Ungayisebenzisa kanjani isidakamizwa i-NovoMix 30 Penfill?

I-NovoMix 30 Penfill ingumuthi we-hypoglycemic osuselwa esenzweni sezinhlobo ezimbili ze-insulin. I-pancreatic hormone yesenzo esifushane inomthelela ekuzuzeni okusheshayo komphumela wokwelapha, kuyilapho i-insulin enesikhathi esiphakathi ikuvumela ukuba ulondoloze umphumela we-hypoglycemic phakathi nosuku. Ukwelashwa kwe-insulin akuvunyelwe ukusetshenziswa yiziguli ezingaphansi kweminyaka engu-18 futhi kuvunyelwe ukuthi isetshenziswe ngabesifazane abakhulelwe, abakhipha izisu.

Igama Lezwe elingafanele

I-Biphasic aspart ye-insulin.

I-NovoMix 30 Penfill ingumuthi we-hypoglycemic osuselwa esenzweni sezinhlobo ezimbili ze-insulin.

I-ATX

A10AD05.

Khipha amafomu nokwakheka

Ifomu lomthamo - ukumiswa kokuphathwa kokuqonda. I-1 ml ka-ketshezi iqukethe i-100 IU yezakhi ezisebenzayo ezihlanganisiwe, ezibandakanya ama-70% we-insulin protamine aspart ngendlela yamakristalu kanye ne-30% ye-solulin ye-insulin. Ukwandisa amanani we-pharmacokinetic, izinto ezisizayo zongezwa ezintweni ezisebenzayo:

• glycerol;
• i-carbolic acid;
• i-sodium chloride ne-zinc;
• metacresol;
• dihydrogenated sodium hydrogen phosphate;
• protamine sulfate;
• i-sodium hydroxide;
• 10% hydrochloric acid;
• oyinyumba amanzi wokujova.

Umuthi ufakwe emigqonyeni yama-cartilitha ayi-3 aqukethe ama-300 IU wezinto ezisebenzayo. INovoMix Penfill (Flexpen) nayo iyatholakala ngesimo sepeni.

Isenzo se-Pharmacological

I-NovoMix imelela i-insulin enezigaba ezimbili, ehlanganisa izifaniso ze-hormone yokuqothula komuntu:

• Ama-30% ahlanganayo lapho esebenza kancane;
• Ama-70% ama-protamine insulin amakristalu anomphumela wesikhathi wesikhathi.

UNovoMix wethula i-biphasic insulin.

I-insulin aspart yenziwa kusetshenziswa ubuchwepheshe be-DNA recombination kusuka kunhlobo yemvubelo yombhaki.

Umphumela we-hypoglycemic ubangelwa ukubopha kwe-aspart kuma-insulin receptors kulwelwitho lwangaphandle lwama-myocyte namaseli we-adipose izicubu. Ngokuhambisana, ukuthintela kwe-gluconeogenesis esibindini kuyenzeka futhi nokuhamba kwe-glucose kwe-intracellular kukhuphuka. Njengomphumela wokuthola umphumela wokwelapha, izicubu zomzimba zithatha ushukela ngokuphumelelayo futhi ziqhubekele kumandla.

Umphumela wesidakamizwa ubonwa imizuzu eyi-15-20, ufinyelela umphumela omkhulu ngemuva kwamahora we-2-4. Umphumela we-hypoglycemic uhlala amahora angama-24.

I-Pharmacokinetics

Ngenxa yokuba khona kwe-aspartic acid, i-insulin aspart ifakwe ngempumelelo ezingxenyeni ezingaphezulu zamafutha esikhumba, ngokungafani ne-insulin. Lapho zingena egazini, izinto ezisebenzayo zifinyelela ekujuleni okuphezulu ku-serum yegazi kungakapheli imizuzu engama-60. Ukuqedwa kwesigamu sempilo kwenza imizuzu engama-30.

Izinkomba ze-insulin zibuyela kumanani azo okuqala kungakapheli amahora angama-15-18 ngemuva kokuphathwa kwe-sc. Izithako zokwelapha zitholakala kusibindi kanye nezinso. Imikhiqizo ye-Metabolism ishiya umzimba ngenxa yokufayiliswa kobukhazikhazi.

Lapho zingena egazini, izinto ezisebenzayo zifinyelela ekujuleni okuphezulu ku-serum yegazi kungakapheli imizuzu engama-60.

Izinkomba zokusetshenziswa

Ukwelashwa kwe-insulin kubekelwe lezi zimo ezilandelayo:

• isifo sikashukela esithembele ku-insulin;
• ushukela ongaxhomekeli kwe-insulin onemikhawulo yokungondleki okungenampilo, ukwandisa ukuzivocavoca umzimba nezinye izindlela zokunciphisa isisindo somzimba.

Contraindication

Umuthi awuvunyelwe ukuthi unikezwe abantu abanokulimala okuthe xaxa ezingxenyeni zamakhemikhali ezenza i-hypoglycemic agent. Lolu hlobo lwe-insulin alulungele abantu abangaphansi kweminyaka engu-18 ubudala.

Ngokunakekela

Iziguli ezinenkinga yokusebenza kwesibindi nezinso ngesikhathi sokwelashwa kwe-insulin zidinga ukubheka isimo sezitho zomzimba ngezikhathi ezithile. Ukungasebenzi kwabo kahle kungadala ukukhathazeka kwe-insulin.

Abantu abanenkinga yokujikeleza kobuchopho kanye nokwehluleka kwenhliziyo okuhlala njalo kufanele baqaphele.

Abantu abanenkinga yokujikeleza kwengqondo kufanele banake.

Ungayithatha kanjani i-NovoMix 30 Penfill

Umuthi uphathwa kuphela ngaphandle kokuzenzela. I-Intramuscularly and intravenly ayivunyelwe ngenxa yokuvela okungenzeka kwe-hypoglycemia.

Umthamo unqunywa udokotela ngokuya ngezinkomba ezizodwa zoshukela wegazi kanye nesidingo sesiguli se-insulin. Iziguli ezinesifo sikashukela esingancedi i-insulin zingabekwa njengeNovoMix njenge-monotherapy ene-insulin futhi zihlanganiswe nama-hypoglycemic agents. Ngokwesifo sikashukela sohlobo 2, kunconywa ukuqala ukusebenzisa i-NovoMix ngomthamo wamaayunithi ayi-6 ekuseni ngaphambi kokudla nakusihlwa. Ukujova kuvunyelwe ngamayunithi ayi-12 omuthi ngomjovo owodwa ngosuku ngaphambi kokudla.

Inqubo yokuhlanganisa i-Insulin

Ngaphambi kokusebenzisa, qiniseka ukuthi izinga lokushisa lokuqukethwe kwebhokisi lebhokisi lokushisa lifana nokushisa kwemvelo. Ngemuva kwalokho, hlanganisa i-insulin ngokuya nge-algorithm elandelayo:

1. Ekusetshenzisweni kokuqala, gingqa ibhokisi lemikhumbi izikhathi eziyi-10 phakathi kwezintende endaweni enezingqimba izikhathi eziyi-10.
2. Phakamisa i-cartridge ngokuthe nkqo izikhathi eziyi-10 bese uyihlisa ngokuqondile ukuze ibhola lengilazi lihambisane nalo lonke ubude bebhokisi. Ukuze wenze lokhu, kwanele ukugoba ingalo kuhlanganwe ngokuhlangana.
3. Ngemuva kokuqeda ukukhohlisa, ukumiswa kufanele kube ngamafu futhi kutholwe i-tint emhlophe. Uma lokhu kungenzeki, izinqubo zokuxuba ziyaphindwa. Lapho uketshezi seluhlanganisiwe, i-insulin kufanele ifakwe ngokushesha.

Isingeniso ngasinye senziwa ngenalithi entsha.

Ukwethulwa kobuncane bama-PIECES ayi-12 ento esebenzayo. Uma inani le-insulin liphansi, lapho-ke udinga ukufaka esikhundleni se-cartridge entsha.

Ungayisebenzisa kanjani ipeni yesirinji

Ngaphambi kokusebenzisa ipeni, hlola ukuhambisana nohlobo lwe-insulin. Ngaphambi komjovo wokuqala, kuxutshwa ngokulinganayo.

Isingeniso ngasinye senziwa ngenalithi entsha. Ukushintsha into kuyadingeka ukunciphisa amathuba wokutheleleka. Ngaphambi kokuwusebenzisa, qiniseka ukuthi inaliti ayigoqiwe noma yonakaliswa. Ukuze unamathisele inaliti, udinga ukulandela i-algorithm elandelayo:

1. Susa isembozo esivikela entweni elahlekayo, bese usonteka ngokuqinile inaliti epeni lesirinji.
2. Isimbobo sangaphandle siyasuswa kodwa asihlukaniswe.
3. Baqeda cap yangaphakathi.

Naphezu kokusebenza okufanele kweNovoMix, umoya ungangena ku-cartridge. Ngakho-ke, ngaphambi kokusebenzisa ipeni lesirinji, kuyadingeka ukuvikela ukungena kwalo izicubu ngokwenza okukhohlisayo okulandelayo:

1. Shayela amayunithi ama-2 nesikhethi sethamo.
2. Ukubamba i-FlexPen iqondile ngenaliti phezulu, thepha kancane ekholiniini ngomunwe wakho amahlandla ama-4-5 ukuze isisindo somoya siqhubekele phezulu kwekhabethe.
3. Ukuqhubeka nokubamba ipeni lesirinji ngokuqondile, cindezela i-valve ye-trigger yonke indlela. Bheka ukuthi okhethiweyo womthamo ubuyile yini esikhundleni 0 futhi kwavela iconsi lomuthi esicongweni senalithi. Uma ungekho umuthi, lapho-ke udinga ukuphinda inqubo. Uma, ngemuva kwezikhathi ezi-6, i-insulin ingangeni ngenalithi, lokhu kubonisa ukungasebenzi kahle kwe-FlexPen.

Ngaphambi kokuwusebenzisa, qiniseka ukuthi inaliti ayigoqiwe noma yonakaliswa.

Umthamo usethwe kusetshenziswa isithasisi somuthi, okufanele sibe sesimweni 0. Isikhethi sokunquma umthamo singaguqulwa ngokuhamba kwesikhathi nangokubala kwewashi. Kepha kwinqubo udinga ukuqaphela - awukwazi ukucindezela i-valve yokuqala, ngaphandle kwalokho kuzoba nokukhululwa kwe-insulin. Inombolo 1 ihambelana neyunithi elilodwa le-insulin. Ungabeki umthamo owedlula inani le-insulin esebhokisini.

Ukuze wenze umjovo, udinga ukucindezela i-trigger valve yonke indlela kuze kube yilapho isikhundla 0 sikhonjiswa esikhethi futhi ngenkathi inalithi ihlala ngaphansi kwesikhumba. Ngemuva kokubeka isikhundla se-zero kwesikhethi, shiya inaliti esikhunjeni okungenani imizuzwana eyi-6, ngenxa yokuthi kuzobe kwethulwe i-insulin ngokuphelele. Ngesikhathi sesingeniso, okhethiwe akufanele avunyelwe ukushintshana, ngoba uma ijikelezwa, i-insulin ngeke ikhishwe. Ngemuva kwenqubo, faka inaliti kwekholi yangaphandle futhi ungakhiphi.

Imiphumela emibi yeNovoMix 30 Penfilla

Ukuphendula okungalungile ezimweni eziningi kucasulwa ukukhethwa komthamo ongafanele noma ukusetshenziswa okungafanele kwesidakamizwa.

Engxenyeni yesitho sombono

Ukuphazamiseka kwe-ophthalmic kuhambisana nokukhula kwamaphutha angama-Refractive kanye ne-retinopathy yesifo sikashukela.

Isistimu yezinzwa ephakathi

Ukuphazamiseka kwesistimu ye-nerve kuvezwa ezimweni ezingandile ngokubonakala kwe-perneheropathy ye-peripheral. Mhlawumbe ukuthuthukiswa kwesiyezi kanye nekhanda.

I-NovoMix 30 Penfill ingadala isiyezi.

Engxenyeni yesikhumba

Imijovo ese-subcutaneous kufanele ibekwe ezindaweni ezahlukene ngaphakathi kwendawo efanayo ye-anatomical ukuvikela ukuthuthukiswa kwe-lipodystrophy. Mhlawumbe ukubukeka kokusabela endaweni yomjovo - ukuvuvukala noma ubomvu. Ukubonakaliswa kwe-allergic ngendlela yamaphashazi noma ukulunywa kuziphumele ngaphandle kokuncipha komthamo noma ukuhoxiswa kwezidakamizwa.

Kusuka emasosheni omzimba

Ukuphazamiseka kokugomela kuhambisana nokuvela:

• i-urticaria;
• isikhumba esikhanyayo;
• ukuqhuma
• ukuphazamiseka kokugaya ukudla;
• ubunzima bokuphefumula
• ukukhuphuka kokujuluka.

Ngasohlangothini lwe-metabolism

Ukuphazamiseka kwemetabolic kubonakaliswa ukulahleka kokulawulwa kwe-glycemic. Ukuthuthukiswa kwe-hypoglycemia akuhlanganisiwe, ikakhulukazi ukusetshenziswa okufanayo kwezidakamizwa ze-hypoglycemic zomlomo.

Iziguli ezinqunyelwe ukusabela kwe-anaphylactic zisengozini yokuthola ukushaqeka kwe-anaphylactic.

Allergies

Ezigulini ezichazwe ngaphambi kokuvela kokuqubuka kwe-anaphylactic, kunengozi yokuqhaqha kwe-anaphylactic, i-angioedema yolimi, umphimbo, ne-larynx. Ngokungabekezeleli komuntu ngamunye kwizakhi zesakhiwo, ukuvela kwesikhumba kungenzeka.

Imiyalo ekhethekile

Ngomthamo onganele we-ejenti ye-hypoglycemic noma ngokuhoxiswa okubukhali kokulashwa, i-hyperglycemia ingahle ikhule. Ukugxila kwe-glucose ephezulu ye-serum kungaholela ku-ketoacidosis yesifo sikashukela uma isiguli singakutholi ukwelashwa okufanele. Ingozi yokuthola inqubo ye-pathological iyanda ezigulini ezinesifo sikashukela sohlobo 1. I-Hyperglycemia ibonakala ngokubonakala kwezimpawu ezinjalo:

• ukoma okukhulu;
• i-polyuria enezinto eziningi zokuchama;
• ubomvu, ikhasi, isikhumba esomile;
• ukuphazamiseka kokulala;
• ukukhathala okungapheli;
• isicanucanu nokuhlanza;
• ulwelwesi lwe-mucous olomile emlonyeni;
• iphunga le-acetone ngesikhathi sokuphefumula.

I-Hyperglycemia ibonakala ngokubonakala komile kakhulu.

I-Hyperglycemia iboniswa isicanucanu nokuhlanza.

I-Hyperglycemia ibonakala nokuphazamiseka kokulala.

I-Hyperglycemia ibonakala ngokukhathala okungapheli.

Ngomsebenzi owandayo womzimba, ukungahambisani nokwelashwa kokudla noma ukweqa umjovo, i-hypoglycemia ingaqhamuka.

Sebenzisa ebudaleni

Iziguli ezineminyaka engaphezu kwengu-65 azidingi ukulungisa umthamo.

Ukuqokwa kweNovoMix 30 Penfil yezingane

Kwenqatshelwe ukufaka lo muthi ezinganeni ezingaphansi kweminyaka engu-18 ngenxa yedatha enganele ngemiphumela yokuhlanganiswa kwe-insulin ekusebenzeni kwezitho ezinganeni nasebusheni.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ukwelashwa kwe-insulin kusiza ngempumelelo ukunciphisa ushukela kwabesifazane ngesikhathi sokukhulelwa. I-Aspart ye-insulin ayithinti ukukhula kwemvelo kwe-umbungu futhi akubangeli ukungasebenzi kahle kwe-intrauterine. Umuthi awudluleli kubisi lwebele, ngakho-ke lungasetshenziswa ngesikhathi sokuqunjelwa.

I-overdose ye-NovoMix 30 Penfill

Ngokuhlukunyezwa kwesidakamizwa se-hypoglycemic, izimpawu zokweqisa kungenzeka. Isithombe somtholampilo sivelelwa ukukhula kancane noma okubukhali kwe-hypoglycemia, ngokuya ngomthamo olungiselelwe. Ukwehla kancane ushukela, ungasusa inqubo ye-pathological ngokwakho ngokufaka ushukela, i-confectionery noma ukudla okuqukethe i-carbohydrate. Ngenxa yokuvela kwe-hypoglycemia, kunconywa ukuthi abanesifo sikashukela baphathe ukudla okunoshukela ophezulu nabo.

Endabeni ye-hypoglycemia enzima, isiguli siphelelwa amandla.

Endabeni ye-hypoglycemia enzima, isiguli siphelelwa amandla. Esimweni esiphuthumayo, kuyadingeka ukuthi kwenziwe umjovo we-intramuscular noma subcutaneous of 0.5 noma 1 mg we-glucagon ngaphansi kwezimo zokuma; isixazululo se-dextrose esingama-40% singalawulwa ngokungena uma ukwazi kwengqondo kwesiguli kungabuyiswanga.

Ukuxhumana nezinye izidakamizwa

Akukho ukungahambelani emtholampilo kweNovoMix nezinye izidakamizwa kwembulwa phakathi nokuhlolwa kliniki. Ukusetshenziswa okufanayo kweminye imithi kuholela ekwandeni noma ekuncipheni komphumela we-hypoglycemic.

Ukuhambisana notshwala

I-Ethanol inegalelo ekulahlekelweni kokulawulwa kwe-glycemic. Utshwala bukhulisa noma buthonya imiphumela yomuthi, ngakho-ke akufanele uphuze utshwala ngesikhathi sokwelashwa.

Ukusetshenziswa okufanayo kweminye imithi kuholela ekwandeni noma ekuncipheni komphumela we-hypoglycemic.

Ama-Analog

Ukushintshela kolunye uhlobo lwe-insulin kwenziwa ngaphansi kokubhekwa kwezokwelapha okuqinile. Kusuka ku-analogues:

• IVosulin;
• IGensulin;
• I-Insuvit;
• I-Insugen;
• I-Insuman;
• UMikstard;
• I-Humodar.

Imibandela yekhefu lekhemisi

Umuthi ungathengwa kuphela ngokubhaliwe.

Ngingakwazi ukuthenga ngaphandle kadokotela

Ngokusetshenziswa kabi kwesidakamizwa, i-hypoglycemia enzima ingakhula, ngakho-ke, ukwelashwa kwe-insulin ngaphandle kwezinkomba eziqondile zezokwelapha akuvunyelwe.

Intengo

Intengo ejwayelekile yomenzeli we-hypoglycemic ngama-ruble ayi-1821.

Izimo zokugcina zomuthi

Ama-Cartridges agcinwe endaweni emnyama ekushiseni kwe- + 2 ... + 8 ° C ngaphandle kweqhwa.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emi-2

Umkhiqizi

INovo Nordisk, eDenmark.

Ukubuyekezwa

UTatyana Komissarova, oneminyaka engama-22 ubudala, eYekaterinburg

Ngesikhathi sokukhulelwa, kwakukhona i-mellitus yesifo sikashukela sokukhulelwa, ngenxa yokuthi ngalandela ukudla okuqinile ngokugcina idayari nokubala amayunithi wesinkwa. Kepha lokhu akuzange kusize: ngemuva kokudla ushukela wakhuphukela ku-13 mmol. U-endocrinologist unikeze i-NovoMix insulin therapy, futhi wenqabela ukuphuza amaphilisi e-hyperglycemia. Ugxilwe amahlandla ama-2 ngosuku imizuzu emi-5 ngaphambi kokudla namayunithi weLevemir 2 ngaphambi kokulala. Ngifunde ukusebenzisa ipeni yesirinji, ngoba ilula kakhulu kunemijovo. Isixazululo asibangeli ukushiswa, kepha kwesinye isikhathi amabhuma avele. Ushukela ushaywe emuva ngokushesha. Ngishiya isibuyekezo esihle.

UStanislav Zinoviev, oneminyaka engama-34, eMoscow

Iminyaka emibili yokujova i-insulin ye-NovoMix. Nginesifo sikashukela sohlobo 2, ngakho ngisebenzisa kuphela amapeni wesirinji futhi angiphuthi amaphilisi. Umuthi wehlisela ushukela ku-6.9-7.0 mmol bese ubamba amahora angama-24. Uma weqa umjovo, khona-ke lokhu akubalulekile - umuthi ungasetshenziswa ngokuhambisana nezinye izinhlobo ze-insulin.Into esemqoka ukuthi umthamo kufanele uhambisane nemiyalo.