Ukusetshenziswa kwe-Idrinol kunesizathu njengento efanelekayo ekwelapheni izinkinga eziningi zenhliziyo ne-neurological, kanye nemibandela ehambisana nokwehla komthamo wokusebenza.
Umuthi unomphumela we-antioxidant futhi usiza ukuthuthukisa ukwelashwa kwezicubu kwezicubu. Lapho usebenzisa umuthi, imithamo ekhonjiswe kwimiyalo kufanele inamathelwe ngokuqinile ukuze kuvikeleke ukuvela kwemiphumela emibi ehlukahlukene.
Igama Lezwe elingafanele
I-INN yesidakamizwa yi-Idrinol.
Ukusetshenziswa kwe-Idrinol kunobulungiswa njenge-adjuential ekwelapheni izinkinga eziningana zenhliziyo ne-neurological.
I-ATX
Ehlukanisweni lwamazwe aphesheya kwe-ATX, umkhiqizo uphethe ikhodi C01EV.
Khipha amafomu nokwakheka
Ukukhishwa kwe-Idrinol kusesimweni sesisombululo somjovo namaphilisi. Kuzo zombili izinhlobo zemithamo, into esemqoka esebenzayo yi-meldonium dihydrate. Ama-capsule e-Idrinol afaka nezingxenye eziningi ezisizayo, kufaka phakathi isitashi, i-calcium stearate, i-silicon dioxide, i-gelatin ne-titanium dioxide. Isixazululo sihlanganisa namanzi alungiselelwe.
Ukukhishwa kwe-Idrinol kusesimweni sesisombululo somjovo namaphilisi.
Isixazululo
Isixazululo se-Idrinol sicacile. Igcwele ngama-ampoule angama-5 ml wengilazi esobala. Umthamo owodwa uqukethe kufika ku-500 mg wento esebenzayo. Ama-Ampoules anesixazululo se-Idrinol agcwele emaphaketheni epulasitiki wamaselula ama-5 ama-pcs. Esiqeshini sekhadibhodi, kungahle kube no-1 noma u-2 walawa mabhulawu.
Amakhandlela
Ama-capsule ama-idrinol anogobolondo obunzima owenziwe nge-gelatin. Umbala we-Shell umhlophe. Ngaphakathi kuqukethe i-powder emhlophe. Okuqukethwe kwezinto ezisebenzayo ku-capsule eyodwa kungama-250 mg. Amaphilisi athengiswa ngamaphakethe ama-10 ama-pcs. Isixha sekhadibhodi sinokuqukatha ama-2 noma ama-4 alawa mabhulawu.
Ama-capsule ama-idrinol anogobolondo obunzima owenziwe nge-gelatin.
Isenzo se-Pharmacological
IMeldonium, okuyisakhi esiyinhloko esisebenzayo se-Idrinol, iyi-analogue yokufakelwa yento y-butyrobetane, etholakala kuwo wonke amaseli omzimba womuntu. Le nto yenza imisebenzi eminingi ebalulekile. Ivimbela ukukhiqizwa kwe-carnitine kanye nokudluliselwa ngokusebenzisa ulwelwesi lweseli lwamafutha acid athile. Lokhu kuholela ekunciphiseni kwamaseli wezinhlobo zama-acid acushiwe ezingakaze zisebenze ku-oxidation.
Ngokuphazamiseka okuhlukahlukene kokujikeleza, into esebenzayo i-Idrinol isusa imiphumela ye-ischemia ngokubuyisela ibhalansi phakathi kokuhamba komoya-mpilo kwezicubu nokusetshenziswa kwayo ngamaseli. Into esebenzayo inomphumela we-vasodilating. Ngaphezu kwalokho, kwandisa isilinganiso sezinqubo ze-metabolic futhi kuvimbela ukwakheka kwezigcawu ze-atherosclerotic ezindongeni zemithambo yegazi.
Into esebenzayo i-Idrinol isiza ukuthuthukisa umsebenzi wesibeletho we-myocardium yenhliziyo, ngakho-ke, inciphisa inani lokuhlaselwa kwe-angina futhi yenyusa ukubekezelela komzimba kwengcindezi.
Into esebenzayo i-Idrinol ithuthukisa umsebenzi wesibeletho we-myocardium yenhliziyo.
Nge-infyoction ye-myocardial, ukusetshenziswa kwe-Idrinol kunganciphisa ukwakheka kwe-necrosis futhi kuvimbele ukubonakala kwe-foci ebanzi yomonakalo we-myocardial. Ngokuthuthukisa ukugeleza kwegazi, into esebenzayo i-Idrinol isiza ukuthuthukisa ukondleka komqondo wobuchopho endaweni ye-necrotic yengqondo ekuphazamisekeni komzimba noma kwe-acute cerebrovascular.
Ngaphezu kwalokho, ubukhulu besifo se-edematous syndrome, esivame ukubonwa ngokuhlaselwa yisifo sohlangothi, siyancishiswa. Ngenxa yokusabela okuyinkimbinkimbi kwe-biochemical reaction, izicubu ezithinteka inqubo ye-ischemic ziqala ukugcwala umoya-mpilo kanye nezakhi zomzimba ngenxa yokuqondisa kabusha kwegazi kuye. Ngenxa yalokhu, ukubanjwa kwe-ischemic ebuchosheni kwenzeka ngemiphumela emibi kakhulu kunokushaywa unhlangothi okungazange kumiswe ngokushesha.
Umuthi unomphumela omuhle ekwelashweni kwe-vascular pathologies yosuku lamehlo.
Ngaphezu kwalokho, isakhi esisebenzayo sinomphumela we-tonic ohlelweni oluphambili lwezinzwa, sisiza ukucindezela ukuphazamiseka kwe-autonomic ne-somatic.
I-Pharmacokinetics
Uma umuthi uphathwa ngokuhlinzwa noma nge-intramuscularly, ukumunzwa kwento yawo esebenzayo egazini kwenzeka ngokushesha okukhulu, futhi emizuzwini embalwa ukuhlukunyezwa kwakho ku-plasma kuba phezulu.
Lapho uthatha umuthi ngendlela yamaphilisi, ukufakwa kwesidakamizwa ezindongeni zendlela yokugaya nakho kuya ngokushesha.
Lapho uthatha umuthi ngendlela yamaphilisi, ukufakwa kwesidakamizwa ezindongeni zendlela yokugaya nakho kuya ngokushesha. Kulesi simo, ukuqoqwa okuphezulu kwento esebenzayo yesidakamizwa ku-plasma ifinyelela phezulu ngemuva kwamahora ama-1-2. I-Metabolism yenzeka ezinso nasezibindini. Imikhiqizo yokubola isuswa emzimbeni kungakapheli amahora angama-4-6.
Izinkomba zokusetshenziswa
Ukuqokwa kwe-Idrinol ekwelapheni ama-pathologies enhliziyo okufana nokuhlaselwa yisifo senhliziyo, i-cardiomyopathy ne-angina pector kufanelekile. Ngalezi ziphazamiso, lo muthi usetshenziswa njengesijobelelo sezidakamizwa zohlu lokuqala okuhloselwe ukwelashwa kwezifo zohlelo lwethambo nenhliziyo. Ukusetshenziswa kwe-Idrinol kuvame ukubekelwa iziguli ezinokuhluleka kwenhliziyo ukwehluleka. Lo muthi ungasetshenziswa ekwelapheni ukuhlaselwa kwe-ischemic yesikhashana nasekuqedeni imiphumela yokushaywa yi-hemorrhagic stroke.
Ngaphezu kwalokho, ukusetshenziswa kwe-Idrinol kuvame ukubekelwa abantu abaphethwe yizinkinga ezithile ngezikhathi ezithile noma ezingamahlalakhona. Ithuluzi lingasetshenziswa ukuqeda izimpawu zezimpawu zokuhoxa ekwelashweni kweziguli ezinotshwala obungamahlalakhona. Kulokhu, ithuluzi lisetshenziswa njengengxenye yokwelashwa ehlanganisiwe eqondisiwe. Ukusetshenziswa kwe-Idrinol kunesizathu ekwelapheni i-retinal thrombosis.
Ekusebenzeni komtholampilo okujwayelekile, ukusetshenziswa kwe-Idrinol kunqunyelwe ezigulini ezinezikhalazo mayelana nokwehla kwamandla okusebenza, kufaka phakathi ukuvuka ngemuva kwesizinda sengqondo nengokomzimba. Ukusetshenziswa kwe-Idrinol kuvame ukunqunyelwa ukuvuselelwa kweziguli ngemuva kokuhlinzwa. Ithuluzi lisiza inqubo yokutakula. Phakathi kokunye, ukuthatha i-Idrinol kusiza ukunciphisa isikhathi sokuvuselela kabusha.
Contraindication
Ukusetshenziswa kwe-Idrinol ekwelapheni iziguli ezine-hypersensitivity yomuntu ngamunye ezingxenyeni ezisebenzayo nezisizayo zomuthi akunconyiwe. Ngaphezu kwalokho, ukusetshenziswa kwomuthi ku-contraindication lapho kukhona ukunyuka kwengcindezi ye-intracranial esigulini. Ukuqokwa kwe-Idrinol akunconywa lapho kukhona ama-intracranial tumors kanye nokwephulwa kwe-venous ukuphuma.
Ukusetshenziswa kwomuthi kuyaphikiswa lapho kukhona ingcindezi ye-intracranial ekhuphukayo esigulini.
Ngokunakekela
Ngokuqapha ngokweqile, leli thuluzi lingasetshenziswa kubantu abanesithuthwane. Ngaphezu kwalokho, lapho uthola ukwelashwa, ukunakwa okukhethekile ngakwudokotela kuyadingeka kwiziguli ezinenkinga yokuphazamiseka kwengqondo, kufaka phakathi i-schizophrenia.
Ungayithatha kanjani i-Idrinol?
Ekuphazamisekeni okubuhlungu nokungamahlalakhona kokujikeleza kwenhliziyo, kubekwa imijovo yesisombululo se-Idrinol, engabhekelwa zombili intramuscularly and intravenously. Umthamo wansuku zonke wala ma-pathologies ngu-500 mg. Inkambo yokwelashwa nge-Idrinol isuka emasontweni amane kuya kwayisithupha. Kungcono ukuthatha inkambo yesibili yesidakamizwa amahlandla ama-2-3 unyaka wonke. Ekwelashweni kwe-multicomponent kwezifo zenhliziyo, umuthi usetshenziswa ku-500-1000 mg ngosuku. Inkambo yokwelashwa kuleli cala isuka emavikini amane kuya kwayisithupha.
Ukwelashwa kokubonakaliswa kwezimpawu zokuhoxa ekudakweni kotshwala kudinga ukusetshenziswa kwe-Idrinol okwesikhathi esine ngosuku.
Ekwelashweni kokubonakaliswa kwe-myocardial dystrophy, umuthi ubekiwe ngendlela yamaphilisi. Ekuseni nakusihlwa, iziguli zidinga ukuthatha ithebhulethi elilodwa lomuthi. Ukwelapha kufanele kuleli cala kuthathe izinsuku eziyi-12.
Ukususa ukubonakaliswa kokugcwala kwengqondo nangokomzimba, ukuthatha umuthi ngendlela yamathebulethi kuyadingeka. Umuthi kumele uphuzwe izikhathi ezine ngosuku ngama-250 mg. Inkambo yezinsuku eziyishumi nambili yokwelashwa yanele. Uma kunesidingo, inkambo yokwelapha inganwetshwa amasonto angama-2-3.
Ukwelashwa kokubonakaliswa kwezimpawu zokuhoxa ekudakweni kotshwala kudinga ukusetshenziswa kwe-Idrinol okwesikhathi esine ngosuku. Umthamo owodwa ngu-500 mg.
Isikhathi sokwelashwa esinconyiwe sisukela ezinsukwini eziyi-7 kuye kwezingu-10.
Ngaphambi noma ngemuva kokudla
Ukudla akuliphazamisi izinga lokufakwa kwezingxenye ezisebenzayo zomuthi.
Ukuthatha umuthi wesifo sikashukela
Iziguli ezihlushwa uhlobo 2 sikashukela i-mellitus, ukusetshenziswa kwe-Idrinol kungahle kuchazwe kumthamo we-250 mg ngosuku. Ngalesi sifo, lo muthi usetshenziswa kuphela njengengxenye yokwelashwa okuyinkimbinkimbi ukuthuthukisa izinqubo ze-metabolic emzimbeni.
Iziguli ezihlushwa uhlobo 2 sikashukela i-mellitus, ukusetshenziswa kwe-Idrinol kungahle kuchazwe kumthamo we-250 mg ngosuku.
Imiphumela emibi ye-Idrinol
Lo muthi uphansi ubuthi, ngakho-ke kuyaqabukela kuholele emiphumeleni emibi.
Amapheshana wesisu
Ezimweni ezingavamile, ngokumelene nesizinda sokuthatha i-Idrinol, kuvela ukubonakala kokuphazamiseka kwengqondo okuyi-dyspeptic, okuvezwa ngumcanucanu, ukuthokomala kanye nesitulo esibi.
Isistimu yezinzwa ephakathi
Ezimweni ezingavamile, ngemuva kokuthatha i-Idrinol, iziguli zithola ukwanda kokuphazamiseka kwengqondo.
Ezimweni ezingavamile, ngemuva kokuthatha i-Idrinol, iziguli zithola ukwanda kokuphazamiseka kwengqondo.
Kusuka ohlelweni lwezinhliziyo
Umphumela omubi wokuthatha i-Idrinol kungenzeka ukuthi weqe ekucindezelweni kwegazi. Ezimweni ezingavamile, kukhona ukwanda kwesilinganiso senhliziyo.
Allergies
Uma isiguli sinokuzwela okwengeziwe kwezingxenye ngazinye ze-Idrinol, ukuqhuma kwesikhumba kungenzeka. Ezimweni ezingavamile, i-edema kaQuincke ingahle ibonwe.
Umthelela ekhonweni lokulawula izindlela
Lapho uthatha inkambo yokwelapha nge-Idrinol, kungakuhle ukuthi uqaphele ikakhulukazi lapho ulawula izindlela eziyinkimbinkimbi.
Imiyalo ekhethekile
Iziguli ezinezifo ezingamahlalakhona zegastrointestinal zelulekwa ukuba zihlolwe ngokuphelele ngaphambi kokuqala ukwelashwa kwe-Idrinol ukuze zinciphise ubungozi bokuqhamuka kwalezi zi-pathologies.
Iziguli ezinezifo ezingamahlalakhona ze-emathunjini zilulekwa ukuba zihlolwe ngokuphelele ngaphambi kokuqala ukwelashwa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukwelashwa kwe-Idrinol ngesikhathi sokukhulelwa akunconywa. Uma kunesidingo esiphuthumayo sokuthi abesifazane basebenzise umuthi ngesikhathi sokukhipha isisu, ukuqedwa kokuncelisa kungadingeka.
Ukunquma i-Idrinol ezinganeni
Umuthi awusetshenziswa ekwelapheni kwezingane nentsha engaphansi kweminyaka engu-18.
Sebenzisa ebudaleni
Ubudala obudala akuyona inkambiso yokusetshenziswa kwe-Idrinol, kepha umuthi kufanele unqunywe kucatshangelwa ukuba khona kwezifo ezingamahlalakhona esigulini.
Ubudala obudala akuyona inkambiso yokusetshenziswa kwe-Idrinol.
Isicelo sokusebenza kokulimala kwezinso
Ezindleleni ezihambisana nobunzima obulinganiselwe bokulimala kwezinso, lesi sidakamizwa singasetshenziswa kuphela. Ekwehlulekeni kwezinso, ukusetshenziswa kwe-Idrinol akunconyiwe.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukusetshenziswa kwe-Idrinol ekwelapheni iziguli ezihlushwa ama-pathologies wesibindi kudinga ukuqaphela okukhethekile.
Ukweqisa kwe-Irdinol
Nge-overdose ye-Idrinol, ikhanda, isiyezi, ubuthakathaka ne-tachycardia kungenzeka. Kulokhu, ukwelashwa okubonakalayo kuyadingeka.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa kwe-Idrinol kuvunyelwe nge-sedative, kufaka phakathi nabantu abanjengoPersen. Ukuthatha i-Idrinol kuthuthukisa ukusebenza kwe-glycosides yenhliziyo. Lesi sidakamizwa sinokuhlanganiswa nama-antiplatelet agents, izidakamizwa ze-antianginal, ama-diuretics, ama-anticoagulants, ama-bronchodilators nama-antiarrhythmics. Ngokuqapha, udinga ukuhlanganisa ukuthatha i-Idrinol ne-alpha-adrenergic blockers, i-Nitroglycerin, i-vasodilators engaphelele, ngoba inhlanganisela enjalo ingavusa i-tachycardia kanye nokwehla komfutho wegazi.
Ukusetshenziswa kwe-Idrinol kuvunyelwe nge-sedative, kufaka phakathi nabantu abanjengoPersen.
Ukuhambisana notshwala
Kuyinto engathandeki ukuphuza utshwala ngenkathi uphathwa i-Idrinol.
Ama-Analog
Izindlela ezinomphumela ofanayo wokwelapha zibandakanya:
- I-Mildronate
- Cardionate
- IVasomag.
- Midolat.
- IMeldonium.
- I-Mildroxin.
Imibandela yekhefu lekhemisi
Umkhiqizo usatshalaliswa ngugqirha.
Umkhiqizo usatshalaliswa ngugqirha.
Intengo ye-Idrinol
Izindleko zesisombululo zisuka kuma-ruble ayi-140 kuye kwangama-300. Intengo yesidakamizwa ngesimo samaphilisi isuka kuma-ruble ayi-180 kuye kwangama-350.
Izimo zokugcina zomuthi
Idrinol kufanele igcinwe endaweni emnyama futhi epholile.
Isikhathi sokuphelelwa yisikhathi
Gcina umuthi isikhathi esingaphezu kweminyaka emi-3.
Umkhiqizi
E-Russia, umenzi wemithi yi-Sotex Pharmheshama CJSC.
Ukubuyekezwa kwe-Idrinol
ULyudmila, oneminyaka engama-38, eSt
Ngokubheka isizinda sezinkinga emsebenzini nasemndenini, waqala ukuzizwa ekhathele. Waphoqa ukuthi akaphume embhedeni ekuseni. Lokhu kuqhubeke isikhathi esingaphezu kwezinyanga ezi-2, kepha noma bekuxazululwa izinkinga, ukukhathala akuzange kunyamalale. Ngemuva kwalokhu, izinhlungu ezithambile enhliziyweni nokungaphatheki kahle kwesifuba zaqala ukuvela ngezikhathi ezithile. Udokotela unqume i-Idrinol izinsuku eziyi-14. Ngemuva kwezinsuku eziningana zokuthatha, ngazizwa ngingcono kakhulu. Ngemuva kokuphothula izifundo ezigcwele, zonke izinkinga zempilo zanyamalala futhi sekuphele unyaka zingazwakali.
UVladislav, oneminyaka engama-40 ubudala, e-Orenburg
Ngemuva kokuhlinzwa komgogodla, amaphilisi we-Idrinol athathwa njengokuyalelwa ngudokotela. Ithuluzi lihle. Kwandisa ubungqabavu futhi kusiza ukubekezelela ukuvuselelwa kalula. Angizwanga yimiphumela emibi futhi ngiyanelisekile ngomphumela wokuphuza umuthi.
UKristina, oneminyaka engama-52, eMoscow
Ngemuva kokushaywa unhlangothi, welashwa nezidakamizwa ezahlukahlukene. Ukuvuselela kabusha kwakunzima kakhulu. Udokotela wezinzwa unikeze ukusetshenziswa kwe-Idrinol. Leli thuluzi selisetshenziswe isikhathi esingaphezu kwenyanga. Ekuqaleni, angizwanga ngomphumela omningi, kodwa-ke ngaqala ukuqaphela ukuthi ukuzivocavoca umzimba kwaqala ukunikezwa lula kakhulu. Ngaphezu kwalokho, inkumbulo yathuthuka kanye nokukhanya okulula kwavela ekhanda. Manje sengiluleme ngokuphelele, kodwa ngihlelele ukuthi ngizokwelashwa no-Idrinol ngokunconywa ngudokotela.
