Izinhlobo zesifo sikashukela sohlobo 2 kufanele ziphuze izidakamizwa ze-hypoglycemic impilo yonke ukuze zigcine impilo ejwayelekile futhi zivikele nezinkinga zesifo.
Odokotela abaningi baluleka ukusebenzisa ama-Actos. Lokhu kuchungechunge lwe-thiazolidinedione lomlomo. Izici nokubuyekezwa kwalo muthi kuxoxwe ngazo esihlokweni.
Ukwakheka kwalo muthi
Isakhi esisebenzayo se-Actos yi-pioglitazone hydrochloride. Izinto ezisizayo yi-lactose monohydrate, i-magnesium stearate, i-calcium carboxymethyl cellulose, i-hydroxypropyl cellulose.
Izenzo 15 mg
Umuthi ukhiqizwa ngendlela yethebhulethi. Kukhona amaphilisi aqukethe into esebenzayo ekugxilweni kwe-15, 30 no-45 mg. Amakhebuli ayindilinga ngesimo, i-biconvex, anombala omhlophe. I- "ACTOS" igxishwe ngakolunye uhlangothi, kuthi "15", "30" noma "45" ngakolunye.
Izinkomba
I-Actos yenzelwe ukwelashwa kwabantu abanesifo sikashukela i-mellitus yohlobo olungathembeki kwe-insulin. Isetshenziswa ihlanganiswe namanye amaphilisi agqugquzela ukukhiqizwa kwe-insulin, imijovo ye-hormone, noma njenge-monotherapy.
Imiyalo yokusebenzisa
Esigulini ngasinye, udokotela ukhetha umthamo ngamunye. Izibhebhe zithathwa ngomlomo nengilazi yamanzi.
Umthamo okhethiwe usetshenziswa kanye ngosuku, ngaphandle kokudla. Nge-monotherapy, umthamo ojwayelekile ngu-15-30 mg. Uma kunesidingo, kuvunyelwe ukuletha ku-45 mg ngosuku (kancane kancane).
Lapho uthatha iphilisi esiswini esingenalutho, i-pioglitazone ku-serum itholakala ngemuva kwengxenye yehora, futhi ukugxilisa kwayo okuphezulu kuyabonakala ngemuva kwamahora ambalwa. Ukudla kubangela ukubambezeleka okuncane (kwamahora angama-1-2) ekufinyeleleni okuqukethwe okuphezulu kwengxenye esebenzayo ku-plasma.
Kepha ukudla akukuguquli ukugcwala kokugcwala. Kwenzeka ukuthi umuthi owodwa awanele. Ngemuva kwalokho i-endocrinologist ikhetha ukwelashwa okuhlanganisa.
Endabeni yokwelashwa okuhlanganisiwe, umthamo we-Aktos uncike emithini eyenziwe ngokufana:
- lapho kususelwa ku-sulfonylurea, i-metformin, khona-ke i-pioglitazone iqala ukuphuza nge-15 noma 30 mg. Uma isimo se-hypoglycemic senzeka, khona-ke umthamo we-metformin noma we-sulfonylurea uyancishiswa. Noma kuhlangene ne-metformin, ubungozi bokuqhamuka nesimo se-hypoglycemic lincane;
- lapho ihlanganiswa ne-insulin, umthamo wokuqala we-Actos ngu-15-30 mg. I-insulin isetshenziswa kumthamo owedlule noma incishiswe ngo-10-25% ngokuthuthukiswa kwe-hypoglycemia. Ukulungiswa okwengeziwe kuyenziwa kucatshangelwa izinga le-glucose ku-plasma.
Ayikho imininingwane ephathelene nokusetshenziswa kwama-Actos ngokuhambisana namalungiselelo we-thiazolidinedione. Lapho usebenzisa ukwelashwa okuhlanganisa, umthamo omkhulu ngu-30 mg ngosuku, esimweni se-monotherapy - 45 mg. Uma isiguli sinokuhluleka kwe-renal, ukulungiswa komthamo akudingeki.
I-Actos iyakwazi ukunciphisa ukusebenza kwezindlela zokuvimbela inzalo ngomlomo. Lapho kuhlangene ne-digoxin, i-glipizide, i-metformin kanye nama-anticoagulants angaqondile, ushintsho kuma-pharmacodynamics nakuma-pharmacokinetics alubonwa. I-Ketoconazole inethonya lokuvimbela i-metabolism ye-pioglitazone.
Odokotela bahlaziya ukusebenza ngempumelelo kwezindlela zokwelapha ngamathebulethi ngeHbAic. Ukuthatha i-ejog ye-hypoglycemic, kuyadingeka ukulawula umsebenzi wezinso, inhliziyo nesibindi.
Uma ukwephulwa okungathi sína kokusebenza kwalezi zitho kwenzeka phakathi nokwelashwa, umuthi uyakhanselwa ngokushesha bese kukhethwa ukwelashwa okusebenzayo.
Uma isiguli sisebenzisa i-ketoconazole ngasikhathi sinye njenge-Actos, ke kufanelekile ukulawula izinga le-glucose ku-plasma. Uma kwenzeka kweqa ngokweqile, kunengozi ye-hypoglycemia. I-antidote ayikho, ngakho-ke ukwelashwa okubonakalayo kuyenziwa.
Gcina ama-Aktos ekushiseni kwama-degrees ayi-15 kuya kwangama-+30 endaweni eyomile futhi emnyama, kude nezingane. Ngemuva kosuku lokuphelelwa yisikhathi, umuthi ulahlwa.
Ngaphambi kokusebenzisa, isiguli kufanele sijwayelane nemiphumela emibi engabakhona ngesikhathi sokwelashwa. Lokhu kufaka phakathi:
- ukwephulwa kokwethembeka kwamazinyo;
- i-anemia
- i-sinusitis
- umsebenzi owandayo we-CPK, ALT;
- i-hypoglycemia;
- i-myalgia;
- pharyngitis;
- ikhanda
- ukwehluleka kwenhliziyo okuguquguqukayo (kaningi ngokuhlanganiswa kwe-Actos ne-metformin);
- kwehle i-visual acuity njengomphumela wokukhula kanye nokuqhubekela phambili kwe-diemaic macular edema;
- ehlise i-hematocrit.
Izinguquko ezifanayo zivame ukuvela ngemuva kwezinyanga ezingama-2-3 zokwelashwa. Abesifazane abane-insulin ukumelana nemijikelezo ye-insulatrate esikhathini se-premenopausal banengozi ye-ovulation nokukhulelwa.
Ngesikhathi sokwelashwa, ivolumu yegazi ingakhuphuka, i-hypertrophic yesicubu senhliziyo ngenxa yokulayisha kuqala. Ngaphambi kokuqala kokwelashwa futhi njalo ezinyangeni ezimbili zokwelashwa ngonyaka wokuqala wokuthatha amaphilisi, umsebenzi we-ALT kufanele ubhekwe.
Contraindication
Ama-Actos akufanele akhethwe ukwelashwa kweziguli:
- ngaphansi kweminyaka eyi-18;
- ngesikhathi se-lactation (Akutholwanga ukuthi ngabe i-pioglitazone hydrochloride enobisi lwebele iyakhishwa);
- ngokuxilongwa kwe-ketoacidosis yesifo sikashukela;
- ngohlobo lokuncika kwesifo sikashukela;
- ngokuhluleka okukhulu kwenhliziyo (ama-degree ama-3-4);
- ngesikhathi sokukhulelwa (izifundo eziphathelene nokuphepha kokuthatha i-Aktos ngesikhathi sokubeletha azizange zenziwe);
- nge-edematous syndrome;
- lapho hypersensitivity to pioglitazone hydrochloride noma izingxenye ezisizayo zamathebulethi ziphawulwa.
Ngokuqapha, umuthi ubekelwe abantu abane:
- i-arterial hypertension;
- i-anemia
- infarction myocardial;
- i-edematous syndrome;
- isifo senhliziyo;
- ukwehluleka kwenhliziyo kwesigaba sokuqala;
- i-cardiomyopathy;
- ukwehluleka kwesibindi.
Izindleko
Umuthi usatshalaliswa kuphela ngomuthi obhaliwe. Izindleko zama-Aktos ziyahluka phakathi kwama-ruble angama-2800-3400.
Intengo incike kumthamo, ukutholakala kwezaphulelo emakhemisi asedolobheni. Ngakho-ke, iphakheji lamathebhulethi angama-28 elinesilinganiso sokusebenza esisebenzayo sama-30 mg sibiza cishe ama-ruble angama-3300. Iphakethe eligcina amaphilisi angama-28 we-15 mg lilinye libiza isilinganiso sama-ruble angama-2900.
Intengo ephezulu yenzelwa ukuthi umuthi ungenisiwe (kukhiqizwa e-Ireland). Amathebhulethi e-Actos hypoglycemic awathengiswa kuwo wonke ama-femu asedolobheni nasendaweni. Ukuthola isidakamizwa kulula ngezinkomba eziku-inthanethi.
Kukhona izinsiza ezikuvumela ukuthi uthole lonke ulwazi mayelana nemithi: intengo, ukutholakala kosokhemisi. Unga-oda futhi umuthi ekhemisi eliku-inthanethi. Lapha amanani angabizi kakhulu.
Kunconywa ukubheka umuthi ezikhangisweni abantu abavamile abazibeka. Namuhla kuneziza ezikhethekile eziklanyelwe ukuhambisa nokubuka izimemezelo ezithengiswayo.
Ukubuyekezwa
Mayelana nokubuyekezwa kwe-ejenti ye-hypoglycemic Aktos kweziguli ezinesifo sikashukela kuxutshwa. Labo bantu ababesebenzisa izidakamizwa zokuqala bathi kunenani elincane lokuphendula okungekuhle nokusebenza kahle okuphezulu. Kunezitatimende ezingezinhle: iziguli ziphawula ukubukeka kwe-edema enzima nokuthola isisindo, ukuwohloka kwe-hemoglobin.
Lokhu okulandelayo ukubuyekezwa kweziguli ezithatha ama-Actos:
- UPauline. Ngineminyaka engama-60. Kube nokoma ngemuva kokudla futhi kwehle isisindo esiningi. Ngokusekelwe emiphumeleni yokuhlolwa, udokotela wahlonza isifo sikashukela futhi wanquma ama-Aktos angama-30 kanye ngosuku. Lawa maphilisi athuthuka ngokushesha. Sekuyizinyanga ezimbili ngiphuza kubo, izinga likashukela ligcinwa ngaphakathi kwebanga elijwayelekile. Angibonanga ukusabela okungekuhle ngesikhathi sokwelashwa;
- I-Eugene. Nginesifo sikashukela sohlobo 2 sonyaka wesishiyagalombili. Muva nje ngishintshele kuma-Aktos ngamathebulethi eSiofor. Ngizwa kahle. Iqiniso kuphela elingelona iqiniso ukuthi ziyabiza futhi azithengiswa kuwo wonke amakhambi emithi;
- Tatyana. Sekuvele izinyanga ezimbili kuma-Aktos. Phambilini, izinga le-glycemia laliphezulu: i-glucometer ikhombise u-6-8 mmol / l. Manje phakathi nosuku ushukela aludluli uphawu lwe-5.4 mmol / L. Ngakho-ke, ngithatha i-Aktos isidakamizwa esihle;
- EValeria. Ngisebenzisa ama-Aktos ngokuhlanganiswa ne-insulin. Ukuhlolwa kwegazi ngesikhathi sokwelashwa sekuthuthukile, ayikho i-hyperglycemia. Kepha wabona ukuthi wayeseluleme, ikhanda lakhe lalibuhlungu ngezikhathi ezithile. Ngakho-ke, ngihlela ukubuyisela amanye la mapilisi amanye.
Amavidiyo ahlobene
Mayelana nezinhlobo zezidakamizwa ezisetshenziselwa ushukela kuvidiyo:
Ngakho-ke, ama-Actos anciphisa kakhulu ukugcwala kwe-glycemia ku-plasma, isidingo se-insulin. Kepha umuthi we-hypoglycemic awulungele wonke umuntu, futhi awubekezelelwa njalo njengengxenye yokwelapha okuhlanganayo.
Ngakho-ke, akufanele uzame impilo yakho futhi uthenge umuthi kwizeluleko zabangani. Isinqumo sokululeka ngokwelapha isifo sikashukela nge-Actos kufanele senziwe uchwepheshe.
