ILiptonorm ibandakanyeka ohlelweni lokukhiqizwa kwe-cholesterol. Umuthi uthinta ukusebenza kwama-LDL receptors, ngaleyo ndlela anciphise ubungozi bokuqalwa kwe-atherosclerosis namanye ama-pathologies emithambo yegazi. Izimo ezidalwe nguye zikuvumela ukuthi wenze ngokwejwayelekile isisindo, kepha lo muthi awunakubizwa njengendlela yokunciphisa isisindo. Ngosizo lwayo, kuphela umphumela otholakala ngokuqeqeshwa nangokudla osekelwayo. Njengethuluzi elizimele, lesi sidakamizwa asisetshenziswa, ngoba asisebenzi ngokwanele.
Igama Lezwe elingafanele
Atorvastatin
ILiptonorm ibandakanyeka ohlelweni lokukhiqizwa kwe-cholesterol.
I-ATX
C10AA05
Khipha amafomu nokwakheka
Umuthi ukhiqizwa ngesimo esiqinile. Iphindisela iqembu lamalungiselelo ecezu linye. Into esebenzayo ekhombisa umphumela wehlise i-lipid yi-atorvastatin, futhi isetshenziswa ngendlela kasawoti we-calcium. Ithebhulethi iqukethe 10 noma 20 mg. Ngaphezu kwalokho, ezinye izinto ezenza eminye imisebenzi ziyasetshenziswa (okungenani zisetshenziselwa ukuthola ukwakheka kwesidakamizwa okufunayo):
- i-calcium carbonate;
- i-microcrystalline cellulose;
- i-lactose;
- Ishumi ayisishiyagalombili;
- i-hydroxypropyl cellulose;
- i-crosscarmellose;
- i-magnesium stearate.
Amathebulethi axutshwe nomjovo okhethekile, onomthelela ekwenzeni kancane kancane kukhishwe izingxenye ezisebenzayo. Ngenxa yalokhu, izinga lobudlova bomuthi buncishiswa kancane. Ngakho-ke, akufanele uhlafuna umuthi, ngoba lokhu kuzoba nomthelela ekukhulisweni kwangaphambi kwesikhathi kwengxenye eyinhloko.
Amathebulethi axutshwe nomjovo okhethekile, onomthelela ekwenzeni kancane kancane kukhishwe izingxenye ezisebenzayo.
Isenzo se-Pharmacological
Ngaphansi kwethonya lomuthi, kuphawuleka ukwehla kokuqukethwe kwezindawo ezihlala abantu abaphansi kakhulu, abathintekayo enqubweni yokuhamba kwe-cholesterol plasma. Babangela ukuphazamiseka kwesistimu ye-vascular: baba neqhaza ekubekweni kwamafutha okusebenzayo ezindongeni zemithambo yegazi, ukuthuthukiswa kwe-atherossteosis, i-myocardial infarction, kanye nesifo sohlangothi. Ezimweni eziningi, kunciphisa i-lumen yemikhumbi kuyaphawulwa, okuholela ekuvinjelweni kokugeleza kwegazi.
Ngosizo lwalesi sidakamizwa, kungenzeka ukugwema ukuthuthukiswa kwezinkinga ezinzima, ngoba into esebenzayo ekwakhiweni kwayo isiza ukunciphisa okuqukethwe kwe-lipid emzimbeni. Lo muthi ungoweqembu lama-statins (wehlisa i-cholesterol yegazi).
I-Pharmacodynamics isuselwa ekuphuleni uchungechunge lokuxhumana kwe-HMG-CoA reductase, i-enzyme ekhuthaza ukuguqulwa kwe-HMG-CoA ibe yi-mevalonic acid. Umphumela ofiselekayo utholakala ngokuxhumana kwama-molecule ento esebenzayo nesayithi le-coenzyme A receptor, elibhekele ukuxhumana neHMG-CoA reductase.
Ezimweni eziningi, kunciphisa i-lumen yemikhumbi kuyaphawulwa, okuholela ekuvinjelweni kokugeleza kwegazi.
Umphumela odingekayo utholakala ngenxa yokuncipha okukhulu ekukhiqizweni kwe-mevalonate, okuyi-Lesemkhatsini wenqubo yokukhiqiza i-cholesterol. Ngenxa yalokhu, izinga le-cholesterol ngaphakathi kwamaseli liyancipha, okusiza ukwenza kusebenze ukusebenza kwama-LDL receptors kanye nokuwohloka kwe-cholesterol kwe-metabolic.
Ithuluzi alibonisi kuphela umphumela wokwehlisa i-lipid, kodwa futhi lihlinzeka ngokuvikelwa kwemithambo yegazi ekuthuthukisweni kokungaphenduki okuhle ngenxa yomthelela wokuvimbela ekwakhekeni kwamangqamuzana e-endothelial. Umphumela oyifunayo utholakala ngokuvimbela ukukhiqizwa kwama-isoprenoids.
Ngaphezu kwalokho, umuthi ukhombisa ezinye izakhiwo: kuthuthukisa isimo sezindonga zangaphakathi zemithambo yegazi, kuvumelana nokwakheka kwegazi. Ibonakala njenge-antioxidant, i-antiproliferative agent. Kukhona ukwanda emazingeni e-HDL, apolipoprotein A.
Inzuzo yeLiptonorm yikhono layo lokuthonya amazinga e-cholesterol ezigulini ezikhubazekile ngofuzo.
Enye inzuzo yeLiptonorm yikhono layo lokuthonya i-cholesterol ezigulini ezikhubazekile ngofuzo (hypercholesterolemia). Ngaphezu kwalokho, iningi lezidakamizwa elehlisa i-lipid alikwazi ukubhekana nalo msebenzi.
I-Pharmacokinetics
Ithuluzi limunca izindonga zendlela yokugaya ukudla cishe ngokuphelele. Inani elikhulu le-atorvastatin ku-plasma lilungiswa ngemuva kwemizuzu engama-60-120. Ukudla kuthinta isilinganiso sokufakwa kwalesi sakhi, noma kunjalo, izinga lokusebenza kwesenzo salo lihlala lingashintshiwe. Lokhu kusho ukuthi okuqukethwe kwe-LDL kwehla ngokuqina ngokulinganayo ngenxa yokuthatha ithebhulethi yeLiptonorm esiswini esingenalutho nangokudla.
I-bioavailability yomuthi iphansi futhi ingu-14%. Lesi sici sichazwa ngomphumela wemvelo ene-acid esiswini kwisidakamizwa ngesikhathi sokudlulela kokuqala nokwenziwa komzimba. Izinga lokusebenza kwalo linqunywa nomthamo we-atorvastatin. Ukuhlanganiswa kwamaprotheni egazi kuphakeme impela (98%). Ukuguqulwa kwengxenye eyinhloko kwenzeka esibindini, lokhu kusungulwa yi-enzymes CYP3A4, CYP3A5 ne-CYP3A7. Umphumela wale nqubo ukukhishwa kwamakhompiyutha ekhombisa ukwehliswa kwe-lipid.
Ithuluzi limunca izindonga zendlela yokugaya ukudla cishe ngokuphelele.
Umphumela oyifunayo utholakala ngezinga elikhulu ngama-metabolites. Umphumela otholwe ngeLiptonorm therapy uhlala isikhathi eside: kusuka emahoreni angama-20 kuye kwangama-30. Ngemuva kwalokho, okuqukethwe kwe-atorvastatin kuyancipha. Inqubo yesigamu sempilo ithatha amahora angama-14. Ngaphezu kwalokho, indlela esemqoka yokususa into esebenzayo emzimbeni ine-bile. Futhi kuphela inani elincane elinqunywe kumchamo (kufika ku-2%). Kufanele kukhunjulwe ukuthi ukuqoqwa kwe-atorvastatin ekuseni kuphakeme okwesithathu kunokuhlwa.
Izinkomba zokusetshenziswa
Kunconywa ukusebenzisa ithuluzi ezimweni ezinjalo:
- Ukwanda okuningi kokuqukethwe kwama-lipoprotein aphansi.
- Ukwanda okungalawulwa kokuhlushwa kwe-cholesterol egazini (hypercholesterolemia), kufaka phakathi nezimo ze-pathological zemvelo efanayo zidalwa ukuphazamiseka kofuzo. Kulokhu, kunconywa ukunquma le khambi kanye neminye imithi, njengezinyathelo ezisizayo zokunciphisa isisindo ngokumelene nesizinda sokudla.
Ukwanda okungalawulwa kokuhlushwa kwe-cholesterol egazini kuyinkomba yokusebenzisa umuthi.
Contraindication
Ungasebenzisi i-ejenti embuzweni ngokuphendula okungekuhle endaweni yayo esebenzayo noma ezinye izinto ezihlanganisiwe ekwakhekeni. Kunemikhawulo ekusetshenzisweni ezimweni zokhubazeka kwesibindi nokusebenza kwezinso. Lezi zitho zinesibopho sokuguqulwa nokuqedwa kwe-atorvastatin, ngakho-ke kubalulekile ukugwema ukucindezela okukhulu kuzo.
Ngokunakekela
Ukuphulwa okuhlobene:
- isifo sesibindi esingamahlalakhona lapho kungekho khona ukubonakaliswa okuyingozi (umlando);
- ukuphazamiseka kwe-metabolic ne-endocrine;
- ushintsho kubhalansi wamanzi we-electrolyte;
- izinqubo ze-septic;
- izimo ezethusayo okunzima ukuzilawula;
- ukulimala
- imisebenzi.
Ungayithatha kanjani iLiptonorm?
Ukwelashwa kuqala ngo-10 mg ngosuku (le ndlela kufanele ithathwe kanye). Ngemuva kwalokho inani elicacisiwe liyakhuphuka kucatshangelwa izinga le-cholesterol egazini. Ukuguqulwa komthamo kuvunyelwe ukwenziwa njalo emavikini ama-4. Inani eliphakeme lesamba le-atorvastatin yansuku zonke yi-80 mg. Lomthamo ubuye futhi usezingeni le-hypercholesterolemia ebangelwa ukuphazamiseka kofuzo.
Ngoshukela
Sebenzisa umuthi ngokuqapha, noma kunjalo, umthamo awulandiswa kuleli cala. Kuvunyelwe ukusebenzisa irejimeni yokwelashwa ejwayelekile (10 mg ngosuku).
Imiphumela emibi
Ithuluzi livusa ukubukeka kwenqwaba yokuphendula okungathandeki. Ngaphezu kwalokho, kukhona ingozi yokuvela kwabo engxenyeni yezinhlelo ezahlukahlukene.
Esikhathini sikashukela i-mellitus, thatha umuthi ngokuqapha.
Kusuka kwizitho zemizwa
I-hydration enganele yezilwelwesi ze-mucous, i-lazy eye syndrome, ukuthikamezwa kwezindlebe, ukuqina kwamehlo, ukuphazamiseka kokuhlala, ukunambitha (ukuguquka noma ukulahleka kwayo okuphelele).
Kusuka ezicutshini zemisipha
Izimo eziguquguqukayo, isifo samathambo, i-tendosynovitis nezinye izifo zokuvuvukala, kanye nobuhlungu bemisuka ehlukahlukene (i-arthralgia, i-myalgia, njll.), Ukuqina kwesivumelwano, ukukhuphuka kwezwi lezicubu ezithambile, i-myopathy.
Amapheshana wesisu
Ubuhlungu esiswini, ukushayeka kwenhliziyo, isicanucanu, ukungasebenzi kahle kwesisu noma ukuqunjelwa, ukuncipha noma ukwanda kwesifiso sokudla, izifo zokuvuvukala zemvelaphi ehlukahlukene, ukopha kwesisu, i-cholestatic jaundice, i-hepatitis ne-hepatic colic, ukuhlanza.
Izitho zeHematopoietic
Izimo ezahlukahlukene ze-pathological ezihambisana nokushintshwa ekwakhiweni kwegazi: i-anemia, i-thrombocytopenia, njll.
Isistimu yezinzwa ephakathi
Ukwehla kwekhwalithi yokulala, isiyezi, ubuthakathaka obujwayelekile, ukozela, i-paresthesia ne-neuropathy, ukulahleka kwenkumbulo (inqubo eguqukayo), ukufiphala, ukudangala, ukukhubazeka kobuso.
Kusuka ohlelweni lokuphefumula
Ngokuvamile waphawula ukuthuthukiswa kwe-rhinitis, i-bronchitis. Okungaphansi kakhulu okutholakala ukuthi inyumoniya, i-asthma ye-bronchial.
Kusuka ohlelweni lwezitho zofuzo
Izifo ze-Urogenital tract, ukuvuvukala, ukopha kowesifazane, i-nephritis, ukungasebenzi kahle kwezocansi (emadodeni), ubunzima bokuchama.
Kusuka ohlelweni lwezinhliziyo
Ubuhlungu esifubeni, ukukhuphuka kwenhliziyo, ikhanda, ukwehla noma ukukhuphuka kwengcindezi, kanye nokuvuvukala kwemithambo yegazi.
Allergies
Ukubonakaliswa okujwayelekile kokuvela okungathandeki kwenzeka: ukuqubuka, ukulunywa, ukudumba, ubunzima bokuphefumula ngenxa ye-angioedema, ukukhulisa ukuzwela kokukhanya, i-erythema, kuhambisane nokukhululwa kwenani elikhulu le-exudate.
Umthelela ekhonweni lokulawula izindlela
Akunamininingwane ngamacala lapho kuthatha iLiptonorm kuthinte kabi isimo somzimba ngenkathi ushayela imoto.
Imiyalo ekhethekile
Ngesikhathi sokwelashwa, umenzeli ocubungwayo ushintsha isimo sesibindi. Kubalulekile ukuqapha umsebenzi walo mzimba ngaphambi kokuqala ukwelashwa, ngesikhathi nangemva kwawo. Kumele kukhunjulwe ukuthi ushintsho emsebenzini wama-enzyme wesibindi lubonwa ezinyangeni ezi-3 zokuqala ngemuva kokuqala kwekhosi.
Uma izimpawu zokuxinana okukhulu kuboniswa ezifweni zohlelo lwe-musculoskeletal, isibindi noma izinso, ukwelashwa kuyamiswa.
Uma izimpawu zokuncipha okukhulu zenzeka ezifweni zesibindi noma ezinso, ukwelashwa kuyamiswa.
Sebenzisa ebudaleni
Ithuluzi livunyelwe ukusebenzisa, ukulungiswa kwamthamo akwenziwanga ngasikhathi sinye.
Isabelo sezingane
Ezigulini ezingaphansi kweminyaka engu-18, lesi sidakamizwa asinconywa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi awuvunyelwe ukusetshenziswa ngesikhathi sokukhulelwa nangesikhathi uncelisa ibele, ngoba umphumela wawo omuhle awuqinisekisiwe kulezi zimo.
Isicelo sokusebenza kokulimala kwezinso
Ayibekelwe ukwehluleka kwalo mzimba.
Sebenzisa umsebenzi wesibindi okhubazekile
Ngokuthola kwe-cirrhosis, okuqukethwe kwezidakamizwa egazini kukhuphuka kaningi. Ngalesi sizathu, ayisetshenziswa. Akunakusetshenziselwa ukwehluleka kwesibindi (ubulukhuni u-A no-B ngokuya ngohlelo lwe-Child-Pugh), ukwanda kokuxineka kwama-hepatic transaminases we-etiology engaziwa nezinye izifo zalesi sigaba esigabeni esisebenzayo, kufaka phakathi lezo ezibonakaliswa imvelo yokutheleleka. Ukuze uthole ukulimala kancane kwe-hepatic, ukulungiswa kwamthamo akudingekile.
Ngokuthola kwe-cirrhosis, okuqukethwe kwezidakamizwa egazini kukhuphuka kaningi.
Ukweqisa
Ngokukhuphuka kwemiphumela emibi okuphikisana nesizinda sokwenyuka kwesibalo somuthi, ukwelashwa okubonakalayo kuyenziwa, i-gastric lavage yenziwa, i-sorbents ibekiwe. Kulokhu, i-hemodialysis ayinakwenzeka ukuyisebenzisa. Kuyadingeka ukugcina imisebenzi eyisisekelo yomzimba.
Ukuxhumana nezinye izidakamizwa
Umuthi okukhulunywa ngawo unqunywe kanye nama-cyclosporins, i-Erythromycin, i-Clarithromycin, izidakamizwa ze-antifungal, ama-immunosuppressants, uma inzuzo idlula ukulimala. Ngokusebenzisa kanyekanye i-atorvastatin nalezi zinto, ukwanda kokuhlushwa kokuqala kuyaphawulwa. Ukusetshenziswa kwama-protease inhibitors ekwelashweni kunikeza umphumela ofanayo.
Ukuhlushwa kweDigoxin kukhuphuka ngo-20%. I-Atorvastatin isebenza futhi ezindleleni ezithile zokuvimbela inzalo ngomlomo ngendlela efanayo.
Ngokusetshenziswa ngasikhathi sinye kwalesi sidakamizwa kanye neColestipol, kukhona ukwanda okukhulu kwezinga lokuphumelela kokulashwa.
I-Warfarin inganciphisa okwesikhashana isikhathi se-prothrombin. Ngemuva kwamasonto amabili, le nkomba ijwayelekile.
Ngokusetshenziswa ngasikhathi sinye kwalesi sidakamizwa kanye neColestipol, kukhona ukwanda okukhulu kwezinga lokuphumelela kokulashwa.
Ukuhambisana notshwala
Umuthi ungasetshenziselwa ukuqeda izimpawu zezimpawu zokuhoxa, kepha ngasikhathi sinye neziphuzo eziqukethe utshwala ungazithatheli.
Ama-Analog
Ukufakwa esikhundleni okusebenzayo:
- ITorvacard
- Atorvastatin;
- I-Liprimar.
Imibandela yeholide yeLiptonorma Pharmacy
Umuthi umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Akunakwenzeka lokho.
Intengo Liptonorm
Izindleko eMoscow zingama-ruble angama-238. Kwezinye izifunda, intengo ingahluka kancane.
Izimo zokugcina zomuthi
Ukushisa komoya okwamukelekayo - hhayi okuphakeme kuno- + 25 ° ะก.
Isikhathi sokuphelelwa yisikhathi
Isikhathi sokusetshenziswa komuthi ngaphandle kokulahleka kwezakhiwo yiminyaka emi-2 kusukela ngosuku lokukhiqizwa.
Umkhiqizi weLiptonorm
E-Pharmstandard, eRussia.
Ukubuyekezwa kokulahlekelwa isisindo mayelana neLiptonorm
UValeria, oneminyaka engama-43, uSimferopol.
Imetabolism yami yehla kancane empilweni, yingakho isisindo esengeziwe. Ngifunde ukuthi lesi sidakamizwa sisiza ukuzigcina sesimweni esihle, ngasheshe ngasithenga. Ngokuphikisana nesizinda sokudla okufanele kanye nemithwalo elinganiselayo, angizange ngibone umphumela, mhlawumbe lokhu kungenxa yokuthi izinyathelo ezisetshenzisiwe zanele kimi, futhi kusesekuseni kakhulu ukuguqukela ezidakamizweni.
U-Ana, oneminyaka engama-35, iKrasnoyarsk.
Ikhambi elihle. Nginesisindo ngokweqile (+ 20 kg ngemuva kokukhulelwa). Kade ngithatha lesi sidakamizwa isikhathi eside, umphumela ubonakala ngokusobala: isisindo sesiyekile ukukhula, kancane kepha ngokuqinisekile sinciphile. Ukuzivocavoca komzimba kuncane ngenxa yokuntuleka kwesikhathi, ngizama ukunamathela ekunakekelweni kahle kwezempilo.Ubuye wasebenzisa amakhambi we-homeopathic futhi wabandakanya umuthi wendabuko waze wathola indlela engcono.
Ukubuyekezwa kodokotela
U-Alekhine, u-E. B., udokotela ohlinzayo, oneminyaka engama-38, uKrasnodar.
Ithuluzi elisebenza kahle. Ukululama okugcwele akunikezeli, kepha kusebenza kahle njengesilinganiso esisizayo, kusheshisa inqubo yokuvuselelwa kwemithambo yegazi.
Ukubuyekezwa kwesifo sikashukela
U-Olga, oneminyaka engama-35, uSamara.
Ngokuphikisana nesizinda sikashukela, kuye kwavela izinkinga eziningi, kufaka phakathi ukukhuluphala ngokweqile. Angazi ukuthi kungani, kodwa kimi lo muthi awunamsebenzi uma inhloso ukunciphisa umzimba. Wenza ngokungakhathali. Umphumela weLiptonorm njengendlela yokusekela ukusebenza kohlelo lwe-vascular luphezulu kakhulu. Ezinye izimpawu zihambile, kufike usizo.
UGennady, oneminyaka engama-39, uStary Oskol.
Wathatha umuthi ukwehlisa i-cholesterol yegazi. Ngesikhathi sokwelashwa, umphumela wazizwa. Lapho eyeka ukuthatha, zonke izinkinga zempilo zabuya.
