I-Actovegin 200 iyisidakamizwa esihlanganisiwe semvelaphi yezilwane. Igazi lezinkomo ezincane lathathwa njengesisekelo somuthi ngenkathi kwenziwa inqubo. Umuthi ungowesigaba semithi ye-metabolic ethinta kahle ukusetshenziswa koshukela kanye ne-oxygen metabolism. Ukuthatha umuthi kunciphisa ingozi yokuqalwa yindlala yama-oksijini futhi kusiza ukuguqula izinqubo ze-metabolic emzimbeni.
Igama Lezwe elingafanele
I-Actovegin. NgesiLatin - Actovegin.
I-Actovegin 200 iyisidakamizwa esihlanganisiwe semvelaphi yezilwane.
I-ATX
B06AB.
Khipha amafomu nokwakheka
I-Actovegin iyatholakala ngohlobo lomthamo wesisombululo somjovo futhi ngendlela yamaphilisi.
Amaphilisi
Ingaphezulu lamathebhulethi liqukethe ifilimu le-membrane efakwe ngaphakathi entweni yombala ophuzi ophuzi, equkethe:
- i-acacia gum;
- sucrose;
- i-povidone;
- titanium dioxide;
- Izinyosi zasezintabeni glycol wax;
- i-talc;
- macrogol 6000;
- i-hypromellose phthalate ne-dibasic ethyl phthalate.
Udayi ophuzi we-Quinoline ne-aluminium varnish anikeza umthunzi othize futhi akhanye. Isisekelo sethebhulethi siqukethe i-200 mg yesakhi esisebenzayo esuselwa egazini lethole, kanye ne-microcrystalline cellulose, talc, magnesium stearate ne-povidone njengezakhi ezengeziwe. Amayunithi omuthi anendawo eyindilinga.
Enye yezindlela zokukhishwa kwe-Actovegin ngamathebulethi.
Isixazululo
Isixazululo siqukethe ama-ampoule wengilazi ayi-5 ml aqukethe ama-200 mg wegceke elisebenzayo - ukugxila kwe-Actovegin, okwenziwe nge-hemato-derivative yegazi lethole, ekhululwe kwizakhi zamaprotheni. Amanzi angcolile womjovo usebenza njengesithako esingeziwe.
Isenzo se-Pharmacological
I-Actovegin iyindlela yezindlela zokuvimbela ukuthuthukiswa kwe-hypoxia. Ukukhiqizwa kwalesi sidakamizwa kuqukethe ukuhlukaniswa kwegazi lezinkomo kanye nokuthola i-hemoderivat. Into elahliwe esakhiweni sokukhiqiza idala inkimbinkimbi enama-molecule enesisindo esifinyelela kuma-5000 dalton. Into enjalo esebenzayo yi-antihypoxant futhi inemiphumela emi-3 emzimbeni ngokufana:
- umzimba
- kuthuthukisa i-microcirculation;
- i-neuroprotective.
Ukusetshenziswa kwomuthi kuthinta kahle ukuthutha nokugaya ushukela ngenxa yesenzo se-phosphoric cyclohexane oligosaccharides, eyingxenye ye-Actovegin. Ukusheshisa ukusetshenziswa kwe-glucose kusiza ukuthuthukisa umsebenzi we-mitochondrial wamaseli, kuholela ekunciphiseni kokuhlanganiswa kwe-lactic acid ngemuva kwesizinda se-ischemia futhi kukhulisa amandla we-metabolism.
I-Actovegin iyindlela yezindlela zokuvimbela ukuthuthukiswa kwe-hypoxia.
Umphumela we-neuroprotective wesidakamizwa kungenxa yokuvinjwa kwe-apoptosis yamaseli wezinzwa ezimweni ezicindezelayo. Ukunciphisa ingozi yokufa kwe-neuronal, umuthi uvimbela umsebenzi wokubhala we-beta-amyloid ne-kappa-bi, obangela i-apoptosis futhi ulawule inqubo yokuvuvukala emithanjeni yohlelo lwezinzwa oluyingozi.
Umuthi uthinta kahle i-endothelium yemikhumbi ye-capillary, yenza inqubo evamile ye-miccirculation ibe izicubu.
I-Pharmacokinetics
Njengomphumela wezifundo zemithi, ochwepheshe behlulekile ukuthola isikhathi sokufinyelela ekuqoqweni okuphelele kwento esebenzayo ku-plasma yegazi, i-half-life kanye nendlela ye-excretion. Lokhu kungenxa yesakhiwo se-hemoderivative. Njengoba into iqukethe kuphela amakhompiyutha womzimba akhona emzimbeni, akunakwenzeka ukukhomba izinhlaka eziqondile ze-pharmacokinetic. Umphumela wokwelapha uvela isigamu sehora ngemuva kokuphathwa ngomlomo futhi ufinyelela inani eliphakeme ngemuva kwamahora we-2-6, ngokuya ngezimpawu zomuntu ngamunye zesiguli.
Emsebenzini wokuthengisa ngemuva, azange kube namacala okwehla komphumela wezidakamizwa ezigulini ezihluleke ngokwe-renal.
Emsebenzini wokuthengisa ngemuva, azange kube namacala okwehla komphumela wezidakamizwa ezigulini ezine-renal noma hepatic insuffence.
Okunqunyelwe
Umuthi ubekwa njengengxenye yokwelapha okuyinkimbinkimbi kulezi zimo ezilandelayo:
- ingozi ye-cerebrovascular;
- ukuwohloka komqondo
- isifo sokujikeleza kwegazi;
- ukuphazamiseka kwasemva kokuxineka kwemizwa ebuchosheni;
- ukwehla emuva kokuhlaselwa kwemisebenzi yokuqonda;
- isifo sikashukela polyneuropathy.
Umuthi usetshenziselwa ukulimala eziteshini ezingemvelo neze-venous kanye nasezinkingeni (ukuthuthukiswa kwezilonda ezindexekile, i-vasopathy).
Contraindication
Umuthi ubizwa ukophulwe kubantu abanokukhubazeka okwengeziwe kwezinto ezisebenzayo futhi ezingeziwe ze-Actovegin kanye nezinye izidakamizwa ze-metabolic. Kuyadingeka ukukhumbula okuqukethwe kwe-sucrose kugobolondo lwangaphandle lwamathebulethi, okuvimbela ukuphathwa kwe-Actovegin kubantu abane-glue glucose-galactose noma ukungabekezeleli ifa. Umuthi awunconyelwanga ngokusweleka kwe-sucrose ne-isomaltase.
Ngokunakekela
Kuyadingeka ukulawula isimo sohlelo lwe-vascular kubantu abanezinhliziyo ezihluleka 2 noma 3 ukuqina. Ukuqapha kufanele kusetshenziswe uma kwenzeka i-pulmonary edema, i-anuria ne-oliguria. Umphumela wokwelapha ungancipha nge-hyperhydrate.
Kuyadingeka ukulawula isimo sohlelo lwe-vascular kubantu abanezinhliziyo ezihluleka 2 noma 3 ukuqina.
Ungayithatha kanjani i-Actovegin 200
Amacwecwe athathwa ngomlomo ngaphambi kokudla. Musa ukuhlafuna umuthi. Umthamo usethwa ngokuya ngohlobo lwe-pathology.
Isixazululo sikhishwa ku / ku noma / m.
| Lesi sifo | Imodeli yokwelapha |
| Ukuwohloka komqondo | Amathebulethi amabili athathwa izikhathi ezi-3 ngosuku izinyanga ezi-5. |
| Ukuphazamiseka kwempilo ejikelezayo, kufaka phakathi i-pathologies ephelezelwa yizinkinga | Umthamo wansuku zonke usukela ku-600 kuya ku-1200 mg wokuqondisa izikhathi ezi-3 ngosuku. Ukwelashwa kuthatha amasonto angama-4-6. |
| Ingozi ye-Cerebrovascular | Isixazululo esingu-5-25 ml iv sezinsuku eziyi-14, kulandele ukuthatha amaphilisi ngomthamo kuye ngezimpawu zomuntu ngamunye. |
| Isigaba esibuhlungu sokuhlaselwa ischemic. Umuthi ubekelwe izinsuku ezingama-5-7 zokwelashwa. | I-intravenous drip ye-2000 mg ngosuku. Ukwelashwa kwenziwa ama-infusions angama-20, kulandelwa ukushintshela amaphilisi (amayunithi ama-2 izikhathi ezi-3 ngosuku). Isikhathi sokwelashwa sisonke singamaviki angama-24. |
| Ingipheral angiopathy | I-20-30 ml yesidakamizwa ixutshwa nekhambi le-isotonic le-0.9%. Kwethulwe iv inyanga yonke. |
| Is stroke | I-20-50 ml ye-Actovegin ihlanjululwe ngo-200-350 ml wesisombululo se-sodium chloride we-sodium noma i-5% ushukela. Amaconsi abekwa isonto lonke, emva kwalokho umthamo we-Actovegin wehliselwa ku-10-20 ml bese ubekwa njengokufakwa kwamasonto amabili. Ngemuva kokuphela kokwelashwa nesixazululo, bashintsha bathathe ifomu lethebhulethi. |
| I-cystitis yemisebe | I-10 ml yesisombululo siphathwa ngokuqhubekayo ngokuhlanganiswa nama-antibhayoriki ngesilinganiso se-2 ml / min. |
| Ukuvuselelwa Okusheshayo | I-10 ml yesidakamizwa ifakwa ngaphakathi noma emzimbeni nge-5 ml ye-Actovegin. Ngokuya ngokubuyiselwa kwezicubu, umuthi ungalawulwa nsuku zonke noma ngezikhathi ezithile 3-4 ngesonto. |
| Ukwelashwa nokuvimbela imiphumela yokwelashwa ngemisebe (yesikhumba nolwelwesi lwama-mucous) | 5 ml iv. |
Ukuthatha umuthi wesifo sikashukela
Uma kwenzeka isifo sikashukela se-polyneuropathy, kunconywa ukufakwa kwe-intravenous komthamo wansuku zonke we-2000 mg. Ngemuva kokudonsa phansi okungama-20, kudingeka ushintsho ekuphathweni ngomlomo kwefomu le-Actovegin yethebhulethi. Ama-1800 mg ngosuku anqunywa ngokuvama kokuphathwa izikhathi ezi-3 ngosuku ngamathebhulethi ama-3. Isikhathi sokulashwa kwezidakamizwa siyehluka kusuka ezinyangeni ezi-4 kuye kweziyi-5.
Uma kwenzeka isifo sikashukela se-polyneuropathy, kunconywa ukufakwa kwe-intravenous komthamo wansuku zonke we-2000 mg.
Imiphumela emibi
Ukuphendula okungalungile kulo muthi kungaqhamuka ngenxa yomthamo okhethwe ngokungafanele noma ngokuhlukumeza umuthi.
Kusuka ohlelweni lwe-musculoskeletal
I-ejenti ye-metabolic ingathinta ngokungaqondile i-calcium metabolism, ephazamisa ukumuncwa kwe-calcium ion. Ezigulini ezichazwe ngaphambilini, ingozi yokuthuthuka kwe-gout iyanda. Kwezinye izimo, ukubukeka kobuthakathaka bemisipha nobuhlungu.
Engxenyeni yesikhumba
Ngengeniso yomuthi engxenyeni yemisipha noma emithanjeni ye-ulnar, redness, phlebitis (kuphela ngokufakwa kwe-iv), ubuhlungu nokuvuvukala endaweni lapho umjovo obekwe khona kungenzeka. Ngokuzwela okwengeziwe kwe-Actovegin, kuvela i-urticaria.
Kusuka emasosheni omzimba
Lapho uthatha i-ejenti ye-metabolic, impendulo yokuzivikela komzimba kanye nenani lama-leukocytes emzimbeni lingancishiswa lapho litholakala nesifo esithathelwanayo.
Allergies
Ezigulini ezine-hypersensitivity yezicubu, i-dermatitis kanye ne-drug fever ingaqhamuka. Ezimweni ezingavamile, i-angioedema ne-anaphylactic shock kungenzeka.
Imiyalo ekhethekile
Lapho ujova nge-intramuscularly, udinga ukufaka kancane kancane ikhambi ungqimba lomisipha olujulile. Inani lomuthi akufanele lidlule i-5 ml. Iziguli ezibekwe ngaphambi kokuvela kokuqubuka kwe-anaphylactic, kubalulekile ukubeka izivivinyo zokungezwani nokwenziwa kwe-2 ml / m ukuthola ukubekezelelana kulo muthi.
Isixazululo sinombala ophuzi. Amandla wokuqina kwemibala ye-gamut angahluka ngokuya nge-batch ekhishwe nenombolo yezakhi ezihleliwe. Lezi zici azithinti kabi amangqamuzana omzimba futhi azinciphisi ukubekezelela umuthi. Ngakho-ke, lapho uthenga, asikho isidingo sokugxila kumbala wesisombululo, kepha awukwazi ukusebenzisa uketshezi olunezinhlayiya eziqinile.
I-ampoule evulekile ayikho ngaphansi kwesitoreji.
Ukuhambisana notshwala
Ngesikhathi sokwelashwa nge-Actovegin kuyenqatshelwa ukusebenzisa utshwala. I-Ethanol iyakwazi ukunciphisa imiphumela ye-metabolic ne-neuroprotective ngenxa yokuvinjwa kohlelo lwezinzwa oluphakathi.
Umthelela ekhonweni lokulawula izindlela
Umuthi awuthinti ukusebenza kwemizwa ye-neuromuscular. Ngokuphikisana nesizinda sokusebenza okujwayelekile kohlelo lwezinzwa oluphakathi nemisipha yamathambo, isiguli ngesikhathi sokwelashwa nge-Actovegin asinqatshelwe ukushayela imoto, senza imisebenzi edinga izinga lokuphendula okukhulu nokuhlushwa, kanye nokulawula amadivayisi we-Hardware.
Ngesikhathi sokulashwa nge-Actovegin, imoto ayinqatshelwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi awuvunyelwe ukusetshenziswa ngabesifazane abakhulelwe. Into esebenzayo ayingenisi isithiyo se-hematoplacental, yingakho ingabeki engcupheni ukukhula okuvamile kwe-embryonic ye-fetus. Umuthi ungafakwa ekwelashweni kwenhlanganisela ye-preeclampia noma kungenzeka okukhulu kokuphuphuma kwesisu.
I-hemoderivative ehluthisiwe ayidalulwa ngemithambo yezilwane ezincelisayo, ngenxa yalokho, ngesikhathi sokwelashwa ngezidakamizwa, ukuncelisa ibele kungenziwa.
Umthamo Actovegin izingane ezingama-200
Izingane ezisanda kuzalwa nezinsana zenqatshelwe ukunikeza amaphilisi e-Actovegin ngenxa yengozi eyandayo ye-asphyxiation. Ukufakwa kukuvumela ukuthi ungene ngokuphepha kulo muthi emzimbeni wezingane futhi ukwandise ukusebenza kwezinto ezisebenzayo. Umthamo usethwa ngudokotela oya kuye ngokuya ngesisindo somzimba wengane. Kunconywa ukuthi izinsana nezinsana ezincane ziphathwe i-Actovegin kanye ngosuku ku / in noma ku / m umthamo ngesilinganiso esingu-0,4-0,5 ml nge-1 kg yesisindo.
Ezinganeni ezisuka eminyakeni engu-1 kuye kwemi-3, umthamo owodwa womuthi ungakhuphuka ube ngu-0,6 ml / kg wesisindo somzimba, kuyilapho ingane isuka eminyakeni emi-4 kuye kwengama-6, ukuphathwa ngomlomo kwezidakamizwa noma ukuphathwa kwe-0.25-0.4 ml / kg intramuscularly noma ngaphakathi ngosuku. Lapho ufaka umuthi ngaphakathi, udinga ukunika izingane amaphilisi ¼. Njengomphumela wokuhlukaniswa kwefomu lomthamo, ukusebenza ngempumelelo kwezidakamizwa kuncishisiwe.
Sebenzisa ebudaleni
I-Actovegin ayidingi izinguquko kuhlobo lwemithamo uma inikezwe abantu abaneminyaka engaphezu kuka-60 ubudala.
I-Actovegin ayidingi izinguquko kuhlobo lwemithamo uma inikezwe abantu abaneminyaka engaphezu kuka-60 ubudala.
Ukweqisa
Ngesikhathi sokuhlolwa kokuhlolwa kwangaphambi kokutholwa, kwatholakala ukuthi i-Actovegin, lapho idlula umthamo ophakanyisiwe izikhathi ezingama-30 ukuya kwengama-40, ayinawo umthelela onobuthi ezinhlelweni zezitho nezicubu zomzimba. Esikhathini sokuthengisa ngemuva kokuzivivinya emitholampilo, awekho amacala abhalwe ngokweqile aqoshwa.
Ukuxhumana nezinye izidakamizwa
Ngokuphathwa okuphathelene ne-Mildronate ne-Actovegin, kuyadingeka ukuqaphela isikhathi sokungangeni phakathi kwamajovo amahora amaningi, ngoba akubikwa ukuthi izidakamizwa ziyaxhumana yini.
I-ejenti ye-metabolic ihamba kahle neCurantil for gestosis (capillary vascular ukuphazamiseka) kwabesifazane abakhulelwe abanobungozi bokuzalwa ngaphambi kwesikhathi.
Inhlanganisela edinga ukuqashelwa
Ngokusetshenziswa okufanayo kwe-Actovegin ne-ACE inhibitors (i-Captopril, iLisinopril), kunconyelwa ukubheka isimo sesiguli. I-angiotensin-converting enzyme blocker ichazwa kanye ne-ejenti ye-metabolic ukwenza ngcono ukuhamba kwegazi ku-ischemic myocardium.
Ukuqapha kufanele kusetshenziswe ngenkathi kuqokwa i-Actovegin nge-potassium-sparing diuretics.
Ama-Analog
Faka esikhundleni umuthi lapho ungekho khona umphumela wokwelapha ongaba izidakamizwa ezinezakhiwo ezifanayo zekhemisi, kufaka phakathi:
- I-Vero-Trimetazidine;
- I-Cortexin;
- I-Cerebrolysin;
- I-Solcoseryl.
Le mishanguzo ishibhile kuhla lwamanani.
Izimo zokuphumula Actovegin 200 kusuka ekhemisi
Umuthi awuthengiswa ngaphandle kwemithi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi ubekelwe kuphela izizathu eziqondile zezokwelapha, ngoba akunakwenzeka ukuthola umphumela we-Actovegin kumuntu onempilo.
Intengo
Izindleko zamakhemisi eRussia ziyahlukahluka kusuka kuma-ruble angama-627 kuya ku-1525. E-Ukraine, umuthi ubiza cishe i-365 UAH.
Izimo zokugcina zomuthi
Kuyadingeka ukugcina umuthi endaweni yokushisa engeqi ku + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Izinyanga ezingama-36.
Umkhiqizi Actovegin 200
I-Takeda Austria GmbH, e-Austria.
Izingane ezisanda kuzalwa nezinsana zenqatshelwe ukunikeza amaphilisi e-Actovegin ngenxa yengozi eyandayo ye-asphyxiation.
Ukubuyekezwa kodokotela neziguli ku-Actovegin 200
UMikhail Birin, Udokotela Wezengqondo, Vladivostok
Umuthi awubekelwe njenge-monotherapy, ngakho-ke kunzima ukukhuluma ngokusebenza kahle. Umuthi osebenzayo yi-hemoderivative, yingakho kudingekile ukubheka isimo sesiguli: akucaci ukuthi umuthi wahlanzwa kanjani ngesikhathi sokukhiqiza, kungaba namiphi imiphumela kusukela ekusetshenzisweni. Iziguli ziyawubekezelela kahle umuthi, kepha ngithanda ukwethemba imikhiqizo yokwenziwa. Ezimweni ezingavamile, kuqhamuke ikhanda.
U-Alexandra Malinovka, oneminyaka engama-34, u-Irkutsk
Ubaba waveza i-thrombophlebitis emilenzeni. UGangrene waqala, futhi umlenze kwadingeka ukuba unqunywe. Isimo besinzima nge-mellitus yesifo sikashukela: ukuthamba kuphulukise kahle futhi kuhlale kuchuma izinyanga eziyisithupha. Kucelwe usizo esibhedlela, lapho abakwa-Actovegin belashwa ngemizwa. Isimo saqala ukuba ngcono.Ngemuva kokukhipha, ubaba uthathe amaphilisi we-Actovegin nemijovo engu-5 ml yangaphakathi ngokuqinile ngokwemiyalo yokuyisebenzisa. Isilonda kancane kancane saphola inyanga. Naphezu kwentengo ephakeme, ngicabanga ukuthi lesi sidakamizwa siyasebenza.
