Ukuze kuzinze umbuso ingcindezi ephakeme, i-Amlodipine neLorista zithathwa ngasikhathi sinye. Izidakamizwa zihambisana kakhulu. Ukwelapha okuhlanganayo kuvumela ukuncishiswa okusheshayo kokunciphisa. Umsebenzi wesicubu senhliziyo uyathuthuka, ubungozi bokukhubazeka kwezifo zenhliziyo buyehla. Ngokusho kososayensi bezinhliziyo neziguli, ukwelashwa kuthuthukisa impilo ngosuku lokuqala, uma udla imishanguzo ngokwemiyalo.
Isimo se-Amlodipine
Umkhiqizo uqukethe i-amlodipine besilate ngesilinganiso esingu-6.9 mg noma we-13.8 mg (5 mg noma we-10 mg we-amlodipine). I-Amlodipine yehlisa ukucindezela kokujwayelekile ngokuvimba iziteshi ze-calcium. Ivimbela ukungena kwe-calcium emangqamuzaneni, ithuthukise ukwanda kwemithambo yegazi. Isidakamizwa sithuthukisa ukuhanjiswa kwegazi kuyi-myocardium ene-angina pectoris. Ngemuva kokuphathwa, izicubu zenhliziyo azidingi i-oksijini futhi inani lokuqina kwemithambo yegazi liyancishiswa.
Ukuze kuzinze umbuso ingcindezi ephakeme, i-Amlodipine neLorista zithathwa ngasikhathi sinye.
Umuthi unciphisa ukucindezela kungakapheli amahora angama-6-10 futhi uvimbele ukunamathela kweplatelet. Umphumela uhlala amahora angama-24. Umphumela uncike kumthamo othathwe. Ukwemukelwa akukhulisi ukushaya kwenhliziyo. Ithuluzi lingathathwa nesifo sikashukela, i-asthma noma i-gout. Ngemuva kokuphathwa ngomlomo, izingxenye ezisebenzayo zimunca kahle futhi zisatshalaliswa kwezicubu zomzimba. Ukuqedwa kwesigamu sempilo izinsuku ezingama-2. Kuthuliswa izinso nangamathumbu. Ezigulini ezihluleka ukwehluleka kwesibindi ukusetshenziswa isikhathi eside, ziqongelela emzimbeni.
Wenza kanjani uLorista
Umuthi uqukethe i-potasium e-losartan enanini le-12,5 mg, 25 mg, 50 mg ne-100 mg. Ingxenye esebenzayo ibangela ukuvimba kwe-angiotensin 2 receptors kwe-AT1 subtype. Akuvimbeli i-enimeensi eguqula i-angiotensin. Ikhuthaza ukumbiwa kwe-uric acid, kuvimbela ukukhishwa kwe-aldosterone. Ngemuva kokuphatha, umsebenzi wesicubu senhliziyo uyathuthuka, ukugcwala kwe-norepinephrine egazini kuyancipha, futhi nengcindezi ijwayelekile.
Umphumela wenzeka kungakapheli amahora angama-5-6. Ithuluzi alithinti izinga le-cholesterol ne-triglycerides, ushukela. Imunca ngokushesha futhi iboshelwe ku-albhamuin. I-Excretion yama-metabolites yenziwa ngamathumbu nezinso phakathi nosuku. Ngokungasebenzi kahle kwesibindi, ukuqoqwa kwento esebenzayo egazini kuyanda.
Umphumela ohlangene we-Amlodipine noLorista
Ukwelapha okuhlanganyelayo kusiza ukwenze umfutho wegazi futhi kuthuthukise ukusebenza kohlelo lwethambo nenhliziyo. Ngemuva kokuphatha, imithambo yehla ngokuhlangana, ubungozi bokuphindaphindeka kokucindezela buncipha, nokujikeleza kwegazi kuthuthuka. Ingcindezi iyancipha kungakapheli amahora ayi-6 futhi umphumela uthatha amahora angama-24.
Ukwelashwa okuhlanganisiwe kunganciphisa ingozi yokuthuthukisa i-pathologies yenhliziyo noma yemithambo yegazi.
Izinkomba zokusetshenziswa ngasikhathi sinye
Kunconywa ukuthatha kanye ne-hypertension ye-arterial. Ukwelashwa kuzonciphisa ngokushesha ukucindezela futhi kuthuthukise inhlala-kahle yesiguli.
Ukuthintana ne-Amlodipine neLorista
Thatha i-Amlodipine neLorista ngasikhathi sinye somfutho wegazi ophakeme kubhekwe kumacala anjengokuthi:
- hypersensitivity kuzakhi zomuthi;
- ukukhulelwa
- ukuncelisa;
- ukusebenza kokuphazamiseka kwesibindi noma izinso;
- inkambo engapheli ye-hypertrophic cardiomyopathy;
- ama-hemodynamics angazinzile esikhathini sokuqothuka;
- ukwethuka
- izifo zokuvuvukala ezinzima ku-urology;
- ukusetshenziswa okufanayo kwezidakamizwa eziqukethe i-aliskiren;
- hypolactasia;
- ukuswelakala kwe-lactase enzyme;
- ukwephulwa kokuqhekeka kwe-galactose ne-glucose;
- ukukhwehlela okomile;
- hyperkalemia
- imithambo ye-varicose.
Ebuntwaneni futhi uma kunesidingo, i-hemodialysis ayinconywa ukuthi iqale ukwelashwa. Iziguli ezine-ischemia, i-lumen encishisiwe yemithambo yezinso, isifo se-cerebrovascular, dehydrate kanye nomfutho wegazi ophansi kufanele zivakashelwe uchwepheshe ngaphambi kokuthatha. Uma uthambekele kwi-angioedema, ukwelashwa akufanele kuqale.
Ungayithatha kanjani i-Amlodipine neLorista
Umthamo wansuku zonke we-hypertension ngu-25 mg uLorista no-5 mg Amlodipine. Amathebulethi ayagezwa phansi ngenani elifanele loketshezi. Umthamo wenyuka waba ngu-100 mg + 10 mg noma we-50 mg + 5 mg uma kungekho mphumela. I-Lorista idinga ukuthathwa ngenani le-12.5 mg noma i-25 mg uma kukhona ukwephulwa komsebenzi wesibindi.
Imiphumela emibi
Kwezinye izimo, imiphumela emibi ingavela ngemuva kokuphatha, njengoku:
- Isiyezi
- ubuthakathaka
- i-hypertension ye-arterial;
- ukukhwehlela
- dyspepsia
- ukuqunjelwa;
- isicanucanu
- ukungezwani komzimba ngendlela ye-urticaria, ukuqubuka kwesikhumba;
- ukungasebenzi kahle kwesibindi;
- ukwehluleka kwezinso;
- ukunyuswa okukhulu kwe-urea, potassium, noma i-creatinine;
- ukuzindla kwenhliziyo;
- ukuvuvukala kwemilenze;
- hyperemia yobuso;
- Ubuhlungu bemisipha
- ukunciphisa umzimba;
- Ubuhlungu besisu
- I-edema kaQuincke;
- izimpandla.
Lapho kukhona ukungezwani komzimba, kubalulekile ukwenqaba ukuphuza umuthi. Izimpawu ziyanyamalala ngemuva kokuyeka ukwelashwa.
Umbono wodokotela
U-Oksana Robertovna, udokotela wezifo zenhliziyo
Zombili lezi zidakamizwa zithathwa zihambisana ne-hypertension, kufaka phakathi okuphikisana nezinye izizinda zesistimu yenhliziyo. I-Amlodipine ikhulula umsipha wemithambo yegazi futhi ithuthukise ukuphuma kwegazi kuye enhliziyweni. I-Lorista ivimbela ukwanda kwengcindezi futhi iguqule umsebenzi wenhliziyo. Ngesikhathi ukwelashwa ngezidakamizwa ze-antihypertensive, i-tachycardia ayenzeki. Ungafinyelela ukwehla kwengcindezi ngenkathi uqamba amanga futhi uhleli. Kufanele kuthathwe ngokwemiyalo ukuvikela ukubukeka kokungafuneki. Ebudaleni, udokotela kufanele akhethe umthamo ofanele.
Ukubuyekezwa kweziguli
UGeorge, oneminyaka engama-39
Wathatha amaphilisi we-arterial and reso hypertension. Ingcindezi yehlela kumanani ajwayelekile kungakapheli amahora angama-2-2 ngemuva komthamo wokuqala. Ukwelashwa kubekezelelwa kahle. Ngosuku lokuqala, isiyezi sangikhathaza, kodwa isimo sakhe saba ngcono. Ngesikhathi sokwelashwa, kufanele uyeke ukudla. Umsoco kumele uqedele.
