Umuthi unomphumela we-enzyme ekhuthaza ukwehlukana kwamafutha okudla. Ngenxa yalokhu, inqubo yokuxoshwa kwabo emgodini wokugaya ukudla iyaphazamiseka. Umphumela ukunciphisa ukuncipha kwesisindo.
Kumele kukhunjulwe ukuthi lesi sidakamizwa sisodwa asifakeli ekulahlekelweni kwesisindo. Ngakho-ke, isetshenziswa ngokuhambisana nokuzivocavoca okulinganiselayo, ukudla.
Inani lezinzuzo liqashelwe: inani eliphansi lemikhawulo ekusebenziseni kanye nemiphumela emibi.
Igama Lezwe elingafanele
I-Orlistat.
Umuthi unomphumela we-enzyme ekhuthaza ukwehlukana kwamafutha okudla.
I-ATX
A08AB01.
Khipha amafomu nokwakheka
Kulungiswa ngokuqinile. Amacwecwe ahlanganiswe nokwenziwa okukhethekile kwefilimu, ngenxa yokuthi ubukhulu bomphumela wobudlova bezinto ezisebenzayo kulolwelwesi lwe-mucous lwethambo lesisu lincipha. Into esemqoka yi-orlistat. Inani layo kwithebhulethi engu-1 ngu-60 no-120 mg.
Ngaphezu kwalokho, izingxenye ezisizayo zifakiwe ekwakhiweni:
- i-sodium lauryl sulfate;
- ludiflash;
- i-acacia gum;
- i-crospovidone;
- Copovidone;
- i-magnesium stearate.
Ungathenga umuthi ngamaphakethe ama-20, 30, 60 no-90 ama-PC.
Kulungiswa ngokuqinile. Izibhebhe zihlanganiswa ngokuhlanganiswa okukhethekile kwefilimu.
Isenzo se-Pharmacological
I-ejenti okukhulunywa ngayo iyiqembu lama-enzyme inhibitors (i-gastrointestinal lipase), umsebenzi ophambili wawo okuyikhono lokwenza inqubo yokugaya (ukwahlukaniswa, ukuncibilika) kwamafutha. Kufanele kukhunjulwe ukuthi le enzyme ayigcini ngokukhuthaza ukwanda kwe-hydrolysis yama-ester-lipid substrates, kodwa futhi iphazamisa umsebenzi wokuguqula amavithamini ancibilikisa amafutha (A, E, D, K) abe amandla wokukhiqiza ukushisa.
Inhloso esemqoka yento esebenzayo kuListata ukunciphisa isisindo somzimba. Iyasebenza esiswini kanye namathumbu amancane. I-pharmacodynamics yesidakamizwa isuselwe emandleni we-orlistat ukwakha isibopho esihlanganayo nge-enzyme (lipase). Ngenxa yalokhu, ukwephulwa komsebenzi wayo kuyaphawulwa, izinga lokuqhekeka kwamafutha liyancishiswa, okuholela ekuveleni kwabo okuthuthukile okuvela emzimbeni. Lokhu kulandelana kungenxa yokuntuleka kwekhono lokuguqula amafutha. Ngendlela ye-triglycerides, ayithakwa umzimba.
Inhloso esemqoka yento esebenzayo kuListata ukunciphisa isisindo somzimba.
Kanye nokususwa kwamafutha, kuyehla ukuncipha kokudla okwenziwa amakhalori nsuku zonke. Le nto inomthelela ekunciphiseni isisindo, ngisho nangasemuva kokuntuleka kwemisebenzi yomzimba, kepha ngenkathi igcina ukudla okunotha kwe-hypocaloric. Ngaphezu kwalokho, kukhona ukwephulwa kokuhlanganiswa kwe-cholesterol, LDL. Ngenxa yalokhu, ubungozi bokuqhamuka nemicimbi engemihle ngenxa yokwehla kwe-lumen yemikhumbi kuyancishiswa.
Ngokwemiphumela yocwaningo, kungaphethwa ngokuthi ezigulini ezithatha i-Listat, ukwehla kwesisindo kwenzeka ngokushesha futhi kakhulu kakhulu kunokuba kubantu abanamathela ekudleni kuphela. Ngokulashwa isikhathi eside nalesi sidakamizwa, ukwehla okukhulu kwenani lamafutha kwenzeka. Ngemuva kokuphuza amaphilisi, ukwanda kwesisindo okuphindaphindekayo kungenzeka, kepha kungabi ngaphezu kwama-25% esisindo sokuqala. Kodwa-ke, lokhu akuwona umthetho: ezigulini eziningi, isisindo somzimba asikhuphuki ngemuva kokuthatha umuthi wokugcina womuthi.
Umuthi futhi unqunyelwe uhlobo lwe-2 sikashukela mellitus ukwenza ngcono ukulawulwa kwe-glycemic. Ngenxa yalokhu, kwenzeka ukuthi unciphise umthamo wama-hypoglycemic agents. Kodwa-ke, kukhona ukwehla kokuxineka kwe-insulin kanye nokumelana ne-insulin. Ngenxa ye-orlistat, amathuba okukhula kwesifo sikashukela sohlobo 2 ancishisiwe, umphumela ofanayo uyabonakala ezimweni zokubekezelelwa kweglucose engalungisiwe.
Umuthi futhi unqunyelwe uhlobo lwe-2 sikashukela mellitus ukwenza ngcono ukulawulwa kwe-glycemic.
I-Pharmacokinetics
Ingxenye esebenzayo yeLeafa ayingeni ngegazi, okuthinta amandla ayo okusabalala emzimbeni wonke. Amafutha adliwayo ayakhululwa ngesikhathi sokuhamba kwamathumbu njengengxenye yamalondolo.
Umphumela omuhle ubonakala ezinsukwini zokuqala ezingama-1-2 ngemuva kokuqala kokwelashwa. Ukuqoqwa kwamafutha esitobhini kutholakala njengokujwayelekile ezinsukwini ezingama-2-3 ngemuva kokuphela kwenkambo.
Umuthi udonswa kancane. Ngisho namahora angama-8 ngemuva kokuthatha umthamo womuthi, isakhi esisebenzayo asitholakali egazini. Inqubo yokuguqulwa kwento esebenzayo yenzeka ezindongeni zamathumbu. Ngenxa yalokhu, kukhululwa ama-metabolites ama-2. Awehlukile ngokusebenza okuphezulu kakhulu, ngakho-ke, empeleni awuthinti umsebenzi we-lipase.
I-Orlistat ikhishwe engxenyeni engashintshiwe (ngamathumbu). Izinso nazo ziba nengxenye kule nqubo, kepha inani eliphelele lomuthi nezinto ezihambisana nento esebenzayo alikho ngaphezu kwe-2% lomthamo. Ukuqedwa kwesigamu sempilo kukude futhi kuyehluka kusuka ezinsukwini ezi-3 kuye kweziyi-5.
Izinkomba zokusetshenziswa
Umuthi unqunywe emacaleni ambalwa:
- ukukhuluphala - kepha inqobo nje uma ngabe inkomba yezinsimbi yomzimba (BMI) ingekho ngaphansi kwama-30 kg / m²;
- ukhuluphele lapho i-BMI ingekho ngaphansi kwama-28 kg / m², ikakhulukazi, uma kunezici zobungozi ezifaka umthelela ekuthuthukiseni ukukhuluphala;
- ukhuluphele ngohlobo 2 lwesifo sikashukela - kulokhu, lesi sidakamizwa okukhulunywa ngaso sisetshenziswa ekudleni okuphathelene ne-hypocaloric kanye nezidakamizwa ze-hypoglycemic.
Umuthi ubekelwe ukwelashwa kokukhuluphala.
Contraindication
Umuthi awunqunyelwe emacaleni amaningi:
- ukusabela okungekuhle komuntu ngamunye kunoma iyiphi ingxenye ekwakhiweni komkhiqizo;
- isifo se-malabsorption syndrome;
- cholestasis.
Ngokunakekela
Uma ukulawulwa kwe-glycemia kukhula, kufanele kwenziwe ukuhlolwa okujwayelekile. Ngenxa yalokhu, lizinga le-glucose egazini linqunywa, isidingo sokuphinda silinganiswe ngomthamo weLeafa noma izidakamizwa ze-hypoglycemic siyahlolwa.
Ungamthatha kanjani uListata
Amacwecwe anconywe ukuphuza ngamanzi, futhi kufanele athathwe ngokudla. Uma lokhu kungenzeki, khona-ke akukho ngaphambi kwehora elilodwa emva kokudla. Lapho isidlo seqa, iphilisi akufanele futhi liphuzwe. Kulokhu, kuyathandeka ukuthi ukudla kuqukethe amafutha, ngaphandle kwalokho ukusebenza komkhiqizo kuncishisiwe.
Ngoshukela
Umthamo onconyiwe ngu-120 mg ngosuku kathathu ngosuku. Umuthi uphuzwa kanye nabenzeli be-hypoglycemic; umthamo wabo ubalwa ngawodwana.
Amacwecwe anconywe ukuphuza ngamanzi, futhi kufanele athathwe ngokudla.
Ukwehla kwesisindo
Inani lomuthi lansuku zonke liyi-120 mg izikhathi ezi-3 ngosuku. Isikhathi sokuphatha sinqunywa ngokuhlukile, kucatshangelwa izinga lokukhuluphala, ukuba khona kwezinye izifo.
Imiphumela Emibi Amaqabunga
Imiphumela emibi engahle ivele ezingxenyeni zomuthi:
- ipheshana esiswini: ukwephulwa kwesakhiwo sesitulo (uketshezi, amafutha), ukuqhakaza; ngokususwa kwamagesi, inani elithile lokuqukethwe kwamathumbu nalo liyathunyelwa, linxenxa ukuwohloka ukuthi kuvame kakhulu; Ubuhlungu esiswini;
- ukulimala kwamazinyo, izinsini;
- ikhanda
- ukuthambekela ekwakhekeni kwezifo ezithathelwanayo, njengomkhuhlane;
- ubuthakathaka obujwayelekile emzimbeni;
- Ukukhathazeka
- ukungahambi kahle kokuya esikhathini, kuboniswa kobuhlungu;
- ukuthambekeka kokutheleleka ngethamo lomchamo.
Umthelela ekhonweni lokulawula izindlela
Uma kungekho ukuphazamiseka kwe-glycemic, akukho mingcele ekubandakanyeni imisebenzi edinga ukunakwa okwandisiwe. Kodwa-ke, iziguli ezinenkinga yesifo sikashukela esitholakele ziyelulekwa ukuthi ziqaphele inqubo yokushayela izimoto nokulawula ezinye izindlela, okubangwa yengozi yokuthola ukusabela okungekuhle ngenxa yokusebenzisa kwama-hypoglycemic agents.
Imiyalo ekhethekile
Umuthi okukhulunywa ngawo uyasebenza ekwelapheni isikhathi eside, okuhloswe ngawo ukunciphisa isisindo somzimba.
Njengoba unikezwe ukuthi umuthi uthinta i-lipase ebandakanyeka ekugayweni kwamavithamini ahlukahlukene ancibilikisa amafutha, kunengozi yokuncipha kokuxineka kwawo emzimbeni, ikakhulukazi ngokwelashwa okuhlala isikhathi eside. Ukuze ugweme ukuthuthukiswa kokuntuleka kwezakhi zomzimba, kunconywa ukuthatha ama-vitamin complexes.
Ngesikhathi sokulashwa nge-Listata, kunconyelwa ukudla kwe-hypocaloric, ngakho-ke izinga lamafutha kufanele ligadwe.
Ngesikhathi sokwelashwa nge-Listata, kunconyelwa ukudla kwe-hypocaloric, ngakho-ke izinga lamafutha kufanele ligadwe. Kunconywa ukuhlukanisa umthamo wansuku zonke wama-carbohydrate, amaprotheni namafutha emithanjeni emi-3. Izithelo nemifino kwethulwa ekudleni.
Ukudla kakhulu amafutha, kuyanda ingozi yokuthola imiphumela emibi ehambisana nokuphazamiseka kwendlela yokugaya ukudla.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngenxa yokuntuleka kolwazi ngomphumela wesidakamizwa esibelethweni nasemzimbeni sowesifazane ngesikhathi sokuzala kwengane, akunconywa ukusisebenzisa ekwelapheni ukukhuluphala nesifo sikashukela.
Akwaziwa ukuthi i-orlistat idlulela obisini lukamama. Ngalesi sizathu, kungcono ukungasebenzisi umuthi onento enjalo ekwakhiweni ngesikhathi sokuncelisa ibele.
Ukunquma Uhlu ezinganeni
Umuthi okukhulunywa ngawo uvunyelwe ukuthi usetshenziselwe ukwelapha iziguli kusuka eminyakeni eyi-12.
Umuthi okukhulunywa ngawo uvunyelwe ukuthi usetshenziselwe ukwelapha iziguli kusuka eminyakeni eyi-12.
Sebenzisa ebudaleni
Akunamininingwane ngomphumela weLista emzimbeni weziguli kuleli qembu. Ngakho-ke, kungcono ukwenqaba ukusebenzisa umkhiqizo.
Isicelo sokusebenza kokulimala kwezinso
Umuthi awunqunyelwe.
Sebenzisa umsebenzi wesibindi okhubazekile
Akunconyelwe ukusebenzisa i-MP ngenxa yokuntuleka kolwazi ngokuphepha kwayo kuma-pathologies alesi sitho.
Akunconyelwe ukusebenzisa i-MP ngenxa yokuntuleka kolwazi ngokuphepha kwayo kuma-pathologies alesi sitho.
Amashidi Ama-overdose
Ukwelashwa isikhathi eside nomuthi kumithamo yokwelapha akufaki iqhaza ekwakhiweni kwemiphumela emibi. Ngokwemiphumela yocwaningo, kuyaphawuleka ukuthi ngisho ukuthatha lo muthi ngo-800 mg ngosuku noma ngaphezulu isikhathi eside akuholeli ekubonakaleni kwezinkinga ezinkulu. Ngaphezu kwalokho, ezinye iziguli, njengoba zichaziwe ngudokotela, zivunyelwe ukuthatha ama-240 mg kathathu ngosuku isikhathi eside (kusuka ezinyangeni eziyi-6 noma ngaphezulu). Kulokhu, akukho ukuwohloka empilweni.
Ukuxhumana nezinye izidakamizwa
Ngokuphatha kanyekanye nezidakamizwa ezinjengeMetformin, i-Insulin, i-sulfonylureas, kwaziwa ukuthi i-carbohydrate metabolism iyabonakala.
Kunconywa ukuthi izinkomba ze-INR zibhekwe uma, kanye ne-Listata, i-warfarin nezinye izidakamizwa ze-anticoagulant zithathwa.
Ukwehla kokuqukethwe kwe-cyclosporine kuyaphawulwa.
Ngokulashwa isikhathi eside ne-Amiodarone ngenkathi uthatha iLeafa, ukusebenza kahle kwemithi yokuqala kungancipha.
Ngokulashwa isikhathi eside ne-Amiodarone ngenkathi uthatha iLeafa, ukusebenza kahle kwemithi yokuqala kungancipha.
I-Acarbose ayisetshenziswa ngasikhathi sinye nomuthi okukhulunywa ngawo, ngenxa yokushoda kolwazi ekuxhumaneni kwale mishanguzo.
Kwenqatshelwe ukusebenzisa inhlanganisela yezidakamizwa ze-leafa nezama-antiepileptic, ngoba kule ndaba ingozi yokuthathwa iyanda.
Ukuhambisana notshwala
Ukuthuthukiswa kokusabela okungekuhle ngokusetshenziswa kwezidakamizwa eziqukethe utshwala akuqinisekiswanga ngesikhathi sokwelashwa nomuthi okukhulunywa ngawo. Kodwa-ke, kungaholela ekunciphiseni kokusebenza kwamashidi.
Ama-Analog
Kuvunyelwe ukusebenzisa ama-analogues alandelayo:
- I-Orlistat;
- I-Orsoten;
- I-Reduxin;
- I-Xenical.
Kuvunyelwe ukusebenzisa zombili izidakamizwa zamakhemisi namakhambi e-homeopathic uma izinga lokuphumelela kokugcina liphezulu ngokwanele.
Imibandela yekhefu lekhemisi
Umuthi umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Alikho ithuba elinjalo.
Intengo ye-Listata
Izindleko ezijwayelekile eRussia ama-ruble ayi-1080-2585.
Izimo zokugcina zomuthi
Endaweni emnyama neyomile endaweni yokushisa yomoya engekho ngaphezulu kwe- + 25 ° C futhi lapho izingane zingafinyeleleki.
Isikhathi sokuphelelwa yisikhathi
Akunconywa ukusebenzisa umuthi ngemuva kweminyaka engu-2 kusukela ngosuku lokukhululwa.
Umkhiqizi
Izvarino Pharma, eRussia.
Ukubuyekezwa kuhlu
UVeronica, oneminyaka engama-22, uPenza
Kwadingeka ukuthi ngiphuze lo muthi, ngoba nginomkhuba wokukhuluphala kusukela ebuntwaneni. Akukho ukwephulwa okusobala (ama-hormone ajwayelekile), kepha ngokuphambuka okuncane ekudleni ngokushesha - inzuzo yesisindo. Ngokwelashwa kwe-Listata, lokhu kuthambekela kwaqanjwa. Akuzange kusebenze ukuthi wehlise isisindo ngokuqinile ngosizo lwe-MP, kodwa bengingalindele ukuthi uzothola umphumela osheshayo. Sekuphele izinyanga ezine ngisebenzisa lo muthi.
UMarina, oneminyaka engama-37, eMoscow
Ngaphambi kokuqala ukufunda imiyalo, ngabona imininingwane mayelana nokuthola isisindo ngemuva kokuphela kokwelashwa. Kuphela angizange ngicabange ukuthi kuzoba kubi njengoba kwenzeka manje. Isisindo asigcinanga nje ngokubuya, kepha saba ngaphezu kokutholwa kweqabunga. Kusukela ngaleso sikhathi, awukho umuthi wokunciphisa isisindo owangiheha. Ukudla okungcono kwe-hypocaloric nemidlalo.
