Imiyalo yokusebenzisa umuthi i-Glimeperid

Isifo sikashukela sidinga ukulawula ushukela wegazi lesiguli.

Kulokhu, odokotela basebenzisa izidakamizwa ezahlukahlukene, banikezwe izici zesithombe salesi sifo.

Kulezi zidakamizwa, kunomuthi obizwa nge- glimepiride.

Imininingwane ejwayelekile, ukwakheka kanye nendlela yokukhululwa

I-drug glimepiride ingenye yezidakamizwa ze-hypoglycemic. Ngokuvamile kusetshenziselwa ukulawula amazinga kashukela, okungukuthi, ngesifo sikashukela.

Ochwepheshe abakukhuthazi ukuthatha lo muthi ngaphandle kokuyalelwa ngudokotela, ngoba ukufaneleka kokwelashwa nakho kuya ngezimpawu zenkambo yalesi sifo.

Umuthi wethulwa ezibhebheni, umbala wegobolondo lawo kuncike kumthamo wento esebenzayo. Umuthi uphuzwa ngomlomo.

Isithako esisebenzayo kulo muthi yi-Glimepiride. Abaxhamli bengeziwe kukho.

I-Glimepiride ikhiqizwa ezibhebheni. Ngokuya ngobungako bento esebenzayo, izinhlobo eziningana ziyahlukahluka kuzo. Inani lezithako ezisebenzayo lingaba yi-1, 2, 3, 4 noma i-6 mg ngeyunithi ngayinye yezidakamizwa.

Phakathi kwezingxenye ezisizayo zikhonjisiwe:

• i-magnesium stereate;
• i-povidone;
• i-starch glycolate;
• i-lactose monohydrate;
• cellulose;
• polysorbate 80.

Umuthi onemithamo ehlukile uhlukile kumbala wegobolondo (wepinki, oluhlaza okotshani, ophuzi noma oluhlaza okwesibhakabhaka), ngakho-ke amaphilisi angaqukatha imidwebo yodayi abahlukahlukene.

Ngokuthengisiwe ungathola i-glimepiride kumaseli we-contour ama-10 ama-pcs. kulelo nalelo (kwiphakheji kukhona amaseli ama-3 noma ama-6) noma emabhodleleni we-polymer enanini lama-30 noma angama-60.

Isenzo se-Pharmacological ne-pharmacokinetics

Isici esiyinhloko somuthi ukuncipha kwenani le-glucose egazini. Lokhu kungenxa yokuchayeka kumaseli we-beta pancreas, aqala ukukhipha insulin ngaphezulu. Lapho uthatha i-Glimepiride, ukuzwela kwamangqamuzana e-beta kuyakhuphuka, kusabela ngokwengeziwe eglucose, ngenxa yokuthi impendulo ye-insulin ku-hyperglycemia iba impumelelo ngokwengeziwe.

Futhi, lesi sidakamizwa sivezwa ngumphumela we-extrapancreatic, oqukethe ekwandiseni ukuzwela kwe-insulin ezindaweni eziphelele. Ama-molecule athutha ushukela glucose izicubu zomzimba kanye ne-adipose akhiqizwa ngobuningi obukhulu.

Ngemithi efanele, isakhi sayo esisebenzayo simunwa ngokuphelele. Le nqubo ayithinteki ngokudla kokudla. Umuthi osebenzayo ufinyelela ezingeni eliphezulu lokuhlushwa amahora angama-2,5 ngemuva kokuthatha amaphilisi.

Lapho la mathebhulethi esetshenziswa, kwakhiwa izibopho ezinzile phakathi kwezingxenye zamaphrotheni omuthi ne-plasma (ngama-90% noma ngaphezulu). Ngesikhathi se-oxidative biotransformation, kuvela i-metabolism ephelele ye-glimepiride. Njengomphumela, kwakhiwa i-carboxyl ne-cyclohexyl hydroxymethyl.

Ama-Metabolites adalulwa emchini (60%) kanye nokugoma (40%). Lokhu kwenzeka kungakapheli izinsuku eziyi-7. Half-life kuthatha cishe amahora angama-8.

Izinkomba kanye ne-contraindication

Ukuze ugweme imiphumela emibi kanye nezinkinga ngenxa yokusetshenziswa kwemithi, imiyalo yazo kumele ibonwe. Lokhu kuyiqiniso ikakhulukazi ngemithi ehloselwe abanesifo sikashukela.

Udokotela kufanele abhekane nemithi kadokotela, futhi lokhu kufanele kwenziwe kuphela ngemuva kokuhlolwa okunemininingwane. Ukusetshenziswa kwesidakamizwa i-Glimepiride akuvunyelwe ngaphandle kwesidingo.

Lo mkhiqizo wenzelwe iziguli ezinesifo sikashukela sohlobo 2. Ingasetshenziswa yodwa noma ihlanganiswe neminye imithi eqhamuka kuleli qembu. Ukwelashwa kwe-Glimepiride kuvame kakhulu nezidakamizwa eziqukethe i-metformin.

Kubalulekile futhi lapho unquma imithi ukuthi icabangele ukuphambana. Kungenxa yabo ukuthi esikhundleni sentuthuko, kungavela izinkinga.

Ukusetshenziswa kwe-glimepiride kuyenqatshelwa ezimweni ezinjengokuthi:

• ukungabekezelelani kwezakhi;
• isifo sikashukela sikashukela;
• thayipha i-1 isifo sikashukela;
• ukulimazeka okukhulu kwezinso;
• isifo sesibindi esithuthukile;
• isifo sikashukela sikashukela (noma i-precoma);
• iminyaka yezingane;
• isikhathi sokukhulelwa;
• ukuncelisa.

Lokhu kwephula umthetho kuqinile. Uma sikhona, lesi sidakamizwa kumele sishintshwe nesinye i-ejenti.

Ngokuqapha, i-glimepiride imiselwe:

• ingozi yokuhlakulela i-hypoglycemia;
• izifo zesisu (isibeletho);
• ushintsho oluhlelekile endleleni yokuphila yesiguli (ukwanda / ukuncipha komsebenzi wokuzivocavoca, ukwenqaba imikhuba emibi, ushintsho ekudleni).

Kulezi zimo, udokotela kufanele aqaphele inqubekela phambili yokwelashwa. Isiguli uqobo kufanele sazise uchwepheshe wazo zonke izehlakalo eziphazamisayo, ngoba zingakhombisa imiphumela emibi yesidakamizwa emzimbeni.

Imiyalo yokusebenzisa

Ukusebenza kokwelashwa kwesifo sikashukela ngaleli thuluzi kuya ngokuthi umthamo wakhethwa kahle kangakanani. Uchwepheshe kufanele akwenze lokhu ngokuhlaziya izici zempilo yesiguli. Kepha inqubo eyinhloko izinga likashukela.

Ekuqaleni kokwelashwa nge-glimepiride, kunconywa ukuthatha i-1 mg ngosuku. Udinga ukwenza lokhu ngaphambi kokudla kwasekuseni noma phakathi naso. Iphilisi kumele lidakwe liphelele. Uma kungekho ukusabela okubi, umthamo ungandiswa. Inani eliphezulu lezinto ezisebenzayo akufanele libe ngaphezu kwe-6 mg ngosuku.

Ukungezelela umthamo kufanele kwenziwe kancane kancane, kugxile emiphumeleni yokuhlolwa kwegazi. Ungangeza i-1 mg ngeviki (noma ngisho amabili). Uma kutholakala imiphumela emibi kakhulu, ukusetshenziswa kwalo muthi kufanele kulahlwe.

Imiyalo ekhethekile

Lesi sidakamizwa sidinga ukuqaphela maqondana nezinye iziguli:

1. Abesifazane ngesikhathi sokukhulelwa. I-Glimepiride ingathinta kabi inkambo yokukhulelwa nokukhula kwe-fetus, ngakho-ke, ngalesi sikhathi, isiguli sinconywa ukwelashwa nge-insulin.
2. Omama abahlengikazi. Ucwaningo kule ndawo lwenziwe kancane, kepha kukhona ubufakazi bokuthi kungenzeka ukungena kwento esebenzayo ubisi lwebele. Lokhu kudala ingozi ethile enganeni, ngakho-ke, ngesikhathi sokuqunjelwa, amazinga kashukela kufanele alawulwe ngezinye izindlela.
3. Izingane. Ebuntwaneni nasebusheni, umuthi ubekiwe. Ukusetshenziswa kwayo kuvunyelwe kuphela kusukela eminyakeni eyi-18.

Lezi zindawo zomuthi kufanele ziphathwe ngokucophelela, ukungakhathalelwa kungaholela ezinkingeni.

Izifo ezibuye zibe yisizathu sokwenqaba ukusebenzisa i-glimepiride.

Umuthi lo ungaholela ekuqhubekeni phambili kwe-pathologies ethile, okubandakanya:

• izifo ezinzima zesibindi;
• ukonakala okungathi sína emsebenzini wezinso;
• ukuphazamiseka ohlelweni lwe-endocrine;
• ukulimala
• imisebenzi;
• ukutheleleka okudala izimpawu zesifo sokuqina.

Ngokuphambuka okunjalo, udokotela kufanele akhethe elinye ithuluzi lokugcina izinga loshukela lisesimweni esijwayelekile.

Imiphumela emibi kanye ne-overdose

I-Glimepiride ingadala ukusabela okuhle.

Phakathi kwazo kukhulunywe ngakho:

• imivimbo yesikhumba;
• i-urticaria;
• ukwephulwa kwamgudu wokugaya ukudla;
• isicanucanu
• ukuphefumula
• ukuncishiswa kwengcindezi;
• jaundice
• ukungahambi kahle komzimba;
• umbono omfiphele.

Uma betholakele, isiguli kufanele sibonane nodokotela. Ngokubonakaliswa okungathí sina, umuthi ukhanseliwe. Kwezinye izimo, kuvunyelwe ukuqhubeka nokwelashwa - uma imiphumela emibi ingekho emincane futhi ingabalulekanga.

Nge-overdose yalesi sidakamizwa, i-hypoglycemia iyakhula.

Kuhambisana nezimpawu ezinjengokuthi:

• ukozela
• iminyakazo
• Izinkinga ngokuxhumana kokunyakaza;
• ukuthuthumela
• isicanucanu

Ezimweni ezinjalo, kunconywa ukuhlanza isisu bese usebenzisa ama-adsorbents. Esimweni esibucayi, ukwelashwa okungalawuleki kungadingeka.

Ukusebenzisana kwezidakamizwa kanye nama-analog

Isici esibaluleke kakhulu ekusebenziseni noma yimuphi umuthi ukuhlangana kwawo ngendlela efanele nezinye izidakamizwa.

Uma usebenzisa i-glimepiride, kuyadingeka ukuqonda ukuthi amaqembu athile wezidakamizwa angawandisa noma enze buthaka umphumela wawo. Lokhu kusho ukuthi uma uthatha le mishanguzo, kufanele ulungise umthamo.

Ukunciphisa umthamo we-glimepiride kuyadingeka lapho kusetshenziswa kanye namaqembu wezidakamizwa njenge:

• Ama-inhibitors e-ATP;
• ama-hypoglycemic agents;
• insulin;
• isikhathi eside esenza ama-sulfonamides;
• Mao inhibitors;
• ama-salicylates;
• Ama-anabolic steroid njll.

Amanye amaqembu ezidakamizwa anciphisa ukusebenza kwalesi sidakamizwa, ngakho-ke ngenxa yazo udinga ukwandisa umthamo.

Lokhu kufaka phakathi:

• i-glucagon;
• ama-barbiturates;
• glucocorticosteroids;
• ama-laxatives;
• i-nicotinic acid;
• ama-estrogens;
• okokugcoba.

Awukwazi ukuguqula isilinganiso somuthi ngokwakho. Lokhu kufanele kwenziwe nguchwepheshe, ngoba nguyena kuphela onaka zonke izinto ezibalulekile.

Ngokungabekezeleli kahle i-glimepiride, isiguli singasifaka kwezinye izidakamizwa ngomphumela ofanayo:

1. Glimax. Umuthi unokwakheka okufanayo nezici zezenzo.
2. Dimaril. Isisekelo somuthi futhi yi-glimepiride.
3. UGlidiab. Into esebenzayo yesidakamizwa yiGliclazide. Kuthinta nomzimba weziguli ngendlela efanayo.

Lapho ushintshela kweminye imithi, ukuqaphela kuyadingeka, ngoba lezo zenzo zingathinta kabi inhlala-kahle. Ngaphandle kokubonisana nochwepheshe, lokhu kwenqatshiwe.

Ividiyo mayelana nesifo sikashukela, izinhlobo zayo, izimpawu nokwelashwa:

Imibono yesiguli

Ukusuka ekubuyekezweni kweziguli ezithatha i-Glimepiride, singaphetha ngokuthi izidakamizwa zehlisa amazinga kashukela kahle futhi intengo yayo isephansi kakhulu kunaleyo yezidakamizwa eziningi ze-analog, noma kunjalo, imiphumela emibi ivame ngokwanele, ngakho-ke kungakuhle ukuthatha umuthi kuphela ngaphansi kokuqashwa kukachwepheshe.

Udokotela ungibekele Glimepiride kanye ne-Metformin. Lokhu kusizile ekulinganiseni amazinga kashukela. Ukwanda kungqubuzana nokudla. Ezimweni ezinjalo, ngandisa umthamo we-Glimepiride kusuka 2 kuya ku-3 mg, khona-ke konke ku-oda. Lokhu kwelashwa kungifanele, angikaze ngiqaphele noma yimiphi imiphumela emibi. Kwezinto ezinhle - ngiphelelwe yisisindo, esithombeni umehluko ekubukekeni uyinto emangalisayo.

UMarina, oneminyaka engama-39

Bengihlala ngithatha i-Amaril, bese ithathelwa indawo nge-Glimepiride eshibhile. Ngomthamo ofanayo, imiphumela yayibuthakathaka - ushukela awuzange unciphe. Udokotela kwadingeka akhuphule umthamo aze afike ku-6 mg. Kungcono kakhulu, kepha kuyangikhathaza ukuthi kufanele ngiphuze umuthi omningi kakhulu. Kepha angikwazi ukukhokhela i-Amaril.

ULyudmila, oneminyaka engama-48

Umuthi lo muhle, yize bekungelula ukuthi ngiwujwayele. Ngenxa yemiphumela emibi, udokotela wayecabanga ukuthi ngiphuza ngaphezu kwesidingo. Kepha-ke zonke izinkinga zahamba, isimo sazinza, azisekho ama-glucose surges. Ukuthatha i-glimepiride ngabona ukuthi ukulandela imiyalo kubaluleke kakhulu.

U-Eugene, oneminyaka engama-56

Intengo yomuthi incike kunani lezinto ezisebenzayo ezibhebheni. Kungaba ukusuka kuma-ruble ayi-160 kuye kwangama-450.