I-Amoxiclav iyinhlanganisela yezinto ezimbili ezisebenzayo: amoxicillin trihydrate ne-clavulanate. Umuthi olwa namagciwane ususelwa ezinhlwini ezinhlobonhlobo zamagciwane abangela ukungena kwezifo ezithweni ezahlukahlukene nezinhlelo.
I-ATX
I-J01CR02 Amoxicillin ehambisana ne-beta-lactamase inhibitor.
Umuthi olwa namagciwane ususelwa ezinhlwini ezinhlobonhlobo zamagciwane abangela ukungena kwezifo ezithweni ezahlukahlukene nezinhlelo.
Khipha amafomu nokwakheka
I-Amoxiclav 250 mg ingahlakazwa kwifomu lethebhulethi noma lokumiswa.
Izibhebhe zine-membrane yefilimu, zingombala ophuzi, octagonal ngesimo, i-convex nhlangothi zombili. Ngamunye uqukethe 250 mg we-amoxicillin no-125 mg we-clavulanic acid potassium usawoti.
I-Powder ingaba mhlophe noma iphuzi ngombala, ukumiswa kumele kube homogeneous. I-5 ml yesidakamizwa, eyenziwe ngokwemiyalelo yokusetshenziswa, iqukethe 250 mg ye-amooticillin no-62,5 mg we-acid.
Kumakhemisi, kunezindlela ezimbili zomuthi - i-powder ezisetshenziselwa umjovo, kanye namaphilisi okusabalalisa. Kepha lezi zinhlobo zinemithamo ehlukene yezinto ezisebenzayo.
Isenzo se-Pharmacological
Amathebulethi kanye ne-powder banezinto ezinama-bactericidal, i.e. ikhono lokubulala amagciwane amancane. Lesi sidakamizwa sisebenza kumagciwane amaningi, ngakho-ke, sibhekisa kuma-anti-spectrum ama-antibiotic.
I-Amoxicillin uhlobo lwe-penicillin (semisynthetic) olungamelana nama-beta-lactamases atholwe amanye amagciwane. Umphumela wazo kungenxa yokuvinjezelwa ku-microorganism yama-enzyme ahileleke ku-biosynthesis ye-peptidoglycan. Ngenxa yokuvezwa kwe-antibiotic, udonga lweseli lwe-bacterium luyabhujiswa, okuholela ekufeni kweseli.
Amathebulethi kanye ne-powder banezinto ezinama-bactericidal, i.e. ikhono lokubulala amagciwane amancane.
I-Clavulanate ayisetshenziswa ngokwehlukana, ngoba i-acid ngokwayo ayinamphumela we-antibacterial, kepha yandisa ukusebenza kwe-amoxicillin ngenxa yomthelela wayo kuma-beta-lactamases.
Emzimbeni, umuthi unomphumela kuwo womabili ama-gram (+) kanye nama-bacterium angenayo i-gram:
- I-Staphylococci.
- Klebsiella.
- E. coli.
- Wand kaPfeiffer.
- Abamele uhlobo lwe-Enterobacter.
- I-Moraxellus cataralis.
Umuthi futhi unemisebenzi yokulwa namanye ama-bacterium, anjenge-bordetella, i-brucella, i-clostridia, i-gardnerella, i-yersinia, i-chlamydia, i-treponema, njll.
I-Pharmacokinetics
Zombili izinto ezisebenzayo zinezimpawu ezifanayo. Zi-soluble kakhulu emanzini nezixazululo ezinezinkomba zomzimba ze-acidity. Ngakho-ke, umuthi udonswa ngokushesha ungene egazini kusuka kwizitho zokugaya, i-bioavailability ifinyelela kuma-70%. Imizuzu engama-60 ngemuva kokuphathwa, ukuqoqwa kwezinto kuncishiswa ngesigamu.
Izinto zitholakala kalula uma zithathwa ekuqaleni kokudla.
Izinto zitholakala kalula uma zithathwa ekuqaleni kokudla.
I-Amoxiclav ayinawo amandla okungena emithanjeni ingena ezingqondweni (uma kungekho zimpawu zokuvuvukala kumagobolondo ayo). Kepha nge-placenta, umuthi ungena, ubuye udlule ubisi lwebele. Amoxicillin trihydrate isuswa emzimbeni ngokusebenzisa izinso, bese i-clavulanate inezindunduma nomchamo.
Izinkomba zokusetshenziswa
Umuthi usetshenziswa ekwelapheni izifo ezithathelwanayo ezibangelwa umsebenzi wamagciwane alwa namagciwane:
- Ukutheleleka kwe-ENT - i-sinusitis yempilo futhi engamahlalakhona, abezindaba ze-otitis, i-tonsillitis, i-tonsillitis, i-sinusitis, i-pharyngitis, njll.
- Izilonda zamaphaphu nesihlahla se-bronchial - inyumoniya kanye ne-bronchitis.
- Ukutheleleka nge-genitourinary and gynecological (isb., Endometritis, prostatitis, cystitis).
- Izilonda zesikhumba nezicubu ezithintekayo.
- Izifo zomlomo (odontogenic).
- I-Cholecystitis ne-cholangitis.
Contraindication
Umuthi olwa namagciwane awunqunyelwe ukusabela komzimba ezingxenyeni zomuthi, kufaka phakathi i-penicillin.
Uma isiguli sinomlando wama-pathologies wesibindi onzima owakhula nomuthi, khona-ke udokotela kufanele anikeze omunye umuthi.
Ngama-pathologies asesiswini, umsebenzi we-hepatocyte okhubazekile, ukwehluleka kwezinso kwe-grade 3, ukukhulelwa nokuncelisa ibele, umuthi unqunywa ngokuqapha. Ngenkathi udla nezidakamizwa ezinciphisa ukuguquguquka kwegazi, isimo sesiguli kufanele sibhekwe.
Ungayithatha kanjani i-Amoxiclav 250
Izibhebhe nokumiswa kwempuphu kuthathwa ngomlomo. Umthamo kanye nerejimeni kunqunywa udokotela ngokuya ngezimpawu zomuntu ngamunye. Izifundo zingahlala amasonto amabili. Ukunyuka kwesikhathi sokwelashwa kwenziwa ngemuva kokuhlolwa nokuhlolwa komzimba.
Indlela yokuhluza
I-powder ixutshwe namanzi ahlanzekile abilisiwe 20-25 ° C. Ngaphambi kokungeza amanzi, ibhodlela kufanele linyakaziswe ngamandla, emva kwalokho engeza u-85 mg koketshezi emthweni ohlukaniswe kabili. Ngemuva kokungezwa ngakunye kwamanzi, ukumiswa kufanele kuzanyazanyiswe kahle ukuncibilikisa i-powder. Umphumela kufanele ube yinto enhle kakhulu yombala omhlophe noma ophuzi-omhlophe.
Umkhiqizo oqediwe ugcinwa esiqandisini isikhathi esingaphezu kwesonto. Ngaphambi kokusetshenziswa, kufanele kulethwe ekushiseni kwegumbi, kepha kungashisi. Musa ukubanda.
Ukuze kube lula ukusebenzisa ukumiswa, kufakwa i-pipette noma isipuni sokulinganisa kwiphakeji ngalinye le-powder.
Ukuze kube lula ukusebenzisa ukumiswa, kufakwa i-pipette noma isipuni sokulinganisa kwiphakeji ngalinye le-powder.
Umthamo wezingane
Ezinganeni ezingaphezulu kweminyaka engu-12-13 ubudala noma enesisindo esingaphezu kwama-39 kg, kusetshenziswa imithamo yabantu abadala.
Ingane eneminyaka eyisithupha ubudala, udokotela ubeka umthamo osuselwa eminyakeni yobudala, isisindo kanye nobunzima balesi simo. Kunconywa umthamo wansuku zonke we-40 mg / kg, ohlukaniswe ngezinhlelo ezi-3.
Kulungele kakhulu ukuba izingane zasenkulisa zinikeze ukumiswa. Ingane efinyelela ezinyangeni ezi-3 inqunywe i-15 mg / kg izikhathi ezi-2 ngosuku. Izingane ezineminyaka engaphezu kwalesi sikhathi - kusuka ku-7 kuye ku-13 mg / kg njalo emahoreni ayi-8 (ngosuku akukho ngaphezulu kwama-40 mg / kg).
Kwabadala
Ukwemukelwa kuncike ebukeni bokutheleleka, ngobumnene nangokulinganiselayo - ithebhulethi engu-1 ekuseni, ntambama nasesitolo sokulala. Uma ukutheleleka kubi kakhulu, udokotela unquma amaphilisi ngomthamo we-500 noma 875 mg amoxicillin.
Isiguli kufanele silandele imiyalo kadokotela futhi singabeki amanye amaphilisi ama-2 we-250 mg nge-500 mg eyodwa.
Umthamo omkhulu wokumiswa okuqediwe ngu-5 ml ngosuku.
Ukuqokwa kwe-Amoxiclav kushukela kunesizathu, ngoba kuvimbela ukutheleleka kwezindawo zesikhumba nge-trophy engasebenzi.
Ukuthatha umuthi wesifo sikashukela
I-Amoxiclav ayithinti ushukela wegazi, akukho bungozi bokuthuthukisa i-hyperglycemia. Inhloso umuthi walesi sifo kufanelekile, ngoba kuvimbela ukutheleleka kwezindawo zesikhumba nge-trophy engalimele.
Imiphumela emibi
Amathebulethi ne-powder enohlu olulodwa lokuphendula okungahambi kahle, indlela yokukhishwa ayithinti lesi sikhombisi.
Amapheshana wesisu
Izimpawu ze-dyspepsia: i-nausea kuze kufike ekuhlanzeni, kuhudo, ebuhlungwini be-epigastric kanye nokuphelelwa yisifiso sokudla. Izinqubo zokuvuvukala emgodleni womlomo (i-stomatitis ne-glossitis) kanye ne-discoloration ye-enamel yezinyo. I-Enterocolitis ne-hemorrhagic colitis kungenzeka emathunjini. Umuthi ungathinta ukusebenza kwesibindi, okubonakaliswa ngokwanda komsebenzi wama-enzyme awo, ukwanda kwe-bilirubin, jaundice, hepatitis.
Izitho zeHematopoietic
Yehla ngenombolo yama-leukocytes nama-neutrophils (aguqukayo), amapuleti egazini. Izimpawu ze-hemolytic anemia, isikhathi esandisiwe sokuqina. Ukwanda kwenani lama-eosinophils nama-agranulocytes.
Isistimu yezinzwa ephakathi
I-Cephalgia nesiyezi, kuyaqabukela ukuqunjelwa.
Kusuka ohlelweni lomchamo
I-Tubulo-interstitial nephritis, igazi, kanye namakristalu emchameni.
Allergies
Ukuzwela ngokweqile kwezingxenye ze-Amoxiclav kungabonakala ngokuqhuma, ukulunywa, i-vasculitis ye-allergic, ukushaqeka kwe-anaphylactic, i-edema kaQuincke.
Imiyalo ekhethekile
Ukwelashwa ngama-antibiotic kufanele kuhambisane nokuqapha ukusebenza komzimba.
Uma kunezimpawu zokuvelela, udokotela ushintsha ukwelashwa.
Ukuthatha i-antibiotic kungashintsha ukwakheka kwe-microflora yamathumbu kanye nowesifazane. Ngakho-ke, udokotela angabeka eminye imishanguzo ukuvikela izimo ezinjenge-dysbiosis ne-candidiasis.
Ukuhambisana notshwala
Ayikho imininingwane ngomthelela wotshwala kuma-pharmacokinetics omuthi. Kodwa odokotela abazikhuthazi iziphuzo eziqukethe utshwala ngesikhathi sokwelashwa. Umzimba buthakathaka ukutheleleka, isibindi nezinso kuthatha ukushaya okuphindwe kabili lapho kwenziwa inqubo nokuqeda ama-metabolites otshwala nomuthi.
Odokotela abazikhuthazi iziphuzo eziqukethe utshwala ngesikhathi sokwelashwa.
Umthelela ekhonweni lokulawula izindlela
Ngenxa yamathuba okuphendula okuphambene nohlelo oluphambili lwezinzwa, imisebenzi edinga ukugxilwa kufanele ihambisane nokuqapha nokunaka ukunakwa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Izakhi zomuthi zidlula kwi-placenta zingene ebisini lwebele, ngakho-ke i-Amoxiclav inqunywa kuphela uma inzuzo yokwelapha idlula ubungozi obukhona.
Sebenzisa umsebenzi wesibindi okhubazekile
Ezigulini ezine-pathologies yesibindi, umuthi unqunyelwe, kepha ngesikhathi sokwelashwa, udokotela kufanele aqaphele ukusebenza kwesitho ngokuhlola izivivinyo.
Isicelo sokusebenza kokulimala kwezinso
Ngezinga eliphansi lokunganele futhi i-creatinine imvume engaphezulu kwama-30 ml / min, umthamo awushintshiwe. Ama-pathologies amakhulu adinga ukulungiswa kokulungiswa nokutholwa noma ukunciphisa imvamisa yokuphatha.
Ama-pathologies amakhulu ezinso adinga ukulungiswa kokuqapha nokutholwa noma ukunciphisa imvamisa yokuphatha.
Ukweqisa
Ukufa okubangelwa yi-overdose akuchazwanga. Izimpawu zokuphuza ngokweqile ziwukungaboni kahle esiswini, uhudo kanye nokuhlanza. Izinkathazo nezinkinga zokulala zingavela, futhi ezimweni ezingazodwa zibanjwa ziqunjelwa.
Ukwelashwa okubonakalayo kwenziwa esibhedlela. Uma ngabe sekudlule amahora angama-4 ngemuva kokuphathwa, khona-ke kuqhamuke ukuhanjiswa kwesisu nemithamo emikhulu yekhabhoni esebenzayo. I-Hemodialysis iyasebenza.
Ukuxhumana nezinye izidakamizwa
Uma isetshenziswa ngasikhathi sinye novithamini C, khona-ke ukumunca izakhi zezidakamizwa ezivela emgudwini wesisu kunganda. Ngokuphambene, ama-antacid, ama-laxatives nama-aminoglycosides anciphisa ukungena kwezinto emzimbeni wegazi.
Izidakamizwa ezivimbela ukucasulwa kwama-tubules zikhulisa ukugcwala kwe-Amoxiclav egazini, ngoba isuswa izinso.
Ukuhambisana ne-metatrexateampofu, ngoba i-amooticlav yandisa ubuthi bayo.
Akunconywa ukunquma nge-rifampicin (abamelene nayo), ama-sulfonamides, ama-tetracyclines nama-macrolides, ngoba yonke le mithi ivimbela umphumela we-Amoxiclav.
Abesifazane beminyaka yokuzala badinga ukucaciswa ukuthi i-Amoxiclav ithinta kabi ukusebenza kwezindlela zokuvimbela inzalo yomlomo, ngenxa yalokho, ezinye izindlela zokuvimbela ukukhulelwa kufanele zisetshenziswe ngesikhathi sokwelashwa.
Abesifazane beminyaka yokuzala badinga ukucaciswa ukuthi i-Amoxiclav ithinta kabi ukusebenza kwezindlela zokuvimbela inzalo ngomlomo.
Analogs of Amoxiclav 250
Umkhakha wemithi unikeza izifaniso eziningi zomuthi:
- Flemoklav Solutab;
- I-Augmentin Syrup;
- I-Amoxiclav Quicktab;
- Kuhlanganiswe;
- I-Ecoclave;
- Panklav;
- I-Clamosar;
- Arlet
- I-Rapiclav;
- INovaklav;
- I-Baktoklav;
- UFibell;
- I-Medoclave;
- I-Amovicomb;
- I-Betaclava;
- Amoxicillin trihydrate + Potassium clavulanate.
- Isikhundla
- I-Foraclav.
Ukufaka umuthi esikhundleni esifanayo kufanele kwenziwe ngudokotela.
I-Augmentin iyi-analogue ye-Amoxiclav.
Imibandela yekhefu lekhemisi
Umuthi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Yize amanye amakhemisi eqhubeka nokuthengisa izidakamizwa ezinikezwa ngaphandle kwemibhalo evela kudokotela, minyaka yonke umthetho uqinisa ukulawulwa.
Intengo
Izindleko ezijwayelekile zempuphu ngama-ruble angama-298, ukufakwa kwamacwecwe ama-ruble angama-245.
Izimo zokugcina i-Amoxiclav 250
Amathebulethi nefulawa kufanele agcinwe emazingeni okushisa asendaweni kanye endaweni emnyama engafinyeleleki ezinganeni. Ukumiswa kugcinwa esiqandisini.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-2 Ukumiswa okulungiselelwe izinsuku eziyi-7.
Ukubuyekezwa kwe-Amoxiclav 250
Odokotela
UValery, owelaphi, eShlisselburg
Umuthi wanamuhla usetshenziswa kabanzi emikhakheni eminingi yezokwelapha. Isebenza ngokuphumelelayo ebangeni elibanzi lamagciwane, kufaka phakathi ama-antipenicillin amelana nemithi elwa namagciwane. Kukhishwa ngokuphelele emzimbeni, kungangeni entanjeni yomgogodla nange-BBB, ngakho-ke ingozi yemiphumela emibi evela ohlelweni lwezinzwa oluphakathi incane.
Ngaphandle kokuthi umuthi uyasebenza futhi uphephile, ngifuna ukuxwayisa iziguli ukuthi zingazinikezeli zona ngokwazo. Ukusetshenziswa okungalawulwa kwemithi elwa namagciwane kungaholela ekwakhiweni kwezinkinga, ukuvela ngokweqile kanye nokuvela kwezingqinamba ezibucayi okuzoba nzima ukuzilwela.
U-Eugene, udokotela wezingane, uNizhny Novgorod
Emithini yesimanjemanje, ukwelashwa kwezifo ezithathelwanayo kuqala ngokuphathwa kwekhambi elisebenzayo, kepha eliphephe kakhulu elinobubanzi besenzo. Umuthi owodwa onjalo yi-Amoxiclav. Izindlela ezahlukahlukene zokukhishwa zikuvumela ukuthi uwuphuze ngokunembile lapho uhanjiswa ezinganeni. Imiphumela emibi ayivelakancane.
UNatalia, udokotela wamazinyo, eSt
Ngasizathu simbe, abesifazane baqala ukuvela lapho bamukela, abanquma ukubuyela ngaphandle ezimeni ezinhlobonhlobo zomqubuko nge-amoxicillin. Ngenxa yalokhu, awukho umphumela, kodwa futhi bazitholela ukusabela okuhlukile ngendlela ye-eczema, dermatitis kanye ne-urticaria. I-Amoxiclav yikhambi elisebenzayo lezifo eziningi, kepha izinduna ziphathwa ngendlela ehlukile.
Iziguli
UTatyana, oneminyaka engama-35, eMoscow
Ithuluzi elisebenzayo elisiza wonke umndeni, ngenkathi lingabizi kakhulu emithini elwa namagciwane. Ingane ibekezelela kahle lapho isencane, banikeza ukumiswa, ngoba kuyimpilo ukusika amaphilisi abe izingxenye eziningi. Umyeni welashwa ngalezi zibhebhe zenyumoniya ekhwehlela okuqinile, kuhlanganiswa neminye imithi. Kepha ayilungele wonke umuntu, ngokwesibonelo, umngane akabekezeleli, uqala ukukhanda nokuhlanza.
ULarisa, oneminyaka engama-55, e-Arkhangelsk
Kuyangithokozisa ukuthi emakhemisi bayekile ukuthengisa ama-antibhiliya ngaphandle kadokotela. Ngaphandle kwalokho, umyeni wami owayene-prostatitis akakwazanga ukukholwa ukuthi aye kudokotela, wazama ukwelashwa yedwa esebenzisa i-Intanethi. Udokotela wenza ukuhlolwa kanye nokwelashwa okunqunyelwe, kuhlanganise ne-Amoxiclav. Phambilini, umyeni wami wagwinya amaphilisi izinyanga eziningi, kodwa esontweni lokuqala lokwelashwa wabona ngcono futhi wakwazi ukulala ngokuthula. Uphuze umuthi olwa namagciwane cishe amasonto amabili, ngalesi sikhathi kwaba nesicanucanu esisodwa ngenxa yokuthi waphuza iphilisi kudala ngaphambi kokudla. Ayikho eminye imiphumela emibi.
