I-Vitaxon yezidakamizwa (i-lat.) Ibulela izidakamizwa ze-neurotropic ezenzelwe ukwelashwa okuyinkimbinkimbi kwezifo zohlelo lwezinzwa. Ngaphambi kokusebenzisa umuthi, iziguli kufanele zifunde ngokucophelela imiyalo futhi zinake imininingwane ngemiphumela emibi kanye ne-contraindication.
Igama Lezwe elingafanele
Akukho.
I-ATX
I-N07XX - izidakamizwa zokwelapha izifo zohlelo lwezinzwa.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngefomu lethebhulethi nangendlela yesisombululo.
Umuthi uyatholakala ngefomu lethebhulethi nangendlela yesisombululo.
Amathebulethi ahloselwe ukusetshenziswa ngomlomo amhlophe futhi aqukethe okulandelayo:
- izithako ezisebenzayo - i-benfotiamine (100 mg) ne-pyridoxine hydrochloride (100 mg);
- ama-excipients - i-povidone, i-MCC (i-microcrystalline cellulose), i-anhydrous colloidal silicon dioxide, i-calcium stearate, i-talc, isitashi sommbila;
- izinto ezihlanganayo - utshwala be-polyvinyl, i-titanium dioxide, i-polyethylene glycol, talc (opadra II 85 F 18422).
Ifomu eliqinile lihanjiswa emakhemisi nasezikhungweni zezokwelapha emaphepheni amakhadibhodi aqukethe amanxeba anamaphilisi angama-30 noma angama-60.
Ukulawulwa kwe-intramuscular, umuthi uyatholakala ngesimo se-ampoules enoketshezi obomvu.
Ukulawulwa kwe-intramuscular, umuthi uyatholakala ngesimo se-ampoules enoketshezi obomvu.
Ukwakheka kwalesi sidakamizwa kufaka phakathi:
- izithako ezisebenzayo - i-cyanocobalamin (50 mg), i-thiamine hydrochloride (50 mg) ne-pyridoxine hydrochloride (50 mg);
- izinto ezengeziwe - amanzi wokujova, i-benzyl alcohol, i-sodium hydroxide, i-sodium polyphosphate, i-lidocaine hydrochloride, i-potasium hexacyanoferrate III.
Isixazululo somjovo sinikezwa ngama-ampoules (2 ml), izingcezu ezi-5 noma eziyi-10 ebhokisini lekhadibhodi.
Isenzo se-Pharmacological
Umuthi ungoweqembu lezidakamizwa ze-neurotropic eziqukethe amavithamini e-B.
Umuthi unomphumela omuhle ezifweni eziwohlokayo neziwohlokayo zohlelo lwezinzwa nezempahla yokusebenza kwezimoto. Umuthi ubekelwe ukuvikela nokuqeda izimo ezingafanele emzimbeni.
Umuthi unomphumela omuhle ezifweni eziwohlokayo neziwohlokayo zohlelo lwezinzwa nezempahla yokusebenza kwezimoto.
Kumthamo ofanele, into esebenzayo igcizelela inqubo ye-hematopoiesis nokujikeleza kwegazi, isebenza njenge-analgesic.
I-Thiamine (i-Vitamin B1) ne-benfotiamine (into ethathwe ku-thiamine) ibandakanyeka ezinqubweni ezibalulekile ze-carbohydrate metabolism futhi ibe nomphumela omuhle esizweni semizwa ye-nerve fibers, ngenkathi inomthelela ekuqhutshweni kwemizwa ye-nerve.
Ukuntuleka kwe-vithamini B1 kuholela ekusebenzeni kwesistimu yezinzwa.
Lapho izinhlayiya ze-phosphoric acid zinanyathiselwe ku-vithamini B6 (pyridoxal-5'-phosphate, PALP), kwenziwa izakhi zomzimba - i-adrenaline, i-tyramine, i-dopamine, i-histamine, i-serotonin. I-Pyridoxine idlala indima ebalulekile ku-anabolism ne-catabolism, ekuphindaphindweni nasekuqhekekeni kwama-amino acid.
IVitamin B6 isebenza njengegalelo ekwakhiweni kwe-α-amino-β-ketoadininic acid.
IVithamini B12, equkethwe ukwakhiwa komuthi, kubalulekile ekutholeni iseli, ukwakheka kwe-choline, i-creatinine, i-methionine, i-nucleic acid. ICyanocobalamin inethonya elihle ezinqubweni ze-hematopoiesis, njengento antianemic factor.
IVithamini B12, equkethwe ukwakhiwa komuthi, kubalulekile ekutholeni iseli, ukwakheka kwe-choline, i-creatinine, i-methionine, i-nucleic acid.
Ngaphezu kwalokho, i-Vitamin B12 idlala indima yokubulala izinzwa.
I-Lidocaine inomphumela wokubulala izinzwa: i-terminal, i-conduction kanye nokungena kwe-anesthesia.
I-Pharmacokinetics
Ngokuphathwa komlomo kwesidakamizwa, i-benfotiamine esetshenziswayo yezinto igxiliwe egazini amahora angu-1-2.
Ngokuphathwa komlomo kwesidakamizwa, i-benfotiamine esetshenziswayo yezinto igxiliwe egazini amahora angu-1-2.
Lapho isithako singena emathunjini, kwakhiwa i-S-benzoylthiamine enenhlanganisela yamafutha. Ngenqubo yokufakwa kwe-vithamini egazini, ukuguqulwa kwayo okuncane kune-thiamine kwenzeka.
I-Pyridoxine hydrochloride igxiliwe ku-plasma emahoreni angama-1-2 futhi iguqulwa ibe yi-pyridoxal-5-phosphate ne-pyridoxamine phosphate.
Ngokuphathwa kwabazali bomuthi, i-thiamine isatshalaliswa emzimbeni, ingena egazini kungakapheli imizuzu eyi-15 futhi ikhishwe ngokuphelele ezinso ngemuva kwezinsuku ezi-2.
I-Pyridoxine idonswa ekujikelezweni kwe-systemic futhi isatshalaliswa kuzitho nezicubu. I-80% yamavithamini B6 ibopha amaprotheni e-plasma futhi ingena kwi-placenta.
I-cyanocobalamin, uma idliwe, yakha amaprotheni okuhambisa amaprotheni, ingene ngokushesha emnkantsheni wethambo, isibindi nezinye izitho zomzimba. IVitamin B12 ibandakanyeka ezinqubweni zamathumbu-hepatic metabolic futhi ingena kwi-placenta.
Izithako ezisebenzayo zicutshungulwa yizinso futhi zichazwe emchameni.
Izinkomba zokusetshenziswa
Amacwecwe amiselwe:
- ukwelashwa kwezifo ze-neurological okubangelwa ukuntuleka kwamavithamini we-B (B1, B6);
- Ukwelashwa okubonakalayo kokuphuza ngokweqile kanye nesifo sikashukela.
Amacwecwe amiselwe ukwelashwa okubonakalayo kwe-alcoholic kanye nesifo sikashukela.
Ukufakwa kokunye nomuthi kusetshenziselwa ukuphazamiseka kwe-pathological of the neurological sphere:
- i-neuralgia (i-trigeminal nerve, neuralgia ye -ostostal);
- i-neuritis (i-retrobulbar neuritis yezinzwa yobuso);
- ukuvuvukala kwemisipha yemisipha;
- tinea versicolor;
- i-polyneuropathy yotshwala ne-diabetes;
- Ubuhlungu emgogodleni (i-radicular syndrome, i-plexopathy, i-dorsalgia, i-lumbar ischialgia).
Contraindication
Ithebhulethi kanye nesisombululo sokuphathwa kwe-intramusky akuvunyelwe kulezi zimo ezilandelayo:
- i-hypersensitivity kanye nokungabekezelelani ezingxenyeni zomuthi;
- ukuthambekela kokuphendula komzimba;
- i-psoriasis
- ukusabela okungekuhle komzimba ku-galactose noshukela;
- ukuntuleka kwe-lactase;
- isigaba esandayo sesilonda esiswini kanye ne-duodenal ulcer ngenxa yokwanda okungenzeka kwe-acidity yejusi yesisu;
- isikhathi sokukhulelwa nokuncelisa ibele;
- encane.
Ukwamukelwa kwalo muthi kuphambane ezinganeni ezincane.
Ngokunakekela
Iziguli ezinezifo zenhliziyo, ezinokwehluleka kwenhliziyo okubunjiwe, kanye nokulimala kokuphazamiseka kwinso nezinzwa hepatic, zibekelwa i-Vitaxone ngawodwana.
Ungayithatha kanjani i-Vitaxone
Isikhathi sezifundo zokwelashwa nomthamo sinqunywa udokotela oya kuye ngokuya ngokuxilongwa nesimo sesiguli. Ifomu eliqinile lomuthi liyanconywa ukuthatha amaphilisi angu-1 noma ama-3 ngosuku ngenani elilinganiselwe uketshezi izinsuku ezingama-30. Ngemuva kwenkambo yokwelashwa, isiguli kufanele sihlolwe kufanele ukuze sihlolwe.
Ezimweni ezinzima futhi lapho kukhona khona ubuhlungu obukhulu, umuthi ufakwa ujule emgudwini we-2 ml ngosuku. Ngemuva kokususa izimpawu zokuqhamuka kwalesi sifo - izikhathi ezi-2-3 ngesonto inyanga e-1.
Ezimweni ezinzima kakhulu futhi lapho kukhona khona ubuhlungu obukhulu, umuthi ufakwa ujule emgudwini 2 ml ngosuku.
Phakathi kwemijovo yesidakamizwa, kusetshenziswa ifomu lethebhulethi.
Ukuthatha umuthi wesifo sikashukela
Isifo sikashukela, ushukela obukhali ubonwa egazini, okuholela ekuthuthukisweni kwe-polyneuropathy. Lapho kutholwa isifo, uhlobo lokwelashwa lukhethwa ngudokotela ohambela yedwa. Ngaso leso sikhathi, kunconywa ngokushesha ukuguqulwa kokusetshenziswa kwethebhulethi yomuthi.
Isifo sikashukela, ushukela obukhali ubonwa egazini, okuholela ekuthuthukisweni kwe-polyneuropathy.
Imiphumela emibi
Lapho usebenzisa amaphilisi ezimweni eziwodwa, imiphumela elandelayo emibi iyabonakala:
- isifiso sokuhlanza;
- imivimbo ku-epidermis, ukulunywa, i-urticaria;
- ukwethuka kwe-anaphylactic;
- ukukhuphuka kwe-acidity yejusi esiswini;
- Ubuhlungu besisu, ukugaya ukudla;
- tachycardia.
Lapho usebenzisa amaphilisi ezimweni ezikhethekile, impendulo engemihle ngendlela ye-urticaria ingabonakala.
Ukusetshenziswa kwe-vithamini B6 izinyanga eziyi-6-12 kungadala ikhanda, ukuqaqanjelwa yizinzwa, i-peripheral sensory neuropathy.
Ngokuphathwa kwe-intramuscular of the drug, izimpawu ezingandile futhi ezidlula ngokushesha ziyaqapheleka:
- ubunzima bokuphefumula
- arrhythmia;
- isicanucanu
- Isiyezi
- iminyakazo
- ukujuluka ngokweqile;
- ukuqunjaza nokulunywa;
- I-edema kaQuincke;
- ukwethuka kwe-anaphylactic.
Ngokuphathwa kwe-intramuscular of the drug, izimpawu ezingavamile futhi ezidlula ngokushesha ziyaqapheleka, ngokwesibonelo, isiyezi.
Umthelela ekhonweni lokulawula izindlela
Uma imiphumela emibi ivela, isiguli siyelulekwa ukuba siqaphele. Ngokuqina kwesiyezi, ukwehluleka kanye ne-arrhythmias, umuntu kufanele ayeke izimoto zokuzishayela.
Imiyalo ekhethekile
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kuyenqatshelwa ngenxa yokuqukethwe okuphezulu kwe-vithamini B6 ekwakhekeni komuthi. Ukwedlula imithamo evunyelwe ngesikhathi sokukhulelwa kungenzeka kuphela esimweni sokushoda okutholakele kwe-thiamine ne-pyridoxine.
Ukusetshenziswa ngesikhathi sokukhulelwa kwenqatshelwe ngenxa yokuqukethwe okuphezulu kwe-vithamini B6 ekwakhekeni komuthi.
Izinga eliphakeme le-vithamini B6 linomthelela ongemuhle ekukhiqizweni kobisi lwebele.
Ukunquma i-Vitaxone ezinganeni
Akuvunyelwe ngenxa yokushoda kwedatha kokusabela komzimba wengane kulo muthi.
Sebenzisa ebudaleni
Umthamo nokuhleleka kokusetshenziswa kwomuthi kunqunywa udokotela ohambela yedwa.
Isicelo sokusebenza kokulimala kwezinso
Uma kukhonjisiwe, kugadwe uchwepheshe wezokwelapha.
Uma kwenzeka umsebenzi we-renal ophazamisekile, ukwelashwa kunqunyelwe ngaphansi kokuqondisa kukachwepheshe.
Sebenzisa umsebenzi wesibindi okhubazekile
Ngokuqapha phambi kokuhlolwa okujwayelekile kwezokwelapha.
Ukweqisa
Uma kwenzeka kusetshenziswa ngokweqile into esebenzayo, imiphumela emibi iyaqina: isicanucanu, isiyezi, ukuqina kokujuluka.
Uma kusetshenziswa amanani amaningi ento esebenzayo, ukujuluka ngokweqile kuyavela.
Ukwelashwa okubonakalayo kuyadingeka.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa kanyekanye kwe-adrenaline / norepinephrine nomuthi oqukethe i-lidocaine kusithinta kabi isimo senhliziyo.
Ukusetshenziswa kwezixazululo ezine-sulfite ekwakhiweni kwazo kunomthelela ekuqothulweni kwe-thiamine ngokuphelele.
Izidakamizwa eziqukethe i-Copper zikusheshisa ukuqhekeka kwe-benfotiamine. Okokugcina, ngaphezu kwalokho, akuhambisani nokuhlanganiswa kwe-alkali ne-oxidizing agents (iodide, i-acetate, i-mercury chloride, i-carbonate).
Imithamo yokwelapha uvithamini B6 inciphisa ukusebenza kwe-levodopa njengesakhi.
Ukuhlanganiswa kwesidakamizwa ne-cyclosporine, ipenicillamine, isoniazid ne-sulfonamides kuvunyelwe.
Ukuhambisana notshwala
Ukugwema imiphumela emibi yomzimba, isikhathi sokwelashwa, iziguli zidinga ukuyeka ukusetshenziswa kophuzo oludakayo.
Ukugwema imiphumela emibi yomzimba, isikhathi sokwelashwa, iziguli zidinga ukuyeka ukusetshenziswa kophuzo oludakayo.
Ama-Analog
Izidakamizwa ezifanayo esenzweni semithi:
- ETrigamai;
- I-Vitagamm
- Kombilipen;
- IMexidant;
- I-Hypoxene;
- IMexiprim;
- IMexidol;
- I-Neurox;
- Cytoflavin.
UMexidol ungenye yokufanekisa kweVitaxone.
Le mithi elandelayo ibizwa nangokuthi ukuqondanisa komuthi:
- Milgma
- Combigamma
- Neurorubin;
- I-Neuromax;
- Neurobion;
- INeurolek.
Izimo zokuphumula zeVitaxone kusuka ekhemisi
Umuthi onikezwe umuthi uyatholakala.
Umuthi onikezwe umuthi uyatholakala.
Ngingakwazi ukuthenga ngaphandle kadokotela
Kunamacala okuthengiswa kwalo muthi ngaphandle kokwethula incwadi egunyaziwe. Kodwa-ke, ukusetshenziswa kwalesi sidakamizwa kungenzeka kuphela uma kunobufakazi. Ukuzelapha kungasenza sibe nzima isimo sesiguli futhi kuholele emiphumeleni engenakuphikwa.
Intengo yeVitaxon
Izindleko ezimaphakathi zohlobo lwethebhulethi yezokwelapha e-Ukraine zingama-70 hhucnias izingcezu ezingama-30 iphakethe ngalinye. Intengo yomuthi kuma-ampoules ingama-75 hhucnias ngezingcezu ezi-5.
E-Russia, izindleko zamatafula (izingcezu ezingama-30 ngephakethe ngalinye) ziyahlukahluka kusuka kuma-ruble angama-200 kuya kwangama-300. Iphakheji equkethe ama-ampoules ayi-5 ibiza kusuka kuma-ruble ayi-150 kuye kwangama-250.
Izimo zokugcina zomuthi
Umuthi kumele ugcinwe endaweni emnyama. Izinga lokushisa eliphakeme elivumelekile lamathebulethi yi- + 25 ° C, ngama-ampoules - + 15 ° C.
Umuthi kumele ugcinwe endaweni emnyama. Izinga lokushisa eliphakeme elivumelekile lamathebulethi yi- + 25 ° C, ngama-ampoules - + 15 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka engu-2 kusukela ngosuku lokukhululwa komenzi.
Umkhiqizi weVitaxon
Inkampani yase-Ukraine i-PJSC Farmak.
Ukubuyekezwa mayelana neVitaxone
U-Irina, oneminyaka engama-42 ubudala, Kazan
Umuthi uyatholakala kuma-ampoules kanye namathebulethi. Ukwelapha i-neuralgia ye -ostostal, udokotela oyi-neuropathologist wanquma imijovo eyaba buhlungu kodwa isebenza. Angikwazanga ukuthola inkambo ephelele yokwelashwa ngemijovo, ngakho-ke kwadingeka ngiphuze amaphilisi. Lokhu kokugcina akuzange kube nemiphumela, yize bengiyisebenzisa izinsuku eziyi-10 zilandelana. Lapho kuvela ithuba, waphinde wavakashela isikhungo sezokwelapha ngomjovo we-2 ml.
UMikhail, oneminyaka engama-38, u-Irkutsk
Waqala ukusebenzisa umuthi we-osteochondrosis - ukuqaqanjelwa emuva emuva futhi wadonsa umlenze wesobunxele. Njengoba wachaza uchwepheshe wezinzwa, umuthi unomphumela omuhle kwezicubu zomzimba kanye nohlelo lwezinzwa. Esimweni sami, kwakudingeka ukwelashwa ngemijovo edambisa ukuvuvukala futhi yehlise izinhlungu. Ngemuva kwemijovo, ngizwe izinhlungu imizuzu eyi-10, futhi amashubhu ahlala endaweni yomjovo. Kepha ukungaphatheki kahle bekufanele - ekugcineni kwenkambo yokwelashwa, zonke izimpawu ezihambisana nazo zadlula.
URegina, oneminyaka engama-31, u-Elabuga
Umuthi wasiza ukuqeda i-pain syndrome nge-neuralgia, kepha ukusetshenziswa kwayo bekuhambisana nemiphumela emibi - isiyezi, ukujuluka ngokweqile. Ngaphambi kokunikeza umjovo, kubalulekile ukubonisana nodokotela wakho.