I-Diabeteson MV - indlela yokulwa nesifo sikashukela

Leli thuluzi lihloselwe ukwelashwa kwesifo sikashukela sohlobo 2. Into esebenzayo ivuselela amaseli e-pancreatic ukukhiqiza i-insulin eningi ukwehlisa ushukela wegazi.

Igama Lezwe elingafanele

I-Gliclazide.

I-Diabeteson MV yenzelwe ukwelashwa kwesifo sikashukela sohlobo 2.

I-ATX

A10BB09.

Khipha amafomu nokwakheka

Kuyatholakala kwifomu lethebhulethi:

• Ama-pcs ayi-15., Egcwele emabhulashini ama-2 noma ama-4 ama-PC. nemiyalo yokusetshenziswa efakwe ebhokisini lekhadibhodi;
• Ama-30 ama-pcs., Ukufakwa okufanayo kwe-1 noma ama-2 ama-blacks ngephakethe ngalinye.

Ithebhulethi eyi-1 iqukethe u-60 mg wento esebenzayo - i-gliclazide.

Izingxenye ezisizayo:

• i-hypromellose 100 cP;
• i-anhydrous colloidal silicon dioxide;
• maltodextrin;
• i-magnesium stearate;
• lactose monohydrate.

I-Diabeteson MV iyatholakala ngesimo sethebhulethi.

Isenzo se-Pharmacological

Umenzeli we-Hypoglycemic.

Into esebenzayo ingukuphuma kwe-sulfonylurea. Uma kuqhathaniswa nama-analog, iqukethe i-nitrogen ene-endocyclic bond kwi-heterocyclic ring. Ngenxa yesenzo se-gliclazide egazini, ingxenyeni enkulu kashukela iyancipha, futhi ukuvikelwa kwe-insulin kukhuthazeka ngamaseli we-beta weziqithi zeLangerhans.

Ukuqina okwandisiwe kwe-C-peptide ne-insprandial insulin kuphikelela iminyaka emi-2 ngemuva kokwelashwa.

Ukudla ushukela ngohlobo 2 sikashukela, lapho uthatha umuthi, kusiza ukubuyisa inani eliphakeme lokuqala le-insulin secretion futhi kuqinise isigaba salo sesibili. I-secretion inyuka kakhulu ngokudla kwe-glucose.

Ukuqina okwandisiwe kwe-C-peptide ne-insprandial insulin kuphikelela iminyaka emi-2 ngemuva kokwelashwa.

Inomphumela we-hemovascular. Into esebenzayo ithinta izinqubo ezinomthelela ekwakhiweni kwezinkinga sikashukela, njengokuthi:

• ukwehla ekuxakekeni kwe-thromboxane B2 kanye ne-beta-thromboglobulin activates;
• ukungavunyelwe okungapheli kokunamathela nokuhlanganiswa kwalezi zinto ezakhiwe.

Ukhuthaza umsebenzi owengeziwe we-izicubu ze-plasminogen activator kanye nokubuyiselwa komsebenzi we-fibrinolytic we-vascular endothelium.

I-Pharmacokinetics

Ukumunca okuphelele kwento esebenzayo kwenzeka ngemuva kokumunca umuthi, kungakhathaleki ukuthi ukudla kudliwani. Kukhona ukwanda kancane kancane kokuhlushwa kwe-plasma emahoreni angama-6 okuqala. Ukulungiswa kwezinga lethafa kungamahora ayi-6 kuya kwayi-12. Ukungabekezelelani okuphansi komuntu ngamunye.

Kufika kuma-95% ento esebenzayo ebopha amaprotheni e-plasma. Umthamo wokusabalalisa ngamalitha angama-30. Ukuthatha ithebhulethi engu-1 ngosuku kugcina ukugxila okudingekayo kwe-gliclazide egazini isikhathi esingaphezu kosuku.

I-Metabolism yenzeka ikakhulu esibindini.

I-Metabolism yenzeka ikakhulu esibindini. Awekho ama-metabolites asebenzayo ku-plasma. Ama-Metabolites adotshwa ikakhulukazi yizinso, ngaphansi kuka-1% - okungashintshiwe. Ukuqedwa kwesigamu sempilo kungamahora ayi-12-20.

Izinkomba zokusetshenziswa

Umuthi unqunyelwe ukuphathwa ngomlomo kulezi zimo ezilandelayo:

• phambi kohlobo 2 lwesifo sikashukela esisebenza kahle ngokudla okuphansi kokudla okusetshenzisiwe, ukuvivinya umzimba nokuncipha kwesisindo;
• ekuvinjelweni kwezinkinga: ukuqapha okunamandla kwe-glycemic yesimo seziguli ukunciphisa ingozi ye-micro- (retinopathy, nephropathy) kanye nemiphumela emincane ye-macrovascular (stroke, infyoction myocardial).

I-Diabeteson MV ibekelwa ukuba khona kohlobo 2 lwesifo sikashukela ngokusebenza okuphansi kokudla okusetshenzisiwe, ukusebenza komzimba kanye nokunciphisa umzimba.

Contraindication

Umuthi awunqunyelwe emacaleni alandelayo:

• hypersensitivity to gliclazide nezinye izingxenye zomuthi, kufaka phakathi ku-sulfonamides;
• Uhlobo 1 sikashukela;
• ukuthatha i-miconazole;
• ukukhulelwa nokuqunjelwa;
• isifo sikashukela nesifo sokuwa;
• ukwehluleka okukhulu kwe-hepatic noma kwe-renal;
• isifo sikashukela sikashukela.

Umuthi ubuye uhlushaniswe nabancane.

Akunconyelwe ukusetshenziswa ezigulini ezine-glucose-galactose malabsorption, galactosemia, ukungabekezelelani kokuzala kwe-lactose.

Ngobukhathaza besifo sikashukela, lesi sidakamizwa asinqunyelwe.

Ngesikhathi sokukhulelwa, ukuqokwa kubekwe kungqubuzana ngokuphelele.

Ngotshwala, umuthi kufanele uthathwe ngokuqapha.

Ekwaluphaleni, iDiabeteson CF kufanele ithathwe ngokuqapha.

Ngokunakekela

Ukuqapha umuthi usetshenziselwa:

• utshwala;
• ukwehluleka kwezitho zangasese noma i-adrenal, renal noma kwesibindi;
• ukuntuleka kwe-glucose-6-phosphate dehydrogenase;
• ama-pathologies wezinhliziyo ezibucayi;
• ukusetshenziswa isikhathi eside kwama-glucocorticosteroids;
• ukudla okungalinganiseli noma okungajwayelekile;
• ukuguga.

Ungayithatha kanjani i-Diabeteson MV?

Umthamo wansuku zonke amaphilisi we-0.5-2 isikhathi esingu-1 ngosuku. Izibhebhe zigwinywa zigcwele ngaphandle kokuchotshozwa nokuhlafuna.

Izibhebhe zigwinywa zigcwele ngaphandle kokuchotshozwa nokuhlafuna.

Ukwemukelwa okulahlekile akunxephezeli ngethamo elandisiwe kulokwamukelwa okulandelayo.

Umthamo unqunywa udokotela ngokuya ngezinga le-HbA1c kanye noshukela wegazi.

Ukwelashwa nokuvimbela isifo sikashukela

Qala ukwelashwa ngethebhulethi ½. Uma kuthathwa ukulawula okwanele, khona-ke le ndlela yanele yokwelashwa kokulondolozwa. Uma ukulawulwa kwe-glycemic kunganele, umthamo ukhuphuka ngokulandelana ngama-30 mg ngemuva okungenani kwenyanga eyi-1 yokuphuza umuthi ngomuthi obekade unikezwe wona, ngaphandle kweziguli ezinamazinga we-glucose angazange anciphe ngemuva kwekhambi lokwelashwa elenziwa amasonto amabili. Okwesibili, umthamo uyanda ezinsukwini eziyi-14 ngemuva kokuqala kokuphatha.

Umthamo omkhulu wansuku zonke yi-120 mg.

Qala ukwelashwa ngethebhulethi ½.

Ezigulini ezisengozini yokuthola i-hypoglycemia, kunikezwa idosi elincane (amaphilisi angu-0.5).

Ngokuvimbela izinkinga zesifo sikashukela, isilinganiso somuthi sikhuphuka kancane kancane size sifinyelele ku-120 mg / ngosuku. Ukuthatha umuthi kuhambisana nokuzivocavoca umzimba nokudla kuze kufike lapho kufinyelelwa khona i-HbA1c. Ngesikhathi sokwelashwa, ezinye izidakamizwa ze-hypoglycemic zingasetshenziswa:

• Insulin
• i-alpha glucosidase inhibitor;
• okususelwa ku-thiazolidinedione;
• I-Metformin.

Ukuthatha umuthi kuhambisana nokudla.

Isicelo sokwakha umzimba

I-bodybuilder idinga inkambo ye-insulin yokuthola isisindo esisheshayo. Kulesi mdlalo, ithandwa ngenxa yokuthi:

• kuthengiswa ngokukhululekile emakhemisi;
• akubeki ingozi empilweni;
• kunomthelela omnene emzimbeni.

Ukusetshenziswa kwesidakamizwa kufanele kuhlanganiswe nokudla okulingene kwembaleki. Kungcono ukubhaka noma ukubila. Umuthi uphuzwa esiswini esingenalutho isigamu sehora ngaphambi kokudla. Ungadli ukudla ngesikhathi sokuziqeqesha kanye ne-± ihora eli-1 ngaphambi nangemva kwalo.

Umuthi uphuza kathathu ngosuku. Umthamo unqunywa yisisindo somsubathi. Ukunyuka kuholela ekudleni ngokweqile, tk. ukuncishiswa koshukela kudinga isinxephezelo ngohlobo lokudla okunama-khalori aphezulu.

I-bodybuilder idinga inkambo ye-insulin yokuthola isisindo esisheshayo.

Imiphumela emibi

Lapho usebenzisa i-gliclazide, njengayo yonke eminye imishanguzo ye-sulfonylurea, umuthi ungadala i-hypoglycemia lapho weqa ukudla noma ukungahambi kahle. Izimpawu ezilandelayo ziyaphawulwa:

• i-bradycardia;
• ukuphefumula okungashonile;
• umuzwa wokungakwazi ukusiza;
• ukulahleka kokuqwashisa ngokuthuthuka okungaba khona kokuphelelwa yithemba lokufa;
• Isiyezi
• iminyakazo
• ukukhathala;
• ubuthakathaka
• paresis;
• ukuthuthumela
• ukulahlekelwa ukuzithiba;
• umbono nokukhubazeka;
• i-aphasia;
• Ukudana
• ukunciphisa isikhathi sokunakwa;
• ukudideka kokwazi;
• ukuvuka
• ukungahambi kahle;
• isicanucanu nokuhlanza
• ukuphazamiseka kokulala;
• umuzwa owengeziwe wendlala;
• ikhanda.

Ngenkathi ukuphuza lo muthi kungadala i-nausea, ukugabha.

I-Diabeteson MB ingadala ukuphazamiseka kokulala.

Umuthi ungadala isiyezi.

Umuthi ungadala ikhanda.

Ukuphendula kwe-Adrenergic nakho kuyaphawulwa:

• angina pectoris;
• arrhythmia;
• Ukukhathazeka
• i-tachycardia;
• izibuko
• umfutho wegazi ophakeme;
• isikhumba esiminyene;
• hyperhidrosis.

Ukuhlolwa kwelebhu kwatholakala ukuthi ukwephulwa komsebenzi wesibindi ngokuthuthukiswa kwe-cholestasis kungenzeka.

Izimpawu zalesi sifo ziyeka ukuthathwa kwama-carbohydrate. Ukuthatha ama-sweeteners akunampumelelo. Akunconywa ukuthatha amanye ama-sulfonylurea derivatives.

Umphumela wecala lomuthi ukushaywa kwenhliziyo.

I-Diabeteson CF ingaba nzima.

I-Diabeteson MV ingadala ukwanda kwengcindezi yegazi.

Amapheshana wesisu

Ukunciphisa le miphumela emibi, udinga ukuthatha umuthi ngenkathi udla ibhulakufesi. Lokhu kufaka phakathi:

• isicanucanu nokuhlanza
• ukuqunjelwa
• isifo sohudo
• Ubuhlungu besisu.

Izitho zeHematopoietic

Akuvamile ukubonwa:

• i-granulocytopenia;
• i-leukopenia;
• thrombocytopenia
• i-anemia

Iguqulelwa kakhulu emuva kokuyekwa komuthi.

I-Diabeteson MB ingadala ubuhlungu besisu.

Isistimu yezinzwa ephakathi

Okulandelayo kuyaphawulwa:

• ukubona okungathinteki kwemvelo;
• isiyezi esinzima.

Kusuka ohlelweni lomchamo

Akukhonjwa.

Engxenyeni yezitho zombono

Ukuphazamiseka okubukwayo kungenzeka ngezinguquko kushukela wegazi. Izici eziningi zesikhathi sokuqala sokwelashwa.

Uma uguqula ushukela wakho wegazi ngenkathi uthatha umuthi, ukubona kwakho kungenzeka kukhubazeke.

Engxenyeni yesikhumba

Kubonwe:

• I-Stevens-Johnson syndrome;
• i-erythema;
• I-edema kaQuincke;
• ukulunywa
• i-necrolysis enobuthi;
• ukuqunjelwa, incl. maculopapullous;
• urticaria.

Engxenyeni yesibindi ne-biliary

Okulandelayo kuyaphawulwa:

• i-hepatitis ezimweni ezingazodwa;
• umsebenzi owengeziwe wama-enzyme wesibindi (i-alkaline phosphatase. AST, ALT).

Ukwelapha kuyeka lapho i-cholestatic jaundice ivela.

Ezimweni ezingavamile, i-hepatitis ingaqhamuka ngenkathi yelashwa nge-Diabeteson MV.

Imiyalo ekhethekile

Umuthi ubekelwe iziguli ezidla ukudla okune-carbohydrate eningi njalo ngesidlo sasekuseni. Ukuvela kwe-hypoglycemia kusungulwa ngu:

• ukuzivocavoca isikhathi eside
• ukuthatha izidakamizwa eziningana ze-hypoglycemic ngasikhathi sinye;
• ukudla okuphansi kwekhalori;
• ukuphuza utshwala.

Izimpawu zokumisa azikhanseli ukubuyela emuva. Ngezimpawu ezinzima, isiguli singaphansi kokulaliswa esibhedlela.

Ingozi ye-hypoglycemia inyuka nge:

• ukweqisa;
• ukuhluleka kwesibindi nezinso ezinzima;
• ukungasebenzi kahle kwe-adrenal ne-pituitary;
• isifo se-yegilo;
• ukungalingani phakathi kwenani lama-carbohydrate athathwe nomsebenzi womzimba;
• ukuphathwa kanyekanye kwezidakamizwa eziningana ezisebenzayo;
• ukungakwazi ukulawula isiguli isimo sakhe;
• ushintsho ekudleni, weqa ukudla, ukuzila ukudla, okungajwayelekile kanye nokungondleki.

Ingozi ye-hypoglycemia inyuka ngesifo se-thyroid.

Ukuhambisana notshwala

Lapho utshwala bunqunywa ngokuqapha. Ukuphuza utshwala kungabangela i-glycemia.

Umthelela ekhonweni lokulawula izindlela

Iziguli zaziswa ngezimpawu ze-hypoglycemia. Kufanele baqaphele lapho bethatha izinyathelo ezidinga ukugxilisa ingqondo kanye nesivinini esikhulu sokusabela kwe-psychomotor, ikakhulukazi ezigabeni zokuqala zokwelashwa.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Imininingwane yokusetshenziswa kwento esebenzayo ngesikhathi sokukhulelwa ayitholakali. Ekuhlolweni kwezilwane, awukho umphumela we-teratogenic owatholakala.

Ngokukhulelwa okuhleliwe kanye nokuqala kwayo ngesikhathi sokwelashwa, kunconywa ukuthi esikhundleni se-oral hypoglycemic agents kube ne-insulin therapy.

Ngenxa yokuntuleka kolwazi ngokutholakala kwento esebenzayo ubisi lwebele, ukuthatha umuthi ngesikhathi sokuncelisa ibelekisiwe.

Imininingwane yokusetshenziswa kwento esebenzayo ngesikhathi sokukhulelwa ayitholakali.

Ukuyalela uDiabeteson MV ezinganeni

Ayikho imininingwane ngomphumela wesidakamizwa ezinganeni ezincane.

Sebenzisa ebudaleni

Ukuguquguquka okubalulekile kwamapharamitha we-pharmacokinetic asebekhulile akubonwa.

Isicelo sokusebenza kokulimala kwezinso

Ekuhlulekeni okukhulu kwezinso, kunconywa i-insulin. Ngezigaba ezithobile futhi ezilinganiselayo zale ndlela, umthamo awushintshiwe.

Sebenzisa umsebenzi wesibindi okhubazekile

Ihlanganiswe ngokwehluleka kwesibindi okunzima.

Ekuhlulekeni okukhulu kwezinso, kunconywa i-insulin.

Ukweqisa

Uma umthamo udluliwe, i-hypoglycemia ingaqhamuka. Uma izimpawu ezilinganiselayo zalesi sifo zibonakala ngaphandle kwezimpawu zemizwa nokuqaqamba kokukhubazeka, khuphula inani lokudla kwe-carbohydrate ekudleni, shintsha ekudleni kanye / noma unciphise umthamo.

Izinhlobo ezinkulu zezimo ze-hypoclycemic, zibonakaliswa ukuphazamiseka okuhlukahlukene kwemizwa, kufaka phakathi ukwethuka kanye nokukhohlisa, okudinga ukulaliswa esibhedlela ngokushesha.

Uma i-hypoglycemic coma noma ukuqala kwayo kusolwa, isixazululo sikashukela esiyi-20-30% kumthamo we-50 ml sinikezwa isiguli ngemithambo yegazi. Ukugcina amazinga kashukela egazini ngenhla kwe-1 g / l, kuphakama isisombululo se-10% sextrose. Emahoreni angama-48, isimo sesiguli siqashwa, ngemuva kwalokho udokotela unquma ngesidingo sokuqashelwa okwengeziwe.

I-Dialysis ayisebenzi, ngoba into esebenzayo ihambisana namaprotheni e-plasma.

Uma umthamo udluliwe, i-hypoglycemia ingaqhamuka.

Ukuxhumana nezinye izidakamizwa

Kuyadingeka ukuthi unikeze inhlanganisela umuthi nama-anticoagulants, ngoba lapho kuthathwa ndawonye, ​​kungenzeka ukwandisa umphumela walokhu okulandelayo.

Inhlanganisela ehlanganisiwe

I-Miconazole ingadala i-hypoglycemic coma uma usebenzisa ijeli elikwi-mucosa yomlomo nasekuphatheni okuhleliwe.

Akuhlanganisiwe ukuhlanganisa

Lokhu kufaka phakathi:

1. I-Phenylbutazone ene-systemic management ngenxa yokwenyuka komphumela we-hypoglycemic. Kungcono ukusebenzisa esinye isidakamizwa ukulwa nokuvuvukala.
2. I-Ethanol, ethuthukisa i-hypoglycemia kuze kufike ekukhuleni komzimba. Ukwenqaba akudingekile otshwaleni kuphela, kepha futhi nasemithini equkethe le nto.
3. UDanazole - usiza ukwandisa ukugcwala kweglucose egazini.

UDanazole - usiza ukwandisa ukugcwala kweglucose egazini.

Inhlanganisela edinga ukuqashelwa

Lokhu kufaka ukuhlanganiswa kwesidakamizwa nemithi ethile. Khulisa ubungozi be-hypoglycemia:

• ama-beta-blockers;
• amanye ama-hypoglycemic agents: Ama-insulin, ama-Acarbose, ama-agonists we-GLP-1, i-thiazolidinidione, iMetformin, i-dipeptidyl peptidase-4 inhibitors;
• I-Fluconazole;
• I-MAO ne-ACE inhibitors;
• i-histamine H2 receptor blockers;
• ama-sulfonamides;
• Ama-NSAIDs
• Clarithromycin

Khuphula ushukela wegazi:

• I-Chlorpromazine kwimithamo ephezulu;
• glucocorticosteroids;
• I-Terbutaline, iSalbutamol, iRitodrin ngokuphathwa kwe-intravenous.

IManinil iyi-analogue yesidakamizwa i-Diabeteson MV.

Analogs of Diabeteson MV

Lokhu kufaka phakathi:

• Maninil;
• IGliclazide MV;
• UGlidiab;
• IGlucophage;
• I-Diabefarm MV.

Izikhwanyana ezisetshenziswa ngemuva kokubonana nodokotela.

Yini engcono: Diabeteson noma Diabeteson MV?

I-Diabeteson MV ihlukile ku-Diabeteson ngesilinganiso sokukhishwa kwento esebenzayo. I- "MV" ukukhishwa okuguquliwe.

Isikhathi sokufakwa kwe-glycoside eDiabeteson asisekho amahora angama-2-3. Umthamo - 80 mg.

I-CF ithathwa isikhathi esingu-1 ngosuku, isebenza kancane, ingozi ye-hypoglycemia incane.

I-Diabeteson MV ihlukile ku-Diabeteson ngesilinganiso sokukhishwa kwento esebenzayo.

Imibandela yekhefu lekhemisi

Umuthi (Diabeteson MR in Latin) umuthi.

Intengo ye-Diabeteson MV

Izindleko ezijwayelekile ngama-ruble angama-350.

Izimo zokugcina zomuthi

Endaweni engafinyeleleki ezinganeni, kumazinga okushisa angaqedi kune- + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emi-2

Umkhiqizi

1. "Umkhakha Wezabasebenzi", eFrance.
2. ISerdix LLC, eRussia.

Ukubuyekezwa mayelana Diabeteson MV

Odokotela

Shishkina E.I., eMoscow

Ukusebenza kahle kuphakeme. Imiphumela emibi ayibonwa. Kuqala ukwenza ngokushesha. Umuthi omuhle wesifo sikashukela.

Isifo sikashukela

UDiana, oneminyaka engama-55, uSamara

Udokotela unqume i-60 ml / ngosuku, kepha ekuseni ukugxila kwe-glucose kwakungu-10-13. Ngokukhuphuka komthamo kuya kumatafula ayi-1.5, izinga lasekuseni lehle laya ku-6 mm. Ukuzivocavoca umzimba okuncane kanye nokudla kuyasiza.