IGlucofage 750 - indlela yokulwa nesifo sikashukela

IGlucofage 750 - umuthi osetshenziselwa ukwelapha isifo sikashukela sohlobo 2.

I-ATX

Ikhodi ye-ATX yi-A10BA02.

Khipha amafomu nokwakheka

Umuthi uyatholakala ngesimo samaphilisi e-biconvex anombala omhlophe. Ithebhulethi eyi-1 iqukethe u-750 mg wento esebenzayo - metformin hydrochloride.

Ngaphezu kwalokho, i-caramellose, i-hypromellose, i-magnesium stearate ifakiwe.

IGlucofage 750 - umuthi osetshenziselwa ukwelapha isifo sikashukela sohlobo 2.

Isenzo se-Pharmacological

Ithuluzi elingeleqembu lezidakamizwa ze-hypoglycemic. Into esebenzayo isuselwa kuma-Biguanides.

I-Metformin ilawula amazinga we-basal ne-postprandial glucose. Umuthi awuthinti ukukhululeka kwe-insulin ngamaseli e-pancreas, ngakho-ke, ngeke kubangele ukwehla okukhulu kwamazinga kashukela.

Umuthi usebenza kuma-insulin receptors akhiwe kwizitho nezicubu. Ijubane lokucubungula ushukela ngamaseli we-peripheral nalo liyakhuphuka. Ngaphansi kwethonya lomuthi, i-gluconeogenesis kuma-hepatocytes ivinjelwe.

Into esebenzayo inciphisa ukumuncwa kwe-glucose ngezindonga zamathumbu. Ngaphansi kwesenzo sawo, ukukhiqizwa kwe-glycogen kuyasheshiswa, umsebenzi wokuthutha wezinhlanganisela obhekene nokudluliselwa kwe-transmembrane kokunyuka kweglucose.

I-Pharmacokinetics

Ukuqina okuphelele kokuthile okusebenzayo ku-plasma yegazi kubonwa cishe imizuzu eyi-150 ngemuva kokuphathwa komlomo kwithebhulethi ye-Glucofage. Ukuthatha isidakamizwa esiswini esingenalutho akukuthinti ukumuncwa umuthi, okuvumela ukuthi uwuphuze ngaphandle kokudla.

Ukusetshenziswa isikhathi eside kwemithamo ejwayelekile ye-metformin akuholeli ekutholakalweni kwento emzimbeni. Uma ingena egazini, into ayibophisi ukuthutha ama-peptide. I-Metformin metabolism yenzeka ngendlela engahlobene. Awekho ama-metabolites asebenzayo atholakele emzimbeni womuntu. Ukuhoxiswa kwenzeka kungashintshiwe.

Umuthi ukhishwa ngosizo lwezinso. Umshini we-excretion ukufiliza okucwebezelayo nokuqothuka kweshubhu. Ukuqedwa kwesigaba sempilo kusukela emahoreni amahlanu kuya kwayi-7. Uma kwenzeka umsebenzi we-renal ophazamisekile, imvume yempahla esebenzayo ye-ejenti iyancipha, futhi nengxenye-yempilo yabo iyanda. Njengomphumela, ukwanda kokuqukethwe kwe-plasma metformin kungenzeka.

Umuthi ukhishwa ngosizo lwezinso.

Izinkomba zokusetshenziswa

IGlucophage imiselwe uhlobo 2 sikashukela. Kusetshenziswa uma kwenzeka ukungasebenzi kahle kokulashwa kokudla. Ingabekwa kokubili njenge-monotherapy, futhi njengengxenye yokwelapha okuyinkimbinkimbi namanye ama-hypoclycemic agents noma i-Insulin.

Contraindication

Ithuluzi ligwetshwe emacaleni alandelayo:

• ukungabekezelelani ngakunye kunoma yiziphi izingxenye ezakha ukwakheka kwazo;
• ukubuyiswa kwesifo sikashukela i-mellitus (ketoacidosis, i-precoma noma i-coma);
• ukungasebenzi kahle kwezinso;
• ukungasebenzi kahle kohlelo lwe-hepatobiliary;
• ukudakwa okungapheli noma ubuthi botshwala;
• izimo ezimbi ezisongela izinkinga zezinso;
• ukwehluleka kwenhliziyo;
• ukwehluleka ukuphefumula;
• izicubu hypoxia yobunzima obukhulu nobunzima;
• i-lactic acidosis;
• ukudla okuphansi kwekhalori;
• ukungenelela kokuhlinzwa nokulimala, okudinga ukwethulwa kwemithamo ephezulu ye-Insulin;
• ukomisa;
• ukwethuka
• Isimo sokudakwa obukhulu.

Ngokunakekela

Kufanele uqaphele lapho unquma umuthi kubantu abaneminyaka engaphezu kwengu-60, abavame ukubhekana nokuzivocavoca okwandayo, okwandisa ingozi ye-lactic acidosis.

Ukwehluleka kwenhliziyo kungukuphikisana nokusetshenziswa kwe-glucophage.

Umuthi awubekelwe ubuphuzo oludakayo.

IGlucophage icutshaniswe nokudakwa kakhulu komzimba.

Ungayithatha kanjani i-Glucofage 750?

Izibhebhe zithathwa ngomlomo. Sebenzisa ngesikhathi sokudla kokugcina kuyelulekwa.

Kwabadala

Abantu abadala abanesifo sikashukela sohlobo 2 sithatha kusuka ku-750 kuya ku-2000 mg we-metformin ngosuku.

Okwezingane

Izingane ezingaphansi kweminyaka engu-18 ubudala ziphikiswa ekusebenziseni lesi sidakamizwa.

Ukwelashwa kwesifo sikashukela Glucofage 750

I-Metformin isetshenziselwa ukwelapha isifo sikashukela sohlobo 2. Kunqunyelwe iziguli ezinesimo sazo esingenakunxephezelwa ngokwelashwa kokudla noma ngokuzivocavoca umzimba. Umuthi unqunywe bobabili njenge-monotherapy, futhi ngokuhlanganiswa ne-Insulin namanye ama-ejenti anomphumela we-hypoglycemic. Akunconywa ukuhlanganisa izidakamizwa ngokwakho. Ukukhethwa kwezokwelapha kufanele kudluliselwe kudokotela.

Ekwelashweni kwesifo sikashukela sohlobo 2, umthamo wansuku zonke we-metformin ungahluka kusuka ku-750 kuya ku-2000 mg. Umthamo ofanele uzokhethwa ngudokotela.

I-Metformin isetshenziselwa ukwelapha isifo sikashukela sohlobo 2.

Ukwehla kwesisindo

Sebenzisa umuthi ukunciphisa umzimba ngaphandle kweseluleko sochwepheshe akukanconywa. Umthamo wansuku zonke wokunciphisa isisindo ngu-100 mg, ohlukaniswe ngemithamo emibili. Inkambo ejwayelekile yokwelashwa ihlala izinsuku ezingama-20. Ngemuva kwalokhu, sekwenziwe ikhefu lokuthatha inyanga yonke. Kungenzeka ukuphinda isifundo uma kunesidingo sokuhlanganisa umphumela.

Lapho uthatha i-metformin, akufanele uqhubeke nokudla okunama-khalori aphansi. Ukungadli ukudla okwanele kuholela engcupheni eyandayo yemiphumela emibi. Inhlanganisela yomuthi neReduxin kungenzeka.

Imiphumela emibi

Amapheshana wesisu

Isicanucanu nokuhlanza, izinguquko esimweni sesitulo, ukuncipha kokudla, izinhlungu esifundeni se-epigastric. Le miphumela engafuneki ibonwa kakhulu ekuqaleni kwenkambo yokwelashwa, ngemuva kwalokho idlulise yodwa. Ukuze unciphise ubungozi bokusabela okungekuhle, akunconywa ukusebenzisa i-metformin esiswini esingenalutho. Ukwanda kancane kancane komthamo nakho kungenzeka, okuvumela umzimba ukuzivumelanisa nezenzo zomuthi.

Isistimu yezinzwa ephakathi

Ukwephula ukunambitheka. Mhlawumbe ukubonakala nokunambitheka kwensimbi emlonyeni.

Kusuka ohlelweni lomchamo

I-Metformin ayibangeli imiphumela emibi evela ohlelweni lokuchama.

Engxenyeni yesibindi ne-biliary

Akuvamile, ukuthi kube khona ukwanda kwezinga lomsebenzi wama-enzyme wesibindi nokuphazamiseka kokusebenza kwezintso. Imiphumela engathandeki inyamalala ngemuva kokuyekiswa.

Njengomphumela wecala, ukwephulwa kwemizwa yokunambitha kungenzeka.

Ekuqaleni kwesifundo, kungaba sengathi kunesicanucanu nokuhlanza.

Ukuze unciphise ubungozi bokusabela okungekuhle, akunconywa ukusebenzisa i-metformin esiswini esingenalutho.

Imiyalo ekhethekile

Abantu abanokulimazeka okukhulu kwezinso basengozini yokuqunjelwa kwe-metamorphine. Ngenxa yalokhu, i-lactic acidosis ingenzeka, okuyinto eyivelakancane, kepha iyingozi empilweni yomuntu nokuphila. Ubungozi bale nkinga bukhona futhi kubantu abanesifo se-hepatic dessfunction, ukuxhomekeka kotshwala, i-ketosis, kanye nesifo sikashukela ngesikhathi sokubola.

I-lactic acidosis ingasolwa uma isiguli sizwa izinhlungu zemisipha, ama-cramp, nokuphazamiseka kwento emgatsheni wesisu ngokumelene nesizinda sokusebenzisa isikhathi eside i-metformin. I-lablication complication iboniswa ngokuncipha kokusabela kwe-acid egazini elingaphansi kwe-7.25, izinga le-lactate lenyuka laya ku-5 mmol / l nangaphezulu. Uma usola ukuthi i-lactic acidosis ithuthukile, thintana nodokotela ngokushesha. Ngenxa yokuqongelela kwenani elikhulu le-lactate, i-coma kungenzeka.

IGlucophage ayinconywa ukuba ithathwe ezinsukwini ezi-2 ngaphambi nangemva kokungenelela kokuhlinzwa noma izinqubo ze-radiological.

Ngaphambi kokuqala inkambo yokwelashwa, kuyadingeka ukuthola umsebenzi wezinso wesiguli. Kulokhu, imvume ye-creatinine iyahlolwa. Ngokusetshenziswa njalo kwe-metformin, ukuhlolwa okuphindaphindayo kufanele kwenziwe okungenani isikhathi esisodwa ngonyaka.

Abantu abanokwehluleka kwesibindi kufanele baphuze izidakamizwa ngokuqapha.

Ukuhambisana notshwala

Ukuphuza utshwala ngenkathi ulashwa nge-metformin akunconywa.

Umthelela ekhonweni lokulawula izindlela

Ngokulashwa okuyinkimbinkimbi kwesifo sikashukela kusetshenziswa amanye ama-hypoglycemic agents, i-hypoglycemia kungenzeka, lapho izindlela zokushayela noma eziyinkimbinkimbi ziphikisiwe.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ngesikhathi sokukhulelwa, isiguli esithatha i-Glucofage kufanele sidluliselwe ekwelashweni kwe-insulin. Uma kunesidingo, ukwelashwa kowesifazane osenkulisa, ingane idluliselwa ekunikezelweni kokufakelwa.

Ngesikhathi sokukhulelwa, isiguli esithatha i-Glucofage kufanele sidluliselwe ekwelashweni kwe-insulin.

Ukusetshenziswa kwomuthi kungenzeka kubantu asebekhulile.

Ngesikhathi ukwelashwa nge-glucophage, akunconywa ukulawula imoto.

Sebenzisa ebudaleni

Ukusetshenziswa kwalesi sidakamizwa kungenzeka kubantu asebekhulile lapho kungekho khona ukungqubuzana okukhonjisiwe kwimiyalo yokusebenzisa.

Ukweqisa

I-overdose ye-metformin ayivelakancane. Lapho usebenzisa umthamo ophindwe kayishumi kunokwelapha, i-lactic acidosis ingakhula. Kulokhu, udinga ukuyeka ukusebenzisa umkhiqizo. Isiguli silaliswa esibhedlela lapho amazinga e-lactate ebhekwa khona. Uma kunesidingo, i-hemodialysis kanye nokwelashwa okubonisa izimpawu.

Ukuxhumana nezinye izidakamizwa

Inhlanganisela ehlanganisiwe

IGlucophage akufanele ihlanganiswe nezindlela eziqukethe iodine futhi isetshenziselwe izifundo ze-radiopaque. Ngaphambi kokwenza imidwebo edinga ukwethulwa kwalezo zinhlanganisela emzimbeni wesiguli, kufanelekile ukuyeka ukusetshenziswa kwe-metformin ezinsukwini ezi-2. Ezinsukwini ezi-2 ngemuva kocwaningo, umsebenzi wezinso uyaqashwa, ngemuva kwalokho isifundo siphinde siqale phansi.

Uma i-lactic acidosis ikhula ngedakamizwa ephezulu kakhulu, kufanele uyeke ukusebenzisa umuthi.

Akuhlanganisiwe ukuhlanganisa

Akunconywa ukuhlanganisa ukusetshenziswa kwe-metformin nokusetshenziswa kotshwala, izidlo ezinama-kilojoule amancane, izidakamizwa ezibandakanya notshwala be-ethyl.

Inhlanganisela edinga ukuqashelwa

Ukunakekelwa okukhethekile kufanele kuthathwe lapho kuhlanganiswa iGlucophage nokulandelayo:

1. UDanazole - ukusetshenziswa okuhlangene kungadala ukwehla kweglucose yegazi. Ukulungiswa komthamo okungenzeka kwe-metformin uma kunesidingo, ukusetshenziswa ngasikhathi sinye.
2. I-Chlorpromazine - ingavimbela ukuvikelwa kwe-insulin, inyuse amazinga kashukela.
3. I-GCS - ikhuphula ushukela wegazi, ingadala i-ketosis.
4. I-Loop diuretics - ngokuhlanganiswa ne-metformin ikhulisa ubungozi bokwakheka kwe-lactate.
5. Ama-agonists e-Beta-adrenergic - andisa i-glycemia.
6. Ama-inhibitors e-ACE - abangela i-hypoglycemia.
7. I-Nifedipine - isheshisa ukumuncwa kwe-metformin futhi ikhuphule ukuqina kwayo okuphezulu egazini.

I-Glucophage idinga ukuqaphela okwedlulele uma kuhlanganiswa nezidakamizwa ezithile.

Ama-Analog

Ukufana kwezidakamizwa kufaka phakathi:

• I-Bagomet;
• I-Glycometer;
• IGlucovin;
• I-Glumet;
• I-Dianormet;
• I-Diaformin;
• I-Metformin;
• Siofor;
• Iphaneli;
• Tefor;
• I-Zucronorm;
• I-Amnorm.

Uyini umehluko phakathi kweGlucophage neGlucophage ende eyi-750?

Umehluko omkhulu phakathi kwendlela ende ye-glucophage ubude besikhathi sesenzo. Ukufakwa kwe-Metformin kuhamba kancane, okukuvumela ukuthi kugcinwe ukuhlushwa kwe-plasma engapheli isikhathi eside.

Imibandela yekhefu lekhemisi

Ngingakwazi ukuthenga ngaphandle kadokotela?

Umuthi usatshalaliswa ngugqirha.

Intengo ye-Glucofage 750

Izindleko zezimali zincike endaweni okuthengwa kuyo.

Izimo zokugcina zomuthi

Gcina endaweni yokushisa engeqi ku-25 ° C kude nezingane.

Isikhathi sokuphelelwa yisikhathi

Umuthi ungasetshenziswa kungakapheli iminyaka emithathu kusukela ngosuku lokukhululwa. Ukusetshenziswa okwengeziwe akunconywa.

Ukubuyekezwa kwe-Glucofage 750

Odokotela

Pavel Samarsky, endocrinologist, eMoscow.

Phakathi kwezinye izidakamizwa ezifanayo, iGlucophage ayihlukaniswa ngokukhethekile. Umuthi ojwayelekile one-metformin, okukhona kuwo inqwaba emakethe. Ngokwesigaba sayo samanani, kusebenza kakhulu, iziguli azivamile ukukhononda ngemiphumela emibi.

Kumkhuba wakhe, wasebenzisa indlela esezingeni futhi ende. Kuhlanganiswe leli thuluzi ne-Insulin nezinye izidakamizwa. IGlucophage isebenza kahle ngokwanele ukuba inconywe kozakwabo, kepha kukhona izidakamizwa ezikhombisa ukungcono kancane. Kepha nanku umbuzo ezweni lokukhiqiza nentengo yamanani.

U-Lydia Kozlova, udokotela wobugqila, uKhabarovsk.

Lesi sidakamizwa silungele isifo sikashukela. Kuyo yonke le minyaka yemikhuba yakhe, bengivame ukuhlangana nabesifazane abazama ukukuthatha ukunciphisa isisindo. Abantu abafuni ukuqonda ukuthi ikhambi alihloselwe lokhu, kepha ukunciphisa umzimba, umuntu angasho, kungumphumela wesenzo sawo.

Ungazindli. I-Metformin akuyona ama-goji amajikijolo, angathinta impilo. Kanye lapho baletha intombazane encane ne-lactic acidic coma. Bengifuna ukwehlisa isisindo, kepha ngathola ubuthi bomzimba wonke nezinkinga zesibindi zokuphila. Yebo, lokho ukwazile ukupompa. Kunesiphetho esisodwa kuphela: uma ufuna ukwehla isisindo, zinakekele, futhi ungabheki amaphilisi omlingo namaphilisi.

Umkhiqizo ugcinwa emazingeni okushisa angadluli ku- + 25 ° C endaweni engafinyeleleki ezinganeni.

Iziguli

UDenis, oneminyaka engama-43 ubudala, u-Arkhangelsk.

Ngithatha uGlucophage kwiseluleko sikadokotela wami. Ngiyawuthanda umuthi ngoba awubangeli noma yimiphi imiphumela emibi uma isetshenziswe kahle, futhi intengo ihamba kahle.

Isiza ukugcina isifo sikashukela sihlolile. Ekuqaleni, wazama ukubhekana nalesi sifo ngokudla, wenza izivivinyo ukuze wehlise isisindo. Isimo sibe sibi kuphela kuze kube yilapho udokotela eqoka uGlucophage. Ngiphila impilo ephelele naye futhi. Kufanele ubonane nodokotela ngezikhathi ezithile, kepha uma unesifo sikashukela, amahlaya mubi. Landela impilo yakho ukuze ungaphuzi amaphilisi ngokuhamba kwesikhathi.

UZhanna, oneminyaka engama-56, Izhevsk.

Cishe iminyaka emi-5 eyedlule ngabona ukuthi sengikhula kakhulu isisindo. Ngonyaka wamaphawundi angama-25 angaphezulu. Okokuqala ngaya kudokotela wezempilo, owangeluleka ukuba ngibonane nodokotela. Ngemuva kokuthatha izivivinyo, ngithole ukuthi nginesifo sikashukela.

Angiyekanga, ngoba ngiyazi ukuthi yize lesi sifo siyingozi, ungaphila. Udokotela wanquma uGlyukofazh, walanda umthamo. Ngiyaqhubeka ukuyisebenzisa cishe iminyaka emi-4. Uthatha ikhefu kuphela lapho udokotela ekhuluma. Ngizama ukubheka impilo yami, ngihlala ngivivinya. Umuthi uyasiza uma ulandela ngokugcwele izincomo zochwepheshe. Ithuluzi lihle, angibonanga imiphumela emibi ngesikhathi sesicelo. Into esemqoka akuyona ukuzindla.

Akunconywa ukuhlanganisa ukusetshenziswa kwe-metformin nokusetshenziswa kotshwala.

Ukulahlekelwa isisindo

U-Ana, oneminyaka engama-27, eMoscow.

Kule minyaka emifushane ngizame izindlela eziningi zokunciphisa umzimba. Futhi ngahlala phezu kwamanzi ngama-apula, futhi amasonto onke wadla ama-buckwheat eyodwa. Umcibisholo esikalini wehle isikhashana, bese uphinde ubuyela kumaki ojwayelekile.

Ngezwa ngise ntombazaneni ukuthi unganciphisa isisindo ngokuthatha i-metformin. Ngiqale ukuthatha i-Glucophage, njengoba ngase ngiphhumelele izivivinyo ngabuye ngabonisana nodokotela. Ngaphuza amaphilisi izinsuku ezingama-20, ngasikhathi sinye ngangizilolongela umzimba futhi ngizama ukudla ukudla okunempilo. Ngezifundo zokuqala ngilahle cishe i-10 kg.

Ngokuthatha ikhefu, waphinda futhi isifundo. Enye ukususa ama-12 kg. Ngigculisekile ngomphumela. Manje into esemqoka ukugcina isisindo.