Umuthi wehlisa izinga lekholesterol embi futhi uvimbele ukwakheka kwawo emzimbeni. Yabela ngokuhlangana nokudla nendlela yokuphila esebenzayo. Umuthi ungasetshenziswa ukuvikela izifo zohlelo lwethambo nenhliziyo.
Igama Lezwe elingafanele
Atorvastatin.
Umuthi i-Atorvastatin wehlisa i-cholesterol embi futhi uvimbele ukwakheka kwayo emzimbeni.
I-ATX
C10AB05.
Khipha amafomu nokwakheka
Ekhemisi, umuthi ukhishwa ngendlela yamathebulethi. Isithako esisebenzayo yi-atorvastatin ngesilinganiso sama-40 mg.
Isenzo se-Pharmacological
Into esebenzayo ivimbela umsebenzi we-HMG-CoA reductase. Ngaphansi kwethonya le-atorvastatin, inqubo yokwakhiwa kwe-cholesterol iyaphazamiseka, izinga layo le-plasma liyancipha.
Ukuthatha umuthi kunciphisa ubungozi besifo senhliziyo, kubandakanya i-atherosclerosis, isifo senhliziyo, isifo senhliziyo kanye nesifo sohlangothi.
I-Pharmacokinetics
Amukelwe ngokugcwele futhi masinyane emgudwini wokugaya ukudla. Ngemuva kokuphathwa komlomo ngemuva kwemizuzu engama-60, ukuqoqwa kwe-atorvastatin esegazini kufinyelela ezingeni eliphakeme. Biotransformed esibindini kanye namathumbu mucosa. Ibopha amaprotheni ngo-95-97%. Igcotshwe ngokuqukethwe kwamathumbu nomchamo.
Okunqunyelwe
Umuthi ukhonjelwa kwizifo ezihambisana nokukhula kwe-triglycerides, i-cholesterol ephelele ne-LDL egazini.
Lokhu kufaka phakathi:
- i-hypercholesterolemia eyinhloko;
- i-hyperlipidemia ehlangene;
- dysbetalipoproteinemia;
- hypertriglyceridemia yomndeni;
- i-homozygous hereditary hypercholisterinemia.
Ukwamkelwa kuyadingeka kwiziguli ezinengozi eyandayo yokuthola isifo senhliziyo (kubandakanya isifo sikashukela, umfutho wegazi ophakeme, umlutha we-nicotine).
Contraindication
Akuvunyelwe ukuthatha umuthi ezimweni ezinjalo:
- ukungezwani komzimba ezakhiweni zomuthi;
- izifo zesibindi ezinzima, kufaka phakathi i-cirrhosis, i-hepatitis;
- umsebenzi owengeziwe wama-enzyme wesibindi;
- ukwehluleka kwesibindi;
- izingane ezingaphansi kweminyaka engu-18.
Ngesikhathi sokukhulelwa nokuqunjelwa, ukuphuza umuthi kuphambene.
Ngokunakekela
Ukuqapha kumele kusetshenziswe lapho kukhona lezi zifo nemibandela elandelayo:
- ukwehluleka kwezinso;
- ukwephulwa kwemali esele ye-electrolyte;
- izifo zesistimu ye-endocrine;
- utshwala;
- ukuphazamiseka kwe-metabolic kanye ne-hormonal;
- ukwehla isikhathi eside komfutho wegazi;
- izifo ezithathelwanayo esigabeni esibuhlungu;
- ukwehluleka okungalawulwa;
- ukuba khona kokulimala.
Ungaphuza lo muthi ngaphambi kokwenza izinqubo zokuhlinzwa ngemvume kadokotela ohambele lo msebenzi.
Ungayithatha kanjani i-atorvastatin 40
Ukwemukelwa kwenziwa ngaphandle kokusetshenziswa kokudla. Umthamo ophakanyisiwe yi-10 mg. Ngemuva kokuhlolwa, udokotela angayandisa umthamo, kepha aze afike ku-80 mg ngosuku. Kuyadingeka ukufaka umthamo ophansi (10 mg) nokusetshenziswa kanyekanye kwe-HIV proteinase inhibitors, i-hepatitis C proteinase inhibitors, uClithithycin, Itraconazole, uCyclosporin, iTelaprevir, iTipranavir.
Ngoshukela
Umthamo wokuqala ngu-10 mg. Ngaphambi kokusebenzisa, udinga ukuphumelela ukuhlolwa.
Imiphumela emibi ye-atorvastastatin 40
Ithuluzi lingadala ukusabela okuhlukahlukene okungathandeki kusuka kuzitho nezinhlelo. Ukugwema imiphumela emibi, kufanele ufunde imiyalo yokusebenzisa.
Amapheshana wesisu
Kukhona ukuqunjelwa, ubuhlungu besisu, ukuqhakaza, ukungasebenzi kahle kwesibindi, isicanucanu, ukuncipha kwesisu, ukugabha, ukuvuvukala kwezicubu zesisu, i-colitis, ukuvuvukala kwamanyikwe, ulcer esiswini, ukopha okuvela esixeni, igazi eliphuma ezinsinini.
Isistimu yezinzwa ephakathi
Ngemuva kokuphuza umuthi, i-migraine, isiyezi, ukuphazamiseka kokulala, ukukhathala, i-tinnitus, ukuzwa okungaboni kanye nombono, futhi kungavela ushintsho ekuthandeni ukunambitheka.
Kusuka ohlelweni lokuphefumula
I-bronchitis iyavela, ulwelwesi lwe-mucous lwe-pharynx noma i-paranasal sinuse luvutha. Akuvamile ukuba asthma.
Engxenyeni yesikhumba
Ezimweni ezingavamile, ukujuluka kuyanda, izilonda noma ifomu lamakhambi esikhunjeni.
Kusuka ohlelweni lwezitho zofuzo
Kukhona ukuvuvukala kwezicubu, ukwephulwa kokuchama, ukopha kwesibeletho, ukungabi namandla, i-proteinuria. Ngesikhathi sokwelashwa, ipheshana lomchamo litholakala kakhulu ezifweni ezithathelwanayo.
Kusuka ohlelweni lwezinhliziyo
Ushintsho ekucindezelweni kwegazi, izinhlungu endaweni yesifuba, ukuphazamiseka kwesigqi senhliziyo, ukuncipha kokuhlushwa kwe-hemoglobin.
Kusuka ohlelweni lwe-musculoskeletal
Ubuhlungu bemisipha, ukungaphatheki kahle emuva, ukukhula komsipha.
Allergies
Ukungezwani komzimba kungaqhamuka ngendlela yokuqhuma kwesikhumba, ukuvuvukala kwezicubu, ukumiswa kwesikhumba kanye nesikhumba.
Umthelela ekhonweni lokulawula izindlela
Umuthi ungadala ukukhathala, isiyezi, futhi ukozela. Kuyadingeka ukwenqaba ukushayela izimoto nezinqubo eziyinkimbinkimbi.
Imiyalo ekhethekile
I-Atorvastatin 40 kufanele ithathwe ihambisana nomsebenzi womzimba nokudla. Ngesikhathi sokwelashwa, udinga ukubheka isimo sesibindi bese ulawula izinga lama-lipids. Ngokukhula isikhathi eside komsebenzi we-enzyme yesibindi noma i-creatine phosphokinase okuhlushwa, umuthi uyamiswa. Uma i-myopathy nomkhuhlane kwenzeka, bonana nodokotela.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Abesifazane abakhulelwe nababambelele kokudla bamaphilisi bayaphulwa.
Ukuncelisa ibele kuyaphazamiseka ngesikhathi sokwelashwa.
Ukuphathwa kwe-Atorvastatin ezinganeni ezingama-40
Ezinganeni, ukuthatha lo muthi kuphambaniswe ngenxa yokuntuleka kwemininingwane yokuphepha.
Sebenzisa ebudaleni
Umuthi unqunywe eminyakeni yobudala.
Umuthi unqunywe eminyakeni yobudala.
Isicelo sokusebenza kokulimala kwezinso
Uma kwenzeka ukwehluleka okukhulu kwe-renal, umuthi awubekiwe.
Sebenzisa umsebenzi wesibindi okhubazekile
Ezimweni ezinzima, umuthi uvunyelwe. Uma ukwephulwa kobunzima obukhulu noma obulinganiselayo, udokotela kufanele anciphise umthamo.
Ukweqisa kwe-Atorvastatin 40
Nge-overdose, imiphumela emibi iyaqina. Ukwelashwa okubonakalayo kuyenziwa.
Ukuxhumana nezinye izidakamizwa
Ngaphambi kokusebenzisa, kubalulekile ukutadisha ukuxhumana neminye imithi:
- ingozi eyengeziwe yokulimala kwemisipha lapho ihlanganiswa ne -cacithromycin, i-fibrate, i-erythromycin, i-nicotinic acid, i-cyclosporine ne-itraconazole;
- ukugcwala kwe-atorvastatin ku-plasma yegazi kukhuphuka ngokuhlangana nama-macrolide antibhicofu, uCyclosporine, Itraconazole, Lopinavir, Saquinavir, Ritonavir;
- ama-antacid aholela ekunciphiseni kokuqoqwa kwento esebenzayo egazini;
- izindlela zokuvimbela inzalo ngomlomo nezidakamizwa ezinciphisa ukuhanjiswa kwama-hormone ama-endo native steroid kufanele zithathwe ngaphansi kokuqondisa udokotela;
- umuthi awuthinti ukuhlangana kwe-terfenadine esegazini.
Ukuthatha ujusi wamagilebhisi kuholela ekwandeni kwe-AUC ye-atorvastatin ngo-40%.
Ukuthatha ujusi wamagilebhisi kuholela ekwandeni kwe-AUC ye-atorvastatin ngo-40%.
Ukuhambisana notshwala
Ukusetshenziswa okuhlangana notshwala kuyaphikiswa.
Ama-Analog
Ekhemisi ungathenga izifanekisisi zalo muthi ekwakhiweni nasezenzweni ze-pharmacological:
- Atoris;
- I-Atorvastatin Teva;
- Atorvastatin 20 Ananta;
- Atorvastatin C3;
- I-Liprimar;
- ITorvacard
- I-Atorvastatin-K.
Ngaphambi kokusebenzisa okunye esikhundleni somuthi, kufanele uvakashele udokotela futhi uhlolwe. Ukuzilapha imvamisa kuholela ekuphenduleni okubi.
Imibandela yekhefu lekhemisi
Umuthi udluliselwa ekhemisi ngokunikezwa ngudokotela ngesiLatini.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi awukhululwa ngaphandle kokuthola umuthi.
Intengo ye-Atorvastatin 40
Izindleko zamathebulethi eRussia zingama-ruble angama-180.
Izimo zokugcina zomuthi
Amathebulethi kufanele agcinwe ekuhlanganisweni Izimo zokushisa akufanele zedlule + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Isikhathi sokugcina - iminyaka emi-3.
Umkhiqizi
I-JSC "ALSI Pharma".
Ukubuyekezwa kwe-Atorvastatin 40
I-ejenti eqenjini lama-statins ibekezelelwa kahle yiziguli, inciphisa ngokushesha i-LDL egazini futhi inyusa izinga le-cholesterol “enhle”. Kusetshenziswa iziguli ukuvimbela nokwelashwa kwezifo zenhliziyo nezemithambo. Ngaphansi kwe-2% yeziguli zenqaba ukuyithatha lapho kwenzeka imiphumela emibi.
Odokotela
U-Alexey Ponomarenko, i-endocrinologist, eMoscow
Ithuluzi liphephile futhi liyasebenza. Umuthi wehlisa i-lipoproteins ne-cholesterol. Umphumela omkhulu wokuphuza umuthi ubonakala ngemuva kwamasonto angama-2-4. Kuyadingeka ukuthatha umuthi ngokuqapha, ngoba ukwedlula umthamo kungaholela ekwakhekeni kwezimbila, ukungasebenzi kahle kwesibindi nezinso, nokuwohloka kwesibindi.
UMarina Evgenievna, udokotela wezifo zenhliziyo, uKazan
Umuthi ungasetshenziswa ngokugxila okuphezulu kwe-cholesterol egazini, kufaka phakathi ne-homozygous hereditary hypercholesterolemia. Umthamo omkhulu ngosuku ngamathebulethi ayi-2. Ngokweqile kwe-cholesterol emzimbeni, ukudla okunamafutha namaswidi akufakiwe ekudleni. Uma isiguli sinomfutho wegazi ophansi, ukuqunjelwa, umlutha onamandla wotshwala noma isifo esinamandla sesibindi, umuthi awuchaziwe.
Iziguli
U-Alena, oneminyaka engama-37, eMoscow
Udokotela ubeke amaphilisi we-cholesterol ephezulu. Ngathatha izinsuku eziyi-14 ngesigamu sethebhulethi (20 mg) ngosuku. Ukwelashwa kwakumele kuhlanganiswe nokwenziwa ngokomzimba nokwelashwa kokudla. Manje i-cholesterol ijwayelekile.
UMaxim, oneminyaka engama-44, u-Omsk
Babeka ikhambi lokwelashwa kwezifo zenhliziyo nezemithambo. Imithamo yansuku zonke yayingu-10 mg. Ubesesibhedlela okwesibili ene-angina pectoris, kwathi i-dyslipidemia yatholakala. Ngithathe ngokwemiyalo. Ngemiphumela emibi, ngingaqokomisa ikhanda, i-tinnitus kanye nokuqunjelwa. Izimpawu zanyamalala ngemuva kokudla ukudla. Wanelisekile ngomphumela.
