I-Biosulin iyi-insulin encibilikayo yokwakheka kofuzo. Isetshenziselwa ukwelapha isifo sikashukela - sincike ku-insulin futhi sincike ku-insulin. Kubhekiswa kwizenzo ezimfishane nezaphakathi.
Igama Lezwe elingafanele
Igama elingathathi hlangothi emhlabeni wonke ngesiLatini yiBiosulin.
I-Biosulin iyi-insulin encibilikayo yokwakheka kofuzo.
I-ATX
Ikhodi yezidakamizwa ye-ATX yi-A10AB01
Khipha amafomu nokwakheka
I-Biosulin P ngokuqala ngokushesha komsebenzi wayo yenziwa ngendlela yesisombululo semijovo. I-1 cm³ iqukethe i-100 IU ml ye-insulin ekhiqizwa kusetshenziswa ubuchwepheshe be-genetic engineering. Ngaphezu kwalokho, ukwakheka kwalo muthi kubandakanya i-glycerin, i-metacresol namanzi akhethekile wokujova. Ama-Ampoules asephakethe lezinhlobonhlobo ze-contour ehlukahlukene.
Ukumiswa
Isenzo sesikhathi esiphakathi se-Biosulin H senziwa ngendlela yokumiswa kwemijovo ngaphansi kwesikhumba. Mhlophe, ubekwe kancane ngesikhathi ugcinwa. Ibuyiselwe kalula ngenkathi kunyakazisa ukunyakaza.
Isenzo se-Pharmacological
I-hormone isebenza ngama-insulin receptors amangqamuzana, ngenxa yokuthi lapho kulungiswa khona ushukela wegazi. Izinqubo zokufakwa kwayo kanye ne-izicubu ze-izicubu zenziwa zisebenze, ukwakheka kwe-glycogen kusebenze, futhi ukukhiqizwa kweglue izicubu zesibindi kuyancishiswa.
Ukuqala kokusebenza kweBiosulin esezingeni eliphakathi nendawo kusuka ku-1 kuye kwayi-2 amahora. Umphumela omkhulu kakhulu wenzeka ngemuva kwamahora ayi-6-12, futhi ubude besikhathi somsebenzi bufika emahoreni angama-24.
I-hormone isebenza ngama-insulin receptors amangqamuzana, ngenxa yokuthi lapho kulungiswa khona ushukela wegazi.
Ukuqala kwesenzo se-hypoglycemic se-Biosulin esifushane esithatha cishe imizuzu engama-30. Umphumela omkhulu kakhulu ngemuva kokuthi umjovo ubonwe ebangeni lamahora angama-2-4, ubude besikhathi somsebenzi ngamahora angama-6-8.
I-Pharmacokinetics
I-Biosulin H yokuqalwa kokusebenza okuphakathi nendawo ifakwe endaweni yomjovo. Kusatshalaliswa ngokungalingani emzimbeni. Ngomvimbelo, i-placenta ayinangeni, ayidluleli ebisini lwebele. Kuwohloka izicubu zesibindi. Imishanguzo eminingi ikhishwa emzimbeni nezinso.
Amafushane noma amade
Ithuluzi linesikhathi esifushane naphakathi. Inhloso yayo incike ohlotsheni lwesifo somuntu.
Izinkomba zokusetshenziswa
I-Biosulin H ikhonjiswa ukuthi isetshenziswe ekuhlolweni kwesifo sikashukela sohlobo 1. Ngohlobo 2, zinikezwa iziguli ngenxa yokumelana kwazo nezidakamizwa zomlomo ezinciphisa ushukela.
I-Biosulin H ikhonjiswa ukuthi isetshenziswe ekuhlolweni kwesifo sikashukela sohlobo 1.
Contraindication
Umuthi uvinjelwe ngokuqinile engcupheni yokuqalwa kwe-hypoglycemia nokuzwela okubukhali kwe-insulin.
Ngokunakekela
Ukuqapha kuyadingeka ukusebenzisa i-hormone ye-hepatological and nephrological pathologies.
Ungayithatha kanjani i-biosulin?
Faka ngaphansi kokhilimu obukhulu besikhumba, ungene emisipha noma emvinini imizuzu engama-30 ngaphambi kokudla noma isidlo esincane esinamakhabhohayidrethi.
Ngoshukela
Umthamo wansuku zonke wezidakamizwa unqunywa ngokuya ngezimpawu zesiguli. Kuyadingeka ukubala kahle inani le-insulin yomzimba. Umthamo ophakathi wesidakamizwa ngosuku usukela ku-0,5 uye ku-1 IU, ngokususelwa esilinganisweni somzimba womuntu. I-insulin elungiselelwe ukuphatha kufanele ibe emazingeni okushisa asekamelweni. Imvamisa, iphathwa izikhathi ezi-3 ngosuku, futhi kwesinye isikhathi iphindwe kabili. Uma inani lansuku zonke lingaphezu kuka-0,6 IU / kg, lapho-ke udinga ukwenza imijovo emi-2 kunoma iyiphi ingxenye yomzimba.
Umthamo wansuku zonke wezidakamizwa unqunywa ngokuya ngezimpawu zesiguli.
I-Biosulin ifakwe is / c esiswini, ethangeni, emabhulokeni, emsipha odlekayo - nomaphi lapho kukhona khona inani elanele lamafutha angaphansi. Izindawo zokujova ziyaguqulwa ukuze kuvinjelwe ukuthuthuka kwenqubo ye-lipodystrophy.
Ukuphathwa kwe-Intramuscularly kuphela ngaphansi kokubhekelwa okusondelene kochwepheshe. Kwesinye isikhathi ihlanganiswa ne-insulin ephakathi yegama elifanayo. Isingeniso esinjalo sidinga ukubhekwa njalo kwezinga le-glycemia.
Indlela yokusebenzisa i-Biosulin iyahluka ngokuya ngohlobo lomuthi olusetshenziswayo. Lapho usebenzisa uhlobo olulodwa kuphela lwe-insulin, ukulandelana kwezenzo kungokulandelayo:
- Ukukhishwa kwegciwane kwe-membrane ebhodleleni eline-ethanol kuyenziwa.
- Ngenisa umoya kwisirinji ngenani elilinganayo nedosi elinqunyelwe, bese ugcwalisa ibhodlela ngenani lomoya.
- Yicishe ibe ngu-180º bese ushayele umthamo obalwe ngaphambilini we-Biosulin.
- Susa inaliti, ususe umoya kwisirinji. Qiniseka ukuthi ukudayela kunembile.
- Yenza umjovo.
Uma usebenzisa izinhlobo ezimbili zemithi, isenzo sesiguli sizoba ngale ndlela elandelayo:
- Ukukhishwa kwe-magciwane okwenziwa emabhodleleni kuyenziwa.
- Udinga ukuhambisa ibhodlela nge-insulin ende kuze kube yilapho isisombululo sinombala olinganayo (hhayi omhlophe).
- Dweba umoya ungene kwisirinji ngokusho komthamo we-insulin ephakathi noma ende. Inaliti ifakwe esitsheni nge-insulin, ikhiphe umoya futhi ikhiphe inaliti. Ngalesi sikhathi, i-insulin ephakathi nendawo noma ende ayingeni isirinji.
- Thatha umoya ungene kwisirinji senani lapho kuzofakwa khona i-insulin emfishane. Adedele umoya kuleli bhodlela. Yiguqule bese udweba inani lemithi elinqunyelwe.
- Thatha inaliti, ususe umoya omningi. Hlola umthamo ofanele.
- Phinda izinyathelo ezifanayo, uqoqe i-insulin ephakathi noma ende kusuka ku-vial. Susa umoya.
- Yenza umjovo kusuka ezingxube ze-insulin.
Ngemuva komjovo, shiya inaliti ngaphansi kwesikhumba cishe imizuzwana eyi-6.
Ithuluzi lingakhiqizwa ekhosombeni elinepeni yesirinji enalithi, 5 ml. Ipeni lesirinji lifaka 3 ml ye-insulin. Ngaphambi kokuyisebenzisa, qiniseka ukuthi ayinacala. Ngemuva kokuthi i-cartridge ifakwe kwisirinji, umucu kufanele ubonakale ngewindi lomphathi.
Ngemuva komjovo, shiya inaliti ngaphansi kwesikhumba cishe imizuzwana eyi-6. Sonke lesi sikhathi inkinobho igcinwa endaweni eyenziwe yasebenza, ngakho-ke ukunemba komthamo kuyaqinisekiswa. Ngemuva kwalesi sikhathi, isibambo singasuswa ngokucophelela. I-cartridge ayihloselwe ukugcwalisa kabusha, ikhiqizwa kuphela ukusetshenziswa komuntu ngamunye.
Ngemuva kokuphela kwe-insulin, kufanele ilahlwe.
Imiphumela emibi ye-biosulin
Imithi yesikhathi esifushane nesiphakathi inemiphumela engathandeki ehambisana nokungasebenzi kahle kwe-metabolic nokuzwela okuphezulu.
Ngasohlangothini lwe-metabolism
Kungadala ukusabela kwe-hypoglycemic. Umuntu angathola lezi zimpawu ezilandelayo:
- i-pallor yesikhumba nolwelwesi lwama-mucous;
- ukukhuphuka kokujuluka
- umuzwa we-palpitations ojwayelekile;
- ukuthuthumela kwemisipha;
- umuzwa obukhali wendlala;
- isasasa elibukhali, kwesinye isikhathi ulaka, intukuthelo, ukuhlangana nokudideka kwemicabango;
- umkhuhlane
- izinhlungu ezibukhali ekhanda;
- ukwephula ukuzwela kwemisipha.
I-hypoglycemia ehlala isikhathi eside ingaholeli ku-hypoglycemic coma:
- i-pallor kanye nomswakama wesikhumba;
- ukukhuphuka okumaphakathi kwesilinganiso senhliziyo;
- umswakama wolimi;
- ukukhuphuka kwethoni yemisipha;
- ukuphefumula okungashoni nangokushesha.
Uma ekhathaza kakhulu, isiguli asikwazi. Akanakho ukukhalipha, ithoni yemisipha iyancipha, izithukuthuku ziyama, ukushaya kwenhliziyo yakhe kukhathazekile. Ukwehluleka okungenzeka kokuphefumula. Ingxaki eyingozi kakhulu ye-hypoglycemic coma yi-edema yamakhemikhali, okuholela ekuboshweni kokuphefumula.
Ngokuthuthukiswa kwalezi zibonakaliso, kubalulekile ukunikeza umuntu ukunakekelwa okudingekayo kwezokwelapha ngesikhathi. Ngokushesha lapho inikezwa, mancane amathuba okuba umuntu abe ne-coma eyingozi ye-hypoglycemic. Ukuphathwa kwe-insulin esimweni sokwehla kwegazi glucose kunemiphumela ebulalayo koshukela.
I-hypoglycemia ehlala isikhathi eside ingaholelwa ku-hypoglycemic coma.
Allergies
Ngenkambo yokujova yokwelashwa kweBiosulin, izimpendulo ze-allergic zingenzeka: ukuqubuka kwesikhumba, i-edema, okungavamile kakhulu - ukusabela kwe-anaphylactoid. Impendulo yendawo endaweni yomjovo ingakhula - ukulunywa, ubomvu, nokuvuvukala okuncane.
Umthelela ekhonweni lokulawula izindlela
Ekuqeshweni kokuqala kwekhambi, ekushintsheni nasezimweni ezicindezelayo, ukuwohloka kwekhono lokushayela imoto nokusebenza ngemishini eyinkimbinkimbi kungenzeka. Kulezi zimo, akukhuthaziwe ukwenza imisebenzi edinga ukunakwa okwandayo nokusabela okuvela kumuntu.
Imiyalo ekhethekile
Kwenqatshelwe ukusebenzisa umuthi uma usushintshe umbala noma izinhlayiya eziqinile zivele kuwo. Ngesikhathi sokwelashwa, udinga ukubheka inani le-glucose egazini. Izici zokubonakala kwe-hypoglycemia yilezi:
- ukungena esikhundleni sohlobo lwe-insulin;
- indlala ephoqelekile;
- ukwanda okubukhali kokuzivocavoca komzimba;
- izifo ezokwehlisa isidingo se-insulin (ngokwesibonelo, ukungasebenzi kahle kwezinso nesibindi, ukuncipha kokusebenza kwe-adrenal, umsebenzi we-thyroid okhubazekile noma i-pituitary gland);
- ukuguqulwa kwesayithi lomjovo;
- ukusebenzisana neminye imithi.
Ukuqhekeka kwemijovo ye-biosulin ezigulini ezinesifo sikashukela esincike ku-insulin kuholela ekuqhubekeni kwe-hyperglycemia. Ukuvezwa kwayo:
- umlomo owomile
- ukuchama njalo;
- isicanucanu ngokuhlanza;
- ubomvu besikhumba nolwelwesi lwe-mucous;
- ukwehla kwesifiso sokudla;
- iphunga le-acetone kanye nama-apula amanzi emoyeni othululiwe.
I-Hyperglycemia kulolu hlobo lwesifo sikashukela ngaphandle kokwelashwa okwanele kungaholela ku-ketoacidosis.
Ushintsho kumthamo we-Biosulin wenziwa nge:
- ukukhuphuka kwamandla omthwalo;
- izifo ezithathelwanayo;
- Isifo sika-Addison;
- ukwephulwa kwe-pituitary gland;
- ukuphazamiseka kwesibindi;
- ushintsho ekudleni.
Kwenqatshelwe ukufaka i-insulin yezenzo zesikhathi eside ekumisweni uma, ngenxa yokuphazamiseka, imhlophe futhi kuyi-opaque. I-hormone enjalo inobuthi futhi ingadala ubuthi obukhulu. Ukusetshenziswa kwomuthi kumaphampu we-insulin akwenziwa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Abukho ubufakazi bokusetshenziswa kweBiosulin ngezikhathi zokuncelisa kanye nokuthinta.
Ukunquma i-Biosulin ezinganeni
Umuthi lo ungasetjenziselwa ukwelapha abantwana. Imithamo nemithamo yempesheni inqunywa kubhekisisa uhlobo lwesifundo sikashukela.
Sebenzisa ebudaleni
Dinga ukulungiswa kwamthamo kubantu abangaphezu kweminyaka engama-65
Ukweqisa kwe-Biosulin
Uma umthamo udluliwe, i-hypoglycemia ingenzeka. Ukushoda kweglucose emnene kuqedwa ukusetshenziswa koshukela noma ukudla okune-carbohydrate. Abantu abanesifo sikashukela badinga ukuba namaswidi noma ukudla okune-carbohydrate okugaya kalula nazo ngaso sonke isikhathi.
Dinga ukulungiswa kwamthamo kubantu abangaphezu kweminyaka engama-65.
Ngomkhwezeli, iDextrose ifakwa emthanjeni, i-glucagon s / c, iye emithanjeni noma emisipha. Lapho nje ukwaziwa kwesiguli kuphola, udinga ukudla ukudla okunothukela.
Ukuxhumana nezinye izidakamizwa
Kunemithi ethinta isidingo sesifo sikashukela se-insulin. Umphumela wehlisela ushukela umuthi kungenzeka
- imithi esehlisa ushukela esetshenziselwa ushukela ngaphakathi;
- I-MAO evimbela izidakamizwa;
- Ama-block-blockers;
- izinto ezivimbela i-ACE;
- ama-sulfonamides;
- ama-steroid nama-anabolics;
- i-carbonic anhydrase shughuli inhibitors;
- Bromocriptine;
- I-Pyridoxine;
- I-Octreotide;
- I-Ketoconazole;
- Mebendazole;
- Theophylline;
- I-Tetracycline;
- ama-ejenti anezakhi ze-lithium;
- yonke imithi equkethe i-ethyl alcohol.
Amakhompiyutha alandelayo anciphisa umsebenzi we-Biogulin:
- imithi yangaphakathi yokuvimbela inzalo;
- I-GCS;
- ama-analog we-thyroid;
- ama-diuretics ochungechunge lwe-thiazide;
- IHeparin;
- abanye antidepressants;
- ama-audiathomimetic agents
- I-Clonidine hydrochloride;
- ama-ejenti avimba umsebenzi wama-calcium tubules;
- Morphine;
- Phenytoin.
Ukubhema kusiza ekwehliseni umphumela we-Biogulin.
Ukuhambisana notshwala
Kwehlisa ukumelana komzimba kwi-ethanol.
Ama-Analog
Ama-analoggs ohlobo oluthathwa njenge-insulin yile:
- Sizoyihola;
- IGensulin;
- I-insulin isophane;
- I-Insuran;
- I-Protamine insulin;
- I-Protafan;
- I-Rinsulin;
- Rosinsulin;
- I-Humulin;
- I-Humulin-NPX.
Imibandela yekhefu lekhemisi
Kuthengiswe kumakhasimende kuphela ngokubhaliwe, okubonisa umthamo. Ungakuthola kuleli cala mahhala.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Ngaphandle kokuqokwa ngudokotela, ungayithola ngemali ekhokhwayo kuphela. Akuthengiswa emakhemisi wonke. Ukuthenga i-insulin ngaphandle kokwethula incwadi yezokwelapha, umuntu uzibeka engcupheni enkulu.
Intengo ye-biosulin
Izindleko zebhodlela le-Biosulin zingama-ruble angama-485. Izindleko zamabhodlela ayi-5 nesirinji nepeni, ibhokisi lokugcwala - kusuka ku-1067 kuya kuma-ruble ayi-1182.
Ngaphandle kwemithi kadokotela, i-Biosulin itholakala kuphela ngemali ethile.
Izimo zokugcina zomuthi
Gcina endaweni lokushisa lika- + 2 ... + 8 ° C, endaweni evikelwe ukukhanya. Ungavumeli iqhwa.
Isikhathi sokuphelelwa yisikhathi
Impilo yeshalofu yezixazululo yiminyaka emi-2. Ngemuva kokuphrinta, umuthi ungagcinwa amasonto ayi-6, kanye nama-cartridge wezinsuku ezingama-28. Kufanele zibe sezimweni zokushisa + 15 ... + 25 ° ะก.
Umkhiqizi
Kwenziwe iMarvel Life-Science, India; E-Pharmstandard Ufa VITA, eRussia.
Ukubuyekezwa mayelana ne-biosulin
Odokotela
U-Irina, oneminyaka engama-40, odokotela abasebenza nge-endocrinologist, uSamara: "Ngokulungiswa ushukela wegazi, ngibeka izinhlobo ezisheshayo neziphakathi zeBiosulin ezigulini. Umuthi ubekezelelwa kahle uma umthamo nesikhathi sokuphatha ubalwa kahle, imiphumela engathandeki ayivezi. Zonke iziguli azizange zithole ukweqa ushukela ngesikhathi izinsuku, okukhombisa ukunxeshezelwa kahle kwesifo sikashukela. "
USvetlana, oneminyaka engama-38, i-endocrinologist, iRostov-on-Don: "Uhlobo oluphumelelayo lwe-insulin yokwelashwa kweziguli ezinefomu lesifo sikashukela esincike kakhulu. Kulokhu, kunikezwa uhlobo olusheshayo lwomuthi, ngoba kubalulekile ukunxephezela ukugxuma kwe-glucose ngaphambi kokudla. Ngohlobo 2 lwesifo sikashukela, ngibeka uhlobo olusezingeni eliphakathi lomuthi ezigulini Kuyasiza ukulawula ngempumelelo ushukela usuku lonke. "
Iziguli
USergey, oneminyaka engama-45, eMoscow: "Ngithatha i-Biosulin P njengenye yezinhlobonhlobo ze-insulin ezifushane. Kwenzeka engxenyeni yehora, okuwukuthi, ukwethulwa kwalo muthi kungaxhunyaniswa kalula nanoma yisiphi isidlo. Ngihlala ngibala ngokucophelela inani le-insulin ngokuya ngesisindo sami nenani lokudla, ngakho-ke iziqephu ze-hypoglycemia ziyaqabukela. Akubanga naminye imiphumela emibi. "
U-Irina, oneminyaka engu-38 ubudala, eSt. , iziqephu ze-hypoglycemia kwesinye isikhathi ziyenzeka. Ngifunde ukuyimisa nokuyiyeka ngesikhathi. "
Isifo sikashukela
U-Igor, oneminyaka engama-50, u-Ivanovo: "Ngisebenzisa i-Biosulin yezinyathelo eziphakathi nendawo ezimfushane ekwelapheni isifo sikashukela. Uma kunesidingo, ngiyiphatha kwisiphuzo esisodwa. Umuthi ngokushesha usebenza futhi awubangeli ukwehla kakhulu ushukela uma bekungekho umthwalo omkhulu noma ukucindezelwa ngaphambili Izimo. Ngokuhambisana nemijovo ye-insulin, ngidla ukudla. Konke lokhu kusivumela ukugcina izinga lami likashukela lilijwayelekile. "
