Ithuluzi lisiza ekulinganiseni umfutho wegazi ophezulu. Iyamukeleka kuphela kwiziguli zabantu abadala. Isakhi esisebenzayo se-lisinopril sidates imithambo yegazi, simise umfutho wegazi futhi sivikele nemisipha yenhliziyo. Umuthi uyakwazi ukuhlanza umzimba we-sodium ngokweqile.
Igama Lezwe elingafanele
Lisinopril
Ithuluzi lisiza ekulinganiseni umfutho wegazi ophezulu.
I-ATX
S09AA03
Khipha amafomu nokwakheka
Lesi sidakamizwa sikhishwa ezibhebheni. Zitholele izingcezu ezingama-20, ezingama-30. ILisinopril (lisinopril) isakhi esinquma umphumela wesidakamizwa.
Isenzo se-Pharmacological
Isithako esisebenzayo yi-ACE inhibitor (into ebalulekile kulawulo lomfutho wegazi). ILisinopril ivimbela ukuguqulwa kwe-angiotensin esebenzayo ye-biologic i oligopeptide ku-angiotensin ii octapeptide. Kunokwehla kwengcindezi yemithambo ye-peripheral, ukwehla kokukhishwa kwenhliziyo, kanye nokwenyuka kwethamo lomchamo. Ngakho-ke, ithuluzi lehlisa umfutho wegazi ophakeme liye emazingeni avamile.
I-Pharmacokinetics
Amaphesenti angama-30 amuncwe emgodini wokugaya ukudla. Ungadla ngaphandle kwesidakamizwa. Inani eliphezulu lezinto ezisebenzayo ku-plasma yegazi lifinyelelwa ngemuva kwamahora angama-6-7. Isikhathi sikhuphuka size sifike emahoreni angama-8-10 esimweni sesikhathi sokwengezelela. Cishe akubophele amaprotheni egazi. Ukuphila kwesigamu umuthi ngendlela engaguquki nomchamo amahora angama-12.
Umuthi udonswa u-30% emgodini wokugaya ukudla.
Izinkomba zokusetshenziswa
Isiguli sidinga ukwelashwa uma kuvela ama-pathologies alandelayo wesistimu yehliziyo nenhliziyo:
- ukukhubazeka kokulimala kwemithambo yethambo elilodwa noma amaningi;
- isiguli sathola ukuhlushwa i-myocardial infarction, kepha imingcele ye-hemodynamic ijwayelekile;
- ukwanda okungapheli kwengcindezi yegazi kuyaphawulwa;
- izinso zithinteka ezigulini ezithembele ku-insulin;
- ukuhluleka kwenhliziyo.
Ngalezi zephula emzimbeni, udokotela unquma isikhathi sokwelashwa kanye nesidingo semithi eyengeziwe.
Contraindication
Kwenqatshelwe ukuphuza amaphilisi kule mibandela elandelayo:
- kwehlisa ukukhanya kwemithambo yegazi ekondla izinso (renal artery stenosis);
- izinso zihlanza igazi kusuka ku-creatinine ngaphansi kwama-30 ml / min;
- kutholakale ukwehluleka kwe-renal okukhulu kakhulu;
- kukhona ukungahambisani nezinto noma izidakamizwa ezicindezela umsebenzi we-ACE;
- ukuthambekela kwe-angioedema;
- hemodialysis;
- i-hypertrophic cardiomyopathy, i-mitral noma i-aortic stenosis enezinkinga zokujikeleza kwegazi;
- ukungakwazi komzimba ukukhiqiza i-lactase;
- ngesikhathi sokuqunjelwa noma ukukhulelwa;
- amapharamitha we-hemodynamic awazinzile ngemuva kokufakelwa kwe-myocardial acute;
- ukwephulwa kokuguqulwa kwe-galactose ibe ushukela;
- glucose-galactose malabsorption syndrome.
Lo muthi ubhekene ne-contraindication ekuhlulekeni kwe-renal acute.
Umphumela we-lisinopril ebuntwaneni awuqondakali ngokuphelele, ngakho-ke, amaphilisi awadliwa kuze kube seminyakeni engu-18.
Ungayithatha kanjani
Ukuphuza umuthi kwenziwa ekuseni. Ngokwengeziwe, udinga ukuphuza uketshezi oluningi. Udokotela uzokwazi ukuthola umthamo ngqo ngemuva kokuxilongwa. Imiyalo ikhombisa imininingwane elandelayo ngokuya ngesifo:
- Umfutho wegazi ophezulu we-Arterial. Okokuqala, phuza ama-5 mg ngosuku. Ngemuva kwezinsuku ezingama-20-30, ungangezelela umthamo wansuku zonke ukuya ku-10-20 mg. Kuvunyelwe ukuthatha isilinganiso esingu-40 mg ngasikhathi.
- I-Hypovolemia, i-metabolism enosawoti wamanzi, iziguli esezikhulile. Inani elidingekayo le-lisinopril ngu-2,5 mg ngosuku.
- I-infarction ye-myocardial e-acute ngengcindezelo eqinile ye-venous. Ama-5 mg adakiwe phakathi nosuku futhi ama-5 mg futhi ngosuku. Ngosuku lwesithathu, umthamo ukhuphuka ufike ku-10 mg. Ngokucindezela kwe-systolic ephansi ezinsukwini zokuqala ezingama-2-3 nikeza isiguli esingu-2,5 mg.
- I-hypterension ye-Arterial. Ukugcina isimo sizinzile, thatha u-2,5 -5 mg ngosuku. Uma umthamo omncane, futhi nomfutho wegazi ophansi uphikelela, yeka ukuthatha i-lisinopril.
- Ukwehluleka kwenhliziyo. Kuyadingeka ukuphuza i-2,5 mg ngosuku. Ngemuva kwenyanga, ungakhulisa umthamo ukuya ku-5 mg.
Ekwehlulekeni kwenhliziyo okukhulu, udinga ukuphuza ama-2,5 mg ngosuku.
Ithebhulethi ngayinye inezinqolo ezihlukanisayo ukwenza lula ukuphatha. Uma kunesidingo, ungahlukanisa kalula ithebhulethi libe izingxenye eziningi. Isikhathi sokwelashwa kwesondlo akufanele singeqi amasonto ayi-6.
Ngoshukela
Uma ngokumelene nesizinda sikashukela, i-albhamuinuria ivela noma umfutho wegazi ukhuphuka, thatha u-2,5 mg. Umthamo wenzelwa umthamo owodwa ekuseni. Ngokusebenza okunciphisiwe kwe-renal, umthamo wokulungisa ungaba ngu-5-10 mg ngosuku. Kuya ngezinga lomfutho wegazi. Kungathathwa isilinganiso esingu-20 mg.
Imiphumela emibi
Umuthi ungadala imiphumela emibi evela ezinhlotsheni nasezinhlotsheni ezahlukahlukene. Ezimweni ezingavamile, umsebenzi we-hepatic transaminases uyanda, ukuqina kwe-creatinine ne-urea ku-serum yegazi kuyanda.
Amapheshana wesisu
Imvamisa iziguli ziphazanyiswa isifo se-stool, isicanucanu. Ubuhlungu bungenzeka esiswini, isicanucanu. Ukusetshenziswa isikhathi eside kungaholela ekuqubukeni kwama pancreas, ukwehluleka kwesibindi, ukukhuphuka kwe-bilirubin egazini.
Lapho uthatha umuthi, isicanucanu kungenzeka.
Izitho zeHematopoietic
Ngaphansi kwethonya le-lisinopril, umfutho wegazi uyancipha. Kwezinye izimo, ukushaya kwenhliziyo okunamandla kuzwakala, i-tachycardia yenzeka, kuthi imithambo kanye nama-arterioles asemaphethelweni aphezulu ayathinteka (iRaynaud's syndrome). Ingxenye esebenzayo yesidakamizwa ingadala ukwephula kokuhlinzekelwa kwegazi emsipha wenhliziyo kanye nokushaywa yi-cerebrovascular, uma ukwamukela kungejwayelekile.
Isistimu yezinzwa ephakathi
Imvamisa ngemuva kokuthatha isiyezi, i-migraine ivela, ukukhathala kuyanda, bese ukunakwa kuncipha. Ukuqina kwemizwelo, i-paresthesia, ukozela, noma ukuqwasha kubalulekile.
Ukudana, ukudangala, nokudideka kwenzeka ngemuva kokusetshenziswa isikhathi eside nokungalawulwa.
Kusuka ohlelweni lokuphefumula
Ngemuva kokuphathwa, kuvela izimpawu ezifana nomkhuhlane: ukukhohlela komile, umphimbo obuhlungu kanye ukoma, mucosa wamakhala nezimpawu zesikhumba. Akuvamile ukuthi kwenzeke i-bronchospasm.
Ngemuva kokuyithatha, ungahlangabezana nezimpawu ezifana nomkhuhlane: ukukhwehlela owomile, umphimbo obuhlungu kanye nomphimbo owomile.
Engxenyeni yesikhumba
Ukwehla komzimba kungenzeka ngesimo sokuvuvukala kobuso nezinye izingxenye zomzimba, i-urticaria. Ezinye iziguli ziba neStevens-Jones syndrome, izinzwa zomzimba kuma-ray e-ultraviolet ziyanda, izinhlungu zemisipha ziyezwakala.
Kusuka ohlelweni lwezitho zofuzo
Umsebenzi we-Renal uvame ukuphazamiseka yi-lisinopril. Ezimweni ezingavamile, kukhona i-uremia, i-proteinuria, ukuntuleka komchamo.
Imiyalo ekhethekile
Ngesikhathi sokulashwa, kuyadingeka ukulawula izinga lomfutho wegazi. Ngaphambi kokuthatha, ama-diuretics akhanselwa ukunciphisa ubungozi bokwehlisa ingcindezi. Ukwelashwa nge-lisinopril akumele kuqalwe uma, ngokuqothuka kwe-myocardial infarction, kuwohloka kubonakale. Ukwelashwa okuphazamisayo kwehluleka kwenhliziyo kuvinjelwe, ngoba izimpawu zingavela futhi ngemuva kwesikhashana.
Sebenzisa ebudaleni
Ebudaleni, umphumela we-lisinopril ungabekwa ngaphezulu. Ukwelashwa kufanele kwenziwe ngokuqapha.
Ebudaleni, umphumela we-lisinopril ungabekwa ngaphezulu.
Umthelela ekhonweni lokulawula izindlela
Ngenxa yokukhathala okwandayo, ukubonakala kwesiyezi nobuhlungu bekhanda kwezinye iziguli, kuyadingeka ukulawula ngokucophelela izimoto.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokukhulelwa, ukusetshenziswa komuthi akuvunyelwe. ILisinopril ingadala ukungasebenzi kahle kwengane, engahle ihambisane nokuphila. Akukho bufakazi bokungena obisini lobisi, kepha kunconywa ukuthi uyeke ukuncelisa ibele ngenkathi uphuza umuthi.
Ukuyalela uLisinopril Stad ezinganeni
Kuze kube yiminyaka engu-18 yobudala, umuthi awubekiwe, ngoba ukuphepha kanye nokusebenza kahle ebuntwaneni akuqondakali ngokuphelele.
Kuze kube yiminyaka engu-18 yobudala, umuthi awubekiwe, ngoba ukuphepha kanye nokusebenza kahle ebuntwaneni akuqondakali ngokuphelele.
Ukweqisa
Ukudla ngokungalawulwa kwamaphilisi kuholela ekubonakala kwe-hyperension ye-arterial, shock, bradycardia, kanye nokwehluleka kwezinso. Isiguli siphazanyiswa ibhalansi ye-electrolyte.
Ukuxhumana nezinye izidakamizwa
Ukuphathwa kanyekanye nezidakamizwa ezithile kudala imiphumela elandelayo:
- ama-diuretics nezinye izidakamizwa ezidala ukwehla kwengcindezi yegazi kungandisa umphumela wesidakamizwa;
- i-potassium-sparing diuretics ingaholela ku-hyperkalemia;
- ngaphansi kwethonya lababambiqhaza kanye nezidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala, umphumela we-hypotensive awutholi ngokushesha;
- uma usawoti we-lithium uphathwa, kuyadingeka ukubheka ukugcotshwa kwento yamakhemikhali egazini;
- umphumela wamakhemikhali we-lisinopril uyathuthuka lapho uthathwa ngamaphilisi okulala nama-anesthetics;
- ama-ejenti akhulisa ukukhishwa kwe-norepinephrine angawenza buthaka umphumela we-lisinopril;
- ukuphathwa kanyekanye ne-Allopuronol, Procainamide, cytostatics, immunosuppressants, systemic glucocorticoids kuholela ekunciphiseni kwamangqamuzana amhlophe egazi;
- umphumela wokuphuza izidakamizwa ze-antidiabetesic buthaka;
- i-sodium chloride iyakwazi ukunciphisa umphumela wezidakamizwa ze-antihypertensive.
Ukuhambisana notshwala
Utshwala bukhulisa umphumela wesidakamizwa, ngakho-ke ukuphuza utshwala akunconywa.
Utshwala bukhulisa umphumela wesidakamizwa, ngakho-ke ukuphuza utshwala akunconywa.
Ngokunakekela
Kufanele kuqashelwe izinhlungu zesifuba ezibangelwa ukunganeli kwegazi okwanele emisipha yenhliziyo. Kuyadingeka ukuthi ubonane nodokotela ngomonakalo emithanjeni yobuchopho, ukuze ungavimbi unhlangothi. Uma kwenzeka umsebenzi we-renal ongasebenzi kahle, umthamo uthathwa kancane.
Ama-Analog
Umuthi une-analogues engangena esikhundleni saleli thuluzi. Lokhu kufaka phakathi:
- Lisinopril. Izindleko zayo azikho ngaphezu kwama-ruble angama-80 wamathebulethi angama-30. Inani lezinto ezisebenzayo ekwakhekeni kwamathebhulethi lingahluka.
- Lisinotone. Kutholakala ngezingcezu ezingama-28 iphakethe ngalinye. Izindleko ezingama-ruble ayi-120-200. Kuqukethe i-sodium. Ngokuhlanza nohudo kufanele kusetshenziswe ngokucophelela. Ebudaleni ayenqatshelwa ukuthatha.
- ILysigamma. Intengo yezingcezu ezingama-30 ingama-ruble ayi-130. Njengengxenye ye-lisinopril nezingxenye ezisizayo. Kunconywa ukuthatha ngokuqapha kwezinye izimo noma izifo.
- Diroton. Bakhiqiza izingcezu eziyi-14, ezingama-56 iphakethe ngalinye. Intengo yesidakamizwa iyahlukahluka kusuka kuma-ruble angama-200 kuye kwangama-700. Ifana neLisinopril Stad. Iphinde isetshenziselwe ukwengeza izinhlaka ezizimele ze-hemodynamic infarction ye-myocardial.
Ngaphambi kokushintsha umuthi nge-analogue, bonana nochwepheshe. Imiyalo ikhombisa imiphumela engaba khona yemiphumela kanye ne-contraindication.
Imibandela yekhefu lekhemisi
Kufanele ulethe incwadi ekhemisi ukuze uthenge umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ikhefu elingaphezu kwekhambi ekhemisi kungenzeka.
Intengo yeLisinopril Stada
Izindleko zamathebulethi eRussia zisuka kuma-ruble ayi-100 kuye kwangama-170.
Izimo zokugcina zomuthi
Gcina iphakethe lethebhulethi endaweni emnyama emazingeni okushisa afinyelela ku- + 25 ° C.
Gcina iphakethe lethebhulethi endaweni emnyama emazingeni okushisa afinyelela ku- + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Ungagcina iminyaka emi-3.
Umkhiqizi
IMAKIZ-PHARMA LLC noma iHemofarm LLC, Russia.
Ukubuyekezwa mayelana neLisinopril Stad
Umuthi awubizi, kepha kunemiphumela emibi eminingana kanye nemiphumela yokungezwani komzimba. Abaningi benqaba ukwamukela ngoba ikhambi aliqali ngokushesha.
Ngesikhathi sokukhulelwa, ukusetshenziswa komuthi akuvunyelwe.
Odokotela
U-Egor Konstantinovich, udokotela wezifo zenhliziyo
Ngibeka iLisinopril Stad kanye nezinye izidakamizwa ukuze ngithole umphumela omuhle kakhulu. Ngaphezu kwalokho, isiguli sidinga ukusungula indlela yokudla. Ekwelashweni okuyinkimbinkimbi, umuthi uholela ekuqabuleni kodonga lwe-vascular kanye nokwehla komfutho wegazi.
UJulia Makarova, udokotela wezifo zemizwa
Ngokwanda kwengcindezi isikhathi eside, umuthi uyasiza. Ikhambi liqala ukusebenza ngemizuzu engama-40-60. Kungcono ukuthatha okungenani inyanga, ulandele izeluleko zikadokotela ohambelayo. Ngenqubo yokwelashwa, kubalulekile ukubheka isimo sezinso. Kumele kukhunjulwe ukuthi akudingekile ukuhlanganisa ukuthatha amaphilisi nge-hemodialysis ngokusebenzisa ulwelwesi olusebenze kakhulu.
Iziguli
USergey Viktorovich, oneminyaka engama-45
Welashwa ngalo muthi futhi ngemuva kwezinsuku eziyishumi wazizwa engcono. Ingcindezi iyakhuphuka, kepha kuyaqabukela. Ubuhlungu bekhanda buyekile ukukhathaza. Ezinsukwini zokuqala ngemuva kokungenela, ulwelwesi lwe-mucous emlonyeni lwalomile futhi luzizwa luhlasimulisa umzimba. Imiphumela emibi inyamalala ngemuva kwesonto. Wanelisekile ngomphumela wokuthatha umuthi.
U-Egor, oneminyaka engama-29 ubudala
Ngemuva kokudla isikhathi eside, kwavela ukukhwehlela nomqala obuhlungu. Udokotela ohambile ukwesule lokhu futhi weluleka ukuthi uthathe esinye isidakamizwa. Ukuqapha kufanele kusetshenziswe ngenkathi kusetshenziswa isikhathi eside.
Anastasia Romanovna, 32 yeminyaka
Umuthi usize ukuguqula umfutho wegazi ngokwejwayelekile kumfutho wegazi ophambili. Ikhambi elisebenzayo umkhulu wami alithatha ngemuva kokushaywa unhlangothi Umkhiqizi omuhle nentengo efanelekile.
