I-Accupro iyisidakamizwa esisetshenziselwa ukwelapha ukwehluleka kwenhliziyo kanye nokwehlisa umfutho wegazi. Ine-metabolic, i-cardio- nemiphumela ye-nephroprotective, enomphumela omuhle ohlelweni lwezinhliziyo. Umuthi uvimba ukuguqulwa kwamakhompiyutha anezakhiwo ze-vasoconstrictor. Umphumela wayo udlulela kuma-enzyme e-plasma kanye nezicubu, ukuhlinzeka ngomphumela omude we-hypotensive.
Igama Lezwe elingafanele
Igama lesiLatini lomuthi: i-Accupro. INN: Quinapril.
I-ATX
Umuthi we-antihypertensive, i-ACE inhibitor. Ikhodi ye-ATX: C09A A06.
I-Accupro iyisidakamizwa esisetshenziselwa ukwelapha ukwehluleka kwenhliziyo kanye nokwehlisa umfutho wegazi.
Khipha amafomu nokwakheka
Kutholakala ngohlobo oluyindilinga, olunxantathu noma oluyindilinga, amaphilisi ahlanganiswe ngefilimu ngombala omhlophe noma obomvu onsundu. Ithebhulethi eyi-1 iqukethe u-5, 10, 20 noma u-40 mg wento esebenzayo - i-quinapril ngesimo se-hydrochloride, kanye nabathola. Iphakethe lekhadibhodi liqukethe amanxeba ama-3 noma ama-5, ngalinye liqukethe amaphilisi ayi-6 noma ayi-10.
Isenzo se-Pharmacological
Umuthi obizwa nge-hypotensive othambisa umsebenzi we-eniotensin-converting enzyme, ngokubamba iqhaza kwe-angiotensin I kuguqulwe kungiotensin II. Lesi sakamuva siyisizinda se-endo native esisebenza kakhulu esandisa umfutho wegazi. Ukwehla kokukhululeka kwaleli khompiyutha kubangela ukukhuphuka kwe-sodium excretion kanye nokubambezeleka kwe-potassium emzimbeni, okunciphisa ukumelana kwemithambo yegazi kanye nokunciphisa umfutho wegazi. Ngokusetshenziswa njalo, inciphisa inqubo yokuqina kwemisipha yenhliziyo nemithambo yegazi, ekhula ngokumelene nesizinda sehypertension.
I-Pharmacokinetics
Ngemuva kokuphathwa komlomo, ukugcwala okukhulu kwe-quinapril ku-serum kutholakala kungakapheli imizuzu engama-60-90. Okungenani i-55% yezidakamizwa iyangenwa.
Ngaphansi kwesenzo sama-enzyme wesibindi, into esebenzayo isekelwa i-quinaprilat, eyi-ACE inhibitor enamandla. I-bioavailability yayo ehlelekile ingama-35%.
Umuthi osebenzayo kanye nama-metabolites awo awangeni emvinjelweni wegazi-lobuchopho futhi kudalulwa ngokuphuma emzimbeni wezinso. Ezigulini ezinomsebenzi wezinso ongasebenzi kahle, isigamu-sokuphila esisuswa siyenyuka ngokuncipha kokuvunyelwa kwe-creatinine.
Izinkomba zokusetshenziswa
Umuthi ubekelwe ukwelashwa kwe-hypertension ye-arterial kanye nokwehluleka kwenhliziyo okungamahlalakhona.
Umuthi ubekelwe ukwelashwa kwe-hypertension.
Contraindication
Ukusetshenziswa kwomuthi kuyaphikiswa phambi kwezifo nemibandela elandelayo:
- hypersensitivity kunoma iyiphi ingxenye;
- umlando we-angioedema ngenxa yokwelashwa okwedlule ngomuthi we-antihypertgency noma ifa kanye / noma isifo se-alidigic;
- ukungabekezelelani kwe-lactose, i-glucose-galactose malabsorption.
Ngokunakekela
Kusetshenziswa ngokuqapha phambi kwezifo nemibandela enjalo:
- i-hypotension hypterension ye-arterial, ikakhulukazi ezigulini ezake zathatha i-diuretics futhi zalandela ukudla ngokudla usawoti okulinganiselwe;
- i-acute syndrome ebangelwa ukungasebenzi kahle kwemisipha yenhliziyo;
- isifo sikashukela mellitus;
- ukwehluleka kwezinso noma kwesibindi;
- izifo ezithinta izicubu ze-autoimmune;
- ukuntuleka kwamakhosi
- hyperkalemia
- ukwehla kwegazi elijikelezayo.
Ekuqaleni kokwelashwa, umuthi unconywa ukuthi usetshenziswe ngokubhekelwa nezinkomba zokucindezela kwegazi.
Ungayithatha kanjani i-Accupro
Isikhathi sezifundo kanye namarejimeni kunqunywa uchwepheshe, kucatshangelwa ukutholwa nezimpawu zomuntu ngamunye. Umuthi uphuzwa ngomlomo, kungakhathalelwa ukudla, i-0.01 g izikhathi ezi-1-2 ngosuku. Uma ungekho umphumela wokwelapha odingekayo, umthamo owodwa ungandiswa ngezikhathi ezingama-2, kepha ungeqi umthamo omkhulu we-0.08 g ngosuku. Kuvunyelwe ukuthatha umthamo wosuku kanye, ngaphandle kokuhlukanisa imithamo eminingana. Umthamo ungakhuphuka kuphela ngokunconywa kukadokotela oholayo hhayi ngaphambi kwamaviki amane kusukela kuqale ukwelashwa.
Ngoshukela
Isidakamizwa sisetshenziswa njengengxenye yokwelashwa okubanzi kwe-antihypertensive, sibheka ukulawulwa ngokucophelela kwe-glycemic kanye nohlobo lokuncoma lomthamo.
Imiphumela emibi
Umuthi empeleni awubangeli ukusabela okungafuneki. Imvamisa, ibonwa ngokuhambisana nesizinda se-hypersensitivity kuzakhi zayo noma uma umthamo onconyiwe ungabhekwa. Ukwelashwa kufanele kunqunywe uchwepheshe ngemuva kokuxilongwa, kucatshangelwa ama-concomitant pathologies.
Amapheshana wesisu
Ukomelela kolwelwesi lwe-mucous lomlomo noma komphimbo, ukuphazamiseka komzimba, isicanucanu, ubuhlungu besisu, ukuncipha kokudla, kanye nokuphambana kokuqonda ukunambitheka kuyaphawulwa.
Isistimu yezinzwa ephakathi
Ngokuphikisana nesizinda sokuthatha umuthi, ukuguquguquka kwemizwelo, i-vertigo, ukuphazamiseka komzimba, ukukhathala okwandisiwe noma ukungaphatheki kahle, isifo sokuzwela kwesikhumba esibonakala ngokuzizwa kanye nokuxineka kungenzeka.
Kusuka ohlelweni lomchamo
Ezimweni ezingazodwa, ukutheleleka kwezifo zomgudu womchamo kuyaphawulwa.
Kusuka ohlelweni lokuphefumula
Imvamisa kuba nokukhwehlela okuphikelelayo, okungakhiqizi okunyamalala ngemuva kokuyekiswa kokwelashwa, umuzwa wokuntuleka komoya, ukuvuvukala kobuhlungu be-mucosa pharyngeal, ubuhlungu besifuba.
Engxenyeni yesikhumba
Ukuphendula okungaba khona kwesikhumba nezicubu ezihlehlayo, njengokukhuphuka kokujuluka, i-erythema kanye ne-desquamation, ukushesha, ukulunywa, ukulahleka kwezinwele ze-pathological, i-pemphigus, indlela yasendaweni noma ye-photosensitivity reaction.
Kusuka ohlelweni lwezitho zofuzo
Ezimweni ezingavamile kakhulu, ukwehla kwe-potency, ukubambezeleka kokuchama kungenzeka.
Kusuka ohlelweni lwezinhliziyo
Ukuphendula okungaba khona kwezitho ze-hematopoietic, njengokuncipha kwenani lamaseli abomvu egazini, ukuncipha kwe-hemoglobin, agranulocytosis, ukwehla kwenani lamaplatelet, kanye nokuntuleka kwazo zonke izinhlobo zamangqamuzana egazi.
Engxenyeni yesistimu yenhliziyo, ukusabela okunjalo okungathandeki kungenzeka njengokuncipha kwengcindezi yegazi, ukungakhululeki endaweni yesifuba, izinzwa zenhliziyo, ukushaqeka kwe-cardiogenic, i-tachycardia, ukwanda kwe-lumen yemithambo yegazi.
Kusuka ezicutshini zemisipha
Imvamisa kubuhlungu emuva. Ezimweni ezingavamile, ngokumelene nesizinda sokusetshenziswa kwomuthi, izifo ezihlangene eziwohlokayo zenzeka.
Kusuka emasosheni omzimba
Ukuphendula kwe-Anaphylactoid, angioedema kungenzeka.
Allergies
Uma kukhona ikhwela laryngeal noma ukuvuvukala izicubu zobuso, ulimi noma izindonga zezwi, ukwelashwa nomuthi kufanele kumiswe ngokushesha. Uma ukudumba kolimi noma i-larynx kusongela ukulimaza ukuhamba komoya emaphashini, kudingeka ukwelashwa okuphuthumayo nokuqapha ngaphambi kokuphinda kube nezimpawu zokungezwani komzimba.
Umthelela ekhonweni lokulawula izindlela
Lapho uthatha umuthi, kufanele kuqashelwe lapho kulawulwa izindlela kanye nokwenza umsebenzi odinga ukunakwa okwandisiwe, ikakhulukazi ekuqaleni kokwelashwa, ngenxa yengozi enkulu yesiyezi ne-hypotension.
Imiyalo ekhethekile
Ukusetshenziswa ngasikhathi sinye kokudla akukuthinti izinga lokutholwa kwalo muthi, kepha kwandisa isikhathi sokufinyelela ekuqoqweni okuphelele kwento esebenzayo.
Lapho uthatha umuthi, kunconywa ukuthi ungafaki ukudla okunamafutha ekudleni.
Kwezinye izimo, ukwelashwa nge-angiotensin-converting enzyme inhibitors kuhambisana nokukhula kwe-hypoglycemia ezigulini ezinesifo sikashukela mellitus, ukuthatha izidakamizwa ze-hypoglycemic zomlomo noma ukuthola i-insulin. Into esebenzayo yesidakamizwa ithuthukisa isenzo se-insulin kanye ne-antidiabetesic agents.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ihlanganiswe nokukhulelwa nokukhulelwa.
Ukuqokwa kwe-Akkupro ezinganeni
Umuthi awusetshenziswanga ukwenza kwezingane ngenxa yokuntuleka kwemininingwane yokuphepha nokusebenza kwayo.
Sebenzisa ebudaleni
Kuvunyelwe ukusetshenziselwa ukungabikho kwe-contraindication. Umthamo wokuqala ophakanyisiwe wezidakamizwa ngu-10 mg kanye ngosuku. Ngaphansi kokuqondisa kukadokotela oholayo, kungakhuphuka ukufezekisa umphumela owuthandayo wokwelapha.
Isicelo sokusebenza kokulimala kwezinso
Ezigulini ezinokungasebenzi komzimba, ukukhuphuka kwengxenye yempilo yento esebenzayo kuyabonakala, ngakho-ke, kuyadingeka ukulungisa umthamo, kucatshangelwa izinkomba zokucaca kwe-creatinine. Imithamo yokuqala yokuqala isukela ku-2,5 kuye ku-10 mg ngosuku. Ukungezelela umthamo wesidakamizwa kungenzeka kuphela ngaphansi kokulawulwa kokusebenza kwesitho. Ukwehluleka ukuhambisana nezincomo zezokwelapha kungaholela ekungasebenzi kahle kwesitho, kubandakanya nengozi yokuthola ukuhluleka kwe-renal acute.
Ukweqisa
Izimpawu zokweqisa ngokweqile kungukuphulwa kwenani le-electrolyte esele, i-arrhythmia enzima, ukwehla kwamandla okuwohloka kwenhliziyo, kanye nokukhubazeka okubukwayo. Ukwelashwa kwenziwa ukuphathwa kanzulu kwezixazululo eziguqula i-plasma ukuze kunyuswe umthamo wamanzi ajikelezayo. Ukusetshenziswa kokwelashwa kwe-dialysis kunomthelela ongemuhle ekuvekeni kwento esebenzayo. Uma kwenzeka kwehla umfutho wegazi, kuyadingeka ukwelashwa okubonakalayo nokusekelayo.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa kanyekanye kwama-tetracycline antibiotic kanye nomuthi we-antihypertgency kunciphisa ukumuncwa kwe-tetracyclines. Ukwelashwa ngamalungiselelo e-lithium nama-inhibitors e-ACE kukhulisa okuqukethwe kwe-serum lithium, kwandise ubungozi bokudakwa. Ukulungiselela kwePotassium kuthuthukisa umphumela we-antihypertensive wento esebenzayo yesidakamizwa, yandisa izinga lezinto zokulandela egazini. Ukwelapha okuhlanganisiwe nezidakamizwa ezivimbela ukusebenza kwethambo kwakhulisa ubungozi be-pathologies yegazi, kufaka phakathi ukwehla kwenqwaba yama-granulocytes nama-neutrophils.
Ukuphathwa kanyekanye kwesidakamizwa esiqukethe i-hinapril ene-Allopurinol, i-Novocainamide, ama-cytostatic agents noma ama-immunosuppressants kwandisa ingozi yokuthola i-leukopenia. Izidakamizwa ze-antihypertensive, ama-anesthetics, kanye ne-opioid analgesics zithuthukisa umphumela we-quotapril, ngenkathi izidakamizwa ezingezona ze-steroidal ezilwa nezifo ziwenza buthaka ngenxa yokugcinwa kwamanzi emzimbeni.
Ukuhambisana notshwala
I-Ethanol ithuthukisa umphumela we-antihypertensive womuthi.
Ama-Analog
Umuthi unezinhlobo eziningi zezigcawu ezingeqembu elilodwa le-pharmacological. Phakathi kwazo kukhona:
- IHinapril-C3;
- Prestarium
- Okwesibili.
Umuthi osebenzayo wezidakamizwa ungahluka, ngakho-ke, ukufakwa komuthi kumele kuvunyelwane nodokotela.
Imibandela yeholide i-Acupro evela ekhemisi
Ukuthenga umuthi we-antihypertensive, ukuqokwa kukadokotela kuyadingeka.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ikhishwe ngumbhalo.
Intengo ye-Acupro
Intengo ephakathi yesidakamizwa ama-ruble angama-535-640.
Izimo zokugcina zomuthi
Gcina endaweni yokushisa yegumbi elawulwayo (hhayi ephakeme kune- + 20 ° C). Gwema kude nemisebe yelanga. Khawulela ukufinyelela kwezingane emithini.
Isikhathi sokuphelelwa yisikhathi
Izinyanga ezingama-36 ngemuva kokuphelelwa yisikhathi okuyinto engamukeleki ukusebenzisa umuthi.
Umkhiqizi u-Akkupro
I-Pfizer Production Dhechland (Germany).
Ukubuyekezwa kwe-Akkupro
Ngaphambi kokusebenzisa umuthi we-antihypertensive, kunconywa ukuthi ufunde ukubuyekezwa kochwepheshe bezokwelapha neziguli.
Gcina endaweni yokushisa yegumbi elawulwayo (hhayi ephakeme kune- + 20 ° C). Gwema kude nemisebe yelanga.
Odokotela
U-Alevtina Ivanova (udokotela wenhliziyo), oneminyaka engama-39, u-Ivanovo
Umuthi osebenza ngempumelelo owenzelwe ukunciphisa umfutho wegazi futhi uthuthukise ukusebenza kwenhliziyo. Ukusetshenziswa isikhathi eside kusiza ukuqinisa izindonga zesistimu yenhliziyo, ukuthuthukisa ukuqina kwabo. Umuthi uhlakazwa ngokuya ngommiselo, ngakho-ke, impatho efanele kufanele inikezwe uchwepheshe ukuze aqede ukungqubuzana okungenzeka futhi anciphise nengozi yokuthola ukusabela okungafuneki.
Iziguli ezithatha umuthi
U-Alina, oneminyaka engama-43 ubudala, uKrasnoyarsk
Wayithatha izinyanga ezimbalwa. Ukusebenza kwezidakamizwa kuphezulu, ingcindezi ibuyela kokujwayelekile ngemuva kwamahora ama-1-2 ngemuva kokuphathwa. Kodwa-ke, waphoqeleka ukuba alahle leli khambi maqondana nomphumela omubi ongemuhle - ukuhlaselwa ukukhwehlela okuhlala isikhathi eside.
U-Ana, oneminyaka engama-28 ubudala, Perm
Umama isikhathi eside wazama ukubhekana nomfutho wegazi ophezulu okwakhe, kodwa ukusebenza kwezindlela zabantu kusesikhashana. Kwakufanele ngibone udokotela. Umama wanikezwa lesi sidakamizwa ngoba bathola ukwehluleka kwenhliziyo. Ngemuva kokuthola ukwelashwa, izinkomba zokucindezela zibuyele kokujwayelekile, izimpawu zokumpontshelwa kwenhliziyo zanyamalala. Akubanga namiphumela emibi kakhulu, bekungadingekile ukuthi ushintshele kuma-analogu abiza kakhulu ngemiphumela emibi embalwa.
