Ungayisebenzisa kanjani isidakamizwa i-Amitriptyline Nycomed?

I-Amitriptyline Nycomed iyilungu leqembu le-tridclic antidepressant. Umuthi uyisigaba samanani aphansi, kubalulekile, ngoba isikhathi esiningi sokwelashwa sinamaviki ambalwa noma izinyanga.

Igama Lezwe elingafanele

I-Amitriptyline.

I-Amitriptyline Nycomed iyilungu leqembu le-tridclic antidepressant.

I-ATX

N06AA09.

Khipha amafomu nokwakheka

Umkhiqizo ukwimo yamatafula. Lokhu kulungiswa kwengxenye eyodwa, kuqukethe izinto ezi-1 ezisebenzayo - amitriptyline. Izibhebhe zinegobolondo, ngenxa yokuthi izinga lomphumela wobudlova besidakamizwa kulolwelwesi lwe-mucous lwento yokugaya luyancishiswa. Ukuqoqwa kwento esebenzayo: i-10 noma i-25 mg (kuthebhulethi eyi-1). I-antidepressant iqukethe izinto eziningi ezingasebenzi ezisetshenziselwa ukuthola ukuvumelana kwesidakamizwa okufisayo:

• i-magnesium stearate;
• i-microcrystalline cellulose;
• isilika;
• i-talc;
• lactose monohydrate.
• isitashi.

I-Amitriptyline ikhiqizwa ngohlobo lwamathebulethi abilisiwe, ngenxa yokuthi izinga lokuphathwa komoya odabukisayo kolwelwesi lwama-mucous lomgudu wesisu lincishisiwe.

Igobolondo lokuvikela lomkhiqizo libuye libe nezinto eziningi:

• i-macrogol;
• dimethicone;
• propylene glycol;
• titanium dioxide;
• i-hypromellose;
• i-talcum powder.

Amacwecwe aqukethe ibhodlela eligcina ama-50 ama-pcs.

Isenzo se-Pharmacological

Umgomo wokusebenza kwama-antidepressants ama-tricyclic usekelwe ekuvinjelweni kokubanjwa kwama-monoamines, amelelwa yi-norepinephrine, dopamine ne-serotonin. Lezi zinto zinomthwalo wemizwa yenjabulo.

Umuthi, njengezinye izindlela zeqembu eline-tricyclic antidepressant, unemiphumela ebalulekile - inani elikhulu lemiphumela emibi eyenzeka ngesikhathi sokwelashwa. Lokhu kungenxa yomgomo wezenzo ongakhethi. Ngenxa yalokhu, umuthi awuthinti kuphela ukubanjwa kwama-monoamines, kodwa futhi uvimbela okunye ukusabela kwe-biochemical.

I-Amitriptyline ngasikhathi sinye yenza imisebenzi eminingana. Impahla yayo eyinhloko i-antidepressant. Ngaphezu kwalokho, umuthi uhlinzeka ngomphumela wokuyenga, okhathazayo, we-hypnotic. Lokhu kusho ukuthi ngesikhathi sokwelashwa akuwona kuphela isimo sengqondo somguli esenziwe ngokwejwayelekile, kodwa futhi nokulala siyabuyiselwa, ukukhathazeka kuyanyamalala.

I-Amitriptyline ihlinzeka ngomphumela we-sedative hypnotic, ngenxa yokuthi isiguli sibuyisela ukulala.

Ngenxa yamandla okuvimbela ukuphinda kuthathwe ama-monoamines, kuye kwanda ukwanda kokuxineka kwabo emgodleni we-synaptic wohlelo lwezinzwa oluphakathi. Ngaphezu kwalokho, isakhi esisebenzayo se-Amitriptyline Nycomed block M1- and M2-muscarinic cholinergic receptors, histamine receptors, futhi ngasikhathi sinye, i-alpha1-adrenergic receptors. Umphumela omuhle wokwelapha nalesi antidepressant ubonakala ngenxa yokuxhuma okukhona phakathi kwama-neurotransmitters akhiwe kuma-synapses obuchopho kanye nesimo sokuzwela.

Esinye isici salo muthi ngumphumela ohamba kancane. Umphumela omuhle awutholakalanga masinyane, kepha ngemuva kokuhlakazwa kwento esebenzayo eplasma yegazi ifinyelela umkhawulo wokulingana. Ngaphezu kwalokho, lapho sesifinyelela izinga elithile (kuyehluka kuye ngethamo), umphumela onamandla we-psycho nawo uyabonakala. Kodwa-ke, umphumela uhlala uqinisekiswa ngokumelene nesizinda sokwanda kwe-metabolite eyinhloko ye-amitriptyline - nortriptyline.

Ngokwanda kanye nokwehla komthamo, izakhiwo zesidakamizwa zishintsha kancane. Ngakho-ke, lapho ifinyelela ezingeni elithile, umsebenzi we-nortriptyline uyancipha, ukusebenza kwe-amitriptyline kuyanda. Kodwa-ke, ukwehla kwemiphumela yokubhekana nezinkinga kwesinye isikhathi kuyaphawulwa. Ngalesi sizathu, awukwazi ukuthatha lesi sidakamizwa wedwa, ngoba kubalulekile ukuzikhethela uhlobo olufanele lokwelashwa unaka izici zomzimba. Kumele kukhunjulwe ukuthi ukuthatha imithamo emincane ngeke kunikeze umphumela oyifunayo.

Nge-amitriptyline, ungalawula ukushaya kwenhliziyo yakho. Lokhu kungenxa yomphumela we-antiarrhythmic womuthi.

Umuthi okukhulunywa ngawo uyasebenza futhi ephula umsebenzi weCCC. Isibonelo, singasetshenziswa ukulawula ukushaya kwenhliziyo. Lokhu kungenxa yomphumela we-antiarrhythmic womuthi. Lapho kunqunywa umuthi ngemithamo yokwelapha, kwehla ukujula kokuqina kwenqubo ye-ventricular conduction.

I-Pharmacokinetics

I-Amitriptyline iboniswa ukumunca ngokushesha. Ngemuva kwamahora we-2-6, inani eliphakeme lomsebenzi walesi zinto lifinyelelwa. Ihlukaniswa ngesilinganiso esiphakathi se-bioavailability (50%). Kodwa ukubopha kumaphrotheni we-serum kuphezulu - 95%. Uma unikezwe ukuthi umuthi unikeza umphumela oyifunayo ngemuva kokufinyelela ekuqoqweni okulinganayo kwengxenye esebenzayo emzimbeni, umphumela omuhle akufanele ulindelwe ngaphambi kweviki elingu-1 ngokuhamba kwesikhathi. Lokhu kungenxa yokuthi inkathi yesikhathi enjalo iyadingeka ukufeza isimo esiyinhloko lapho izimpawu ze-pathology ziqala ukunyamalala.

Into esebenzayo ikhiqizwa esibindini. Okokuqala, idokhumenti enkulu, i-nortriptyline, iyakhishwa. Ngemuva kwalokho, zombili i-amitriptyline ne-metabolite yayo esebenzayo zi-hydroxylated, zilandelwe ukukhishwa kwezinto ezinamandla amakhulu. Ukuphila kwesidakamizwa kuyahlukahluka kusuka emahoreni ayi-9 kuye kwangama-46, okuthintwa yisimo somzimba, ukuba khona kwamanye ama-pathologies.

Kuyalulekwa ukusebenzisa lesi sidakamizwa ukucindezelwa kwezinhlobo ezahlukahlukene, okuhambisana nokuphazamiseka kokulala.

I-Amitriptyline inqunyelwe ukuphazamiseka kwesinye i-bladder (enuresis nge-expression ebusuku).

I-Amitriptyline ikhonjiswa nge-bulimia.

Okunqunyelwe

Kuyalulekwa ukusebenzisa lesi sidakamizwa ekuphazamisekeni okuningi kwengqondo, ikakhulukazi:

• izinhlobo ezahlukahlukene zokucindezelwa, okuhambisana nokuphazamiseka kokulala, ukukhathazeka, ngenkathi umuthi okukhulunywa ngawo usetshenziswa njengesilinganiso esiyinhloko sokwelapha;
• njengengxenye yokwelapha okuyinkimbinkimbi, isithasiselo sokudambisa izinhlungu sinqunywa emacaleni amaningi: zokuziphatha, i-phobic, ukuphazamiseka kwemizwelo, ukungasebenzi kahle kwe-bladder (enuresis enezimpawu ebusuku), i-anorexia, i-bulimia.

Contraindication

Kunemikhawulo eminingi ekusetshenzisweni kwalesi sidakamizwa:

• ukusabela okungekuhle kokuthile kunoma iyiphi ingxenye ekwakhiweni (kuyasebenza futhi akusebenzi);
• infarction myocardial, kubandakanya umlando we;
• ubuthi be-ethanol acute;
• izimo zokugula ezihambisana nokungazi kahle;
• ubuthi ngezidakamizwa (antidepressants, psychotropic or hypnotics);
• arrhythmia;
• ukuvala i-glaucoma;
• ukwephulwa kwe-intraventricular, i-atrioventricular conduction;
• ukuhlukunyezwa kofuzo okuhambisana nokushoda kwe-lactase, ukungabekezeleli kwe-lactose, i-glucose-galactose malabsorption syndrome;
• ukwakheka ngokweqile kwamaseli emithanjeni ye-Prostate gland, okuholela ekunciphiseni kokukhanya kwe-urethra;
• ukuqina kwamathumbu okhubazekile;
• ukwehla kwamazinga e-potassium;
• bradycardia.

Umuthi awubekelwe i-bradycardia.

Umuthi uphulwe ku-myocardial infarction, kufaka phakathi umlando.

Ngokuqapha, i-amitriptyline imiselwe umfutho wegazi ophakeme.

Ngokuquleka, umuthi unqunywa ngokuqapha.

Isifo se-Bipolar ukuphikisana okuqhathaniswa nokuqokwa kwe-amitriptyline.

Ngokuqapha, umuthi ubekelwe izimo ze-pathological, ezihambisana noshintsho ekwakhekeni nasezakhiweni zegazi.

Ngokunakekela

Ukuphulwa okuhlobene:

• umfutho wegazi ophakeme;
• izimo ze-pathological ezihambisana noshintsho ekwakhekeni nasezakhiweni zegazi;
• ukukhuphuka kwengcindezi ye-intraocular nezinye izifo zezitho zombono;
• noma yikuphi ukugula okuhambisana nokugcinwa komchamo;
• iminyakazo
• i-schizophrenia
• isithuthwane
• ukuphazamiseka kwengqondo okuguquguqukayo;
• ukwephulwa kwe-gland yegilo (hypothyroidism).

Ungayithatha kanjani i-Amitriptyline Nycomed

Ukukhethwa kwerejimeni yokwelashwa kwenziwa ngokubheka uhlobo lwesifo. Cabanga iminyaka, izinga lokuthuthuka kwe-pathology, ukuba khona kwemikhawulo ekusetshenzisweni kwe-Amitriptyline Nycomed. Amathebulethi akufanele ahlafunwe. Nikeza umuthi ngemuva kokudla.

Ishedyuli yokushona kwabadala

Ukwelashwa kufanele kuqale ngomuthi ka-50-75 mg. Ngemuva kwalokho yanda, uma kunesidingo, ngo-25-50 mg. Leli nani lithathwa kanye ngaphambi kokulala noma lihlukaniswe ngemithamo emibili. Kodwa-ke, awukwazi ukudlula umthamo nsuku zonke we-200 mg. Isikhathi sesifundo - izinyanga eziyi-6.

I-Amitriptyline Nycomed ngokuqapha imiselwe ukwephula i-gland yegilo.

Nikeza umuthi ngemuva kokudla, amaphilisi awakwazi ukuhlafunwa.

Isikhathi sokwelashwa nge-amitriptyline izinyanga eziyisithupha.

Amitriptyline Nycomed umthamo wesithako wezingane

Yabela nama-envesis: 25 mg kanye kwiziguli ezisukela eminyakeni engu-7 kuye kwengu-12 ubudala, ngaphezulu kweminyaka engu-12 - 50 mg. Kungcono ukuthatha imali ngaphambi kokulala.

Ukuthatha umuthi wesifo sikashukela

Umuthi okukhulunywa ngawo uthinta umphumela oboniswe yi-insulin, futhi ungavusa ushintsho ekugxilisweni kwe-glucose. Ngalesi sizathu, ezimweni eziningi, ukulungiswa kwamthamo kuyadingeka. Inani lomuthi linqunywe ngokuhlukile.

Malini okuvumelekile

Ithuluzi linikeza umphumela emasontweni ambalwa. Kuqala ukusebenza phakathi namahora okuqala ngemuva kokuqala kokwelashwa. Umphumela umphumela uhlala izinsuku ezingama-1-2.

Ungayikhansela kanjani i-Amitriptyline Nycomed kahle

Ukugwema ukuhoxiswa kwesifo, kunconywa ukunciphisa kancane kancane umthamo.

Imiphumela emibi

Kumele kukhunjulwe ukuthi umuthi okukhulunywa ngawo unomthelela ekubonakala kwemiphumela emibi eminingi.

Amapheshana wesisu

Isicanucanu, ulwelwesi olomile, izinguquko zesakhiwo se-stool (ukuqunjelwa). Ukusuka ohlelweni lokugaya ukudla, izimpawu ezilandelayo zivame ukwenzeka: ukungaphatheki kahle emlonyeni, ukuvuvukala, ama-caries. Okungaphansi kakhulu, isifo sohudo, ukuhlanza, ukuvuvukala kolimi, i-hepatitis, i-jaundice, ukuvinjwa kwamathumbu.

Ukusetshenziswa kwe-amitriptyline kungahle kuhambisane nesimo sokuwa.

Ngesikhathi sokwelashwa, kuvela kweminye imizwa emibi njengokuthuthumela kwemikhawulo kuyaphawulwa.

Ngemuva kokuphuza lo muthi, kuvame ukuvela ikhanda, okuwuphawu lomphumela wecala.

Ngokuphikisana nesizinda sokusebenzisa umkhiqizo, isiyezi singabonakala.

I-Amitriptyline ingadala ushintsho kusakhiwo se-stool (ukuqunjelwa).

Izimo ezivame ukwenzeka ngemuva kokuthatha amaphilisi kubhekwa njengokungakhululeki emlonyeni, ukuvuvukala, amasenti.

Izitho zeHematopoietic

Umsebenzi wamathambo ongasebenzi kahle, izimo eziningana ze-pathological lapho kukhona khona ushintsho ekwakhekeni nasezakhiweni zegazi.

Isistimu yezinzwa ephakathi

Ubuthakathaka obujwayelekile, ukozela, ukwehla kwemilenze, ukukhanda ikhanda nesiyezi, ukunakwa okungahambi kahle, ukukhuluma, ukunambitha.

Ngasohlangothini lwe-metabolism

Shintsha esimweni sokudla: yanda, yehle. Ngenxa yalokhu, isisindo somzimba siyakhuphuka noma sinciphe.

Allergies

IVasculitis, i-urticaria, ebonakaliswa ukulunywa, ukuqubuka.

Umthelela ekhonweni lokulawula izindlela

Ngesikhathi sokulashwa, kufanele wenqabe ukushayela izimoto, ngoba umuthi unomthelela ekungasebenzi kahle kohlelo lwezinzwa, uthinta izitho zombono nokuzwa, futhi ucasule ukungahambi kahle kwengqondo.

Imiyalo ekhethekile

Ukwelapha kuqala ngokulawulwa kwengcindezi yegazi.

Lapho ushintsha isikhundla somzimba, ukunakekelwa kufanele kuthathwe; ukunyakaza okubukhali akunakwenziwa.

Ukusabela kokungezwani nomuthi kukhonjiswa i-urticaria, ukulunywa, ukuqubuka.

Ngesikhathi sokulashwa, kufanele wenqabe ukushayela izimoto, ngoba umuthi unomthelela ekungasebenzi kahle kohlelo lwezinzwa, uthinta izitho zombono nokuzwa.

In kubantu abasha (kuze kube iminyaka engama-24), ubungozi bokuzibulala belashwa nge-Amitriptyline Nycomed luyanda.

Iziguli ezineminyaka engaphezu kwengu-50 ubudala zisengozini eyengeziwe yokuqhuma kwamathambo.

Kwezinye izikhathi kungadingeka ukulawula ukubalwa kwegazi.

I-Suicidal phenomena iyaqhubeka kuze kube yilapho ingxenye esebenzayo isiza ukunciphisa izimpawu zokuphazamiseka kwengqondo.

In kubantu abasha (kuze kube iminyaka engama-24), ubungozi bokuzibulala belashwa nge-Amitriptyline Nycomed luyanda.

Ngaphambi kokwenza imisebenzi ebanzi, izinqubo zamazinyo, kufanele uyeke ukuthatha lo muthi.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ayabelwe.

Sebenzisa ebudaleni

Kwamukelekile ukusebenzisa isinciphisi sokucabanga embuzweni, kepha kufanele siqashelwe. Udinga ukuqala inkambo yokwelashwa nge-25-30 mg (kanye ngosuku). Khuphula inani lomuthi kufanele ube yisikhathi esingu-1 njalo ezinsukwini ezi-2. Umthamo omkhulu wansuku zonke yi-100 mg.

Isicelo sokusebenza kokulimala kwezinso

Ezigulini ezinezifo zalesi sitho, ukumbiwa kwe-metabolites esebenzayo ye-Amitriptyline Nycomed kusuka emzimbeni kuncishiswa. Ayikho imikhawulo eqinile ekuphuzeni umuthi.

Sebenzisa umsebenzi wesibindi okhubazekile

Kuvunyelwe ukusetshenziswa ngokuqapha. Ngokusebenza okunganele kwesibindi, umthamo uyancishiswa.

Uma kwenzeka ukungasebenzi kahle kwesibindi, i-amitriptyline ivunyelwe ukuthi isetshenziswe ngokuqapha.

Ezigulini ezinesifo sezinso, ayikho imikhawulo eqinile ekusetshenzisweni kwalo muthi.

Ngesikhathi sokukhulelwa nokuqunjelwa, i-amitriptyline ayinqunyelwe.

Ebudaleni kuvunyelwe ukusebenzisa i-amitriptyline, kepha kufanele kuqashelwe ngokuqapha.

Uma umthamo we-amitriptyline udluliwe, isisu kufanele sihlanzwe ukwehlisa izinga lobuthi besidakamizwa.

Iziphuzo eziqukethe utshwala ne-amitriptyline azihlanganisiwe.

Ukweqisa

Amanani amaningi we-amitriptyline angadala ukuvimbela okukhulu kwe-intraventricular blockade. Eminye imiphumela emibi iyandiswa. Ukwelashwa: isisu siyagezwa ukuze sinciphise izinga lobuthi bomuthi, kunqunywa ama-sorbents, uma kunesidingo, ama-inhibitors we-cholinesterase ayabhalwa, ukucindezelwa kokujwayelekile kuyadingeka, futhi ibhalansi yama-electrolyte iyagcinwa.

Ukuxhumana nezinye izidakamizwa

Ukuvinjwa kohlelo lwezinzwa oluphakathi kukhuliswa ngokuhlanganiswa kwesidakamizwa okukhulunywa ngaso kanye nama-antipsychotic, izidakamizwa, ama-hypnotics, ama-anesthetics, ama-narcotic analgesics.

Ngokubambisana ne-Amitriptyline, ama-inhibitors we-MAO awasetshenziswa. Kuyinto engathandeki ukuyihlanganisa ne-Adrenaline, Ephedrine, Dopamine, Noradrenaline, Phenylephedrine.

Ukuhambisana notshwala

Iziphuzo eziqukethe utshwala kanye ne-antidepressant okukhulunywa ngazo azihlanganisiwe.

Ama-Analog

Izidakamizwa ezisebenzayo ezisetshenziswayo esikhundleni se-Amitriptyline Nycomed:

• I-Anafranil;
• UMelipramine;
• ILadisan;
• UDoxepin nabanye

Enye indlela, ungakhetha i-doxepin.

Ungabuyisela umuthi umuthi onjenge-doxepin.

Uma kunesidingo, umuthi ungathathelwa indawo ngeMelipramin.

Uyini umehluko phakathi kwe-Amitriptyline ne-Amitriptyline Nycomed

Umuthi obizwa ngokuthi i-Nycomed ngegama awenziwa ngendlela yesisombululo. Ingathengwa kuphela ezibhebheni. I-Amitriptyline itholakala ngezindlela ezahlukahlukene: i-solid, liquid (umjovo). Ukulungiselela kwalawa maqembu kusigaba esifanayo samanani. Kungehluka kunani lesithako esisebenzayo.

Izimo zeholide Amitriptyline Nycomed kusuka ekhemisi

Umuthi umuthi.

Ngingakwazi ukuthenga ngaphandle kadokotela

Cha.

Intengo ye-Amitriptyline Nycomed

Izindleko ezijwayelekile ngama-ruble angama-60.

Izimo zokugcina zomuthi

Izingane zidinga ukuvala ukufinyelela komkhiqizo. Izimo zesitoreji ezinconyiwe: + 15 ... + 25 ° С.

Isikhathi sokuphelelwa yisikhathi

Umuthi ugcina izakhiwo zawo iminyaka engu-5 kusukela ngosuku lokukhululwa.

Umkhiqizi Amitriptyline Nycomed

Takeda Pharma A / S, eDenmark.

Ukubuyekezwa mayelana ne-Amitriptyline Nycomed

Izazi Zengqondo

UChukhrov V.V., udokotela wezifo zengqondo, oneminyaka engama-49 ubudala, uChelyabinsk

Umuthi osuphelelwe yisikhathi, ama-analogues amasha manje avele abonakala ngemiphumela emibi embalwa yokwelashwa.

I-Kochev V.O., Psychiatrist, iminyaka engu-34, uStavropol

I-antidepressant ephumelelayo, ngaphezu kwalokho isusa amakhanda nge-psychosomatics. Kungavusa ukubambezeleka kwinqubo yokuchama.

Iziguli

ULarisa, oneminyaka engama-34, uBarnaul

Ngithathe amaphilisi ayi-10 mg. Umphumela wokwelapha wenzeka ngemuva kwamaviki ama-3, okude. Kepha, ekugcineni, ukudana kwenqotshwa.

UMarina, oneminyaka engama-41, eMoscow

Thatha lesi sidakamizwa. Kuphela isikhathi eside angikwazanga ukubamba. Okokuqala, udokotela uxwayise ngokuthi umphumela omuhle uvela ngaphakathi kwenyanga yokuqala ngemuva kokuqala kwesifundo. Okwesibili, imiphumela emibi yaleli khambi ayizange ivumele ukwelashwa okuqhubekayo.