Kunezidakamizwa eziningi zokunciphisa umfutho wegazi nokubuyisa i-CVS. Enye yalezi yi-Lozap AM.
Igama Lezwe elingafanele
ILosartan igama lomhlaba wonke lesidakamizwa.
Ath
Abaphikisi be-C09DB Angiotensin II ngokuhambisana ne-BKK.
I-Lozap AM iyisidakamizwa sokwehlisa umfutho wegazi nokubuyisa i-CCC.
Khipha amafomu nokwakheka
ILozap yiphilisi elisegobolondweni elimhlophe. Kunezindlela eziningana zokukhishwa, ngokuya ngenqwaba yengxenye eyinhloko - 12.5, 50, 100 mg.
Ukwakheka:
- izithako eziyinhloko ezisebenzayo yi-losartan potassium;
- i-microcrystalline cellulose, isitashi, i-sodium stearate, amanzi, i-crospovidone, i-silicon dioxide.
Isidakamizwa sithengiswa emaphepheni amakhadibhodi ka-3, 6 noma 9 amabhulukwe.
Isenzo se-Pharmacological
Umuthi ungoweqembu lezidakamizwa ze-antihypertensive futhi unezinto eziningi ezisebenzayo:
- kunciphisa ukumelana okuphelele kwemithambo nama-capillaries;
- kunciphisa ukuhanjiswa kwe-adrenaline ye-hormone, ngenxa yokuthi ibuthisa umsebenzi wemisipha yenhliziyo;
- kwehlisa umfutho wegazi;
- kukhiqiza umphumela wokugaya.
Umuthi unciphisa ukumelana okuphelele kwama-veins nama-capillaries.
I-anginotensin, ngaphansi kwethonya lomuthi, iguqulwa iguqulwe kuma-angiotensin ii (nge-AT1 ne-AT2 receptors), athinta i-vasoconstriction.
I-Pharmacokinetics
Umuthi udonswa ngokushesha ngokwanele emgudwini wokugaya ukudla futhi udonswa ngokusetshenziswa kwesibindi nge-isoenzyme inhibitor.
Ukucaciswa kwe-plasma ye-losartan kungama-600 ml / min, kanti i-metabolite esebenzayo ku-plasma ingama-50 ml / min.
Ukukhishwa kweRenalap kabusha - ama-74 ml / amaminithi. Ama-Metabolites akhishwa ngamathumbu nezinso.
Izinkomba zokusetshenziswa
Umuthi unqunyelwe abantu abadala nezingane kusuka eminyakeni eyi-6 abanezifo ezilandelayo:
- umfutho wegazi ophakeme (umfutho wegazi ophakeme);
- ukuvimbela infarction myocardial;
- arrhythmia, ischemia kanye nezinye izifo ezingama-CVS;
- umfutho wegazi ophezulu ezigulini ezinesifo sikashukela i-mellitus.
Contraindication
Umuthi uphuliwe:
- izingane ezisanda kuzalwa;
- abesifazane ngesikhathi sokukhulelwa nangesikhathi sokuqunjelwa;
- nge-hypotension;
- ngokungezwani komzimba nokungabekezelelani ezintweni.
Ngokunakekela
Ungaphuza lo muthi ngemithamo emincane ngalezi zinto ezilandelayo:
- ukwehluleka kwenhliziyo;
- hyperkalemia
- ukungalingani kwamanzi-electrolyte;
- i-arterial hypotension ezinganeni ezingaphansi kweminyaka engu-6.
Ungayithatha kanjani i-Lozap AM
Ithebhulethi zithathwa ngomlomo, kungakhathaleki ukudla. Umthamo ojwayelekile ngu-50 mg ngosuku. Ilungiswa ngokuya ngezimpawu zomuntu ngamunye zesiguli. Kwi-pathologies yenhliziyo engapheli, umthamo wokuqala ngu-12,5 mg. Uma kungabikho miphumela emibi, inyuka iye kuma-50 mg ukufeza umphumela omkhulu.
Ngokuvimbela ukushaya kwenhliziyo kwesibili, i-50 mg ithathwa isikhathi esingu-1 ngosuku. Ukwelapha kugcina njengokuyalelwa yi-cardiologist.
Ukuthatha umuthi wesifo sikashukela
Awukwazi ukuthatha umthamo ophelele okokuqala. Kuyadingeka ukuhlola ukusabela komzimba, ngakho-ke kunconywa ukuqala nge-50 mg ngosuku. Ngokulashwa okuqhubekayo, umthamo unyuka ufike ku-100 mg ngosuku. Ungasebenzisa ngokushesha i-100 mg noma i-50 mg kuma-2 sets.
Ku-mellitus yesifo sikashukela, umthamo ophelele akufanele uthathwe okokuqala.
Imiphumela emibi
Uma umuthi ungasifanele isiguli noma usiphuza ngendlela engafanele, imiphumela emibi ingavela. Amathebulethi kuvame ukubekezelelwa, kepha imiphumela engahle ibe khona kufanele yazi.
Amapheshana wesisu
Ukungasebenzi kwesibindi, ukungasebenzi kahle kwamapheshana emathunjini, ukuqunjelwa noma isifo sohudo, ukungaphatheki kahle nobuhlungu esiswini.
Izitho zeHematopoietic
Ngenxa yokuphatha okungalungile, ukuvela ngokweqile noma ukuntuleka kwensimbi, i-lithium, namavithamini kungenzeka. Ngenxa yalokhu, kuphakama izifo eziningi - i-anemia, i-leukocytosis, njll.
Ngenxa yokuphatha okungalungile, ukuvela ngokweqile noma ukuntuleka kwensimbi, i-lithium, namavithamini kungenzeka.
Isistimu yezinzwa ephakathi
Ukomela, ukungakhathaleli, isiyezi, ukuphazamiseka kokulala, ukungabekezeleleki ngokweqile.
Kusuka ohlelweni lomchamo
Ukuwohloka kokusebenza kwe-reso, okuholela ku-amyloidosis (sedimentation of the protein in the organisation) noma acidosis (umthwalo wezinso ngenxa yokwanda kwendawo ye-alkaline egazini). I-Urea esegazini iyakhuphuka futhi ukuchama kukhubazekile.
Kusuka ohlelweni lokuphefumula
I-Dyspnea imvama, ingaphansi kwe-1% yeziguli.
I-Urticaria kanye nokulunywa kwenzeka ngenxa yokusabela okwenziwa yizakhi zezakhi zokwenziwa komuthi.
Engxenyeni yesikhumba
I-Urticaria kanye nokulunywa kwenzeka ngenxa yokusabela okwenziwa yizakhi zezakhi zokwenziwa komuthi.
Kusuka ohlelweni lwezitho zofuzo
I-Pollakiuria yinqubo ye-pathological eyenzeka ngenxa yomsebenzi wokuphazamiseka wezinso. Iziveza ngokuchama kaningi. Ngenxa yalokhu sifo, ukuvuvukala kanye nezinye izifo zengqondo kungenzeka.
Kusuka ohlelweni lwezinhliziyo
I-Arrhythmia noma i-angina pectoris ingahle ivele. Ngenxa yokungabekezeleli, umuthi uvusa i-tachycardia ye-ventricular.
Kusuka ohlelweni lwe-musculoskeletal
Ubuhlungu emhlane, amadolo, izindolowane, izindunduma, ubuthakathaka emilenzeni, izinhlungu esifubeni (hhayi ukudideka ngenhliziyo).
I-Pollakiuria yinqubo ye-pathological eyenzeka ngenxa yomsebenzi wokuphazamiseka wezinso.
Ngasohlangothini lwe-metabolism
Ukungalingani ekusebenzeni kwe-metabolism kuvame ukwenzeka ngenkathi uthatha i-Lozap nezinye izidakamizwa ezingahambisani ne-losartan.
Allergies
Ukusabela komzimba kungenzeka nge-overdose noma ukungabekezelelani ngakunye ezingxenyeni zokwakheka. Kubonakaliswa ukuqubuka, ukulunywa, ubomvu besikhumba. Ezimweni ezingavamile, ukuthimula noma ukukhwehlela kungenzeka.
Imiyalo ekhethekile
Ukuze ungalimazi impilo, ngaphambi kokwelashwa ngalezi zibhebhe ze-antihypertensive, udinga ukuzijwayeza nemiyalo ethile yokwamukelwa.
Ukuhambisana notshwala
Uma usebenzisa umuthi, kwenqatshelwe ngokuphelele ukuphuza utshwala, ngoba i-losartan ayihambelani ngokuphelele notshwala be-ethyl.
Lapho usebenzisa umuthi, kwenqatshelwe ngokuphelele ukuphuza utshwala.
Umthelela ekhonweni lokulawula izindlela
Ngemuva kokuthatha lo muthi, azikho izifundo ezenziwayo mayelana nokuphendula kanye nekhono lokushayela izimoto. Kunconywa ukugwema ukushayela, ngoba imiphumela emibi ingaba nokusabela okungekuhle - ukuhamba kancane, isiyezi.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kwenqatshelwe ukusebenzisa umuthi ku-trimesters wokuqala nowesithathu, ngoba kunobungozi bokukhula ngokomzimba okungaphansi. Ngesikhathi se-HBV, futhi akunconywa ukusebenzisa izidakamizwa ze-antihypertensive ukuze ungalimazi ingane. Ucwaningo luveze ukuthi i-losartan ingaholela ekuqandeni i-fetus.
Kuchaza uLozap AM ezinganeni
Ucwaningo lwesayensi olwenzelwe izingane ezisanda kuzalwa alwenziwe, ngakho-ke amaphilisi awasetshenziswa ezinganeni. Kunconywa ukuthi ugweme ukuthatha lo muthi ezigulini ezingaphansi kweminyaka engu-18. Kwesinye isikhathi kubekelwe izingane kusuka eminyakeni eyi-6, uma umphumela olindelekile udlula ubungozi obukhona.
Sebenzisa ebudaleni
Ngemuva kweminyaka engama-60, umuthi unqunyelwa ukwehluleka kwenhliziyo nokuvikela ukuvikeleka kwe-myocardial infarction. Udinga ukuthatha ama-50 mg ngosuku.
Ngemuva kweminyaka engama-60, umuthi unqunyelwa ukwehluleka kwenhliziyo nokuvikela ukuvikeleka kwe-myocardial infarction.
Isicelo sokusebenza kokulimala kwezinso
Njengomphumela wezifundo ze-pharmacokinetic, kwavela ukuthi ngenxa yokuthatha i-Lozap, ukwehluleka kwe-renal kungakhula, ngakho-ke, abantu abanomsebenzi wezinso ophazamisekile badinga ukusebenzisa umthamo omncane okungenani ngosuku. Uma kungenakuqashelwa, kungenzeka ukuphazamise ngokuphelele ukusebenza komzimba, okuzoholela ekuguqukelweni kwezinso.
Sebenzisa umsebenzi wesibindi okhubazekile
Ezigulini ezinomlando wokungasebenzi kahle kwesibindi, kuthathwa umthamo omncane. Kunconywa ukusebenzisa umuthi ngaphansi kokuqondisa kukadokotela ukuze ulandelele amandla futhi, uma kunesidingo, ulungisa umthamo.
Sebenzisa ukwehluleka kwenhliziyo
Ingxenye eyisebenzayo ingadala ukuphazamiseka ekushayweni kwenhliziyo, ngakho-ke, uma kwenzeka ukwehluleka kwenhliziyo okungapheli, kubalulekile ukulandela umthamo futhi uthathe umuthi kuphela njengoba kuyalelwe ngudokotela, ukuze ungasifaki lesi simo.
Ukweqisa
Ngomthamo ongalungile, imiphumela emibi ingabonakala:
- ukwanda kwegazi alanine aminotransferase;
- ukwehla ngokweqile komfutho wegazi;
- i-vertigo - ukulahleka kokuzwa, kunciphe i-acuity ebonakalayo, isiyezi, i-tinnitus;
- ukubonakaliswa kwe-arrhythmia ukwephula isigqi senhliziyo (i-tachycardia ne-bradycardia).
Ngomthamo ongalungile, ukwanda kwegazi kwe-alanine aminotransferase kungabhekwa.
Uma kwenzeka kwe-overdose, i-diuresis ephoqelekile yenziwa ukunciphisa ukuhlushwa kwe-losartan.
Ukuxhumana nezinye izidakamizwa
Amathebulethi angasetshenziswa:
- ngama-antihypertgency agents;
- nge-hydrochlorothiazitis;
- ngemithi ethile ye-diuretic.
Inhlanganisela ehlanganisiwe
Kwenqatshelwe ukusebenzisa i-Lozap ngokuhambisana ne-diuretics, enomthelela ekuqongeleleni i-potassium, ngokwesibonelo ne-Amiloride, Spironolactone, ngoba i-hyperkalemia ingabangelwa.
Kwenqatshelwe ukusebenzisa i-Lozap ngokuhambisana ne-diuretics, enomthelela ekuqongeleleni i-potassium.
Akuhlanganisiwe ukuhlanganisa
Kungcono ukulahla ukuphathwa kanyekanye kweLozap ngezidakamizwa eziqukethe i-lithium. Ngokukhuphuka kwe-lithium egazini, ukuphazamiseka kwesistimu yezinzwa ephakathi kanye ne-gastrointestinal kungenzeka.
Inhlanganisela edinga ukuqashelwa
Ngokusetshenziswa kanyekanye kwezidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala neqembu, umphumela we-lazartan ungancipha, ngakho-ke ukuqedwa kwe-hypertension kuzoba yize, njengomuthi weqembu le-placebo (ongewona owokwelapha).
Ama-Analog
Uma ngenxa yesizathu esithile i-Lozap ingenakuthathwa, ingathathelwa indawo izidakamizwa ezinomphumela ofanayo:
- ngesisekelo se-hydrochlorothiazitis - i-Angizar, i-Amlodipin, i-Amzaar, iGizaar, iLorista, iLozap plus (izidakamizwa zaseRussia);
- ngesisekelo se-candersartan - Kandekor, Kasark, Hizart-N;
- Isakhi esiyinhloko se-telmisartan nguMikardisplyus, iTelpres, iTalmista.
Ngaphambi kokusebenzisa i-analog, udinga ukubonana nochwepheshe. Ezigulini esezikhulile ezingabekezelelani, iLogap ithathelwa indawo nge-Amlodipine.
Imibandela yekhefu lekhemisi
Lo muthi usatshalaliswa kuphela ngumbhalo.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ngaphandle kokuthola umuthi, lesi sidakamizwa singayalwa kuphela ekhemisi eliku-inthanethi, kepha akunasiqiniseko sokuthi umthengi ngeke awele amaqhinga wabakhwabanisi futhi ngeke athole mbumbulu. Kungcono ukuya kudokotela uthenge ngokuqinile amaphilisi okufaka ukuze ungalimazi impilo yakho.
Intengo ye-Lozap AM
Izindleko zalo muthi zincike ephuzwini lokuthengisa. Ensimini yeRussian Federation, intengo ejwayelekile ye-Lozap 5 mg + 50 mg ngama-ruble angama-500.
Izimo zokugcina zomuthi
Gcina endaweni yokushisa engeqi ku-25 ° C kude nelanga. Ngenxa yezizathu zokuphepha, fihla ezinganeni.
Ngaphandle kokuthola umuthi, lesi sidakamizwa singabalelwa kuphela ekhemisi eliku-inthanethi.
Isikhathi sokuphelelwa yisikhathi
Impilo yeshelufu - azidluli izinyanga ezingama-24 kusukela ngosuku okhiphe ngalo. Kuyabonakala emaphaketheni.
Umkhiqizi
Benza lo muthi eKorea, umakhi yiHanmi Farm. Co, Ltd.
Ukubuyekezwa ku-Lozap AM
Ukubuyekezwa mayelana naleli thuluzi kukuhle kusuka ezigulini nakuchwepheshe.
Izazi zezenhliziyo
USvetlana Aleksandrovna, uPhlebologist, uRostov-on-Don
Ngeluleka iziguli eziningi ukuthi zithathe i-Lozap, ngoba ithinta ngempumelelo i-CVS futhi yehlise umfutho wegazi, zivikele izifo eziningi. Ngokusekelwe kudatha yemitholampilo, lesi esinye sezidakamizwa ezinhle kakhulu ngokumelene ne-hypertension.
USergey Dmitrievich, udokotela wezifo zenhliziyo, u-Irkutsk
Nginikeza iziguli eziningi ngemuva kokuhlinzwa ukuze zigcine umfutho ojwayelekile, ukuqeda ukuhlaselwa umfutho wegazi ophakeme.
Iziguli
U-Olga Vasilievna, oneminyaka engama-56, uKurganinsk
Sekuphele iminyaka engu-5 ngithatha i-Lozap. Nginesifo sikashukela sesigaba 2. Umuthi waneliseke ngokuphelele, ingcindezi ihlala ijwayelekile, ayikho imiphumela emibi.
U-Ivan, oneminyaka engama-72, eMoscow
Isazi sezinhliziyo esinqunyelwe ukuvimbela ukuhlaselwa yisifo senhliziyo, ngoba nginesifo se-coronary artery isifo. Yize kuyasiza, ngizizwa ngisemncane ngeminyaka engama-30.
