I-Insulin glargine iyi-analogue ye-pancreatic hormone yabantu, etholakala ngokuphindaphinda kwamagciwane e-DNA ohlobo oluthile.
Kubonakala ngokuncibilika okuncane endaweni engathathi hlangothi. Le nto iyisakhi esiyinhloko somuthi obizwa ngokuthi iLantus.
Lesi sidakamizwa sinomphumela oqinile we-hypoglycemic futhi sisetshenziselwa ukulawula i-glucose metabolism. Umbhalo olandelayo uqukethe imininingwane ephelele mayelana nomuthi iLantus, ama-analogues nawo angatholakala lapha.
Incazelo yesidakamizwa
Kusetshenziswa uma isiguli sinesifo sikashukela i-mellitus, okumele siphathwe nge-insulin. Ikakhulu kaningi, umuthi ubekelwe abantu abadala, intsha kanye nezingane ezingaphezu kweminyaka emibili. Umenzeli we-hypoglycemic uqobo unokuvela koketshezi olucacile nolungenamibala.
Insulin lantus
Ngemuva kokuthi yethulwe ngaphansi kwesikhumba, ukuphendula kwe-acidic kwekhambi akuhlangene ngokuphelele, okuholela ekubukekeni kwama-microprecipitate, okuvela lapho izingxenyana ezimbalwa ze-insulin glargine zikhishwa njalo. Into esebenzayo iguqulwa ibe yimetabolites esebenzayo emibili i-M1 ne-M2.
Okwamanje, ukusebenza ngempumelelo okuphezulu kwalesi sidakamizwa sekufakazelwe. Ezinganeni ezingaphezulu kweminyaka emibili ubudala ezinesifo sikashukela sohlobo 1, inhlala-kahle iyathuthuka kakhulu ngemuva kokuphathwa.
Contraindication
Umuthi awunconyelwe ukuthi usetshenziswe ne:
- ukuzwela okuphezulu kwengxenye esebenzayo yomuthi;
- izingane ezingaphansi kweminyaka emibili;
- ngokuqapha kwabesifazane kuzo zonke izigaba zokukhulelwa.
Imiphumela emibi
Omunye wemiphumela emangazayo yokusebenzisa lesi sidakamizwa yi-hypoglycemia.
Imelela ukusabela okuvame kakhulu komzimba ekwelashweni kwe-insulin. Lokhu kungenzeka ezimweni lapho umthamo walesi hormone mkhulu kakhulu ngokuqhathaniswa nezidingo zomzimba.
Izimpawu zalesi sifo zibonakala ngokuzumayo. Kepha, imvamisa yokuphazamiseka kwe-neuropsychiatric ngokumelene nesizinda se-neuroglycopenia yandulelwa yizimpawu zokuphikisana kwe-adrenergic.
Ungangena kanjani?
Lesi sidakamizwa sibonakaliswa isikhathi sokuvezwa, ngakho-ke kungcono kakhulu ukukhetha uma ukhetha, ngokwesibonelo, ezinye iziqubulo zeLantus insulin. Kunqunyelwe iziguli ezinesifo sikashukela esincike ku-insulin, futhi kulokhu asikhulumi kuphela ngohlobo lwesifo sokuqala.
Ama-analogues ajwayelekile athatha indawo ye-insulin Lantus yiNovorapid, Humalog, ne-Apidra.
ILantus, njengokufana okuthile kwe-insulin, ilawulwa ngomjovo ongaphansi komhlaba. Akuhloselwe ukuphathwa kwe-intravenous. Ngokumangazayo, isikhathi sokusebenza kwalesi sidakamizwa sibonwa kuphela lapho singeniswa kumafutha angaphansi.
Uma ungawunaki lo mthetho futhi uwuthula ngobuhlakani, ungavusa ukuvela kwe-hypoglycemia enzima. Kufanele kwethulwe ungqimba lwamafutha wesisu, amahlombe noma amabhuzu.Kubalulekile ukuthi ungakhohlwa ukuthi awukwazi ukufaka umjovo we-insulin endaweni efanayo, ngoba lokhu kugcwele ukwakheka kwama-hematomas.
I-analogues kaLantus, njengaye, akuyona into yokumiswa, kepha iyisisombululo esivele ngokuphelele.
Kubalulekile ukubonisana nodokotela wakho mayelana nokusebenzisa hhayi umuthi uqobo, kepha ama-analogues awo athandwayo, anemiphumela efanayo.
Ama-Analog
Ukuze kuqedwe izibonakaliso ezingezinhle zesifo sikashukela, ochwepheshe banquma isidakamizwa iLantus nezichasiso zayo ezidumile. Esikhathini eside kakhulu, izidakamizwa ezinjalo ziye zathola ukuqashelwa kancane kancane kanti okwamanje zibhekwa njengezokuqala ekulweni nalokhu kwephulwa kohlelo lwe-endocrine.
Izinzuzo eziningana ze-hormone yokwenziwa kwe-pancreatic:
- kusebenza kakhulu futhi uyakwazi ukunciphisa ukubonakaliswa kwesifo sikashukela;
- inephrofayili yokuphepha enhle kakhulu;
- elula ukuyisebenzisa;
- ungavumelanisa imijovo yesidakamizwa nokufihla kwayo kwehomoni.
Ama-analogues alesi sidakamizwa aguqula isikhathi sokuchayeka kwi-hormone yomuntu wamanyikwe ukunikeza indlela yomuntu ngamunye yokwelashwa nokwelashwa okuphelele nesiguli esinezinkinga ze-endocrine.
Le mithi isiza ekuzuzeni ibhalansi eyamukelekayo phakathi kobungozi bokwehla kushukela wegazi futhi kufinyelelwe izinga le-glycemic okuhlosiwe ngalo.
Isidakamizwa uHumalog
Okwamanje, kunezindlela eziningi ezivame kakhulu ze-pancreatic hormone yabantu:
- i-ultrashort (Humalog, Apidra, Novorapid Penfill);
- isikhathi eside (Lantus, Levemir Penfill).
Izidakamizwa zesikhathi eside uLantus Solostar analogue, naye - U-Tciousba uthathwa njengomunye wodumo.
ILantus noma iTresiba: yikuphi okungcono?
Okokuqala, kufanele ubheke ngamunye wabo ngamunye. Into esebenzayo yesidakamizwa ebizwa ngeTresiba yi-insulin degludec. NjengoLantus, yi-analogue ye-human pancreatic hormone. Ngenxa yomsebenzi odabukisayo wososayensi, lesi sidakamizwa sathola izakhiwo ezihlukile.
Ukuyidala, i-biotechnologies ekhethekile ye-DNA ephindaphindayo yasetshenziswa ngokubandakanyeka kwe-Saccharomyces cerevisiae uhlobo, futhi nesakhi samangqamuzana esinsulin somuntu sashintshwa.
Isidakamizwa Tresiba
Okwamanje, lo muthi ungasetshenziswa yiziguli, uhlobo lokuqala nolwesibili lwesifo sikashukela. Kubalulekile ukuqaphela ukuthi kunezinzuzo ezithile uma uqhathanisa nezinye i-insulin analogues, okukhona kuzo ukuthi kunesibalo esikhulu manje.
Ngokwezethembiso zabakhiqizi, ayikho i-hypoglycemia okufanele yenzeke lapho kusetshenziswa umuthi iTresiba.Kunenye inzuzo yesidakamizwa: ukuhlukahluka okungatheni ezingeni le-glycemia phakathi nosuku. Ngamanye amagama, ngesikhathi sokwelapha usebenzisa umuthi weTciousba, ukugcotshwa koshukela egazini kugcinwa amahora angama-25.
Le yinzuzo ebaluleke kakhulu, ngoba ukusetshenziswa kwale analogue yeLantus kukuvumela ukuthi ungacabangi nge-insulin hhayi kuphela phakathi nosuku, kodwa futhi nasebusuku.
Kepha leli thuluzi linokubuyisa okukodwa okubalulekile: akunconyelwe ukusetshenziselwa abantu abangaphansi kweminyaka eyishumi nesishiyagalombili, abesifazane abakhulelwe nababambekile. Angeke futhi futhi siphathwe ngomjovo we-intravenous. Ukuvunyelwa kokusebenzisa kuphela
Ngokuqondene noLantus, zonke izinzuzo zako zichazwe ngenhla. Kepha uma sidonsela ukufana phakathi kwalezi zinto ezifakwa esikhundleni se-insulin, singaphetha ngokuthi izinga le-hemoglobin ye-glycated lincipha kakhulu ngokusetshenziswa komuthi weTresib ukwedlula neLantus. Kungakho ukuqondanisa kokugcina kusebenza kakhulu.
I-Lantus analogues eRussia
Okwamanje, ezweni lethu izifaniso ezaziwa kakhulu zalokhu okwenziwa esikhundleni se-insulin yabantu iTresiba noDetemir (Levemir).
Umuthi u-Levemir
Njengoba izici ezinhle zeTresiba zichaziwe ngenhla, amagama ambalwa kufanele ashiwo ngeLevemir. Kubhekwa okuthiwa yi-analog engenantambo yomshuwalense womuntu wesenzo eside, esikhishwa cishe kanye noma kabili ngosuku.
Okwamanje, iLevmir isetshenziselwa ukuqala ukwelashwa kwe-insulin sikashukela sohlobo 2. Iyakwazi ukuhlinzeka nokugcina umthamo owanele we-insulin egazini. Lokhu kukuvumela ukuthi ulawule i-glycemia.Phakathi kwezinzuzo zale analogue ukuthi iqinisekisa ubungozi obuphansi be-glucose ephansi kubantu.
Ngaphezu kwalokho, maqondana nomphumela waso onenzuzo ebusuku, uma uqhathanisa nezinye izidakamizwa, kukuvumela ukuthi ukhethe ngokunembile imithamo yokufeza okuhlushwa ushukela we-plasma. Ngaphezu kwalokho, akacasuli iqoqo lamaphawundi angeziwe.
Ngokuqondene nesikhathi sokwelashwa, kuya ngomthamo. Okokuqala, kufanele usebenzise i-Levemir kanye ngosuku. Umthamo wokuqala ezigulini ezingayitholi i-insulin ngaphambili cishe amayunithi ayi-9 noma amayunithi angama-0,1-0.2 / kg anesisindo somzimba esijwayelekile.
Amavidiyo ahlobene
Incazelo eningilizayo nezincomo zokusetshenziswa kwe-insulin Lantus kuvidiyo:
Umenzi weLantus akekho ezweni elilodwa, kodwa emibili - iJalimane neRussia. Ingathengwa kumakhemisi athile, kepha muva nje ama-analogues awo noma isithako esisebenzayo zivame ukusetshenziswa. Lokhu kungenxa yokuthi muthi muva nje bekunzima kakhulu ukusithola. E-Lantus, iresiphi yesiLatini imvamisa ibukeka kanjena: "Lantus 100 ME / ml - 10 ml".
Ukwelashwa ngokujulile okusebenzisa lo muthi kungathuthukisa kakhulu impilo enhle futhi kulawule i-glycemia kubantu abanezinhlobo zombili zesifo sikashukela. Kubalulekile ukusondela ngokucophelela ekwamukeleni ukuze kungabikho miphumela emibi. Qiniseka ukuthi ulandela umthamo obekwe udokotela ukuvikela izinhlobo ezahlukene zezinkinga nemiphumela yokusetshenziswa.
