Ungasisebenzisa kanjani isidakamizwa i-Ofloxin 200?

I-Ofloxin 200 iyisidakamizwa esivela eqenjini le-fluoroquinolones, i-ejenti ebanzi ye-antimicrobial ejenti. Lokhu kungenye yemithi elwa futhi esetshenziswa kakhulu elwa namagciwane.

Igama Lezwe elingafanele

INN - Ofloxacin.

I-ATX

J01MA01.

Khipha amafomu nokwakheka

Kutholakala ngezindlela ezahlukahlukene zomthamo - uqinile, uketshezi, uthambile. Inezindlela ezahlukahlukene zokusebenzisa. Into esebenzayo yazo zonke izinhlobo yi -loloacacin, i-quinolone yesizukulwane se-II.

I-Ofloxin 200 iyisidakamizwa esivela eqenjini le-fluoroquinolones, i-ejenti ebanzi ye-antimicrobial ejenti.

Amaphilisi

Kumbozwe futhi kuqukethe inani elihlukile lemigomo esebenzayo. Amathebulethi e-Ofloxin, ngaphezu kwe-syntloxoticin esetshenziswayo ye-antiloxacin (200 no-400 mg ngamunye), aqukethe lezo zinto ezengeziwe:

• ushukela wobisi;
• isitashi sommbila;
• i-talc;
• hypromellose 2910/5.

Amacwecwe ahlanganiswa futhi aqukethe inani elihlukile lesimiso esisebenzayo.

Amathebulethi ahluka ngesimo futhi aphrinta okubonisa inani lempahla esemqoka (200 no-400 mg lilinye). Ibhokisi ngalinye liqukethe 1 iqubu eliqukethe amaphilisi ayi-10.

Amaconsi

Amaconsi endlebe nawamehlo ayatholakala. I-1 ml yesisombululo esicacile iqukethe:

• I-3 mg ye -loxacin;
• isisombululo se-saline;
• i-benzalkonium chloride;
• i-hydrogen chloride;
• amanzi alungiselelwe.

Ipakishwe ebhodleleni lepulasitiki eline-dropper.

I-Ofloxin 200 iyatholakala ngesimo samadlebe endlebe nawamehlo.

Powder

Alunayo le ndlela yokukhishwa.

Isixazululo

Isixazululo sokufakwa kombala ophuzi oluhlaza okotshani sifakwe ku-100 ml vials. Ibhodlela liqukethe i-200 mg yento esemqoka kanye nalabo abathola kuyo:

• isisombululo se-saline;
• Trilon B;
• i-hydrogen chloride;
• amanzi alungiselelwe.

Amakhandlela

Amaphilisi we-yellow gelatin ane-cap-brown cap aqukethe:

• i-ofloxacin - 200 mg;
• i-hypromellose;
• i-sodium lauryl sulfate;
• ushukela wobisi;
• calcium phosphate bisubstituted i-anhydrous;
• i-talcum powder.

Amakhebuli we-gelatin aphuzi agcwele emabhulini ezingcezu eziyi-10.

Amakhemikhali ahlanganiswa ngamabhulashi ezingcezu eziyi-10.

Amafutha

Umuthi utholakala ngefomu emnene - umgcwabo wokwelapha amanxeba (i-Oflokain) kanye ne-eye yokugcoba iso ekubekweni esikhwameni se-conjugate. Amafutha afakelwe amashubhu ka-15 noma ama-30 g. Ku-1 g yomkhiqizo uqukethe:

• I-1 mg ye -loxacin;
• I-30 mg lidocaine hydrochloride;
• propylene glycol;
• ipoloxamer;
• macrogol 400, 1500, 6000.

Amafutha wamehlo akhiqizwa kumashubhu we-3 ne-5 g, aqukethe:

• i-ofloxacin - 0,3 g;
• i-nipagin;
• nipazole;
• i-petroleum jelly.

Umuthi uyatholakala ngesimo esithambile - amafutha okuphulukisa amanxeba kanye namafutha okugcwala esikhwameni esikhwameni se-conjugate.

Amakhandlela

Ama-suppositories we-Vaginal ayatholakala ngaphansi kwamagama omkhiqizo ahlukahlukene.

Isenzo se-Pharmacological

Izici ze-bactericidal ze-Ofloxin 200 zibangelwa ukuvimbela kwe-DNA-gyrase - ama-enzyme abhekele ukwakheka kwe-DNA kumaseli wamagciwane kanye nokuzala kwawo. Lama-enzyme abandakanyeka ezinhlotsheni ezimbili ezibaluleke kakhulu - ukukhiqizwa kanye nokuqina kokuqina kwawo. I-Fluoroquinolone inegalelo ekubhujisweni kolwelwesi lwamagciwane, ngakho-ke ubungozi bezindlela zokuphikisa lusezingeni eliphansi.

Umuthi osebenza kakhulu ngokumelene namagciwane angena gamu. I-Ofloxin 200 kwelitshe lapho ivezwa kubo yi-topoisomerase II. Eqenjini le-fluoroquinolones, umuthi umi ngokuqondene nomsebenzi wawo othile ngokumelene ne-cocci-positive cocci. Umgomo wayo yi-topoisomerase IV.

Umuthi osebenza kakhulu ngokumelene namagciwane angena gamu.

I-pharmacodynamics yento isuselwe ekubhujisweni kokuxhumeka phakathi kwezidakamizwa ze-DNA (ukubekeka amandla ayo), okuholela ekufeni kweseli lamagciwane. Ukuqokwa okunjalo kuholele ekuthandweni kwe -loloacacin namanye ama-fluoroquinolones - iningi lamagciwane alwa nezinye izinhlobo zama-antibiotics nama-sulfonamides anika umphumela wawo olimazayo.

Umuthi unesibalo esincane semiphumela enobuthi, njengoba isebenza kuphela ezintweni ezibonakalayo zeseli yamagciwane, ngaphandle kokulimaza ukwakheka kwe-DNA yomuntu. Ngakho-ke, umuthi usetshenziswa ekuziphatheni kwezingane kwe-andrological.

I-Pharmacokinetics

Umuthi usheshe futhi ugcwale ngokuphelele emathunjini, ufinyelela ekuxakaneni okuphezulu kwegazi ngemuva kwamahora ama-1-3. Ukudla kuvimbela kancane inqubo yokufakwa, kepha akukuthinti ukuphelela kwawo. Umuthi unesinye sezinga eliphakeme kakhulu le-digestibility phakathi kwe-fluoroquinolones - cishe i-100%.

Umuthi usheshe futhi ugcwale ngokuphelele emathunjini, ufinyelela ekuxakaneni okuphezulu kwegazi ngemuva kwamahora ama-1-3.

Ukuphila kwayo okuyingxenye kungamahora angama-5- 10, ngakho-ke umuthi ungathathwa izikhathi ezi-1-2 ngosuku. Ukuqoqwa kwento kwezicubu ilingana noma iphakeme kune-serum. Uma kutholakala umthamo omkhulu womuthi, khona-ke into leyo inqwabelana ku:

• Isistimu yezinzwa ephakathi;
• amashubhu bronchial;
• isikhwama sokucaca;
• uhlelo lwe-urogenital;
• ngaphakathi kwamaseli omzimba.

Ngenxa yalezi zakhiwo, umuthi uyasebenza ekwelapheni ukutheleleka kwe-intracellular. I-Ofloxacin ibhekana nezinga eliphansi lokuguqulwa emzimbeni - ama-75-90% ento aqedwa angaguquki emchameni, obalulekile ekwelashweni kwe-pathologies yezinso nepheshana lomchamo.

Into ejikeleza kuyi-plasma yegazi ayiboshelwa kumaprotheni futhi ingangena ngokukhululeka isuka embhedeni wemithambo iye kwezicubu.

Into ejikeleza kuyi-plasma yegazi ayiboshelwa kumaprotheni futhi ingangena ngokukhululeka isuka embhedeni wemithambo iye kwezicubu. Umuthi uhlukile:

• ukusebenza nganoma iyiphi i-pH;
• ukuntuleka komthelela kuma-pharmacokinetics ama-methylxanthines;
• ukuba khona kwesenzo se-postantibiotic;
• izehlakalo eziphansi ze-dysbiosis;
• iphrofayili yokuphepha evumayo.

Umuthi awuthinti ukukhula kwe-intrauterine nokukhula kokubeletha kwengane.

Izinkomba zokusetshenziswa

Kubhekiselwe ukwelashwa kwezifo:

• uhlelo lomchamo;
• izitho zangasese zowesifazane nowesilisa;
• STI
• amathumbu;
• uhlelo lwebhiliary;
• nosocomial kanye ne-postoperative;
• ipheshana lokuphefumula;
• i-septicemia ne-bacteremia;
• Isistimu yezinzwa ephakathi;
• isifo sofuba, uchoko.

I-Ofloxin 200 iboniswa ekwelapheni izifo ezithinta umchamo.

I-Ofloxin 200 iboniswa ekwelashweni kwezifo zokuphefumula zezifo zokuphefumula.

I-Ofloxin 200 ikhonjiswa ekwelashweni kwezifo zangasese zowesilisa.

Amafutha asetshenziselwa ukwelapha i-pathologies yesikhumba, izifo zamazinyo, kanye nokwelashwa kwamanxeba athelelekile.

Contraindication

Umyalo njenge-contraindication kusetshenziswa i-Ofloxin 200 kubonisa:

• hypersensitivity;
• ukukhulelwa nokuqunjelwa;
• ukwelashwa kwezingane ezingaphansi kweminyaka engu-18;
• isithuthwane kanye nokuqina kokubeletha;
• ukuba khona komonakalo we-tendon ngenxa yokusetshenziswa kwe-fluoroquinolones;
• ukuswelakala kwe-cytosolic enzyme (G6FD).

I-Ofloxin 200 i-contraindicated uma kwenzeka kuba ne-hypersensitivity.

I-Ofloxin 200 iphikisiwe ku-lactation.

I-Ofloxin 200 icashunwe ezinganeni ezingaphansi kweminyaka engu-18.

Ngokunakekela

Imiselwe ngokucophelela i:

• i-arrososososis yobuchopho;
• ukuphazamiseka kokujikeleza ebuchosheni;
• umsebenzi wezinso ongonakalisiwe;
• ukhubazeka kwentuthuko kanye nesimo sohlelo lwezinzwa oluphakathi;
• ukuhluleka kwesigqi senhliziyo nokwelula isikhathi sokuphumula se-QT.

Imibango eminingi ibuyekeziwe.

Ukuqapha umuthi kubekelwe ukuphazamiseka kokujikeleza ebuchosheni.

Ukuqapha umuthi kubekelwe umsebenzi wezinso ongasebenzi kahle.

Ukuqashelwa kukhonjiswa ukwehluleka kwenhliziyo isikhathi eside sokuphumula kwe-QT.

Ungayithatha kanjani i-Ofloxin 200

Iziguli zabantu abadala zinqunywe i-200-600 mg. Isikhathi sesifundo yizinsuku ezingama-7-10. Umuthi okw umthamo we-400 mg ungathathwa kanye, mhlawumbe ekuseni, uhhafu wehora noma ihora ngaphambi kokudla, umthamo omkhulu uhlukaniswe ngemithamo emi-2. Kunconywa ukugwinya amaphilisi wonke ngamanzi. Ekulimaleni okukhulu nokukhuluphala, ukukhuphuka komthamo okufika kuma-800 mg / ngosuku kuvunyelwe.

Uma izifo zokuvuvukala zohlelo oluphansi lwe-urinary (i-prostatitis, cystitis, urethritis) zingadideki, khona-ke sekwanele ukuthatha isikhathi esingu-200 mg 1 ngosuku ngezinsuku ezingama-3-5. Ukwelashwa kwe-gonorrhea, kunconywa umthamo owodwa we-400 mg.

Umthamo kanye nenqubo yokwelashwa ezigulini ezinokwehluleka kwe-renal kuncike ekuqinisekisweni kokuqalwa kokuqamba:

Ukwelashwa kuqala ngokuphathwa kwe-intravenous futhi, ngemuva kokuzinza kwalesi simo, ukuphathwa komlomo ku-dosage efanayo kunqunyelwe.

Uma weqa umthamo

Uma isiguli sikhohliwe ukuthatha umuthi, khona-ke uvunyelwe ukuwuphuza masisha lapho isiguli sikhumbula ngakho.

Umuthi okw umthamo we-400 mg ungathathwa kanye, mhlawumbe ekuseni, uhhafu wehora noma ihora ngaphambi kokudla.

Ukuthatha umuthi wesifo sikashukela

Iziguli ezinenkinga yesifo sikashukela esitholakele phakathi ne-Ofloxin 200 zidinga ukulawulwa kweglucose, ngoba Ukwelashwa kanyekanye ngezidakamizwa ezinciphisa ushukela, i-insulin ne-fluoroquinolones kungavusa i-hypo- noma i-hyperglycemia.

Imiphumela emibi ye -loxine 200

Umuthi ubekezelelwa kahle - ukusabela okungekuhle kwakha amacala angama-0.5-10%. Kodwa-ke, imiphumela emibi ibonwa ngezikhathi ezithile.

Iziguli ezinenkinga yesifo sikashukela esitholakele phakathi ne-Ofloxin 200 zidinga ukulawulwa kweglucose.

Amapheshana wesisu

Ubuhlungu kanye nokulimazeka kwesisu, ukuphazamiseka komzimba. Akuvamile kakhulu:

• gastralgia;
• isifiso sokudla;
• i-hyperbilirubinemia;
• ihepatitis.

Izitho zeHematopoietic

I-anemia, i-leukopenia, i-pancytopenia, i-thrombocytopenia iyaphawulwa.

Isistimu yezinzwa ephakathi

Ngendlela yesiyezi, ukukhathazeka, ukuphazamiseka kokulala. Kuboniswa kancane:

• isimo senjabulo noma sokuphazamiseka;
• i-psychosis ne-phobias;
• ukukhuphuka kwengcindezi ye-intracranial;
• imibono;
• ukudangala

Umphumela wecala ovela ohlelweni lwezinzwa oluphakathi: isiyezi.

Imiphumela emibi evela ohlelweni lwezinzwa oluphakathi: ukungalali kahle.

Imiphumela emibi evela ohlelweni lwezinzwa oluphakathi: ukudangala.

Kusuka ohlelweni lwe-musculoskeletal

Okungaba khona:

• i-tendonitis;
• ukuwohloka kwemisipha;
• ukuvuvukala kwamathuluzi okuhlangana nawokuqina;
• ubuthakathaka bemisipha nobuhlungu.

Kusuka ohlelweni lokuphefumula

Akumakiwe.

Engxenyeni yesikhumba

Ngendlela i-petychia, umqubuko, isikhumba.

Kusuka ohlelweni lwezitho zofuzo

Akuvamile ngesimo se:

• i-hypercreatininemia;
• i-jade;
• wandise urea.

Ukusuka esikhunjeni, kungaba nemifantu.

Engxenyeni yesistimu yenhliziyo, umfutho wegazi uyancipha.

Ukusuka ohlelweni lwe-musculoskeletal, kungaba nezimpawu zobuthakathaka nobuhlungu emisipha.

Kusuka ohlelweni lwezinhliziyo

Isigqi senhliziyo siphukile, umfutho wegazi uyancipha, imithambo yegazi iye yashiswa, ukuwa kukhula.

Uhlelo lwe-Endocrine

Akutholakali.

Allergies

Isikhumba ukuqubuka, ukulunywa, ukuphefumula, ukuqina komzimba, ukudumba kobuso noma intamo, i-pneumonitis ye-allergic, i-edema kaQuincke, ukushaqeka kwe-anaphylactic.

Umthelela ekhonweni lokulawula izindlela

Kuyenqatshelwa ukushayela izimoto futhi usebenze ngezinqubo eziyinkimbinkimbi ezidinga ukugxilwa.

Ngemuva kokuthatha umuthi, kwenqatshelwe ukushayela izimoto.

Imiyalo ekhethekile

Ayisebenzi i-pathologies ebangelwa yi-pneumococci noma i-mycoplasmas - i-bronchitis, i-pneumonia, i-bronchitis.

Uma kunezimpawu zokungezwani komzimba, ukusabela okungekuhle kusuka ohlelweni oluphambili lwezinzwa, kufanele ukhansele umuthi.

Ngesikhathi sokulashwa, ukusatshalaliswa, ukuvezwa emisebeni ye-UV kulanga le-solarium ne-physiotherapy kufanele kungafakwa ngaphandle.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

I-Contraindicated ngenxa yokusongela ukuthuthukiswa kwe-pathologies yamalunga kanye nama-ligaments ku-fetus. Lapho uncelisa ibele, kuyadingeka ukudlulisa ingane ifomula yosana.

Kuchaza u-Ofloxin ezinganeni ezingama-200

Izingane azibeki umuthi kuze kube ukukhula nokwakhiwa kohlelo lwe-musculoskeletal kuqedile. Kodwa-ke, ngenxa yezizathu zezempilo futhi uma ungekho umphumela omuhle kwezinye izinto ezibulala amagciwane, i-Ofloxin 200 ingalashwa umthamo ka-7.5 mg nge-1 kg yesisindo somzimba. Okuvunyelwe okuphezulu yi-15 mg / kg.

Izingane azibeki umuthi kuze kube ukukhula nokwakhiwa kohlelo lwe-musculoskeletal kuqedile.

Sebenzisa ebudaleni

Kunqunywa ngokucophelela ngenxa yezinguquko ezihlobene nobudala kanye nobungozi bokusabela okungekuhle.

Isicelo sokusebenza kokulimala kwezinso

Kuyadingeka ukulungisa umthamo ngaphansi kokulawulwa kwamazinga we-creatine.

Sebenzisa umsebenzi wesibindi okhubazekile

Ithuluzi lisetshenziselwa ukubhekelwa njalo kwenani le-bilirubin, ngokunyuka komthamo, lo muthi uyaguqulwa noma ukhanseliwe.

Uma kwenzeka ukungasebenzi kahle kwesibindi, umuthi usetshenziselwa ukubhekisisa njalo inani le-bilirubin.

I-overdose ye-Ofloxin 200

Izimpawu zokudakwa ziyaphawulwa:

• ukubonakaliswa kwe-dyspeptic;
• i-hypersomnia;
• ukudideka.

Umuthi ukhanseliwe, kwenziwa i-gastric lavage. Ngokudakwa kanzima, i-hemodialysis kungenzeka.

Ukuxhumana nezinye izidakamizwa

Isebenzisana ngokuhlukile namaqembu ehlukene wezidakamizwa.

Inhlanganisela ehlanganisiwe

Ungasebenzisi ngasikhathi sinye nge:

• Ama-NSAIDs - ngokunokwenzeka anciphise umkhawulo wokubanjwa kwenhliziyo;
• ama-quinolones nezidakamizwa ezine-metabolism ye-renal - ukwanda kokuxineka kwe -loloin nokwandisa isikhathi sokuphuma kwayo
• ama-antihypertensive agents, ama-barbiturates - ukwehla okubukhali kwengcindezi yegazi kungenzeka;
• i-glucocorticoids - ingozi eyengeziwe ye-tendonitis;
• ama-anthocyanins - anciphise ukugaya izidakamizwa;
• kusho ukuthi ukuguqula i-pH yomchamo ohlangothini lwe-alkali - umphumela we-nephrotoxic kungenzeka.

Ungasebenzisi ngasikhathi sinye

Ngeke isetshenziswe ngasikhathi sinye nama-anthocyanins - anciphisa ukumba umuthi.

Ayikwazi ukusetshenziswa ngasikhathi sinye nama-NSAIDs - kungenzeka ukuthi wehlise umkhawulo wokubanjwa kwensimbi.

Akuhlanganisiwe ukuhlanganisa

Akuvunyelwe ukuhlanganisa ne:

• Abaphikisi baka-Vitamin K - kungenzeka ukuthi bakhuphuke kakhulu begazi;
• I-Glibenkamide - ingakhuphula ukugcwala kwe-glibenclamide ku-serum yegazi;
• ngesikhathi sokucwaninga, umuthi unganikeza ukusabela okuhle kokungezwani nama-opiates nama-porphyrins omchamo.

Inhlanganisela edinga ukuqashelwa

Amacala omsebenzi owandayo wesenzo sokulwa komlomo abikwe ngokuphathwa kanyekanye nge-fluoroquinolones.

Ngokuphathwa kanyekanye kwezidakamizwa ezephula isigqi se-sinus, kuyadingeka ukulawula i-ECG.

I-Ofloxin 200 ayihambelani ne-ethylate.

Ukuhambisana notshwala

Iyahambisana ne-ethylate.

Ama-Analog

Izikhwanyana ezifakiwe zibandakanya: i-Ofaxin, i-Oflo, iFlksan, i-Oftagel, i-Ofor.

Imibandela yekhefu lekhemisi

Umuthi.

Ngingakwazi ukuthenga ngaphandle kadokotela?

Cha.

Intengo ye-Ofloxin 200

E-Ukraine - 133.38-188 UAH. Ensimini yeRussian Federation - ama-ruble ayi-160-180.

Umuthi umuthi.

Izimo zokugcina zomuthi

Endaweni emnyama, epholile, ngaphandle komswakama.

Isikhathi sokuphelelwa yisikhathi

Akudluli iminyaka emithathu.

Umkhiqizi

I-republic yaseCzech.

Ukubuyekezwa kwe-Ofloxin 200

Uthole ukubuyekezwa okuhle kodokotela neziguli.

Odokotela

UMaxim Alexandrovich, udokotela wezifo zomchamo, uMinsk: "Kuwo wonke umsebenzi wami wezokwelapha bengisebenzisa i-fluoroquinolones ekwelapheni iziguli. Ngicabanga ukuthi i-Ofloxin 200 iyasebenza. Inikeza umphumela omuhle futhi ibekezelelwa ngaphandle kwemiphumela emibi."

UGalina Sergeevna, udokotela wezifo zamazinyo, eKiev: "Imvamisa ngichaza i-Ofloxin 200 yeziguli zami ezinezifo ze-urogenital. Yindlela elula, kuhle ukulawula nokugcina umthamo. Kuhle ukuthi udinga ukuyisebenzisa izikhathi ezi-1-2 ngosuku."

Iziguli

U-Olga, oneminyaka engama-32, uKaluga: "Umuthi uphuzwe ekwelashweni kwe-cystitis. Kwakunzima. Ngemuva kwezinsuku ezimbalwa zokuphuza i-Ofloxin 200, zonke izinkomba zanyamalala.

UMikhail, oneminyaka engama-22, u-Omsk: "Ngathola umkhuhlane emsebenzini, kwatholakala nezinkinga nge-urology.Udokotela unqume amaphilisi we-Ofloxin 200 - basebenza ngokushesha. Isizile kahle. "

UTamara, oneminyaka engama-40, uHorlivka: "Ngithole isivivinyo esingesihle sokutheleleka kwezifo zakamuva. Ngokunconywa ngudokotela, ngathatha inkambo ye-Ofloxin. Muva nje ngiye elabhorethri futhi - umphumela waba mubi. Konke kwahamba ngokushesha ngaphandle kwezinkinga."