I-Orlistat - umuthi wokunciphisa umzimba: imiyalo, intengo, ukubuyekezwa

Ukwakheka nefomu lokukhululwa

I-Orlistat iyatholakala ngesimo samaphaphu, ngaphakathi kuwo kukhona amapelethi anento esebenzayo - i-orlistat. Lokhu kuvumela umuthi ukuthi udlule endaweni enolaka yesisu futhi ungadedeli okuqukethwe ngaphambi kwesikhathi.

Umuthi ukhiqizwa ngemithamo emibili: 60 no-120 mg. Inani lamaphilisi wephakethe ngalinye liyahlukahluka lisuka kwangama-21 liye kwangama-84.

Izici ze-Pharmacological

Eqenjini layo le-pharmacological, i-orlistat iyi-inhibitor ye-lipase esiswini, okusho ukuthi ivimba okwesikhashana umsebenzi we-enzyme ekhethekile yakhelwe ukudiliza amafutha ekudleni. Isebenza ngokukhanya kwesisu kanye namathumbu amancane.

Umphumela uba ukuthi amafutha angakagcwalisi awakwazi ukungenwa ezindongeni ze-mucous, futhi kambalwa amakhalori angena emzimbeni, okuholela ekunciphiseni isisindo. I-Orlistat cishe ayingene ekujuleni kwegazi, itholakala egazini ezimweni ezingatheni kakhulu nakwimithamo ephansi kakhulu, engaholeli emiphumeleni emibi ye-systemic.

Imininingwane yemitholampilo ibonisa ukuthi abantu abanokukhuluphala nohlobo 2 lwesifo sikashukela bathuthukisile ukulawula kwe-glycemic. Ngaphezu kwalokho, ngokuphatha i-orlistat, okulandelayo kwabonwa:

• ukuncishiswa komthamo wama-ejenti we-hypoglycemic;
• ukwehla kokuxakeka kwamalungiselelo we-insulin;
• ukwehla kokumelana ne-insulin.

Ucwaningo lweminyaka emi-4 luveze ukuthi kubantu abakhuluphele bathambekele ekubeni nesifo sikashukela sohlobo 2, ingozi yokuqalwa kwayo incishiswe cishe yi-37%.

Isenzo se-orlistat siqala ezinsukwini eziyi-1-2 ngemuva komthamo wokuqala, okuqondakalayo ngokususelwa kokuqukethwe kwamafutha ezithombeni. Ukwehla kwesisindo kuqala ngemuva kwamaviki ama-2 wokudla okungapheli futhi kuthatha izinyanga ezi-6 kuya kwezi-12, noma kulabo bantu abangazange banciphise isisindo ekudleni okukhethekile.

Umuthi awukhuthazi ukuzuza okuphindwe kabili kwesisindo ngemuva kokuyeka ukwelashwa. Iyeka ngokuphelele ukukhipha umphumela wayo ngemuva kwezinsuku ezingama-4-5 ngemuva kokuthatha i-capsule yokugcina.

Izinkomba kanye ne-contraindication

Izinkomba:

1. Inkambo ende yokwelashwa kwabantu abakhuluphele abane-BMI yabo engaphezu kwama-30.
2. Ukwelashwa kweziguli ezine-BMI engaphezu kwama-28 nezici zobungozi eziholela ekukhulupheni.
3. Ukwelashwa kwabantu abanesifo sikashukela sohlobo 2 kanye nokukhuluphala okuthatha izidakamizwa ze-hypoglycemic ngomlomo kanye / noma ne-insulin.

Izimo lapho i-orlistat inqatshelwe noma ivinjelwe:

• Hypersensitivity kunoma yiziphi izingxenye.
• Iminyaka engu-12.
• Isikhathi sokukhulelwa nokukhulelwa.
• Ukufakwa okungafanele kwezakhamzimba emathunjini amancane.
• Izinkinga ngokwakhiwa nokuphuma kwe-bile, ngenxa yokuthi ingena duodenum ngenani elincane.
• Ukuphathwa kanyekanye nge-cyclosporine, i-warfarin nezinye izidakamizwa.

Yize imiphumela yocwaningo lwezilwane ingazange iveze imiphumela emibi ye-orlistat esibelethweni, abesifazane abakhulelwe bayenqatshelwa ukusebenzisa lesi sidakamizwa. Amathuba ento esebenzayo engena ubisi lwebele ayikasungulwa, ngakho-ke, phakathi nesikhathi sokwelashwa, ukuqunjelwa kufanele kuqedwe.

Imiyalo yokusebenzisa

Kunamaphilisi angama-60 no-120 mg. Odokotela bavame ukunquma umthamo ka-120, ngoba usebenza kangcono ngokukhuluphala.

Umuthi kufanele udakwe i-capsule eyi-1 ngokudla ngakunye okuyinhloko (okusho ukuqhekeka okugcwele, ukudla kwasemini kanye nokudla, hhayi ukudla okulula). I-Orlistat isetshenziswa ngokushesha ngaphambi, ngesikhathi, noma kungakapheli ihora ngemuva kokudla. Uma ukudla bekungekho mafutha, ungangeqa ukuphuza umuthi.

Uhlobo lokuncoma lomthamo olujwayelekile olunconywa luyi-120 mg izikhathi ezi-3 ngosuku. Udokotela ohambelayo angalungisa imvamisa yokuphatha kanye nedosi ngokubona kwakhe. Inkambo yokwelashwa nge-orlistat isungulwa ngawodwana, kepha imvamisa ihlala okungenani izinyanga ezi-3, ngoba ngalesi sikhathi kuphela ongaqonda ukuthi umuthi ubhekana kahle kanjani nomsebenzi wawo.

Ukweqisa komzimba nemiphumela emibi

Ukuhlolwa kwenziwa ngokusetshenziswa kwemithamo emikhulu ye-Orlistat isikhathi eside, imiphumela emibi yesistimu ayitholakalanga. Noma i-overdose ibonakala ngokuzumayo, izimpawu zayo zizofana nemiphumela ejwayelekile engathandeki, edlula ngokushesha.

Kwesinye isikhathi kuvela izinkinga ezibuyela emuva:

1. Kusuka ipheshana lesisu. Ubuhlungu besisu, i-flatulence, uhudo, ukuhamba kaningi ukuya endlini yangasese. Ezingathandeki kakhulu yilezi: ukukhishwa kwamafutha angalungisiwe kusuka ku-rectum nganoma yisiphi isikhathi, ukukhipha amagesi ngenani elincane lamanyala, ukungasebenzi kwe-fecal. Ukulimala kwezinsini namazinyo kwesinye isikhathi kuyaphawulwa.
2. Izifo ezithathelwanayo. Kuqashelwe: umkhuhlane, izifo zangaphansi neziphezulu zokuphefumula, izifo ezithinta umchamo.
3. Ukukhohlisa umzimba. Ukwehlisa ukugcwala koshukela egazini ngaphansi kuka-3.5 mmol / L.
4. Kusuka ohlelweni lwe-psyche nolwezinzwa. Ubuhlungu bekhanda nokukhathazeka.
5. Kusuka ohlelweni lokuzala. Umjikelezo ongahambisani.

Ukuphazamiseka kusuka esiswini namathumbu kukhuphuka ngokulingana nokwanda kokudla okunamafutha ekudleni. Zingalawulwa ngokudla okukhethekile kwamafutha amancane.

Ngemuva kokuthi i-orlistat yasekuqaleni ikhishwe emakethe yezemithi, izikhalazo ezilandelayo ezibhaliwe zezinkinga ziqale ukufika:

• ukopha okungunxande;
• ukulunywa nokuqhuma;
• ukubekwa kukasawoti we-oxalic acid ezinso, okuholele ekuhlulekeni kwezinso;
• i-pancreatitis

Imvamisa yale miphumela emibi ayaziwa, ibingaba ngokulandelana okukodwa noma ingahlobene ngqo nomuthi, kepha umenzi kufanele abhalise kwimiyalo.

Imiyalo ekhethekile

Ngaphambi kokuqala ukwelashwa ne-Orlistat, kuyadingeka ukuthi utshele udokotela ngayo yonke imishanguzo ephuzwa njalo. Ezinye zazo kungenzeka zingahambelani. Lokhu kufaka phakathi:

• ICyclosporin. I-Orlistat inciphisa ukuqina kwayo egazini, okuholela ekuncipheni komphumela we-immunosuppression, ongathinta kabi impilo. Uma udinga ukuthatha zombili izidakamizwa ngasikhathi sinye, lawula okuqukethwe yi-cyclosporine usebenzisa izivivinyo zaselebhu.
• Izidakamizwa ze-antiepileptic. Ngokuphatha kwabo kanyekanye, ukwehluleka kwesinye isikhathi bekubhekwa, yize ubudlelwano obuqondile phakathi kwabo abuzange buvezwe.
• UWarfarin nokunye okunjalo. Okuqukethwe ngamaprotheni egazi, okubandakanyeka ekuqhekekeni kwaso, kungenzeka kunciphe, kwesinye isikhathi okuguqula amapharamitha egazi lelebhu.
• Amavithamini ancibilikayo amafutha (E, D no-β-carotene). Ukumunca kwabo kuyancipha, okuhlobene ngqo nezenzo zomuthi. Kunconywa ukuthatha imishanguzo enjalo ebusuku noma amahora ama-2 ngemuva komthamo wokugcina we-Orlistat.

Inkambo yokwelashwa nomuthi kufanele imiswe uma, ngemuva kwamasonto ayi-12 wokusetshenziswa, isisindo sehlile singaphansi kwe-5% yoqobo. Kubantu abanesifo sikashukela sohlobo 2, ukuncipha kungancipha.

Abesifazane abathatha izindlela zokuvimbela inzalo kwithebhulethi kufanele baxwayiswe ukuthi uma kuvela izihlalo ezivulekile ezivulekile phakathi nokwelashwa nge-Orlistat, kuvikelekile isithiyo esivimbayo, ngoba umphumela wezidakamizwa ze-hormonal kule ingemuva uncishisiwe.

Analogs of Orlistat

Umuthi wokuqala yiXenical. Yakhiwa yinkampani yezokwelapha yaseSwitzerland ngasekupheleni kwekhulu lama-20. Abantu abangaphezu kwezinkulungwane ezine babamba iqhaza ezivivinyweni zokwelashwa.

Amanye amagama:

• I-Orliksen
• I-Orsoten;
• ULeafa;
• I-Xenalten.

Ezinye izinkampani ezikhiqiza izidakamizwa zikhiqiza izidakamizwa ngaphansi kwegama lento esebenzayo: Akrikhin, Atoll, Canonfarma, Polfarma, njll Cishe zonke izidakamizwa ezisuselwa ku-orlistat zinqunyelwe, ngaphandle kwe-Orsoten Slim, equkethe ama-60 mg wezithako ezisebenzayo.

Ezinye izidakamizwa zokunciphisa umzimba kanye nokwelashwa kwesifo sikashukela sohlobo 2

Ukubuka konke kwezidakamizwa

Inani lentengo emakhemisi

Izindleko ze-orlistat zincike kumthamo (60 no-120 mg) nokufakwa kwamaphaphu (21, 42 no-84).

Le mishanguzo kufanele ibekwe udokotela kuphela futhi ngemuva kokuthi ukwelashwa kokudla kanye nokuzivocavoca komzimba kunganikanga umphumela oyifunayo. Abantu abavamile ngaphandle kwezinkinga zempilo, abaphakanyisiwe.

Ukubuyekezwa