Umuthi ubekelwe iziguli ezinesifo sikashukela sohlobo 2. Ngokusetshenziswa njalo, umkhiqizo uvimbela ukuthuthukiswa kwezinkinga, ususe i-arrhythmia futhi unciphise ukunamathela kweplatelet.
Igama Lezwe elingafanele
I-Glibenclamide
IManinil inqunyelwe iziguli ezinesifo sikashukela sohlobo 2.
I-ATX
A10VB01
Khipha amafomu nokwakheka
Umenzi ukhiqiza umuthi ngohlobo lwamathebulethi wokuphathwa komlomo, ukwakheka okuyisicaba okuyipinki. Ithebhulethi elilodwa liqukethe i-3.5 mg ye-glibenclamide kwifomu yemicronized. Izinto ezihlangeneyo: i-lactose, isitashi, i-magnesium stearate, i-silicon dioxide.
Isenzo se-Pharmacological
Umuthi osebenzayo uvimba ukumbiwa kwe-potassium kumaseli we-pancreatic beta. Ithuluzi lisebenza ukukhiqizwa kanye nokungena kwe-insulin egazini. Ngenxa yalokho, kukhona ukwehla kokuxineka kwe-glucose egazini.
I-Pharmacokinetics
I-Glibenclamide iyathathwa kusuka emgudwini we-gastrointestinal. Umuthi udonswa ngokuphelele egazini ngemuva kokuwusebenzisa. Ngemuva kwamahora we-1.5-2, ukuqoqwa kwento esebenzayo esegazini kufinyelela inani layo eliphezulu. Kungakapheli izinsuku ezingama-2-3, ama-metabolites angasebenzi aqedwe ngokuphelele emzimbeni ngohlelo lwe-genitourinary. Ezigulini ezinokwehla kokusebenza kwesibindi, isikhathi esithathwa kwimikhiqizo ye-metabolite eyindilinga isikhathi eside.
IManinil iyatholakala ngesimo samathebulethi okuphatha ngomlomo, ukuma okuyisicaba kombala opinki. Ithebhulethi elilodwa liqukethe i-3.5 mg ye-glibenclamide kwifomu yemicronized.
Izinkomba zokusetshenziswa
Kubhekelwa ezibhebheni ezigulini ezinesifo sikashukela sohlobo 2.
Contraindication:
Ukusetshenziswa ku-contraindicated kulezi zifo nemibandela elandelayo:
- ukungabekezelelani komuntu ngamunye ezingxenyeni zomuthi;
- uhlale usesimweni se-hyperglycemic ne-diabetesica;
- isimo ngemuva kokwelashwa kokuhlinzwa kwe-pancreas;
- ukwehluleka kwezinso okwenzeka kakhulu;
- ukwehluleka kwesibindi okukhulu
- i-leukopenia;
- thayipha i-1 isifo sikashukela;
- isifo esingapheli samathumbu;
- izifo ezithathelwanayo ezihlasela kakhulu;
- ukukhulelwa nokuncelisa ibele.
Izingane nentsha engaphansi kweminyaka engu-18 ubudala baphuza lo muthi.
Ukusetshenziswa kweManinil kufakwe emzimbeni wesifo samathumbu esingamahlalakhona.
Ngokunakekela
Ukuqapha kumele kusetshenziswe ezimweni ezinjalo:
- ukungasebenzi kwe-yegilo;
- ukuqagela kokuquleka nokuqaqanjiswa kwesithuthwane;
- ukubonakaliswa kwezimpawu ze-hypoglycemia;
- izindlela ezahlukahlukene zokudakwa komzimba.
Kuyo yonke inkathi yokwelashwa, ukuhlolwa kweziguli njalo kwenziwa phambi kwe-pathologies engenhla.
Ungayithatha kanjani iManinil 3.5
Umuthi ubekwa ngemuva kokuhlola ukugcwala koshukela egazini. Ukwemukelwa kwenziwa ngasikhathi sinye, ngaphambi kokudla, amaphilisi okuphuza ngamanzi ahlanzekile. Isikhathi sokuphatha sincike esimweni sesiguli.
Ngoshukela
Umthamo wansuku zonke onconywayo yi-1 ithebhulethi. Inani elikhulu ngosuku ngamathebhulethi ama-3.
Ngo-mellitus onesifo sikashukela esincike emthini, lesi sidakamizwa asinqunyelwe.
Imiphumela emibi yeManinil 3.5
Ngesikhathi sokuphatha umuthi, izinkinga zingavela ekusebenzeni kohlelo lokugaya ukudla. Akuvamile, ushintsho ekusebenzeni kwezinso nesibindi kwenzeka. Ngokuphikisana nesizinda sokwemukelwa, i-hyperthermia, i-tachycardia, ukukhathala kungenzeka.
Ngasohlangothini lwe-metabolism
Kunomuzwa ongalawulwa wendlala, ukwanda kwesisindo somzimba, ikhanda, ukuwohloka kokuqina kokunakwa, ukwephulwa kwezinqubo zokulawulwa kokushisa. Ukuthatha umuthi kungaholela ekuthuthukisweni kwe-hypoglycemia.
Lapho uthatha iManinil, kuvela ikhanda. Ukwelashwa kufanele kwenziwe ngaphansi kokuqashwa ngokuqinile kodokotela nokubheka njalo ushukela wegazi.
Kusuka emasosheni omzimba
Ukunyuka kokushisa komzimba kuyaphawulwa.
Engxenyeni yesibindi ne-biliary
Kukhona ukwanda komsebenzi wama-enzyme wesibindi kanye ne-intrahepatic cholestatic syndrome. Izifo zesibindi zokuvuvukala zingavela.
Amapheshana wesisu
Kukhona ukungakhululeki nobuhlungu esiswini. Izinkinga zokucanuzela kwenhliziyo nokuhlanza kwenzeka. Isiguli singathola ukunambitheka okuxakayo nokunomunyu emlonyeni.
Izitho zeHematopoietic
Kunokwehla kwenani lamaplatelet namaseli amhlophe egazi ku-plasma yegazi.
Allergies
Ezimweni ezingavamile, kwenzeka i-photosensitivity - ukusabela kwesikhumba okukhuse emisebeni ye-ultraviolet. Kuvela izigaxa zesikhumba kanye nama-hemorrhages wesikhumba.
Umthelela ekhonweni lokulawula izindlela
Lapho uthatha umuthi, kunconywa ukwenqaba ukushayela nokwenza izinto ezihambisana nezinqubo eziyingozi. Umkhiqizo ungadala ukozela noma isiyezi.
Lapho uthatha umuthi, kunconywa ukwenqaba ukushayela. Umkhiqizo ungadala ukozela noma isiyezi.
Imiyalo ekhethekile
Ngaphambi kokusebenzisa ezinye izidakamizwa, kunconywa ukuthola izeluleko zochwepheshe eziqeqeshiwe.
Ukuvimbela i-hypoglycemia, udinga ukudla ukudla okulinganiselayo futhi ulawule ushukela wegazi lakho. Kuyadingeka ukunciphisa umthamo noma ukuyeka ukusetshenziswa kwamathebulethi uma kulimala, ukushiswa kanye nezifo ezithathelanayo.
Sebenzisa ebudaleni
Ekwaluphaleni, kunengozi yokuba ne-hypoglycemia. Ukwelashwa kufanele kwenziwe ngaphansi kokuqashwa ngokuqinile kodokotela futhi uvame ukukala amazinga kashukela egazini.
Ebudaleni, ukwelashwa ngeManinil kumele kwenziwe ngaphansi kokuqashwa ngokuqinile kodokotela futhi kuvame ukukala amazinga kashukela egazini.
Ukuqokwa kukaManinila izingane ezi-3.5
Umuthi awubekelwe iziguli ezingaphansi kweminyaka engu-18.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Nikeza umuthi ophulwe kwabesifazane abakhulelwe nababephambile.
Isicelo sokusebenza kokulimala kwezinso
Umuthi uphambaniswe neziguli ezihluleka kakhulu yizinso. Ukuvimbela ukukhula kwe-hypoglycemia kwezifo zezinso ezingapheli, umthamo uyalungiswa.
Sebenzisa umsebenzi wesibindi okhubazekile
Umuthi awunqunyelwe lapho kukhona ukwehluleka okukhulu kwesibindi.
I-overdose yeManinil 3.5
Uma uthatha umthamo omkhulu womuthi, izimpawu ze-hypoglycemia zingavela, kufaka phakathi ukulahlekelwa ukwazi kanye nethonya.
Izimpawu zokuqala isiyezi, ukujuluka, ushintsho lwesilinganiso senhliziyo, ukungaboni kahle nobuthakathaka. Uma isiguli sisesimweni esibucayi, ukulaliswa esibhedlela kuyadingeka.
Ukuxhumana nezinye izidakamizwa
Umphumela owandayo we-hypoglycemic ungabangelwa ukuphathwa kanyekanye kwezidakamizwa ze-hypoglycemic (acarbose), ama-diuretics, i-sulfonylureas, i-biguanides, i-ACE inhibitors, i-cimetidine, i-reserpine, i-sulfonamides kanye nama-tetracyclines.
Ukwehla komphumela we-hypoglycemic kwenzeka ngokusetshenziswa kanyekanye kwama-barbiturates, ama-phenothiazines, i-GCS, i-Rifampicin, amaphilisi okulawula ukuzalwa kwe-hormonal kanye ne-Acetazolamide.
Ukuhambisana notshwala
Uma uhlanganiswa neziphuzo eziqukethe utshwala, umuthi ungadala i-hypoglycemia. Ngesikhathi sokwelashwa, utshwala kufanele bungabandakanywa.
Ama-Analog
Lesi sidakamizwa sinama-analogues ezenzakalweni zamakhemikhali:
- UGlidiab;
- Isifo sikashukela;
- I-Amaryl;
- Vipidia;
- Glyformin;
- IGlucophage;
- Maninil 5.
I-Amaril iyafana nesenzo kuManinil.
Ngayinye yazo, imiyalo ikhombisa ukuphikisana kanye nemiphumela emibi. Ngaphambi kokufaka esikhundleni se-analogue, udinga ukuvakashela udokotela futhi uhlolwe.
Imibandela yekhefu lekhemisi
Ikhishwa ngemithi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ithuluzi lingathengwa kuphela ngokubhaliwe.
Intengo yeManinil 3.5
Izindleko ezijwayelekile zokupakishwa ngama-ruble ayi-175.
Izimo zokugcina zomuthi
Gcina endaweni eyomile futhi emnyama emazingeni okushisa afinyelela ku- +25 ° C. Gcina ungafinyeleleki ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Impilo yeshalofu yamathebulethi yiminyaka emi-3. Kwenqatshelwe ukusebenzisa umuthi ngemuva kosuku lokuphelelwa yisikhathi.
Umkhiqizi
Umenzi wamatafula yinkampani yezokwelapha yaseJalimane iBerlin-Chemie AG.
Ukubuyekezwa mayelana neManinil 3.5
Isidakamizwa Maninil 3.5 mg sinqunyelwe ngaphezu kokudla nendlela yokuphila esebenzayo. Iziguli ziqaphela umphumela osheshayo, futhi odokotela - ukungabikho kwemiphumela emibi lapho belandela imiyalo.
Odokotela
U-Oleg Feoktistov, udokotela we-endocrinologist
Ngohlobo 2 sikashukela, ngibeka lesi sidakamizwa ezigulini. Ngaphansi kwethonya lomuthi, inani loshukela esegazini liyancipha, ngoba isibindi nemisipha kuqala ukumunca ngamandla ushukela. Umuthi ubekezelelwa kahle. Uma isetshenziswa njalo, ithuthukisa ukukhishwa kwe-insulin futhi inomphumela we-antiarrhythmic.
UKirill Ambrosov, udokotela wezokwelapha
Umuthi unganciphisa ukushona kweziguli ezinesifo sikashukela. Amaphilisi asiza ukuguquguqula izinga le-glucose egazini, anciphise okuqukethwe kwe-cholesterol "embi". Isithako esisebenzayo simunwa ngokushesha, futhi isenzo sithatha amahora angama-24. Ukugwema ukuzuza isisindo, udinga ukuzivocavoca futhi udle ngendlela efanele.
Isifo sikashukela
UTatyana Markina, oneminyaka engama-36
Kunikezwe ithebhulethi eyodwa ngosuku. Ithuluzi lisiza ukulawula amazinga kashukela. Ngilandela ukudla okune-carb ephansi futhi ngizama ukushukuma njalo. Ezinyangeni ezi-4 zokwelashwa, isimo saba ngcono. Emiphumeleni emibi bekuyizitulo ezazicasukile kanye ne-migraine. Izimpawu zanyamalala ngemuva kwamasonto amabili. Ngihlela ukuqhubeka nokwamukela.
U-Anatoly Kostomarov, oneminyaka engama-44
Udokotela ubhale incwadi ebhalela umuthi owenzelwe i-mellitus engaxuthi ne-insulin. Angibonanga imiphumela emibi, ngaphandle kwesiyezi. Bekumele nginciphise umthamo ube yingxenye yepilisi. Ushukela uvamile futhi uyajabulisa. Ngiyayincoma.
