Amathebulethi eGlibomet aklanyelwe iziguli ezinesifo sikashukela esincike kakhulu ku-insulin (uhlobo II). Umphumela ohlangene ukuvumela ukuthi uzuze ukusebenza okuphezulu kakhulu ekwelashweni kwalo muthi.
Igama Lezwe elingafanele
Metformin + glibenclamide (metformin + glibenclamide).
I-ATX
A10BD02.
I-Glibomet iyatholakala ngesimo samathebulethi egobolondweni.
Khipha amafomu nokwakheka
Amaphilisi egobolondo. Izithako ezisebenzayo kwithebhulethi e-1: 2,5 mg glibenclamide, 400 mg metformin hydrochloride. Ezinye izinto:
- i-microcrystalline cellulose;
- isitashi sommbila;
- i-magnesium stearate;
- i-talc;
- diethyl phthalate;
- cellulose acetate;
- i-colloidal silicon dioxide.
Isenzo se-Pharmacological
Umuthi ungowezidakamizwa eziningana ezihlanganisiwe ze-hypoglycemic. Inomphumela we-extrapancreatic ne-pancreatic.
I-Glidenclamine isuselwa kwizizukulwane ezimbili ze-sulfonylurea. Isebenzisa ukukhiqizwa kwe-insulin ngokwenza okuphathelene nama-beta receptors pancreas, ithuthukisa izinga lokumelana kwe-insulin yamaseli e-pancreatic futhi ikhuphule ukukhishwa kwe-insulin kanye nesenzo se-insulin maqondana nokufakwa kweglucose yisibindi nemisipha, kubambezela izinqubo ze-lipolytic ezakhiweni zezicubu ze-adipose.
I-Metformin iyi-greatuanide. Umuthi uthuthukisa ukuzwela kwezakhi zezicubu emiphumeleni ye-insulin, wehlise izinga lokufakwa kweglucose emgodini wokugaya ukudla futhi kunomthelela ovimbela i-gluconeogeneis. Ngenxa yalokhu, i-lipid metabolism yenziwa ihlelwe ngokwejwayelekile, futhi isisindo somzimba kwiziguli ezinesifo sikashukela siyancishiswa.
Umuthi ungowezidakamizwa eziningana ezihlanganisiwe ze-hypoglycemic. Inomphumela we-extrapancreatic ne-pancreatic.
I-Pharmacokinetics
I-Glibenclamide icwilisa ngokuphelele futhi isheshe idonswe izindonga zendlela yokugaya ukudla. Isikhathi sokufinyelela ku-Cmax sisuka kumaminithi angama-60 kuye kwangama-120. Igcotshwa yi-bile nezinso ngevolumu elinganayo. Ukuphila kwesigamu kuyahluka phakathi kwamahora angama-5 ukuya kwangu-10.
I-Metformin nayo idonswa ukwakheka kwamathumbu. Umzimba awuphuli. Kukhululwa izinso ngesimo sazo sokuqala. Ukuqedwa kwesigamu sempilo kufinyelela emahoreni ayi-7.
Izinkomba zokusetshenziswa
Umuthi usetshenziselwa ukwelapha isifo sikashukela sohlobo lwe-2 isifo sikashukela (sincike ku-insulin) lapho kungekho khona amandla asuka ku-monotherapy nezinye izidakamizwa ze-hypoglycemic kanye nokwelashwa kokudla.
Umuthi usetshenziselwa ukwelapha isifo sikashukela sohlobo 2.
Contraindication
- i-pathologies enzima ehambisana nokuwohloka emsebenzini wezinso / isibindi noma i-hypoxic phenomena;
- ukungabekezelelani ngakunye;
- ukungasebenzi kahle kwesibindi;
- isifo sikashukela sikashukela / i-precoma;
- isikhathi sokuncelisa kanye / noma sokukhulelwa (ngokuqapha);
- uhlobo lwesifo sikashukela ketoacidosis;
- i-hypoglycemia enkulu;
- i-lactic acidosis;
- thayipha i-1 mellitus yesifo sikashukela esincike ku-insulin.
Ungayithatha kanjani i-Glibomet
Izibhebhe zithathwa ngomlomo. Ukudla kuthuthukisa ukumunca umuthi. Imithamo imiselwe ngawodwana, kucatshangelwa ukuhlangana kwe-plasma kashukela egazini kanye nokuqina kwe-carbohydrate metabolism.
Imithamo imiselwe ngawodwana, kucatshangelwa ukuhlangana kwe-plasma kashukela egazini kanye nokuqina kwe-carbohydrate metabolism.
Ukuthatha umuthi wesifo sikashukela
Umthamo wokumaphakathi ojwayelekile uvela kumaphilisi angu-1 kuye kwayi-3 ngosuku, khona-ke umthamo ukhuphuka kancane kancane kuze kube yilapho isamba sembuyiselo se-pathology sitholwa. Umthamo omkhulu wansuku zonke wesidakamizwa ngamathebulethi ayi-5 ngosuku.
Imiphumela emibi yeGlybomet
Amapheshana wesisu
- i-hepatitis;
- i-cholestatic jaundice;
- ukuhlanza
- ukwephulwa kwesisu;
- isicanucanu.
Izitho zeHematopoietic
- ukwehla kwezinga lamangqamuzana egazi abomvu, amangqamuzana amhlophe egazi nama-platelet (kuyaqabukela);
- i-megaloblastic / hemolytic anemia.
Isistimu yezinzwa ephakathi
- ukuncipha kokuzwa;
- i-paresis (ezimweni ezingavamile);
- ukuxhumeka kwezimoto okungahambi kahle;
- ikhanda.
Ngasohlangothini lwe-metabolism
- kukhona ingozi yokuhlakulela i-hypoglycemia.
Engxenyeni yesikhumba
- hypersensitivity to light (kuyaqabukela),
Allergies
- ukuqhuma
- ukudumba;
- i-allergic rhinitis;
- ukwanda kokushisa;
- izinhlungu zokuhlangana nezemisipha.
Umuthi ungadala izinhlungu emisipha nasekuhlanganeni.
Umthelela ekhonweni lokulawula izindlela
Ngesikhathi sokuthatha amaphilisi, kungenzeka ukuthi kube ne-hypoglycemia, ngakho-ke, ukulawulwa komshini kanye nezinqubo kufanele kugwenywe.
Imiyalo ekhethekile
Lapho usebenzisa umuthi, umuntu kufanele alandele ngokuqinile izincomo zikadokotela ngokuya ngohlobo nemithamo yemithamo. Ngaphezu kwalokho, ngesikhathi sokulashwa, kuyalulekwa ukulandela indlela odla ngayo, ukuthuthukisa uhlelo lokuzivocavoca umzimba futhi uhlole njalo ushukela wegazi.
Ukuqunjelwa kwe-metformin kuvusa ukwanda kokuhlungwa kwe-lactic acid egazini, okungaholela esimweni esiyingozi njenge-lactic acidosis. Ngakho-ke, lapho uthatha umuthi, izici zobungozi njengokuzila isikhathi eside, isigaba esinciphile sesifo sikashukela, ukusetshenziswa kabi kotshwala kanye nanoma yiziphi ezinye izimo ezihambisana ne-hypoxia kufanele zingafakwa.
Ukuvimbela i-lactic acidosis, ukuzila ukudla okuhlala isikhathi eside kufanele kugwenywe ngesikhathi sokwelashwa kwe-Glibomet.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kuvinjelwe. Isikhathi sokwelashwa kusuka ekunceliseni ibele kufanele senqabe.
I-Glybomet kadokotela yezingane
Amacwecwe asetshenziselwa ukwelapha iziguli ezineminyaka engaphansi kweminyaka engu-18.
Sebenzisa ebudaleni
Ukulungiswa komthamo akudingeki.
Isicelo sokusebenza kokulimala kwezinso
Ngokuphathwa kanyekanye kwama-diuretics nezidakamizwa ze-antihypertensive, kufanele kuqashelwe. Ngaphezu kwalokho, imvume ye-creatinine kufanele ibhekelwe iziguli ezinenkinga yezinso.
Sebenzisa umsebenzi wesibindi okhubazekile
Iziguli ezingasebenzi kahle isibindi kufanele zisebenzise umuthi ngokucophelela.
Iziguli ezingasebenzi kahle isibindi kufanele zisebenzise umuthi ngokucophelela.
I-Glybomet overdose
Izimpawu zobuntu: kukhona ubungozi be-hypoglycemia ne-lactic acidosis. Lawa ma-pathologies aboniswa yizimpawu ezilandelayo:
- ukuhlanza
- ubuqili;
- ukunganaki
- ukuncipha kwengcindezi yegazi;
- ukwephulwa kokuqondiswa kwendawo;
- ukujuluka
- ukukhuphuka kwenhliziyo;
- indlala yesikhumba;
- ukuthuthumela
- isicanucanu
- bradyarrhythmia (Reflex);
- ukungakhululeki emgodini wesisu;
- ukuphazamiseka kokulala;
- Ukukhathazeka
- ukozela
Noma yikuphi ukusola kwe-lactic acidosis ne-hypoglycemia, isiguli sidinga ukulashwa esibhedlela ngokushesha.
Ngefomu emnene ye-hypoglycemia, udinga ukudla ucezu olunoshukela noma uphuze isiphuzo esinoshukela. Lokhu kuzokwenza ngokwejwayelekile ukusebenza kwamanyikwe.
Indlela ephumelela kunazo zonke yokwelapha inqubo ye-hemodialysis.
Ukuxhumana nezinye izidakamizwa
I-Beta-blockers, i-allopurinol, i-oxytetracycline ne-dicumarol zandisa umsebenzi we-hypoglycemic wesidakamizwa okukhulunywa ngaso.
Ukuhlanganiswa kwe-cimetidine nezinye izinto ze-sulfonylurea kukhulisa ubungozi be-lactic acidosis.
Ukuhambisana notshwala
I-Alcohol ehambisana nomuthi ingaholela ku-hypoglycemia kanye nemibandela efana ne-disulfiram. Ngakho-ke, ngesikhathi sokwelashwa kufanele balahle inhlanganisela yabo.
I-Alcohol ehambisana nomuthi ingaholela ku-hypoglycemia kanye nemibandela efana ne-disulfiram.
Ama-Analog
Esikhundleni somuthi ongaba khona:
- Siofor;
- I-Metformin;
- I-Gluconorm;
- I-Metglib;
- Amandla we-Metglib;
- Ama-Glucovans;
- IGluconorm Plus.
Imibandela yekhefu lekhemisi
Amaphilisi kadokotela.
Amaphilisi kadokotela.
Intengo ye-Glibomet
Kumakhemisi aseRussia, amaphilisi ahlanganisiwe abiza phakathi kwama-ruble angama-330-360. kwephakethe lekhadibhodi eliqukethe amapuleti ama-4 amaphilisi ayi-10 kuleyo nemiyalo yokuyisebenzisa.
Izimo zokugcina zomuthi
Izimo ze-Optimum: indawo eyomile, emnyama engafinyeleleki ezinganeni, izinga lokushisa akufanele libe ngaphezulu kuka + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Ayidluli izinyanga ezingama-36. Ungathathi amaphilisi aphelelwe yisikhathi.
Umkhiqizi
Inkampani yaseJalimane "Berlin-Chemie Menarini Group / AG".
Ukubuyekezwa kweGlibomet
UNadezhda Khovrina, oneminyaka engama-40, eMoscow
Ngaphambi kokuthi udokotela anikeze lesi sidakamizwa somlomo, ngangisebenzisa i-Glucofage. Kodwa-ke, bekungekho lutho oluzuzayo kuye. Lawa amaphilisi kwehlisa ushukela ngempumelelo nangokuphumelelayo. Lokhu kufakazelwa ukuhlaziya.
UGalina Guseva, oneminyaka engama-45 ubudala, eSt
Sekuyisikhathi eside ngithatha lo muthi. Umphumela uyaphikelela, umenyezelwe. Muva nje ngiye kudokotela ukuthola ukuthi kungahlanganiswa nemithi yokuhlaselwa amagciwane, ngoba benginokusola i-helminthiasis. Udokotela wakuvumela ukwamukelwa kwabo kanyekanye. Manje sengingalala ngokuthula.
