I-phosphoncial yisidakamizwa esinomphumela we-hepatoprotective. Umphumela wokwelapha ubangelwa ukuhlanganiswa kwezakhiwo zezakhi zemvelo ezisebenzayo ezisuselwa kwisithako sesitshalo thistle yobisi - phosphatidylcholine ne-silymar. Izithako ezisebenzayo zisetshenziswa ku-gastroenterology ekwelapheni izifo zesibindi nepheshana le-biliary. Ezimweni ezikhethekile isetshenziswa ezenzakalweni zezimboni ukunciphisa ubungozi bokudakwa uma isiguli sisebenza ngamakhemikhali.
Igama Lezwe elingafanele
Phospholipids. Ubisi Thistle Khipha
I-phosphoncial yisidakamizwa esinomphumela we-hepatoprotective.
I-ATX
A05C.
Khipha amafomu nokwakheka
Umuthi ukhishwa emaphaketheni. Iyunithi lokulungiselela limbozwe ngesisekelo se-gelatin esinzima sombala wewolintshi, oqukethe inqwaba yemibala ephuzi nsundu enephunga elithile ngaphakathi. I-1 capsule iqukethe inhlanganisela yezithako ezisebenzayo - 70 mg we-silymar ne-200 mg ye-lipoid C100 (phosphatidylcholine). Njengezinto ezisizayo ekukhiqizweni kokusebenzisa:
- i-silloon dioxide ye-colloidal dehydrate;
- i-magnesium stearate;
- i-povidone;
- dihydrate ye-trehalose ne-calcium phosphate.
Umuthi ukhishwa emaphaketheni.
Igobolondo langaphandle lesidakamizwa liqukethe i-gelatin ne-titanium dioxide. I-tint ye-orange inikezwa kudayi ophuzi ngokusekelwe kwensimbi.
Isenzo se-Pharmacological
Umuthi umuthi wokuhlanganisa osetshenziselwa ukwelapha nokuvikela isibindi kanye nepheshana lesibindi. Umphumela wokwelapha usekwe ekukhiqizweni kabusha kwemiphumela yemithi yama-phospholipids abalulekile nama-flavolignans - amakhemikhali asebenzayo amakhemikhali obisi olubonakalayo (ngokuya nge-silibinin).
Umphumela we-hepatoprotective kungenxa yezenzo ezilandelayo ze-phosphatidylcholine:
- i-normalization yamaprotheni, i-phospholipid ne-lipid metabolism;
- ukuhlanganiswa kwamakhompiyutha amasha adingekayo ekusebenzeni okujwayelekile kwama-hepatocytes;
- umsebenzi wokukhuphuka kokukhula emzimbeni kumaseli wesibindi, ngenxa yokuthi i-metabolism emzimbeni ishesha kakhulu;
- ukusekela ukusebenza kwesitho ngesikhathi sokuwohloka kwamaseli omdlavuza noma ukubonakala kwe-benign neoplasm;
- ukwenziwa ngcono kwemisebenzi yama-enzymes wesibindi nowesibindi;
- kusebenze nokuvikelwa kwezinhlelo ze-enzyme kuncike kuma-phospholipid metabolism.
Umuthi usiza ukugcina futhi wenze imisebenzi ethile yeseli yamaseli wesibindi ibe ngaphansi kwezimo zokucindezela okwandayo noma ukudakwa.
Umuthi usiza ukugcina futhi wenze imisebenzi ethile yeseli yamaseli wesibindi ibe ngaphansi kwezimo zokucindezela okwandayo noma ukudakwa. Izinto ezisebenzayo zilawula futhi zisheshise ukwenziwa kabusha kwe-hepatocytes, zivimbela i-necrosis yezindawo ezinempilo (necrosis). Njengomphumela, ukuguqulwa kwamaseli wesibindi ngezicubu ezixhunyayo kuyamiswa, ngenxa yokuthi umuthi usetshenziselwa ukuvikela isifo se-cirrhosis. Ivimbela ukonakala kwamafutha kwesibindi.
Umuthi unomphumela we-choleretic ovusayo ngokumelene ne-cholestasis (ukwehla kokugeleza kwe-bile ku-duodenum ngenxa yokwephulwa kokubumbeka kwawo).
I-Pharmacokinetics
Lapho ihanjiswa ngomlomo, umuthi udonswa ngokuphelele emathunjini amancane. I-Bioavailability ifinyelela ku-100%. Ukudla akuphazamisi ukumunyaniswa kwamakhompiyutha, ngakho-ke, isilinganiso sokutholwa asishintshi. Uma ingena egazini, isakhi esisebenzayo sibopha ama-lipoprotein aphezulu, lapho i-phosphatidylcholine ingena khona nge-hepatocytes bese isatshalaliswa esibindini. Ukuphila kwesigamu kungamahora angama-66 okuhlanganiswa kwe-phosphotidylcholine, okunamafutha acid egcwele ukubola ngemuva kwamahora angama-32.
Izinkomba zokusetshenziswa
Umuthi ubekelwe ukwelashwa nokuvimbela izifo ezibangelwa ukulimala kwesibindi, njengengxenye yokwelapha izidakamizwa ezihlanganayo:
- uhlobo olubi futhi olungamahlalakhona lwe-hepatitis (ukuvuvukala esibindini), ithuthukiswe ngenxa yokudakwa kotshwala, izidakamizwa noma ubuthi bokudla;
- ukugula kwemisebe;
- ama-neoplasms esibindini semvelo enobungozi ne-benign;
- ukwehla kwamafutha kwesitho se-etiologies ehlukahlukene, kufaka phakathi izinqubo zokutheleleka nesifo sikashukela;
- i-toxicosis sekwephuzile ngesikhathi sokukhulelwa - gestosis;
- ukonakala kwamafutha kwesibindi kanye ne-cirrhosis;
- i-hepatic coma;
- ukwephulwa kwesibindi ezifweni zesimo esithile;
- i-lipid metabolism disorder.
Umuthi usetshenziswa njengendlela yokwelapha i-adjunct ye-psoriasis.
Contraindication
Ukuphela kokwephulwa komthetho ekusebenziseni umuthi ukwanda kokuthaka kwezicubu ezingxenyeni zezakhi zomuthi. Ukwakheka kwalo muthi kufaka i-estrogen-like silymar (isitshalo esisuselwa enkomeni yobisi), okufanele sisetshenziswe ngokuqapha uma kwenzeka kuphazamiseka i-hormonal, i-carcinoma yezitho zomzimba wesibeletho (i-prostate, ama-ovari, isibeletho) kanye ne-mammary gland, i-endometriosis ne-uterine myoma.
Ungayithatha kanjani iPhosphoniale
Umuthi wenzelwe ukuphathwa ngomlomo. Amakhompiyutha anconyelwa ukuphuza uketshezi oluningi. Awukwazi ukuhlafuna igobolondo le-gelatin, ngoba lokhu kungathinta isilinganiso sokumunwa kanye nokufezeka komphumela wokwelapha.
Umuthi wenzelwe ukuphathwa ngomlomo.
Kubalulekile ukukhumbula ukuthi umthamo wansuku zonke kanye nobude besikhathi sokwelashwa kunqunywa kuphela kudokotela ohambelayo. Uchwepheshe wezokwelapha uncike ezimweni zomuntu (isisindo somzimba, ubudala), imininingwane yocwaningo lwelebhu. Indima ebalulekile ekunqumeni uhlobo lokwelashwa idlalwa ngobunzima benqubo ye-pathological, ukutholwa kwendawo kwesifo kanye nesimo sesibindi.
| Lesi sifo | Imodeli yokwelapha |
| IHepatitis yemisuka ehlukahlukene | Kunconywa ukuthatha amaphilisi angama-4-6 ngosuku, ahlukaniswe ngemithamo engama-2-3. Kufanele uphuze lesi sidakamizwa ngokudla. Isikhathi sokwelashwa siyizinyanga ezi-3. Uma kunesidingo, udokotela angakunquma inkambo yesibili yokwelashwa. Nge-hepatitis ye-etiology yegciwane, ikakhulukazi ngefomu B no-C, kunconywa ukwelula inkambo yokwelashwa kuze kube izinyanga eziyi-12. |
| I-Cirrhosis | Amaphilisi ama-2 izikhathi ezingama-2-3 ngosuku izinyanga ezintathu. Uma kunesidingo, inkambo yokwelashwa ngezidakamizwa iyelulwa ngokuya ngobunzima balesi sifo. |
| Psoriasis | Thatha amayunithi we-1-2 wezokwelapha amahlandla ama-3 ngosuku. Ukwelashwa kwezinkukhu kuhlala izinsuku eziyi-14 kuye kwezingama-40. |
| Ukudakwa noma ukudakwa kwezidakamizwa | Thatha amaphilisi angama-4-6 ngosuku, uhlukanisa imithamo kube yimithamo engama-2-3 izinsuku ezingama-30 ukuya kwengama-40. |
| I-Gestosis | Thatha amaphilisi ama-2-3 izikhathi ezintathu ngosuku izinsuku ezingama-10-30. |
| Njengesilinganiso sokuvimbela esihlobene nemisebenzi yobungcweti | Ngezinsuku ezingama-30-90, ikhavalela eyi-1 kufanele ithathwe kathathu ngosuku. |
Ngoshukela
Umuthi awuthinti ngokuqondile amaseli e-pancreatic noma ukugcwala kwe-plasma ye-glucose egazini. Ngokushintshwa ngokwejwayelekile kwe-carbohydrate kanye ne-lipid metabolism, ukwehla okuningana kwezinga loshukela emzimbeni kuyabonakala. Ngesikhathi sokwelashwa kwe-hepatic pathologies ngomuthi wokulwa noshukela ongaxekile ku-insulin, ukulungiswa komthamo owengeziwe akudingeki.
Imiphumela emibi ye-phosphoncial
Lapho wenza ukwelashwa kwezidakamizwa ngamaphilisi we-phospholipid, ukubonakaliswa noma ukwanda kokuphendula okungathandeki ngendlela yokungezwani komzimba, isicanucanu, ukuhlanza, nobuhlungu esifundeni se-epigastric kungenzeka.
Lapho wenza ukwelashwa kwezidakamizwa ngamaphilisi we-phospholipid, ukubonakaliswa noma ukwanda kwemiphumela emibi ngendlela yokungezwani kungenzeka.
Umthelela ekhonweni lokulawula izindlela
Umuthi awusithinti ngokuqondile noma ngokungaqondile isimo sohlelo lwezinzwa oluphakathi, ngakho-ke, ngenkathi uthatha umuthi, uvunyelwe ukushayela imoto, uxhumana nezinqubo eziyinkimbinkimbi neminye imisebenzi edinga isiguli ukuba siphendule ngokushesha futhi sigxile.
Imiyalo ekhethekile
Iziguli zithambekele ekubonakalisweni kokuphendula kwe-anaphylactic, ngaphambi kokunquma ukwelashwa kwezidakamizwa, kunconyelwa ukwenza izivivinyo zokungezwani nokubekezelelwa kwezinhlaka zezakhiwo.
Isabelo sezingane
Kuyenqatshelwa ukusebenzisa kuze kube seminyakeni engu-18, ngoba izifundo ezanele zomtholampilo azange zenziwe ngemiphumela yezidakamizwa ekuthuthukiseni ebusheni nasebuntwaneni.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Isisekelo somuthi (i-silymar) ingxube yotshwala ye-benzyl ekwazi ukungena ekuvinjelweni kwe-placental. Ngakho-ke, ukuthatha umuthi ngesikhathi sokukhula kombungu kwenqatshelwe. Isidakamizwa sisetshenziswa kuphela ezimweni eziphuthumayo, lapho ingozi empilweni yowesifazane okhulelwe idlula engcupheni yokuthola i-intrauterine pathologies ku-fetus.
Ekwelashweni nge-phosphatidylcholine, kunconyelwa ukukhansela ibele, ngoba akukho datha ekhonweni lezinto ezisebenzayo zokuthululwa obisini lukamama.
Ukweqisa kwePhosphoniale
Ezimweni zokwelashwa, awekho amacala okweqa ngokweqile aqoshwa ngokusetshenziswa kanyekanye komthamo omkhulu womuthi. Uma usola ukudakwa, kunconywa ukuthi ohlukunyeziwe enze i-gastric lavage, ahlanze futhi anikeze i-adsorbent ngesimo sekhabhoni esetshenzisiwe. Ayikho into ethile ephikisayo, ngakho-ke, ezimeni zokuma, ukwelashwa kwenziwa ngenhloso yokuqeda isithombe esinophawu esivelile.
Uma usola ukudakwa, kunconywa ukuthi ohlukunyeziwe enze udambiso lwesisu.
Ukuxhumana nezinye izidakamizwa
Ingxenye yamakhemikhali ye-silymar iyakwazi ukucindezela isenzo se-cytochrome P450, yingakho ngenkathi uthatha umuthi ngeVinblastine, Alprazole, Diazepam neKetoconazole, kungenzeka ukukhuphula amanani aphezulu kakhulu we-plasma yegazi. Akukho ukungahambelani kwemithi namaqembu ahlukahlukene wezidakamizwa okwabonwa ngenkathi kuvivinywa umtholampilo ezilwaneni.
Ukuhambisana notshwala
Umuthi unomphumela we-hepatoprotective futhi ukhuthaza ukubuyiselwa kwamaseli wesibindi, ngakho-ke, utshwala abuvunyelwe ngesikhathi sokwelashwa. I-ethyl alcohol ibangela ukudakwa, okuholela emiphumeleni enobuthi kumaseli wesibindi. Lapho uthatha amakhompiyutha ne-ethanol, umphumela wokwelapha awubonwa. Uphuzo oludakayo luvimbela imiphumela ye-silymar ne-phosphotidinquinol futhi lubangele ukufa okukhulu kwe-hepatocytes, okwenza izindawo ze-necrotic zithathelwe indawo yizicubu ezithintekayo.
Ngaphezu kwalokho, kunomthelela omubi ezinhlelweni eziphakathi nendawo zenhliziyo, ezidingekayo ukulawula ukuhlangana kwe-plasma yomuthi osegazini.
Ukuthatha umuthi ngesikhathi sokukhula kombungu kwenqatshelwe.
Ama-Analog
Ukufana kwezakhiwo zesidakamizwa noma okufakwa esikhundleni sokwenza okuthile kufaka lokhu okulandelayo:
- I-Essliver;
- I-Brenziale forte;
- I-Antraliv;
- Okubalulekile H;
- I-Eslidine;
- Resale Pro;
- ILivolife Forte.
Ukwenza ushintsho oluzimele komunye umuthi akunconywa. Ngaphambi kokushintsha umuthi, kufanele uthintane nodokotela wakho.
Imibandela yekhefu lekhemisi
Umuthi uthengiswa ngomuthi onikezwe wona.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ngenxa yengozi eyandayo yokusabela okubi lapho isetshenziswa ngaphandle kwezinkomba zezokwelapha, ukuthengiswa kwamahhala kwalo muthi kukhawulelwe.
Intengo yePhosphoni
Izindleko ezijwayelekile zesidakamizwa ziyehluka ebangeni lentengo ukusuka kuma-ruble angama-435 kuya kwangama-594.
Izimo zokugcina zomuthi
Kunconywa ukugcina umuthi endaweni eyomile, ukhawulelwe kusukela elangeni, emazingeni okushisa afinyelela ku + 25 ° C. Ungavumeli umuthi uwele ezandleni zezingane.
Isikhathi sokuphelelwa yisikhathi
Iminyaka engu-2 kusukela ngosuku lokukhipha olukhonjiswe kwiphakheji. Kwenqatshelwe ngokuqinile ukuthatha isidakamizwa ngemuva kosuku lokuphelelwa yisikhathi.
Umkhiqizi
ICJSC Canonfarm Production (Russia).
Ukubuyekezwa kwePhosphoni
UValentina Uksarova, oneminyaka engama-50, eSt
Udokotela unikeze umyeni wakhe lo muthi lapho esasesibhedlela. Kwakunezidakamizwa eziningi, ngoba zaziphatha ukwelashwa okuyinkimbinkimbi ukusekela isibindi. Udokotela ohambelayo unquma ukuphuza amaphilisi njalo ngonyaka ngonyaka ngenxa yesibindi, ngoba umyeni uthanda ukuphuza ubhiya. Ngiqale nokuphuza amaphilisi ukuvikela isibindi njengoba kunconywa ngudokotela. Nginqume ukunakekela ukubuyiselwa kwesitho ngenxa yothando lokudla okunezipayisi nokuthosiwe. Lapho ngiphuza iphilisi izinyanga ezintathu, umunyu emlonyeni nasezinhlungwini lapho unyakaza endaweni eyi-hypochondrium efanelekile. Uzwa ukukhanya.
UVadim Kovalevsky, oneminyaka engama-35, uRostov-on-Don
Ngenxa yesinye isifo, kwadingeka ngiphuze amaphilisi amaningi ahlukahlukene. Ngacabanga ngesimo sesibindi lapho siqala ukugcwala ohlangothini lwami lwesokudla. Ngifunde futhi amafomu nezincomo eziku-inthanethi, ngaya kudokotela oyobonisana naye. Amaphilisi abekiwe okulungiswa kwesibindi. Umuthi ubiza kakhulu kunabalingani bawo emakhemisi, kodwa lapho ufunda imiyalo yokusetshenziswa, cishe akukho mibiko noma imiphumela emibi etholakele. Nginqume ukuzijwayeza. Akukho ukusabela okungekuhle ngesikhathi sokulashwa, imiphumela yako ayibonakalanga. Kepha izinhlungu zazingasekho, isibindi sasesijwayelekile ngemuva kokwelashwa.
USvetlana Kovrezhinkova, oneminyaka engama-45, uVladivostok
Intengo iphansi kunaleyo ye-Essentiale, eyamangaza. Nginqume ukuyisusa, ngoba idonsela imvelaphi yezitshalo zezakhi. I-ubisi thistle emithini yesintu inomphumela onenzuzo esibindini futhi iyasiza ukuyibuyisela. Ngazama zonke izinhlobo zezidakamizwa ukusekela isibindi, kepha ngangizizwa ngikhululekile kuphela kulamaphilisi. Yize isenzo leso sifana no-Evesil noCarsil. Amakhompiyutha mancane, ngakho-ke kufanele uphuze izingcezu ezi-4-6 ngosuku, kepha akudingeki uhlupheke lapho ugwinya. Unganamatheli ku-esophagus. Thatha isinyathelo ngokushesha. Inkambo yokwelashwa yathatha izinyanga ezintathu.
U-Alexander Vasilevsky, oneminyaka engama-44 ubudala, u-Astrakhan
Ngonyaka owedlule, umkakhe wathola ukuwohloka komdlavuza esibindini. Kwaqala ukukhula isimila, odokotela banquma ukwelashwa ngemisebe. I-Chemotherapy ayibonakalisanga kuphela kuma-metastases, kodwa emzimbeni wonke. Isibindi asenzanga imisebenzi yaso. Ukusekela ukusebenza komzimba, ochwepheshe bahlongoza ukuthi baphuze lesi sidakamizwa okungenani unyaka. Ubuhlungu babubuthuntu, umfazi wayekwazi ukudla futhi athathe inqwaba yezidakamizwa, nayo enomphumela onobuthi. Umuthi wasiza ukuxhasa isibindi futhi waba nomthelela ekululameni okuyingxenye.
