanele bayeke ukwelashwa ngezidakamizwa. Lokhu kungenxa yokuntuleka kwemininingwane edingekayo ethonyeni lezinto ezisebenzayo ekukhuleni kwengane. Uma kunesidingo, ukudla okuphoqelekile kwemithi okwehlisa ushukela komama abakhulelwe noma abakhulelwe kufanele bashintshele ekwelashweni kwe-insulin.

Imiphumela emibi kanye ne-overdose

Ukuthatha umuthi kubangela ukusabela okulandelayo kwezinye iziguli:

• mayelana nohlelo lwe-hematopoietic - i-leukopenia, i-thrombocytopenia, i-agranulocytosis;
• i-hypoglycemia;
• ikhanda, ukukhathala, ukozela, isiyezi;
• ukungaboni kahle
• i-angina pectoris, i-hypotension ne-extrasystole;
• kusuka ohlelweni lokugaya ukudla - isicanucanu, ukuhlanza, isihlalo sokucasuka, i-cholestasis, ukulahleka kwesifiso;
• I-Stevens-Johnson syndrome;
• i-urticaria, ukuqubuka, ukulunywa;
• izinhlungu azizwe endaweni yesifuba.

Ukweqisa izidakamizwa kuholela ku-hypoglycemia.

Kulokhu, isiguli sizwa izimpawu zesimo salesi simo:

• umuzwa wendlala;
• i-tachycardia;
• ukuqwasha
• ukukhuphuka kokujuluka;
• ukuthuthumela
• ukukhubazeka kwenkulumo.

Ungamisa ukubonakaliswa kwe-hypoglycemia ngokudla ukudla okune-carbohydrate ngaphakathi. Uma umuntu engazi lutho ngalesi sikhathi, khona-ke ukululama kwakhe kuzodinga i-glucose ye-intravenous. Ukuvimbela ukuphindeka kwe-hypoglycemia, isiguli kufanele sibe nokudla okungeziwe ngemuva komjovo.

Ukusebenzisana kwezidakamizwa kanye nama-analog

Umphumela we-hypoglycemic we-Glenrenorm uyathuthukiswa ngokusetshenziswa kanyekanye kwezidakamizwa ezinjengokuthi:

• Glycidone;
• I-Allopurinol;
• Ama-inhibitors e-ACE;
• ama-analgesics;
• ama-antifungal agents;
• Clofibrate;
• Clarithromycin;
• ama-heparins;
• Ama-Sulfonamides;
• insulin;
• ama-ejenti omlomo anomphumela we-hypoglycemic.

Izidakamizwa ezilandelayo zinomthelela ekwehleni kokusebenza kweGlyurenorm:

• Aminoglutethimide;
• i-sympathomimetics;
• ama-hormone egilo;
• I-Glucagon;
• izindlela zokuvimbela inzalo ngomlomo;
• imikhiqizo equkethe i-nicotinic acid.

I-Glurenorm ingenye yezidakamizwa ezivame ukuqokwa ukwenza i-glycemia iqonde kubantu abanesifo sikashukela sohlobo 2.

Ngaphezu kwaleli khambi, odokotela bangancoma i-analogues yalo:

• IGlairie
• Lungisa;
• I-Glianov;
• IGlllada;
• I-Glibetic.

Kufanele kukhunjulwe ukuthi ukulungiswa kwamthamo nokufakwa esikhundleni kwezidakamizwa kufanele kwenziwe kuphela ngudokotela.

Izinto zevidiyo eziphathelene noshukela nezindlela zokugcina ushukela wegazi:

Imibono yesiguli

Ukusuka ekubuyekezweni kweziguli ezithatha i-Glurenorm, singaphetha ngokuthi umuthi wehlisela ushukela kahle, kepha unemiphumela emibi impela, ephoqa abaningi ukuthi baphendukele ezidakamizweni ze-analog.

Sekuphele iminyaka eminingi ngihlaselwa isifo sikashukela sohlobo 2. Ezinyangeni ezimbalwa ezedlule, udokotela wami ungibhalele uGlyurenorm, ngoba u-Diabeteson wayengekho ohlwini lwezidakamizwa zamahhala ezazitholakala. Ngithathe inyanga kuphela, kepha ngafinyelela esiphethweni sokuthi ngizobuyela kusidakamizwa esidlule. I-Glurenorm, yize iyasiza ukugcina ushukela ojwayelekile, kepha ibangela imiphumela emibi eminingi (umlomo owomile, ukuqunjelwa kanye nokulahlekelwa isifiso sokudla). Ngemuva kokubuyela kumuthi owedlule, izimpawu ezingemnandi zanyamalala.

UKonstantin, oneminyaka engama-52

Lapho kutholakala ukuthi nginesifo sikashukela, ngokushesha banquma uGlyurenorm. Ngiyawuthanda umphumela womuthi. Ushukela wami ucishe uvamile, ikakhulukazi uma ungaphuli ukudla. Angikhononde ngomuthi.

U-Ana, iminyaka engama-48

Nginesifo sikashukela seminyaka engu-1.5. Ekuqaleni, zazingekho izidakamizwa; ushukela kwakujwayelekile. Kepha wabe esebona ukuthi izinkomba zikhuphuka esiswini esingenalutho. Udokotela unikeze amaphilisi eGlurenorm. Lapho ngiqala ukuzithatha, ngokushesha ngawuzwa umphumela. Ushukela ekuseni ubuyile kumanani ajwayelekile. Ngisithandile isidakamizwa.

UVera, 61

Intengo yamathebulethi angama-60 eGlurenorm cishe ama-ruble angama-450.