Abaphenyi baseRussia baklame izinto lapho umuthi ungenziwa ukubuyisela nokugcina impilo ye-pancreatic yohlobo 1 sikashukela.
Kuma-pancreas, kunezindawo ezikhethekile ezibizwa ngokuthi amaLangerhans Islands - yizo ezihlanganisa i-insulin emzimbeni. Le hormone isiza amaseli ukuthola ushukela egazini, futhi ukungabi bikho - okuyingxenye noma okuphelele - kubangela ukwanda kwamazinga kashukela, okuholela kwisifo sikashukela.
I-glucose eyeqile inyusa ukulingana kwe-biochemical emzimbeni, kwenzeka uxinzelelo lwe-oxidative, futhi ifomu lama-radical lamahhala kakhulu emangqamuzaneni, okuphazamisa ubuqotho bala maseli, libangele ukulimala nokufa.
Futhi, i-glycation ivela emzimbeni, lapho i-glucose ihlangana khona namaprotheni. Ebantwini abaphilile, le nqubo nayo iyaqhubeka, kepha kancane kancane, futhi kwishukela ikhuphuka futhi ilimaze izicubu zomzimba.
Umbuthano onobungozi obuqapheleka ubonwa kubantu abanesifo sikashukela sohlobo 1. Ngalo, amangqamuzana e-Langerhans Islets aqala ukushona (odokotela bakholelwa ukuthi lokhu kungenxa yokuhlaselwa kwe-autoimmune komzimba uqobo), futhi yize bekwazi ukwahlukana, ngeke bakwazi ukubuyisa inani labo lasekuqaleni, ngenxa yengcindezi ye-glycation nengcindezi oxidative ebangelwa yi-glucose eyeqile kufa ngokushesha okukhulu.
Ngolunye usuku, iphephabhuku i-Biomedicine & Pharmacotherapy lashicilela i-athikili ngemiphumela yocwaningo olusha olwenziwa ososayensi abavela e-Ural Federal University (Ural Federal University) kanye ne-Institute of Immunology and Physiology (IIF UB RAS). Ochwepheshe bathole ukuthi izinto ezikhiqizwa ngesisekelo se-1,3,4-thiadiazine zivimbela ukusabela kwe-autoimmune okukhulunywe ngenhla ngendlela yokuvuvukala, ebhubhisa amaseli we-insulin, futhi, ngasikhathi sinye, kususa imiphumela yokuxineka kwe-glycation kanye ne-oxidative.
Emiphungeni enesifo sikashukela sohlobo 1, esivivinya okususelwa ku-1,3,4-thiadiazine, izinga lamaprotheni okuzivikela ezifweni egazini lancishiswa kakhulu kwathi i-hemoglobin ye-glycated yanyamalala. Kepha okubaluleke kakhulu, ezilwaneni inani lamaseli ahlanganisa i-insulin emanyikweni likhuphuke kathathu futhi izinga le-insulin ngokwalo lakhuphuka, okunciphisa ukuncipha kweglucose egazini.
Kungenzeka ukuthi izidakamizwa ezintsha ezenziwe ngesisekelo sezinto ezisetshenziswe ngenhla zizoguqula ukwelashwa kwesifo sikashukela sohlobo 1 futhi zinikeze izigidi zeziguli amathemba athembisayo ngekusasa elizayo.
