I-Amix isidakamizwa sokwelashwa okuyinkimbinkimbi kwesifo sikashukela sohlobo 2. Isiza ekukhiqizweni kangcono kwe-insulin ngamaseli e-pancreatic. Ngasikhathi sinye, ukuzwela kwezicubu ku-insulin ehlanzekile kuyanda, futhi ukukhipha kwayo kuba ngcono.
Igama Lezwe elingafanele
Isidakamizwa se-INN: Glimepiride.
Umuthi unesandla ekukhiqizweni kangcono kwe-insulin ngamaseli e-pancreatic.
I-ATX
Ikhodi ye-ATX: A10BB12.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo sethebhulethi. Igama ngqo lomuthi lincike ekutheni isithako esingakanani esisebenzayo siqukethwe kwithebhulethi eyodwa.
Into esebenzayo yi-glimepiride. Umsizi:
- i-povidone;
- cellulose;
- amanye ama-lactose;
- isilika;
- i-magnesium stearate;
- i-iron oxide;
- udayi.
I-Amix-1 iqukethe 1 mg ye-glimepiride. Amaphilisi ayindilinga futhi apinki. Amix-2 - luhlaza. Ine-2 mg yento esebenzayo. I-Amix-3 iqukethe u-3 mg we-glimepiride. Amaphilisi aphuzi. I-Amix-4 ngombala oluhlaza okwesibhakabhaka ngombala, aqukethe i-4 mg yento.
Zonke izibhebhe zigcwele emabhulashini akhethekile ama-10 ama-pcs. lilinye. Esiqeshini sekhadibhodi kungabakhona ama-3, 9 noma ama-12 alawa mabhulawu.
Lapho usebenzisa umuthi, ukuzwela kwe-insulin kwezicubu ze-pancreatic kuyanda.
Isenzo se-Pharmacological
Umuthi unomphumela we-hypoglycemic. Into esebenzayo - i-glimepiride - ibhekisela kokuphuma kwe-sulfonylurea. Ithuthukisa ukusebenza kwe-insulin secretion ngamaseli e-pancreatic angaphakathi. Kulokhu, ukukhishwa kwe-insulin kwenzeka ngokushesha, futhi ukuzwela kwezicubu ze-pancreatic kuyo kuyanda.
I-Pharmacokinetics
I-bioavailability kanye nekhono lokubopha ezinhlakeni zamaprotheni cishe ziyi-100%. Ukudla kumane kuvimbela ukumuncwa kwalesi sidakamizwa ngomgudu wokugaya ukudla. Ukugcotshwa okuphezulu kakhulu kwento esebenzayo egazini kuqashelwa amahora ambalwa ngemuva kokuthatha iphilisi. I-Metabolism yenzeka ikakhulu esibindini. Umuthi osebenzayo udonswa ndawonye nomchamo nangaphakathi kwamathumbu kungakapheli amahora ayisithupha emva kokuba into ingene emzimbeni.
Izinkomba zokusetshenziswa
Umuthi usetshenziswa ekwelapheni okuyinkimbinkimbi kohlobo lwesifo sikashukela sohlobo 2, ikakhulukazi kulezo zimo lapho izinga kashukela wegazi lingalawulwa ngokudla, ukunciphisa isisindo kanye nokuzivocavoca okulula komzimba.
Umuthi lo usetshenziswa ekwelapheni isifo sikashukela sohlobo 2 lapho amazinga kashukela wegazi angalawulwa ngokudla.
Contraindication
Kunemikhawulo ethile mayelana nokusetshenziswa kwomuthi:
- thayipha i-1 isifo sikashukela;
- ketoacidosis;
- isifo sikashukela;
- isikhathi sokukhulelwa nokuncelisa ibele.
Konke lokhu kuphambana kumele kubhekwe ngaphambi kokuqala ukwelashwa. Isiguli kufanele sazi ngobungozi obukhona kanye nemiphumela emibi yokwelashwa.
Ngokunakekela
Ngokuqaphela okukhulu, thatha amaphilisi wabantu abanokuzwela okuphezulu kwezinye izingxenye zomuthi, kwezinye izinto ezisusulililide.
Ungayithatha kanjani i-Amix
Umthamo wesidakamizwa unqunywa yimiphumela yokuhlolwa. Impumelelo yokwelashwa incike ekunamatheleni ekudleni okhethekile nasekubhekisiseni njalo ekuhlolweni kwegazi nomchamo.
Ekuqaleni, 1 mg ngosuku inqunyelwe. Umthamo ofanayo usetshenziselwa ukwelashwa kokulungiswa. Uma umphumela owufunayo ungatholakali, umthamo unyuka uye ku-2, 3 noma 4 mg ngosuku njalo emavikini ama-2. Isilinganiso esiphezulu singafinyelela ku-6 mg ngosuku. Kodwa kungcono ukungadluli uphawu lwe-4 mg.
Impumelelo yokwelashwa incike ekunamatheleni ekudleni okhethekile nasekubhekisiseni njalo ekuhlolweni kwegazi nomchamo.
Kulezo ziguli ezingalunxephezeli ukuphazamiseka kwe-carbohydrate metabolism, ukwelashwa kwe-insulin okungeziwe kuqalwa kuphela ezimweni ezinzima kakhulu. Ukuze wenze lokhu, sebenzisa ama-cartridges akhethekile anesidakamizwa umthamo we-125 mg. Ezimweni ezinjalo, ukwelashwa nge-Amix kuyaqhubeka kumthamo owabekwa ekuqaleni, kanti umthamo we-insulin uqobo uyakhula kancane kancane.
Ukwelashwa kwesifo sikashukela
Ngokuvamile kunconywa ukuthatha umthamo wansuku zonke kanye ngesikhathi sokudla kwasekuseni. Uma isiguli sikhohliwe ukuthatha iphilisi, khona-ke ngokuzayo kufanele ungangezi umthamo.
Ngesikhathi sokwelashwa, ukuzwela kwe-insulin kuyanda futhi isidingo se-glimepiride siyancipha. Ukuvimbela ukukhula kwe-hypoglycemia, kungcono ukwehlisa umthamo noma kancane kancane uyeke ukuyithatha. Ukwelashwa kwesifo sikashukela sohlobo 2, inhlanganisela ye-Amix ne-insulin emsulwa imvamisa isetshenziswa.
Imiphumela emibi
Izimpawu ze-hypoglycemia kwesinye isikhathi ziyakhula. Okuvame kakhulu phakathi kwabo:
- isicanucanu futhi ngisho nokuhlanza;
- ikhanda elinzima nesiyezi;
- ukozela
- ukunganaki
- ukwanda okubukhali kwesifiso sokudla.
Ngaphezu kwalokho, ukugxilisa ukunakwa kuyashintsha. Kuvela i-Convulsive syndrome kanye nokuqhaqhazela. Umuntu uba nengcindezi, abe nolaka kakhulu. I-Insomnia iyavela, ukuthikamezeka okubukwayo. Imvamisa kuba nokwanda kwe-sodium egazini.
Amapheshana wesisu
Ukucanuzelelwa kwenhliziyo, ukuhlanza, ubuhlungu besisu, ukuguquguquka kokusebenza kwesibindi, ukwanda komsebenzi wayo we-enzymatic akunqunyelwe.
Izitho zeHematopoietic
Engxenyeni yezitho ze-hemopoietic, ukwephulwa okunzima kuvame ukubonwa. Kwezinye izimo, i-thrombocytopenia, i-agranulocytosis, i-anemia ne-leukopenia iyabonakala.
Kusuka endaweni yokubukwa
Ekuqaleni kokulashwa, kungenzeka kukhubazeke okwesikhashana ukubonwa, okuwumphumela wokugxuma okubukhali ku-glucose wegazi.
Kusuka ohlelweni lwezinhliziyo
Imvamisa ye-arterial hypertension, i-tachycardia, i-angina engazinzile kanye ne-arrhythmia enzima ikhula. Ezinye iziguli zine-bradycardia kuze kufike ekulahlekelweni ukwazi.
Allergies
Kwezinye izimo, ukungezwani komzimba kungenzeka. Iziguli ziqaphela ukuvela kwama-rashes athile esikhumbeni, ukulunywa, i-urticaria. Ukuthuthukiswa kwe-edema ye-Quema ne-anaphylactic asikukhiqizwa. Uma kuvela izimpawu ezinobungozi ezinjengalesi, ukwelashwa kufanele kumiswe ngokushesha.
Imiyalo ekhethekile
Izimpawu ze-hypoglycemia zingavela kusukela ekuqaleni kokwelashwa, ngakho-ke, umthamo kufanele ubhekwe ngokuqinile futhi ushintsho esimweni sempilo sesiguli kufanele lubonwe. Ukwenza ngcono ukugcwala kweglucose egazini kunomthelela ekungondlekeni kahle, ukwehluleka ukuhambisana nokudla okunqunyelwe kanye nokudla ngokweqa njalo ukudla.
Ukuhambisana notshwala
Awukwazi ukuhlanganisa ukuphuza kwamatafula neziphuzo zotshwala. Izimpawu zokudakwa kuleli cala zandiswa kakhulu, umphumela wezidakamizwa ohlelweni lwezinzwa oluphakathi luyakhula. Umphumela we-hypoglycemic wokusetshenziswa kwe-Amix cishe awuboniswa.
Umthelela ekhonweni lokulawula izindlela
Ngesikhathi sokwelashwa ngezidakamizwa, kungcono ukwenqaba ukuzishayela. Umuthi uthinta ukunakwa kokunakwa, usiza ekuvimbeleni ukusabela kwengqondo okudingekayo ezimweni eziphuthumayo.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Awukwazi ukusebenzisa umuthi kuyo yonke inkathi yokuzala ingane. Into esebenzayo ingena ngokushesha kwisithintelo esivikela i-placenta futhi ingavusa ukwakheka kokungahambi kahle kwe-fetus. Uma kunesidingo esiphuthumayo sokwelashwa, owesifazane okhulelwe udluliselwa kumthamo omncane we-insulin.
Uma kudingekile ukwenza ukwelashwa nge-insulin, owesifazane ungcono ukulahla ibele.
Ukunquma i-Amix ezinganeni
Umuthi awusetshenziswa neze emikhubeni yezingane.
Lapho welapha i-Amix neziguli esezikhulile, kunqunywa umthamo omncane wezidakamizwa.
Sebenzisa ebudaleni
Lapho welapha i-Amix neziguli esezikhulile, kunqunyelwa umthamo omncane wesidakamizwa, ngoba uthinta umsebenzi wezitho eziningi nezinhlelo. Abantu abadala basethubeni lokuqhamuka nezinkinga ezivela ohlelweni lwezinhliziyo, ngakho-ke udinga ukubheka ngokucophelela noma iziphi izinguquko esimweni esejwayelekile sesiguli ngesikhathi sokwelashwa.
Isicelo sokusebenza kokulimala kwezinso
Sebenzisa ukuqaphela lapho uthatha amaphilisi lapho kukhona ama-renal pathologies. Kungcono ukukhetha umthamo omncane osebenza kahle ukuvikela ukukhula kokwehluleka kwe-renal acute. Konke kuncike ekuthini imvume ye-creatinine. Lapho izinkomba zalo ziba ziningi, kuyodingeka umthamo omncane womuthi.
Sebenzisa umsebenzi wesibindi okhubazekile
Gcina umkhondo waluphi ushintsho kuzivivinyo zomsebenzi wesibindi. Imithamo emikhulu ineqhaza ekuthuthukiseni ukwehluleka kwesibindi. Kulokhu, umthamo kufanele wehliswe ube mncane. Uma isimo sesiguli siqhubeka siba sibi kakhulu, kungcono ukukhansela ukuthatha i-Amix.
Ukweqisa
Uma kwenzeka kuba ne-overdose, i-hypoglycemia ingahle ibe nezimpawu zayo ezingabonakala emahoreni ambalwa kuya kwezinsuku ezimbalwa. Kuvela:
- isicanucanu
- ukuhlanza
- ikhanda
- Ubuhlungu be-epigastric;
- ukweqile okuqinile;
- ukungaboni kahle
- ukuqwasha
- ukuthuthumela
- iminyakazo.
Uma kwenzeka kusetshenziswa i-overdose, i-gastric lavage iyenziwa.
Kulokhu, isiguli kufanele silaliswe esibhedlela.
I-Gastric lavage kanye ne-detoxification therapy iyenziwa. Qiniseka ukuthi usebenzisa izixazululo ngokuqukethwe okukhulu kweglucose. Ukwelashwa okuqhubekayo kuyimpawu.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa kwe-Amix neminye imithi kungaholela ekuqinisweni okungathandeki noma buthaka umphumela we-hypoglycemic yento esebenzayo. Ukuphela kokunye izidakamizwa ze-immunomodulatory.
Inhlanganisela ehlanganisiwe
Ukuphathwa kanyekanye kwe-Amix ngezidakamizwa ezinjalo kuyaphulwa:
- phenylbutazone;
- insulin;
- i-salicylic acid;
- ama-anabolic steroid;
- ama-hormone ocansi abesilisa;
- ama-anticoagulants.
Ukuphathwa kanyekanye kwe-Amix nge-Insulin kuchazwe ngemininingwane ethile.
Ngokuhlanganiswa kwabo kanyekanye, i-hypoglycemia kungenzeka.
Akuhlanganisiwe ukuhlanganisa
Ukwehla kokusebenza kwomuthi noma ukwanda kwezinga le-glucose egazini kucasulwa ukuphathwa kwawo kanyekanye nezidakamizwa ezinjalo:
- i-estrogen;
- iprogesterone;
- okokugcobisa;
- glucocorticosteroids;
- Adrenaline
- i-nicotinic acid;
- ama-laxatives;
- ama-barbiturates.
Ukuphendula kungaba ngokuzumayo, ngakho-ke udinga ukuthatha lezi zidakamizwa ngokunakekela okukhulu.
Akunconywa ukuhlanganisa umuthi nezidakamizwa ezinomphumela we-diuretic.
Inhlanganisela edinga ukuqashelwa
Ukusetshenziswa kanyekanye kwe-Amix ngabaphikisi be-H2-receptor, amanye amaprotheni e-plasma, kanye nama-b-blockers kanye ne-Reserpine kuholela ekwehleni okungenzeka kweglucose yegazi. Izidakamizwa ezifakwe kuhlu ziyakwazi ukufihla izimpawu zokuphazamiseka kwe-adrenergic, lapho kuvela khona i-hypoglycemia.
Ama-Analog
Kunezinhlobo zezichazi ezifanayo nezidakamizwa ngokuya ngezinto ezisebenzayo kanye nomphumela wokwelapha. Okuvame kakhulu phakathi kwabo yilezi:
- I-Amaryl;
- I-Amapyrid;
- IGlairie
- Glimax;
- I-Glimepiride;
- Dimaril;
- I-Altar
- Perinel.
Le mithi kulula ukuyithola emakhemisi, futhi ishibhile.
I-Glimax ingasebenza njenge-analogue yesidakamizwa.
Imibandela Yokuphumula Ye-Amixa Pharmacy
Umuthi usatshalaliswa emakhemisi kuphela ngencwadi ekhethekile evela kudokotela oya kuyo.
Intengo
Namuhla, umuthi cishe akunakwenzeka ukuwuthola kunoma yiziphi izitolo zasekhemisi. Njengoba itholakala nomuthi, futhi akunakwenzeka ukuyithenga emakhemisi online, ngakho-ke akukho datha ezindleko.
Intengo yama-analogues eRussia iqala kusuka kuma-ruble ayi-170, futhi e-Ukraine izidakamizwa ezinjalo zizobiza kusuka kuma-35 kuye kwangama-100 UAH.
Izimo zokulungisa ukulungisa
Umuthi ugcinwa kuphela kwiphakheji yangempela. Endaweni eyomile futhi emnyama, ekushiseni komoya okungekho ngaphezulu kuka- + 30 ° C, kude nezingane ezincane nezilwane ezifuywayo.
Isikhathi sokuphelelwa yisikhathi
Impilo yeshelufu lamathebulethi yiminyaka emi-2 kusukela ngosuku lokukhululwa olukhonjiswe kwiphakheji yasekuqaleni.
Umkhiqizi
Inkampani yezokukhiqiza: Zentiva, Czech Republic.
Ubufakazi bodokotela neziguli kuma-Amiks
Ukubuyekezwa mayelana nomuthi akushiywanga odokotela kuphela, kodwa futhi nasezigulini eziningi.
Odokotela
U-Oksana, oneminyaka engama-37, odokotela abaphethwe yi-endocrinologist, uSaratov: "Ngivame ukunikeza lesi sidakamizwa kwiziguli ukuthi zelashwe i-mellitus yesifo sikashukela. Ukubuyekezwa mayelana nakho kuhluke kakhulu. Abanye basiza kahle, abanye baphoqeleka ukuthi babuyela ku-insulin. Umphumela womuthi muhle. Ngokubona okujwayelekile komzimba, umphumela wokwelapha utholakala ngokushesha" .
UNikolai, oneminyaka engama-49 ubudala, udokotela obulala izidakamizwa, uKazan: "Yize lesi sidakamizwa sivame ukubekelwa iziguli, asifanele wonke umuntu. Ezinye iziguli zinegciwane lonke lokuphikiswa okwenza ukuthi kube nzima ukuthatha umuthi. Ngaphambi kokuqala ukwelashwa, ngihlala ngiqoqa ngokucophelela impilo yesiguli nomlando wezifo ukuze. Gwema izinkinga ezingezinhle. "
Iziguli
UPetr, oneminyaka engama-58, eMoscow: "Umuthi usizile. Kungenzeka ukuthi kubuyiswe amazinga kashukela egazini isikhathi eside. Kepha ekuqaleni ukwelashwa, ikhanda lami lalimala futhi ngaba nenhliziyo encane yokuhlanza. Ngemuva kwezinsuku ezimbalwa, isimo sami sabuya saba sezingeni elifanele. Ngenelisekile ngomphumela wokwelashwa."
U-Arthur, oneminyaka engu-34, uSamara: "Umuthi awuzange ubengekho. Ngemuva kokuvela kwepilisi yokuqala, ukuqubuka kwesikhumba, ngaqala ukulala kabi, ngathukuthela kakhulu. Ngaphezu kwalokho, isimo sami sempilo saba sibi kakhulu. Udokotela wangeluleka ukuthi ngibuyele ekuphuzeni i-insulin."
U-Alina, oneminyaka engama-48, eSt. Petersburg: "Ngigculisekile ngokuphelele ngomphumela wokwelashwa. Umuthi muhle. Ngawusebenzisa esikhundleni se-insulin. Angizwanga yimiphumela emibi. Umphumela wokwelashwa ubusuhlala cishe izinyanga ezine."
