IGalvus Met umuthi osetshenziselwa ukuguqula isimo somzimba sinesifo sikashukela. Ine-contraindication, ngakho-ke kufanele isetshenziswe njengokuyalelwa udokotela.
Igama Lezwe elingafanele
I-Vildagliptin + metformin.
IGalvus Met umuthi osetshenziselwa ukuguqula isimo somzimba sinesifo sikashukela.
I-ATX
A10BD08.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo samaphilisi omumo oyindilinga, ophekwe ngefilimu ye-enteric yombala obomvana. Ngakolunye uhlangothi kukhona umbhalo othi "NVR", ngakolunye - "LLO". Ithebhulethi ngayinye iqukethe:
- i-vildagliptin (50 mg);
- metformin hydrochloride (100, 1000 noma 850 mg);
- i-hyprolose;
- i-magnesium stearate;
- titanium oxide yomzimba;
- i-macrogol;
- i-iron oxide ibomvu.
Amacwecwe ahlanganiswe kumaseli we-contour zezingcezu eziyi-10, iphakethe lekhadibhodi liqukethe i-1 blister nemiyalo
Isenzo se-Pharmacological
Izinto ezisebenzayo zinezakhi ezilandelayo:
- Vimbela umsebenzi we-dipeptidyl peptidase-4, okhulisa ukugcwala kwe-enzyme efana ne-glucagon egazini. Lokhu kwenza amaseli we-pancreatic azwele ushukela. Lokhu kwandisa ukukhiqizwa kwe-insulin edingekayo ukuze kuqhekeke ushukela. Izinga lokujwayelekile komsebenzi wamaseli we-gland lincike ohlotsheni lomonakalo.
- Khulisa okuqukethwe kwe-enzyme efana ne-glucagon, ekuvumela ukuthi ulawule ukukhiqizwa kwe-glucagon. Ukwehla kokuqukethwe kwe-peptide ngemuva kokudla kunomthelela ekunciphiseni kokumelana ne-insulin. Ukwanda kwesilinganiso se-insulin / glucagon ngokumelene nesizinda samazinga kashukela ancishisiwe kuvimbela ukukhiqizwa kwe-glycogen ngokweqile esibindini.
- Yehlisa okuqukethwe kwama-lipoprotein aphansi egazini, okuchazwa ngokukhuthaza amaseli we-islet wamanyikwe.
- Khuphula ukumelana kwe-glucose ezigulini ezinesifo sikashukela sohlobo 2. Yehlisa amazinga kashukela egazini ngaphambi nangemva kokudla.
- Musa ukubangela ukwehla okukhulu ekugxileni kwe-glucose egazini noma kwabanesifo sikashukela, noma kubantu abaphilile. Ukwelashwa ngomuthi akufaki sandla ku-hyperinsulinemia. Ukuqalwa kwe-insulin kuhlala kungashintshiwe, kuyilapho inani le-hormone egazini lingahlukahluka ngokuya ngokudla.
- Ibuyisa imetabolism yamakhemikhali e-protein-fatty, yehlisa i-cholesterol ne-triglycerides emzimbeni.
I-Pharmacokinetics
I-60% yomthamo othathwe ngomlomo ungene egazini. Ukwelashwa kwe-plasma okwelaphayo kutholakala ngemuva kwamahora angama-2-2,5. Ukudla kunganciphisa ukumuncwa kwezinto ezisebenzayo. Ngomjovo owodwa womuthi, iningi lawo lithululwa lingashintshiwe emchameni. Umuthi awuguquki esibindini futhi ungangeni ku-bile. Ukuphila kwesigamu kwenhlanganisela yezinto ezisebenzayo kuthatha amahora angama-17.
Izinkomba zokusetshenziswa
Izinkomba zokusetshenziswa kwomuthi onesifo sikashukela yilezi:
- ukungasebenzi kahle kokusetshenziswa okuhlukile kwezinto ezisebenzayo ezakha i-Galvus Met;
- ukwelashwa okuhlanganiswa ne-metformin ne-vildagliptin, okusetshenziselwa ukwenza iziqu;
- ukuthola ukwelashwa kwe-insulin ngaphandle kokulawulwa okwanele kwe-glycemic;
- ukwelashwa kokuqala kweziguli ezinesifo sikashukela sohlobo 2 ngokungasebenzi kahle kokudla nokuzivocavoca umzimba.
Contraindication
Umuthi awunqunyelwe ukuthi:
- ukungabekezelelani ngakunye kwezithako ezisebenzayo nezisizayo;
- ukomisa komzimba;
- izimo ze-hypoxic;
- ukwehluleka kwenhliziyo okuqatha nokungamahlalakhona;
- infarction myocardial;
- ukwephulwa kwemisebenzi yohlelo lokuphefumula;
- i-metabolic acidosis;
- ukulungiselela ukungenelela kokuhlinzwa nokuhlolwa kwe-x-ray (umuthi awuthathwa amahora angama-48 ngaphambi kwenqubo);
- Uhlobo 1 sikashukela;
- ukudakwa okungapheli, ukudakwa ngokweqile;
- Ukulandela ukudla okune-khalori ephansi.
Ngokunakekela
Ukuphulwa okuhlobene kufaka phakathi:
- ubudala obudala nobudala bokuphamba;
- ukusebenza kanzima ngokomzimba, okwandisa ingozi ye-lactic acidosis.
Ungayithatha kanjani iGalvus Met
Ngoshukela
Umthamo usungulwa ngokuya ngobucayi be-pathology nokubekezelela ukwelashwa. Ungeqi umthamo ophelele ovunyelwe we-vildagliptin (100 mg). Ukwehlisa ubunzima bemiphumela emibi yepilisi, kunconywa ukuphuzwa ngesikhathi sokudla. Esimweni sikashukela esinzima, umuthi uphuzwa esiswini esingenalutho. Ukwelapha okuhlanganayo kuqala ngokufakwa kwe-50 + 500 mg yesidakamizwa izikhathi 2 ngosuku. Uma kungekho kusebenza kahle, umthamo we-metformin ukhushulelwa ku-850 mg.
Imiphumela emibi yeGalvus Met
Ngokuphikisana nesizinda sokwelashwa noGalvus Met, okulandelayo kungenzeka:
- ukuphazamiseka kwemithambo yezinzwa (ikhanda, isiyezi, ukwethuka kwemikhawulo, ukwazi ukungasebenzi kahle, ukukhathala okwandayo);
- ukuphazamiseka kwe-metabolic (hypoglycemia);
- ukusabela kwesikhumba (ukulunywa, imivimbo erythematous, ukujuluka okunyukayo);
- ukuphazamiseka kokugaya ukudla (isicanucanu, ukuhlanza, umuzwa wobunzima esiswini, istulo esingazinzile);
- izimpawu zomonakalo ohlelweni lwe-musculoskeletal (imisipha nobuhlungu obuhlangene);
- eminye imiphumela emibi (ukuvuvukala kwamaphethelo aphansi, ukushaqeka kwe-anaphylactic, ukumuncwa kwe-vitamin B12).
Umthelela ekhonweni lokulawula izindlela
Umphumela wesidakamizwa kokuhlushwa kanye nezinga lokuphendula kwe-psychomotor alifundwanga. Umuthi ungadala isiyezi, ngakho-ke, ngesikhathi sokwelashwa unqaba ukushayela nezinqubo eziyinkimbinkimbi.
Imiyalo ekhethekile
Sebenzisa ebudaleni
Ekwelapheni asebekhulile ne-senile, ukulungiswa kwamthamo kuyadingeka. Ngenkathi yokwelashwa, ukuhlolwa kwegazi okujwayelekile kuyadingeka.
Isabelo sezingane
Ukuphepha kwezinto ezisebenzayo zomzimba wengane akukaze kufakazelwe, ngakho-ke ukusetshenziswa kweGalvus Met ngeziguli ezisencane kunqatshelwe.
Ekwelapheni asebekhulile ne-senile, ukulungiswa kwamthamo kuyadingeka.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi wehlula umgoqo we-placental bese ungena ebisini. Ukuphepha kwezinto ezisebenzayo zezinsana kanye nengane ebisi lwebele akufundiwe. Ngakho-ke, ukukhulelwa nokukhishwa kufakwa ohlwini lwe-contraindication.
Isicelo sokusebenza kokulimala kwezinso
Ngokwesifo sezinso esinzima, kungadingeka ukuthi kuncishiswe umthamo weGalvus Met.
Sebenzisa umsebenzi wesibindi okhubazekile
Uma kwenzeka ukungasebenzi kahle kwesibindi, ukwelashwa nomuthi kudinga ukubhekwa njalo kwamakhemikhali wezinto eziphilayo.
Ukweqisa kweGalvus Met
Ukweqisa imithamo ebekwe udokotela ithuthukisa imiphumela emibi. Ukwelashwa kuyesekela ngokwemvelo. I-Dialysis isebenza kahle, ngakho ayisetshenziswa.
Ngokwesifo sezinso esinzima, kungadingeka ukuthi kuncishiswe umthamo weGalvus Met.
Ukuxhumana nezinye izidakamizwa
I-Thiazide diuretics inyusa izinga lokuphuma kwe-Galvus Met. I-Nifedipine inyusa ukumunca umuthi. I-Glibenclamide ayithinti izinga lokufakwa kwe-metformin ne-vildagliptin. Ama-glycosides e-Cardiac angabopha i-metformin, anciphise isilinganiso se-metabolic. Ukuphatha ngokubambisana umuthi ngama-antipsychotic akunconyiwe.
Ukuhambisana notshwala
I-Ethanol yandisa ingozi ye-lactic acidosis, ngakho-ke bayenqaba ukuphuza utshwala ngesikhathi sokwelashwa.
Ama-Analog
Ama-ejenti alandelayo anomphumela ofanayo:
- I-Amaryl M;
- Galvus;
- I-Glibomet;
- UGlatiniin.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela
Kudingeka umuthi ukuthenga umuthi.
IGalvus Met Intengo
Intengo ephakathi yepakethe lamathebhulethi angama-30 ingama-ruble ayi-1,500.
Izimo zokugcina zomuthi
Umuthi ugcinwa endaweni emnyama, angavumeli ukufudumeza ngenhla kuka + 30 ° C.
Isikhathi sokuphelelwa yisikhathi
Izinyanga eziyi-18 kusukela ngosuku lokukhishwa.
Umkhiqizi
Umuthi ukhiqizwa yinkampani yaseSwitzerland iNovartis Pharma.
Ukubuyekezwa kweGalvus Met
UVictoria, oneminyaka engama-45, eMoscow: "Kudala nginesifo sikashukela sohlobo 2, ngakho-ke udokotela wanikeza umuthi oqukethe zombili i-metformin ne-vildagliptin ngasikhathi sinye. Lezi zingxenye ziyahambisana, ngakho-ke umuthi usheshe wehlise ushukela wegazi futhi usize ukuligcina likhona amanani ajwayelekile. "
U-Arthur, oneminyaka engama-34, eMoscow: "Nginenkinga yesifo sikashukela sohlobo lwe-2. Ngaphambilini ngaphathwa ngeMetformin. Lapho ushukela uqala ukukhuphuka futhi, uDiabeteson wafakwa ohlelweni lokwelapha. Noma kunjalo, ukwelashwa akuzange kunikeze umphumela oyifunayo. Manje ngithatha amaphilisi weGalvus Met. Ushukela awukhuphuki kaningi, okwenza ukuthi kwenzeke ngaphandle kwe-insulin. "
