Ukukhishwa kwesidakamizwa i-Glucophage Long 500 kwenziwa ngendlela yamathebulethi, afakwa izingcezu eziyi-15 ezishayweni zepulasitiki ezivalwe nge-aluminium foil. Amabhola afakwa emaphaketheni ezingcezu ezi-2 noma ezi-4. Kwiphakeji ngalinye, imiyalo yokusebenzisa umuthi ifakiwe.
IGlucophage Long 500 iyisidakamizwa esidumile kakhulu se-hypoglycemic phakathi kwabanesifo sikashukela. Ukuthandwa kwaso kungenxa yesenzo esenzeka isikhathi eside sengxenye esebenzayo, evumela ukusetshenziswa okuvame kakhulu kwezidakamizwa ukulawula izinga loshukela emzimbeni.
Kumele kuqashelwe ukuthi kwenqatshelwe ngokuphelele ukuthatha i-Glucofage ngokwakho bese ukhetha umthamo wokwelashwa.
Ukuqokwa kwemithi kanye nokukhethwa komthamo wayo kwenziwa ngudokotela oqhubekayo ngemuva kokwenza ukuhlolwa kwesidumbu esifanele sesiguli esinesifo sikashukela mellitus.
Isakhi esiyinhloko salo muthi - i-metformin hydrochloride ingeyeqembu le-Biguanides.
Ukwakheka komuthi, uhlobo lokukhululwa, ukugcinwa kanye nemibandela yokuthengisa
Umuthi ukhiqizwa imboni yamakhemikhali kuphela ngendlela yepilisi.
Ngaphandle, ithebhulethi inesimo esibhidlikile, ngakolunye uhlangothi kukhona okuqoshwe ku-500 mg, okusho okuqukethwe kwengxenye esebenzayo, ohlangothini oluhle kunombhalo wegama lomenzi.
Ngaphezu kwenhlanganisela esebenzayo esebenzayo, amaphilisi nawo afaka amakhemikhali asizayo amakhemikhali.
Izingxenye ezilandelayo zidlala indima yokulekelela kuGlucofage Long 500:
- i-hypromellose;
- i-magnesium stearate;
- i-povidone;
- i-carmellose sodium;
- iselula in microcrystals.
Lesi sidakamizwa sisetshenziselwa ikakhulukazi isifo sikashukela sohlobo 2. Ngalesi sifo, wasiza iziguli eziningi ukuthi zehlise ushukela wegazi lazo ngokwazi ukuthi kuthathwe ushukela amaseli abo. Futhi, umuthi unomphumela omuhle enqubweni yokulahlekelwa isisindo sesiguli, futhi le nkinga ihlala itholakala ezigulini ezinesifo sikashukela i-mellitus.
Kumele kwaziwe ukuthi ithuluzi linokubuyekezwa okuhle, okubonisa ukuthi akusona kuphela isidakamizwa sokwelapha esisebenza kahle, kodwa futhi kulimaza umzimba omncane. Ukubuyekezwa kwalo muthi kukhombisa ukuthi umphumela omuhle wokuphuza umuthi ugcwala kakhulu ekubonakaleni kwemiphumela emibi futhi kubangele ukulimala okuncane emzimbeni.
I-Pharmodynamics ne-pharmacokinetics yesidakamizwa
Uma ujwayela imiyalo yokusebenzisa umuthi ngokuningiliziwe, kuyacaca ukuthi yiziphi izinzuzo zokusebenzisa lesi sidakamizwa, nokuthi isebenza kanjani emzimbeni womuntu.
Isenzo esikhulu se-pharmacological sento esiqukethwe ku-glucophage long 500 sihloselwe ukwehlisa ngempumelelo ushukela egazini lomuntu.
IMetformin, eyingxenye yemithi, ayikwazi ukukhuthaza ukukhiqizwa kwe-insulin eyengeziwe ngamaseli e-beta. Ngalesi sizathu, ukuthatha lo muthi akuvusi ukukhula kwesimo se-hypoglycemic emzimbeni. Isenzo sengxenye esebenzayo sihlose ukwenza ukuthi ama-receptors of izicubu zomzimba ancike kwi-insulin atholakale kulolwelwesi lwamaseli.
Ngemuva kokuthatha i-Glucofage Long 500, ukwanda kokuzwela kwama-cell receptors kuma-insulin kuyabonakala, okuholela ekwandeni kwezinga lokusebenzisa i-glucose kusuka ku-plasma yegazi.
Ngaphezu kwalokho, kunokwehla okukhulu kwesilinganiso se-glucose eyenziwe ngamaseli wesibindi ngenxa yokwenza kusebenze izinqubo zokuvimbela i-glycogenolysis ne-gluconeogeneis.
I-Metformin, eyingxenye yamathebulethi, ibangela ukubambezeleka kokufakwa kwe-glucose kusuka ku-lumen yamapheshana esiswini ngamaseli odonga wamathumbu. Yikuphi okwehlisa ukudonswa kwama-carbohydrate ku-plasma yegazi. Lokhu kubuye kunciphise ukuhlanganiswa kwezakhi zomzimba ze-carbohydrate emzimbeni.
I-Metformin isebenzisa izinqubo ezibhekele ukwenziwa kwe-glycogen. Ukwenza kusebenze kwenzeka ngenxa yomphumela we-metformin ku-glycogen synthetase.
Ukungena kwengxenye esebenzayo emzimbeni kukhulisa umthamo wanoma iyiphi i-membrane glucose transporter.
Iningi leziguli ezithatha i-Glucofage Long libonisa ukuthi umuthi ubasizile ukuthi bawenze ngokwejwayelekile amazinga abo kashukela.
Ngaphezu kwalokho, ithuluzi likhuthaza ukulahleka kwesisindo elifanele, okuyinto ebalulekile ekwelapheni isifo sikashukela.
Ngokwengeziwe, umuthi unomthelela ku:
- ukwenziwa okujwayelekile kwezinqubo ze-metabolic;
- ukutjheja ukuqhekeka kwama-carbohydrate angena emzimbeni kanye nokudla;
- ukulungiswa kwendlela yemvelo yokukhiqizwa kwe-insulin, ngenxa yalokho isilinganiso se-carbohydrate;
- ukulawula kwe-cholesterol yegazi.
Ukusekela lokhu, ukubukeza kweziguli kuzwakala, ngokwesibonelo, ukuthi, ngiphuza noma ngiphuza i-Glucofage futhi ngenxa yalokho, isisindo somzimba wami sibuyele kokujwayelekile.
Lapho uthatha i-Glucofage, kukhona ukwehla kwesifiso sokudla, okunciphisa izinga lokuqotshwa kwamafutha emzimbeni.
Ukwehla kwesifiso sokudla kufaka isandla esivamile kwesisindo somzimba sesiguli esinesifo sikashukela.
Imiphumela emibi nokusebenzisana nezinye izidakamizwa
Izici ezinhle iGlucophage Long 500 enazo zichaziwe ngenhla.
Manje udinga ukucacisa ukuthi imiphi imiphumela emibi lo muthi ongaba nayo, futhi nokuthi yikuphi lapho kungcono khona ukwenqaba ukwelashwa ngalo muthi.
Ngakho-ke, kungaziphi izimo lapho kungcono ukungawuphuzi umuthi:
- isikhathi sokukhulelwa kwabesifazane, kanye nesikhathi lapho umama ancelisa ingane yakhe;
- ukuphuza ngokweqile utshwala;
- lapho kunezinkinga ezisobala ngesibindi;
- ukhubazeka kwisifo sikashukela;
- nezinkinga zokuchama, okuhambisana ne-pathology yezinso;
- emva kwe-myocardial infarction;
- lapho kuba nezinkinga ngohlelo lokuthinta kwenhliziyo;
- isimo esibuhlungu esibuhlungu noma esisetshenziswayo.
Kuzo zonke lezi zimo, kungcono ukwenqaba ukwelashwa ngalo muthi. Ngasikhathi sinye, futhi ungasebenzisi izifaniso zalo muthi. Umthelela wento ebalulekile esebenza emzimbeni kulezi zimo ezingenhla ungadala ukulimala okungalingani empilweni yabantu.
Vele, kunezimo eziningi lapho umuthi usize isiguli ngempela, kodwa futhi kunobufakazi bokuthi bungaba yingozi empilweni.
Ikakhulu ikakhulukazi, iqiniso lokugcina kwenzeka ezimweni lapho iziguli zinganaki izeluleko zikadokotela futhi ziqale ukwelashwa zodwa.
Imiyalo yokusebenzisa umuthi
Ukusiza ukuguqula ushukela emzimbeni wesiguli, umphumela uba lapho isiguli sibona kahle umthamo ngesikhathi sokwelashwa kanye nohlobo lomuthi.
Ngenxa yokuthi umuthi uqukethe indawo esebenza isikhathi eside, kwanele ukuthatha amaphilisi kanye ngosuku. Futhi kungcono ukukwenza ebusuku.
Uma ukwelashwa kwenziwa ngokuya ngemiyalo yokusetshenziswa, kuyakhonjiswa - isikhathi sokuthatha umuthi sithatha izinsuku eziyishumi kuya kweziyi-20. Ngemuva kwalokho, ikhefu elifushane lenziwa lihlala inyanga eyodwa kuya kwezinyanga ezimbili, kuthi emva kwalokho ukwelashwa kuqhubeke ngokuhambisana nemiyalo kadokotela oholayo.
Uhlobo oluthile lokwelashwa lungabekelwa isiguli ngasinye, kucatshangelwa izici zomzimba wakhe kanye nokuxilongwa okukhulu. Imvamisa, le ndlela yokwelashwa inqunywa udokotela osebenza ngokuphelisa, ekuqaleni enza ukuhlolwa okugcwele kwesiguli, futhi kuphela emva kwalokho onquma inkambo oyifunayo yokwelashwa.
Lokhu kungenxa yokuthi umuntu ngamunye onesifo sikashukela unezimpawu zakhe zomzimba. Ngamanye amagama, emvelweni ayikho into enjalo yesibili ebingaba nezimpawu ezifanayo. Ngakho-ke, irejimeni yokwelashwa ihlala ichazwa ngudokotela uqobo futhi ingahlukahluka kulezo zincomo udokotela azinika esinye isiguli.
Kulokhu, akunzima ukuphetha ngokuthi akumele uqale ngokuphuza umuthi ngokwakho. Okokuqala udinga ukubonana nodokotela onolwazi we-endocrinologist.
Lo muthi, kanye nama-analogues awo, nawo afaka iMetformin Long, unqunyelwe ekuhlonzeni okunjalo:
- thayipha isifo sikashukela 2 ezigulini ezisencane;
- ukwelashwa kwezifo ezinoshukela ngaphandle kokusebenzisa ezinye izidakamizwa ezinciphisa ushukela (i-monotherapy);
- ezigulini ezineminyaka engaphansi kwengu-18 ubudala, umuthi usetshenziswa ngokuhlanganisa ukwelashwa ne-insulin therapy;
- lapho ukudla nokuzivocavoca kungasizanga ukususa ushukela omningi emzimbeni;
- nezinkinga zesisindo somzimba (zokunciphisa umzimba okusebenzayo).
Ngokusekelwa kulolu lwazi, kuba sobala ukuthi umuthi usetshenziselwa ikakhulukazi abanesifo sikashukela, abathi, ngemuva kwesifo esiyisisekelo, banezinkinga ezisobala zokukhuluphala ngokweqile.
Kuyaqapheleka ukuthi incazelo yesidakamizwa esiqukethwe imiyalo inikezela ngemininingwane ephelele yokuthi umuthi usebenza kanjani emzimbeni nokuthi yiziphi izinqubo zokuphila eziyisisekelo ezithinta wona
Noma yisiphi isiguli kufanele siphuze umuthi wokukhipha isikhathi eside kuphela ngokuya ngemithamo enconywe udokotela ohambayo nangokuhambisana ngqo nerejimthi yokwelashwa eyenziwe ngudokotela obambelela endocrinologist.
Ukubuyekezwa kwezidakamizwa zeziguli nezeluleko zezokwelapha
Umuthi onjengeGlucofage Long 500 umuthi wesizukulwane esisha. Ilungele lezo ziguli ezifuna isenzo eside. Kuyasiza ukunciphisa kahle ushukela wegazi lesiguli. thuthukisa ukuthathwa kwe-glucose futhi wenze ngokwejwayelekile i-insulin synthesis.
Kepha lezi kuphela yizici eziyinhloko ze-Glucophage Long 500 imiyalelo yokusetshenziswa futhi kuphakamisa ukuthi umuthi usiza kakhulu ngesifo sikashukela nokukhuluphala.
Kodwa-ke, ukuze asize isiguli ngempela, kufanele uqale uhlolwe ngokuphelele bese uthola ukuthi isiguli sitholwa yini ngempela. Lokhu kuzosiza ukunquma irejimeni yokwelashwa efanele futhi, uma kunesidingo, ukukhetha imithi ezothathwa ihlanganiswe nalesi sidakamizwa. Kubalulekile futhi ukubekela eceleni ukungqubuzana okungenzeka kwesiguli esithile.
Kucace bha ukuthi namhlanje kukhona izifaniso zalesi sakhi sokwelapha. Kepha udinga ukuzikhetha ngokweseluleko sikadokotela kuphela, awunakuzinqumela ukuthi yiziphi izifanekiso zomuthi obekiwe ezingcono futhi ushintshe irejimeni yokwelashwa ekhona.
Ngokuqondene nokubuyekezwa okufana nesitayela se- "Glucophage, ngisindiswe unomphela kusuka kwesisindo eseqile" noma "bengihlale ngiphuza lo muthi iminyaka eminingi futhi isisindo sami sijwayelekile", bangaba yiqiniso impela, kepha kuphela uma lesi siguli sinaso Izinkinga ukumunca ushukela, ngamanye amazwi, isifo sikashukela. Thatha umuthi kuphela ukuze wehlise isisindo, ngaphandle kokuhlolwa kwasekuqaleni ngudokotela akunakwenzeka.
Iziguli eziningi zijabule ngezindleko zomuthi. Kumele kuqashelwe ukuthi intengo yezimpahla inengqondo kakhulu, ngakho-ke, iziguli eziningi zingakwazi ukukhokhela umkhiqizo. Kuyiqiniso, kukhona ukufana kwalo muthi, udokotela ohambelayo kuphela okufanele awutuse. Akufanele uthathe izingozi bese ukhetha ikhambi elilodwa noma elinye, kungcono ukwethemba uchwepheshe.
Isenzo samakhemikhali weGlucophage sichazwe kule vidiyo ekulesi sihloko.
