Ekucindezelweni okuphezulu, iLisinopril ne-Indapamide asetshenziswa ngokuhlanganiswa. Izidakamizwa ziyahambisana kahle, futhi umphumela ngenkathi uzithatha uphezulu kakhulu. Kungakapheli amahora angama-24, ingcindezi iyancipha, nomsebenzi wesicubu senhliziyo uyathuthuka. Ukhipha uketshezi oluvela emzimbeni luyakhuphuka, imikhumbi iyanda, futhi isimo somzimba jikelele sithuthuka nge-hypertension ye-arterial. Ukwelapha ukuhlanganisa kusiza ukunciphisa ingozi yezinkinga zesistimu yenhliziyo.
Isimo seLisinopril
Umuthi ungoweqembu le-ACE inhibitors. Into esebenzayo yi-lisinopril dihydrate ngesilinganiso se-5.4 mg, 10,9 mg noma i-21.8 mg. Umuthi uvimbela ukwakheka kwe-angiotensin octapeptide, esiza ukwandisa umfutho wegazi. Ngemuva kokuphathwa, imithambo iyanda, umfutho wegazi uyancipha, futhi umthwalo osemisipha yenhliziyo uyancipha.
Ekucindezelweni okuphezulu, iLisinopril ne-Indapamide asetshenziswa ngokuhlanganiswa.
Ngokuhluleka kwenhliziyo, umzimba uvumelana ngokushesha nokusebenza ngokomzimba. Umuthi unomphumela we-antihypertensive, uvimbela ukwanda okubuhlungu ku-myocardium futhi kunciphisa ingozi yemiphumela emibi yemithambo yegazi nenhliziyo. Kuhlikiwe ngokushesha nangokuphelele kusuka emgodini wokugaya ukudla. Umenzeli uqala ukusebenza ngemuva kwehora eli-1. Kungakapheli amahora angama-24, umphumela uyakhuphuka, futhi isimo sesiguli sibuyele kwesejwayelekile.
Isebenza kanjani i-Indapamide
Leli thuluzi libhekisela kuma-diuretics. Ukwakheka kuqukethe into esebenzayo yegama elifanayo enanini le-1.5 noma le-2,5 mg. Umuthi ukhipha i-sodium, calcium, chlorine ne-magnesium emzimbeni. Ngemuva kokufaka isicelo, i-diuresis ivame kakhulu, futhi udonga lwe-vascular lube buthaka kancane esenzweni se-angiotensin 2, ngakho-ke ingcindezi iyancipha.
Umuthi uvimbela ukwakheka kwama-uree radical emzimbeni, wehlise okuqukethwe uketshezi kwizicubu, futhi uhlambe nemithambo yegazi. Akuthinti ukuhlangana kwe-cholesterol, glucose noma triglycerides egazini. Idonswa emgodini wokugaya ngama-25%. Ngemuva komthamo owodwa, ingcindezi iyaqina phakathi nosuku. Isimo sithuthuka kungakapheli amasonto ama-2 ukusetshenziswa njalo.
Umphumela ohlangene we-lisinopril ne-indapamide
Zombili lezi zidakamizwa zinegalelo ekunciphiseni ingcindezi esheshayo futhi ephumelelayo. Ngaphansi kwesenzo se-indapamide, ukulahleka kukamanzi kwenzeka futhi imikhumbi iphumule. ILisinopril dihydrate iphinde ithuthukise ukuphumula kwemithambo yegazi futhi ivimbele ukwanda okuphindaphindiwe kwengcindezi. Ukwelapha okuyinkimbinkimbi kunomphumela omenyezelwe ngokwengeziwe we-hypotensive.
ILisinopril ne-Indapamide zifaka isandla ekunciphiseni ingcindezi okusheshayo nokusebenzayo.
Izinkomba zokusetshenziswa ngasikhathi sinye
Ukuphatha okuhlanganisiwe kukhonjiswa ngokwenyuka isikhathi eside komfutho wegazi. I-Indapamide ngaphezu kwalokho isusa i-edema ekuhlulekeni kwenhliziyo okungapheli.
Contraindication eLisinopril nase-Indapamide
Akuvunyelwe njalo ukwamukela lezi zimali ngasikhathi sinye. Inhlanganisela yezidakamizwa icutshwa kwezinye izifo nemibandela ethile:
- ukukhulelwa
- ubudala
- ukungahambisani nezakhi zezidakamizwa;
- umlando we-angioedema;
- ukwehluleka kwezinso;
- izinga le-creatinine elingaphansi kwama-30 mmol / l;
- okuqukethwe kwe-potassium ephansi;
- ukungakwazi ukumunca i-lactose;
- ukwephulwa kokuguqulwa kwe-galactose ibe ushukela;
- isikhathi sokuncelisa;
- izingane ezingaphansi kweminyaka engu-18;
- isifo sikashukela mellitus;
- umfutho wegazi ophakeme.
Kwenqatshelwe ukuthatha ngasikhathi sinye imali equkethe i-Aliskiren. Ukuqapha kufanele kusetshenziswe ngokuqukethwe okunyukayo kwe-uric acid esegazini, isifo senhliziyo somoya, ukuphuma komzimba, inhliziyo engapheli kanye nokwehluleka kwezinso. Iziguli ezine-revenue stenosis yamazwe amabili, i-potassium ephezulu, kanye nokuntuleka kwe-cerebrovascular kudingeka zinciphise ukuphuza. Awukwazi ukuqala ukwelashwa ngokuhlinzwa kanye nokuhlinzwa, ukusetshenziswa kwama-anesthetics, amalungiselelo we-potassium kanye nesitho sokugeleza kokugeleza okuphezulu.
Ungayithatha kanjani iLisinopril ne-Indapamide
Ukwemukelwa kwenziwa ngaphandle kokubukwa kokudla. Umthamo wezidakamizwa uncike esimweni sesiguli kanye nokuphendula ekwelashweni nezidakamizwa ezihlanganisiwe.
Ngaphambi kokuqala ukwelashwa, udinga ukubona udokotela futhi uhlolwe.
Ukusuka ekucindezelweni
Isithako sansuku zonke esinconywayo somfutho wegazi ophakeme yi-1.5 mg ye-indapamide ne-5.4 mg ye-lisinopril dihydrate. Ngokubekezelela okuhle, umthamo ungakhuphuka kancane kancane. Isikhathi sokwelashwa okungenani amaviki ama-2. Umphumela wenzeka kungakapheli amasonto angama-2-4 ukwelashwa.
Ekuseni noma kusihlwa
Amathebulethi athathwa kangcono kanye ekuseni.
Imiphumela emibi
Ngesikhathi sokuphatha, ezinye izindlela ezingezinhle zingavela:
- komzimba
- Isiyezi
- ukukhwehlela
- ikhanda
- ukuthuthumela
- ukwehluleka
- ukuzindla kwenhliziyo;
- umlomo owomile
- ubunzima bokuphefumula
- umsebenzi owengeziwe wama-enzyme wesibindi;
- I-edema kaQuincke;
- ukukhuphuka kwegazi glucose;
- ukwehla kokuxineka kwe-chloride egazini;
- ukozela
- umsebenzi wokulimala we-renal kanye we-hepatic.
Uma kuvela izimpawu ezingenhla, kufanele ukhansele ukwamukela.
Umbono wodokotela
Elena Igorevna, udokotela wezifo zenhliziyo
Inhlanganisela ephumelelayo ye-diuretic ne-ACE inhibitor. Kuphephile kakhulu futhi kusebenza ngempumelelo kune-analogues. Ingcindezi iyancipha kungakapheli amasonto angama-2-4.
UValentin Petrovich, udokotela wenhliziyo
Ubungozi obuncane bemiphumela emibi. Kepha ebuntwaneni, inhlanganisela ayinqunyelwe, futhi iziguli esezikhulile nabantu abanokulimala kwesibindi noma ukusebenza kwezinso bangadinga ukulungiswa komthamo.
Ukubuyekezwa kweziguli
U-Elena, oneminyaka engama-42
Ngiqale ukuthatha izidakamizwa ezi-2 ngomthamo owengeziwe ngasikhathi sinye nge-hypertension - i-10 mg ye-lisinopril ne-2,5 mg ye-indapamide. Ngaphuza amaphilisi ekuseni, kwathi kusihlwa ngazizwa kahle. Ngemuva kwalokho ingcindezi yenyuka kakhulu yaba ngu-140/95 mm. Hg Bekufanele nginciphise umthamo. Imiyalo futhi ibhala ngemiphumela emibi ngendlela yokukhwehlela kanye nenausea. Izimpawu ziyavela ngokusetshenziswa isikhathi eside.
UmRoma, oneminyaka engama-37
Ngidla izidakamizwa ezi-2 ngokucindezela. Ayikho imiphumela emibi. Kwesinye isikhathi uzizwa unesiyezi, ngakho-ke udinga ukushayela ngokucophelela imoto.
