IHydrochlorothiazide izosiza ukubhekana nokusebenza okulimazayo kwezinhlelo ezahlukene zomzimba. Umuthi unomphumela omuhle ekucindezelweni, futhi usiza ukubhekana namatshe ezinso nezinye izinkinga.
Igama Lezwe elingafanele
Igama ngesiLatini yiHydrochlorothiazide.
Ngokwegama lomhlaba wonke elingahambisani nokuhweba, lo muthi ubizwa ngokuthi yi-hydrochlorothiazide.
IHydrochlorothiazide izosiza ukubhekana nokusebenza okulimazayo kwezinhlelo ezahlukene zomzimba.
Ath
Ikhodi ye-ATX yi-C03AA03.
Khipha amafomu nokwakheka
Ezibhebheni, into esebenzayo ikhona ngesimo sehydrochlorothiazide. Inani lezakhi zingama-25 mg noma ama-100 mg. Izithako ezisizayo yilezi:
- isitashi sommbila;
- cellulose;
- i-lactose monohydrate;
- i-magnesium stearate;
- i-povidone.
Indlela yokusebenza
Iqembu le-pharmacological lomuthi yi-thiazide diuretics. Ithuluzi linezenzo ezilandelayo:
- ingcindezi yangaphansi (umphumela we-hypotensive);
- isusa i-magnesium ne-potassium ions emzimbeni;
- izicupho ze-calcium ion;
- iphazamisa ukubuyiselwa kabusha kwe-chlorine ne-sodium.
Umuthi i-hydrochlorothiazide wehlisela umfutho wegazi.
Ukubonakaliswa kwepropathi ye-diuretic kwenzeka ngemuva kwamahora ama-2.
I-Pharmacokinetics
Umuthi unezimpawu ezilandelayo:
- ifinyelela ekuphakameni okuphezulu emva kwamahora ayi-1.5-3;
- egxiliwe esibindini;
- ukumbiwa kumchamo ngenani lama-50-70%;
- ubopha amaprotheni (40-70%);
- buthelela kumaseli abomvu egazi.
Okunqunyelwe
Umuthi uhloselwe ukwelashwa kweziguli ezinezinkomba ezilandelayo:
- i-edematous syndrome yemvelaphi ehlukahlukene, kufaka phakathi ngenxa yokwehluleka kwenhliziyo okungapheli;
- i-arterial hypertension;
- uhlobo lwesifo sikashukela sikashukela.
Contraindication
Ayinqunyelwe lapho kukhona ama-pathologies kanye ne-contraindication:
- isifo sikashukela, esibonakaliswa isigaba esibi sokuthuthuka;
- i-hypersensitivity yezidakamizwa ezivela eqenjini le-sulfonamide;
- ukwehluleka kwesibindi;
- Isifo sika-Addison;
- ukuqina okunzima kwe-gout;
- ukwehluleka okukhulu kwe-renal (nezinguquko ze-pathological emsebenzini wezinso).
Ngokunakekela
Ukuba khona kwale mibandela nezimo ezilandelayo kudinga ukunqunywa ngokucophelela ngomuthi:
- isifo senhliziyo;
- ukuqina kwesibindi;
- i-hypokalemia;
- gout
- ukusetshenziswa kwezidakamizwa ezihlobene ne-glycosides yenhliziyo;
- amazinga aphansi e-sodium (hyponatremia);
- ukukhuphuka kokuqina kwe-calcium (hypercalcemia).
Ungayithatha kanjani i-hydrochlorothiazide
Ukuze uqale ukwelashwa, qiniseka ukuthi uthintana nodokotela futhi uthole izincomo. Imodi yokusebenzisa umuthi inqunywe ngawodwana.
Izici ezijwayelekile zokuphuza umuthi yilezi ezilandelayo:
- umthamo nsuku zonke - 25-100 mg;
- inani elilodwa lomuthi ngu-25-50 mg.
Umthamo wansuku zonke we-hydrochlorothiazide ungama-25-100 mg
Ukuvama kokusetshenziswa kwomuthi kuzoncika ekuthini umzimba wesiguli kanye nesifo esivele sikhona.
Ngoshukela
Ukwemukelwa kwe-hydrochlorothiazide kwenziwa ngokusho kwezincomo zochwepheshe.
Ngesikhathi sokwelashwa, isiguli kufanele sibe ngaphansi kokuqondisa udokotela.
Imiphumela emibi
Amapheshana wesisu
Imiphumela emibi ibonakala ngokuvela kwalezi zimpawu:
- isifo sohudo
- ukuhlanza
- isicanucanu
Ezimweni ezingavamile, i-pancreatitis ivela - ukulimala kwezicubu ze-pancreatic.
Izitho zeHematopoietic
Ngakolunye uhlangothi lwezitho ze-hematopoietic kanye ne-heestasis ezimweni ezingavamile, ukusabela komzimba okulandelayo ekuphuzeni umuthi kuvela:
- ukuncishiswa kokunciphisa kwama-granulocytes;
- ukwehla kwesibalo seplatelet egazini.
Ukusabela kokuthatha i-hydrochlorothiazide kungaba ukwehla kwenani lamapuleti egazini.
Isistimu yezinzwa ephakathi
Isiguli sinokuboniswa okufanayo:
- ukunciphisa isikhathi sokunakwa;
- ukukhathala nobuthakathaka;
- isiyezi.
Engxenyeni yezitho zombono
Ezimweni ezingavamile, ikhwalithi yokubona iyehlakala ezigulini.
Kusuka ohlelweni lwezinhliziyo
Ezimweni eziningi, lezi zibonakaliso ziyavela:
- ukukhuphuka kwenhliziyo;
- hypotension yohlobo lwe-orthostatic;
- ukuphazamiseka kwesigqi senhliziyo.
Uma usebenzisa i-hydrochlorothiazide, kungahle kube nokuphulwa kwesigqi senhliziyo.
Uhlelo lwe-Endocrine
Uma imiphumela emibi ithinta uhlelo lwe-endocrine, khona-ke izinga le-potassium egazini liyakhuphuka.
Allergies
Ukuboniswa akuvamile. Ezimweni eziningi, iziguli zine-dermatitis ye-allergic.
Imiyalo ekhethekile
Ukuhambisana notshwala
Kwenqatshelwe ukuthatha umuthi kanye nemikhiqizo equkethe utshwala ngasikhathi sinye.
Umthelela ekhonweni lokulawula izindlela
Umuthi ungaholela ekwehleni kokuxineka, okuzoba nomthelela ongemuhle ekuphatheni kwezokuthutha.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokuzala ingane, ikhambi linqunyelwe kuphela ngenxa yezizathu zezempilo, ngoba zikhona izingozi ezinganeni. Lapho uncelisa ibele, akunconywa ukusebenzisa umuthi ngenxa yokungena kwento esebenzayo ebisini.
Lapho uncelisa ibele, akunconywa ukuthatha i-hydrochlorothiazide.
Ukuphathwa kwe-hydrochlorothiazide ezinganeni
Umuthi unqunyelwe ukuthi ucabangele isisindo somzimba - i-1-2 mg nge-1 kg. Ekwelashweni kwezingane ezingaphansi kweminyaka emi-2 ubudala, umuthi awusetshenziswa.
Sebenzisa ebudaleni
Abantu asebekhulile bakhetha umthamo ophansi wesidakamizwa.
Isicelo sokusebenza kokulimala kwezinso
Kuyadingeka ukulawula imvume ye-creatinine nokugxila kwe-plasma electrolyte. Ukuphazamiseka okuthe xaxa ekusebenzeni kwezinso kungukuphula umthetho kokuphuza umuthi.
Sebenzisa umsebenzi wesibindi okhubazekile
Akuvunyelwe ukuthatha umuthi lapho ukhona umsebenzi wesibindi ongasebenzi kahle, kubandakanya nokwehluleka.
Ukweqisa
I-overdose ihambisana nokubonakala kwezimpawu:
- umlomo owomile
- kwehla umthamo wansuku zonke womchamo;
- ukuqunjelwa
- ukukhathala
- arrhythmias.
I-overdose ye-hydrochlorothiazide ihambisana nokuvela kwezimpawu ze-arrhythmia.
Ukuxhumana nezinye izidakamizwa
Izici ezilandelayo ziyatholakala:
- ukusebenza kwama-ejenti we-hypoglycemic kuyancipha;
- ukuzwela ukukhuphuka kwe-tubocurarine;
- ukwanda kwe-neurotoxicity yama-salicylates;
- amathuba okukhula kwe-hypokalemia ngenxa yama-corticosteroids ayanda;
- ukusebenza kwe-hydrochlorothiazide kuyancipha ngenkathi kusetshenziswa i-cholestyramine;
- umphumela we-hypotensive uyancipha lapho usebenzisa izidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala, kufaka phakathi i-indomethacin;
- Umphumela we-diuretic uyanda ngenxa yokusetshenziswa kwama-NSAIDs, anticoagulants engaqondile kanye ne-clofibrate.
Le mithi elandelayo ingaqhakambisa umphumela we-hydrochlorothiazide:
- I-Diazepam;
- ama-anticepressants ama-tricyclic;
- ama-beta-blockers;
- ama-barbiturates;
- ama-vasodilators.
Ukuthatha i-hydrochlorothiazide kunciphisa ukusebenza kwama-hypoglycemic agents.
Ama-Analog
Izidakamizwa ezilandelayo zinomphumela ofanayo:
- I-Hypothiazide;
- I-Britomar;
- Furosemide;
- URamipril;
- I-Captopril;
- Trifas;
- I-Enalapril;
- IValsartan;
- Indapamide;
- Torasemide;
- I-Veroshpiron;
- I-Enap;
- I-Trigrim;
- I-Bufenox.
I-Hypothiazide ekwelapheni umfutho wegazi ophakemeUkuphila okuhle! Imithi nelanga. Furosemide. (07.14.2017)I-Kapoten ne-Captopril - imithi ye-hypertension kanye nokwehluleka kwenhliziyoNgokushesha ngezidakamizwa. I-EnalaprilNgokushesha ngezidakamizwa. IValsartan
Imibandela yekhefu lekhemisi
Ifuna umuthi ogcwaliswe ngudokotela ngesiLatini.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi usatshalaliswa ngokuqinile ngokuya ngommiselo.
Intengo ye-hydrochlorothiazide
Izindleko zalo muthi zivela kuma-ruble angama-60 kuye kwangama-280.
Izimo zokugcina zomuthi
Umkhiqizo akufanele ube sezindaweni izingane ezifinyelela kuzo. Umuthi kumele uvikeleke ekuchayweni ngamazinga okushisa aphezulu nelanga.
IHydrochlorothiazide akufanele ibe sezindaweni izingane ezifinyelela kuzo.
Isikhathi sokuphelelwa yisikhathi
Umuthi ufanele iminyaka engu-5 kusukela ngosuku lokukhishwa olukhonjiswe kwiphakheji. Kwenqatshelwe ukusebenzisa umuthi ngempilo yeshalofu ephelelwe yisikhathi.
Umkhiqizi
Umuthi lo ukhiqizwa yizinkampani ezilandelayo:
- I-LECFARM;
- I-Borschagovsky Chemical-Pharmaceutical Plant;
- I-Valenta Pharmaceuticals.
Ukubuyekezwa kwe-Hydrochlorothiazide
Odokotela
USergey Olegovich, udokotela wezifo zenhliziyo
Ukonakala kwe-hydrochlorothiazide kuhlotshaniswa nokuvezwa okusesilinganisweni futhi okunobumnene, ngenxa yokuthi iziguli mancane amathuba okuthola imiphumela emibi. Umuthi ungasetshenziswa ku-monotherapy noma njengengxenye yendlela ehlanganisiwe, kuya ngesimo sesiguli kanye nohlobo lokwephulwa okukhona.
UViktor Konstantinovich, udokotela ojwayelekile
Umkhiqizo yi-diuretic ephakathi nendawo. Umuthi uyasebenziseka phambi kwe-edema nomfutho wegazi ophakeme. Kodwa-ke, kufanele usebenzise umuthi ngokuqapha ngesikhathi sikashukela, esihambisana nokuphuza imithi ukwehlisa ushukela.
Umuthi hydrochlorothiazide unomphumela omuhle ekucindezelweni.
Iziguli
ULarisa, oneminyaka engama-47, Syktyvkar
Esikhundleni se-hydrochlorothiazide, wayevame ukuthatha umuthi obizayo. Usizile, kepha angizizwa sengathi ngisebenzisa imali enkulu njalo emithini. Ngiye kudokotela, ngamaphilisi we-hydrochlorothiazide anqunyelwe. Umzimba ukubekezelele ukufaka umuthi esikhundleni somuthi, futhi ngesikhathi sokwelashwa bekungekho zimpawu zangaphandle.
UMargarita, oneminyaka engama-41, eYekaterinburg
Umyeni wakhe wanikezwa amaphilisi e-hydrochlorothiazide. Iqiniso ngukuthi oshade naye waqala waba nezinkinga zezinso. Ngesikhathi sokuxilongwa, bathola itshe esitho, ngakho babhala imali yokwelashwa. Ekuseni, umyeni uvuke nge-edema ngenxa yale mishanguzo, ngakho-ke udokotela wathi athathe ipilisi elilodwa le-hydrochlorothiazide. Isimo saba ngcono ngemuva kwezinsuku ezi-2, ukuvuvukala kwehle.
