Umfutho wegazi ophakeme (i-arterial hypertension) ungenye ye-pathologies ejwayelekile. Imvamisa lesi simo siyisidingo sokuqalwa kwezifo ezahlukahlukene zohlelo lwethambo nenhliziyo, okungaholela ekufeni. Ukulungisa umfutho wegazi ngokwejwayelekile, izidakamizwa ziyasetshenziswa, imvamisa odokotela banquma i-Kapoten noma i-Captopril.
Zisebenza kanjani izidakamizwa?
Ngokwakhiwa kweKapoten neCaptopril, i-captopril iyisithako esiyisisekelo esisebenzayo, ukuze izakhiwo zabo zokwelapha ziyefana.
Ngokwakhiwa kweKapoten neCaptopril, i-captopril iyisithako esiyisisekelo esisebenzayo, ukuze izakhiwo zabo zokwelapha ziyefana.
Kapoten
I-Kapoten yezidakamizwa ingeyeqembu lezidakamizwa ze-antihypertensive. Ukukhishwa ifomu - amaphilisi. Isetshenziselwa ukwehlisa umfutho wegazi. Isithako esikhulu esisebenzayo yi-Captopril.
I-Kapoten ingeyeqembu le-ACE inhibitors. Umuthi futhi usiza ukuvimbela ukukhiqizwa kwe-angiotensin. Isenzo somuthi sihlose ukucindezela ama-complements asebenzayo we-ACE. Umuthi uthoba imithambo yegazi (yomibili imithambo nemithambo), usiza ukususa umswakama owedlulele kanye nesodium emzimbeni.
Uma umuthi usetshenziswa njalo, lapho-ke inhlala-kahle yomuntu iyathuthuka, ukukhuphuka kokukhuthazela, kanye nesikhathi sokuphila siyakhula. Izenzo ezingeziwe zifaka:
- ukuthuthuka kwesimo esejwayelekile ngemuva kokuzikhandla komzimba, ukululama ngokushesha;
- kugcina imithambo yegazi isesimweni esihle;
- ukujwayelekile kwesigqi senhliziyo;
- ngcono ukusebenza kwenhliziyo yonke.
Lapho uthathwa ngomlomo, ukumuncwa kokugaya ukudla kwenzeka ngokushesha okukhulu. Iqoqo eliphezulu lento esegazini lizofinyelelwa ngehora. I-bioavailability yesidakamizwa icishe ibe ngama-70%. Ukuqedwa kwesigamu sempilo kufike emahoreni angama-3. Umuthi udlulela ezingxenyeni zohlelo lomchamo, cishe ingxenye yempahla isiyonke engashintshiwe, kanti eminye ibe yimikhiqizo yokuwohloka.
I-Captopril
I-Captopril ingeyeqembu lezidakamizwa ezingama-antihypertensive. Kunqunyelwe ukwehlisa umfutho wegazi kuma-pathologies ahlukahlukene enhliziyo, amasistimu wokujikeleza, amasosha omzimba, izifo ze-endocrine (isibonelo, isifo sikashukela). Umuthi uyatholakala ngesimo samathebulethi okuphatha ngomlomo. Isithako esikhulu esisebenzayo se-Captopril yisimo segama elifanayo.
Into yi-angiotensin eguqula i-enzyme inhibitor. Ivimbela ukukhiqizwa kwento ebangela ukuguqulwa kwe-angiotensin ibe yinto esebenzayo yezinto eziphilayo, okuvusa imithambo yemithambo yegazi ngokuncipha okuthe xaxa kwe-lumen yabo kanye nokwanda komfutho wegazi.
I-Captopril ivuthulula imithambo yegazi, ithuthukisa ukuphuma kwegazi, inciphisa ukucindezela enhliziyweni. Ngenxa yalokhu, amathuba okuthuthuka kwezinkinga zenhliziyo ezihambisana ne-hypertension ancishisiwe.
I-bioavailability yesidakamizwa okungenani i-75%. Inani elikhulu lento esegazini liqashelwa imizuzu engama-50 ngemuva kokuthatha amaphilisi. Iphuka isibindi. Ukuqedwa kwesigamu sempilo kwenza amahora ama-3. Kukhishwa ngohlelo lokuchama.
Ukuqhathanisa kweKapoten neCaptopril
Ngaphandle kwamagama ahlukile, uKapoten noCaptopril bafana kakhulu ngezindlela eziningi. Ziyakwazi ukufana.
Ukufana
Ukufana kokuqala phakathi kweCaptopril neKapoten ukuthi bobabili bangamalungu eqembu elilodwa lemithi - i-ACE inhibitors.
Izinkomba zokusetshenziswa kwalezi zidakamizwa yilezi ezilandelayo:
- i-arterial hypertension;
- ukwehluleka kwenhliziyo;
- ukwehluleka kwezinso;
- isifo sikashukela se-nephropathy;
- infarction myocardial;
- umfutho wegazi wezinso;
- ukungasebenzi kwengqondo yesokunxele yenhliziyo.
Indlela yezidakamizwa yesifo somfutho wegazi ophezulu injalo futhi efanayo. Kufanele ukuphuza umuthi ihora elilodwa ngaphambi kokudla. Kwenqatshelwe ukugaya amaphilisi, kuphela ukugwinya kuphela nengilazi yamanzi. Umthamo unqunywa ngudokotela ngawodwana, inikezwe uhlobo lwalesi sifo, ubulukhuni baso, isimo esivamile sesiguli. Umthamo omkhulu wansuku zonke yi-25 g. Ngesikhathi sokwelashwa, singangezelelwa izikhathi ezi-2.
Uma kunesidingo, izidakamizwa zingahlanganiswa nama-glycosides enhliziyo, ama-diuretics, ama-sedative.
Kepha akuvunyelwe njalo ukusebenzisa imishanguzo enjalo. I-Kapoten ne-Captopril nazo zinokuchasana okufanayo:
- isifo sezinso nesibindi;
- umfutho wegazi ophansi;
- ukungasebenzi komzimba okungenamandla;
- ukubekezelela umuntu ongemuhle ngomuthi noma ngezakhi zawo;
- ukukhulelwa nokuncelisa ibele.
Izingane ezingaphansi kweminyaka engu-16 ubudala nazo azibekelwa leyo mishanguzo.
Uyini umehluko
ICaptopril neKapoten cishe ziyefana ekwakhekeni. Kepha umehluko omkhulu yizinto ezihlanganayo. I-Kapoten iqukethe isitashi sommbila, i-stearic acid, i-microcrystalline cellulose, i-lactose. I-Captopril inezinto ezengeziwe ezisizayo: isitashi samazambane, i-magnesium stearate, i-polyvinylpyrrolidone, i-lactose, i-talc, i-microcrystalline cellulose.
I-Kapoten inomphumela omnene kakhulu emzimbeni kune-Captopril. Kepha zombili lezi zidakamizwa zinamandla, ngakho-ke angeke zithathwe ngokungalawulwa. Ngokuqondene nemiphumela emibi, i-Captopril ingaba nokulandelayo:
- ikhanda kanye nesiyezi;
- ukukhathala;
- ukukhuphuka kwenhliziyo;
- isifiso sokudla, Ubuhlungu besisu, ukukhubazeka;
- ukukhwehlela okomile;
- i-anemia
- ukuqhuma kwesikhumba.
I-Kapoten ingadala le miphumela emibi:
- ukozela
- Isiyezi
- ukukhuphuka kwenhliziyo;
- ukuvuvukala kobuso, imilenze nezingalo;
- ubukhulu bolimi, izinkinga ngokunambitheka;
- ukomisa ukuphuma kolwelwesi lwe-mucous lomphimbo, amehlo, impumulo;
- i-anemia
Lapho nje imiphumela emibi ivela, kufanele uyeke ukusebenzisa le mishanguzo uye esibhedlela.
Yikuphi okushibhile
Intengo yeKapoten ibiza kakhulu. Kwiphakheji lamathebhulethi angama-40 elinokuqoqwa kwengxenye enkulu engama-25 mg, izindleko zingama-ruble angama-210-270 eRussia. Ibhokisi elifanayo lezibhebhe ze-Captopril lizobiza cishe ama-ruble angama-60.
Kubantu okufanele basebenzise i-ACE inhibitors njalo, lo mehluko ubalulekile. Ngasikhathi sinye, izazi zezenhliziyo zivame ukutusa uKapoten, okubonisa ukuthi umphumela wakhe wokwelapha unamandla.
Yikuphi okungcono: iCototen noma i-Captopril
Zombili lezi zidakamizwa ziyasebenza. Yizi-analogues, ngoba zinento efanayo esebenzayo (Captopril). Kulokhu, imithi inezinkomba ezifanayo kanye ne-contraindication. Imiphumela emibi ihluke kancane nje kuphela ngenxa yezakhi ezahlukahlukene ezisizayo ekwakhiweni. Kepha lokhu akukuphazamisi ukusebenza kwezidakamizwa.
Lapho ukhetha umuthi, kufanele ukhumbule okulandelayo:
- Le mishanguzo inesithako esisodwa esisebenzayo - i-capopril. Ngenxa yalokhu, izinkomba kanye ne-contraindication yazo ziyafana, kanye nokuhambisana nezinye izidakamizwa, indlela yokusebenza komzimba.
- Zombili lezi zidakamizwa zenzelwe ukwelashwa isikhathi eside kwe-hypertension.
- Zombili lezi zidakamizwa ziyasebenza, kodwa kuphela uma uzithatha njalo futhi ulandela umthamo.
Lapho ukhetha umuthi, kunconywa ukugxila kwizincomo zikadokotela.
Lapho ukhetha umuthi, kunconywa ukugxila kwizincomo zikadokotela. Uma ibheka iKapoten njengeyona ndlela engcono kakhulu, ungasebenzisi izifaniso zayo. Uma udokotela engenakho okuphikisana nakho, khona-ke ungakhetha umuthi oshibhile.
Ukubuyekezwa kodokotela
I-Izyumov OS, udokotela wezenhliziyo, eMoscow: "I-Kapoten iyisidakamizwa ekwelapheni isimo esilinganiselwe se-hypertensive esibangelwa yizinto ezahlukahlukene. Siyasebenza, kepha simnene. Kunomphumela ophansi ezigulini ezinezifo ezinama-fig, kanye nakwabanye abantu asebekhulile. Ngicabanga ukuthi "ukuthi ithuluzi elinjalo kufanele ligcinwe kwikhabethe lomuthi wasekhaya. Angikaze ngihlangabezane nanoma yikuphi ukusabela okungesihle kulo mkhuba wami."
I-Cherepanova EA, isazi sezinhliziyo, iKazan: "I-Captopril ijwayele ukusetshenziswa njengezosizo oluphuthumayo lesimo se-hypertgency. Isebenza ngempumelelo, futhi izindleko zamukelekile. Imvamisa ngiyayala, kepha ikakhulukazi ezimweni lapho udinga ukunciphisa umfutho wegazi ngokuphuthumayo, uma bukhali. lenyukile. Ngezinye izinhloso, kungcono ukukhetha izidakamizwa ezinomphumela omude. "
Ukubuyekezwa kweziguli kweCapoten ne-Captopril
U-Oleg, oneminyaka engama-52, u-Irkutstk: "Nginomfutho wegazi ophakeme onesipiliyoni, ngakho-ke ngihlala ngiphapheme. Bengilokhu ngisebenzisa iKapoten unyaka wesithathu. Ngibonga yena, umfutho wami wegazi wehla ngokushesha. Ngisho nengxenye yethebhulethi yanele. Ngokwesimo esibi kakhulu, ngemuva kwengxenye yehora ngithatha ingxenye yesibili. Kungcono ukuncibilikisa, njengoba umkhuba ukhombisile. "Futhi uma uliphuza ngamanzi, lihamba kancane."
UMarianna, oneminyaka engama-42, u-Omsk: "Ingcindezi ikhuphuka ngezikhathi ezithile. Ngizama ukugwema amaphilisi noma nini lapho kungenzeka. Kepha ngonyaka ophelile, ngenxa yokuhambela kaningi nezinguquko ezindaweni ezinesimo sezulu, ngaba nenkinga yokuxineka kwezinsuku eziningi. Angikwazanga ukwehlisa ingcindezi. Ngakhumbula ukuthi lapho wabe eseyalulelwa nguCaptopril. amaphilisi ama-2 - kwathi ngemuva kwemizuzu engama-40 ingcindezi yaqala ukuncipha. Ngosuku olulandelayo yayivele ihlelekile. Manje ngigcina iCaptopril kwikhabethe lomuthi. "