I-CardiASK isidakamizwa esiyingxenye eyodwa. Yenza imisebenzi eminingana ngasikhathi sinye: kunciphisa ubukhulu bokuvuvukala, ivimbela inqubo yamaplanethi we-gluing, amangqamuzana abomvu egazi. Ngenxa yalokhu, hhayi nje kuphela ukuthi isimo esijwayelekile siyathuthuka, kepha ubungozi bokuhlakulela i-venous thrombosis nabo buyancipha. Umuthi awunawo nolaka omncane kulwelwesi lwe-mucous lwethambo lesisu ukwedlula iningi leqembu le-NSAID. Lokhu kungenxa yokuba khona kolwelwesi olukhethekile olumboza amaphilisi.
Igama Lezwe elingafanele
Acetylsalicylic acid (ngesiLatini - Acetylsalicylic acid).
I-CardiASK isidakamizwa esiyingxenye eyodwa.
I-ATX
B01AC06 Acetylsalicylic acid
Khipha amafomu nokwakheka
Umuthi ungathengwa kuphela ngefomu lepilisi. Iphakethe liqukethe ama-pcs angama-30 noma angama-60. I-Acetylsalicylic acid isetshenziswa njengento esebenzayo. Ukuhlushwa kwethebhulethi engu-1 ngu-50 mg. Kungenzeka ukuthenga umuthi ngomthamo wento esebenzayo eyi-100 mg. Umuthi uyinto eyodwa, ezinye izakhi ezakhiwe azikhombisi imisebenzi yokulwa nokuvuvukala kanye ne-antiplatelet:
- i-acid entshontsha;
- isitashi sommbila;
- i-lactose monohydrate (ushukela wobisi);
- uwoyela we-hydrogenated castor;
- i-povidone;
- i-polysorbate;
- i-microcrystalline cellulose.
Umuthi ungathengwa kuphela ngefomu lepilisi.
Isenzo se-Pharmacological
Umuthi ubonakala ngezici ezifana: nokulwa nokuvuvukala, i-antipyretic, i-analgesic, i-antiplatelet. Ukwehla kwezinga lokushisa komzimba kungenxa yomthelela ezikhungweni ze-thermoregulation ze-hypothalamus. Ukuqina kobuhlungu kuyancipha ngenxa yekhono lama-salicylates (derivatives of ASA) ukufaka umphumela emsebenzini we-aldogenic we-bradykinin. Ngaphezu kwalokho, le nto ithinta izikhungo zokuzwa izinhlungu.
Umuthi okukhulunywa ngawo uthinta ukwenziwa kwama-prostaglandins, uvimbela ukwakheka kwe-adenazine triphosphate. Ngesikhathi esifanayo, ukwehla kwezinga lomsebenzi we-hyaluronidase kuyaphawulwa, imvume ye-capillaries iyancipha. Umgomo wokusebenza kwama-NSAIDs uyefana: inqubo engenakulungiswa yokuvimbela umsebenzi we-cycloo oxygenase isoenzymes iba. Ngokungafani nezinye izifaniso, umenzeli osuselwa ku-ASA ukhetha i-COX-1.
Ngasikhathi sinye, imvume yama-capillaries iyancipha.
Ama-enzymes weCycloo oxygenase-1 anikela ngokulawula ukukhiqizwa kwalawo ma-prostaglandins abhekele ukuthembeka kwe-mucosa emathunjini, ukugcinwa kokusebenza kweplatelet, kanye nokujwayelekile kokugeleza kwegazi lezinso. Umsebenzi oyinhloko we-CardiASK ukuvimbela umsebenzi walezi enzymes, okuholela kokuphazamiseka okuningi ekusebenzeni kwezitho nezinhlelo, ngokwesibonelo, ukwehla kokuqina kokuhlanganiswa kweplatelet, ngaphezu kwalokho, ukunamathela kwabo ezindongeni zemithambo yegazi kuyehla, kanjalo namandla okubambelela komunye nomunye. Umphumela uba umphumela we-antiplatelet.
Ngesikhathi esifanayo, umphumela ongemuhle esiswini uyaphawulwa. Ukuze unciphise lo mphumela, amaphilisi ahlanganiswe nomjovo we-enteric, ngenxa yokuthi into esebenzayo ikhishwa kancane kakhulu, le nqubo iqala ukukhula emathunjini. Ngenxa yalokhu, ulwelwesi lwama-mucous esiswini alivezwanga emiphumeleni eyingozi ye-acetylsalicylic acid, ukuqina kwemiphumela emibi kuyancipha.
I-Pharmacokinetics
Ukukhishwa kwento esebenzayo kwenzeka emathunjini amancane. Ukusebenza ngempumelelo kwezidakamizwa kutholakala emahoreni angama-3. Inqubo yokuguqulwa kwe-acetylsalicylic acid ikhula esibindini. Ngaphezu kwalokho, le nto isebenza kuphela ngokwengxenye. Ngenxa yalokhu, kuhlanganiswa amakhompiyutha angasebenzi kancane.
Inqubo yokuguqulwa kwe-acetylsalicylic acid ikhula esibindini.
Ingxenye-yokuphila imfushane - imizuzu eyi-15. Izinso zinesibopho sale nqubo. Ngaphezu kwalokho, kuyaphawuleka ukuthi ama-metabolites ento esebenzayo ashiya umzimba ngokuya kancane, kungakapheli amahora ama-3. Umphumela we-antiplatelet unikezwa ngokushesha, noma ngemuva kokuthatha inani elincane le-acetylsalicylic acid. Iyaqhubeka iviki eli-1.
Okusizayo
Izinkomba zokuqokwa kwezimali okukhulunywa ngazo:
- ukuvimbela ukuthuthukiswa kwe-myocardial infarction, uma kunezici ezingezinhle ezifaka ukubukeka kwalesi simo se-pathological, ngokwesibonelo, isifo sikashukela, umfutho wegazi ophezulu, isiguli esikhulile, ngokweqile, njll;
- ukuvimbela ukufakwa kwe-myocardial infarction;
- ukuvimbela ukuthuthukiswa kwe-ischemic stroke;
- ingozi ye-cerebrovascular;
- angina pectoris;
- ukuvimbela ukuvalwa kwemithambo yegazi yi-thrombus, amathuba okuba lokhu kukhuphuke ngesikhathi sokuhlinzwa, kanye nokungenelela okungahlaseli okubandakanya ukuhlaselwa kokuhlinzwa: i-coronary artery kanye ne-arteriovenous bypass grafting, endarterectomy kanye ne-angioplasty yemithambo ye-carotid;
- ukuvimbela ukuthuthukiswa kwezifo ezihambisana nokuvinjwa kwemithambo: i-venous thrombosis, i-pulmonary embolism, njll.
Izinkomba zokuqokwa kwesidakamizwa okukhulunywa ngaso - i-venous thrombosis.
Contraindication
Izimo eziningana ze-pathological ziyabonakala lapho kwenqatshelwe ukusebenzisa umenzeli okukhulunywa ngakho:
- ukusabela komuntu ongemuhle ngesikhathi sokwelashwa nge-acetylsalicylic acid, kanye nezinye izidakamizwa zeqembu le-NSAID eziqukethe ezinye izinto ezisebenzayo;
- ukuguguleka okukhula kulwelwesi lwama-mucous esiswini noma emathunjini;
- ukopha emgodini wokugaya ukudla;
- ukwephulwa komsebenzi wohlelo lokuphefumula ku-asthma ye-bronchial, eyathuthukiswa ngama-salicylates;
- i-Fernand-Vidal triad, ehambisana nokuvela kanyekanye kwezimpawu zokungabekezeleli ku-ASA, isifuba somoya nesifo se-sinus polyposis;
- i-diathesis, lapho kunokukhishwa kwegazi ngaphesheya kwezindonga zemikhumbi, kuleli cala, kunokushintshwa kombala wenamba engaphandle yangaphandle.
Ngokunakekela
Leli qembu lemikhawulo lifaka ukungqubuzana okuhlobene:
- umlando wokuphuma kwegazi nezinqubo zokuguguleka kusuka kwipheshana lesisu;
- gout
- i-hyperuricemia
- i-asthma ye-bronchial, engahlobene nokuchayeka kuma-salicylates, kanye nezinye izifo zokuphefumula;
- hay fever;
- ukuntuleka kwe-Vitamin K ne-glucose-6-phosphate dehydrogenase;
- i-sinus polyposis;
- ukungahambi kahle komzimba kunoma yiziphi izidakamizwa;
- ukusetshenziswa kanyekanye ne-metatrexate kumthamo ongeqi ku-15 mg ngeviki.
Iqembu lemikhawulo lifaka ukungqubuzana okuhlobene kokungafani komzimba kunoma iyiphi izidakamizwa.
Ungayithatha kanjani i-CardiASK
Amathebulethi kufanele aphuzwe ngamanzi, ngaphandle kokuhlafuna, ngoba ukugaya umuthi ngaphambi kokuhlela (kuze kube kungena amathumbu) kusongela ngezinkinga ezinkulu. Ukudla akukuphazamisi ukusebenza komuthi kanye nemetabolism yawo. Izinhlobo zokwelashwa ezijwayelekile zezifo ezahlukahlukene:
- ukuze uvimbele ukuqothuka kwe-myocardial kanye nezimo lapho kunobungozi bokukhula kwe-thrombosis noma i-thromboembolism: 0.05-0.2 g ngosuku, kuyamukeleka ukusebenzisa lesi sidakamizwa zonke ezinye izinsuku, kuleli cala inani le-ASA lenyuka laya ku-0.3 g ngosuku, okokuqala ithebhulethi iyahlafunwa, okuzomisa ngokushesha izimpawu eziyingozi zesimo se-pathological;
- phambi kwezici ezingezinhle ezifaka isandla ekuthuthukisweni kwe-myocardial infarction, hlela u-0,05-0.1 g ngosuku, ezimweni lapho umuthi uthathwa zonke ezinye izinsuku, umthamo ukhuphuka ufike ku-0,3 g;
- ukuvimbela ezinye izimo (ukuphindaphindwa kwe-myocardial infarction, angina pectoris, njll): 0.05-0.3 g ngosuku.
Umthamo ngqo, kanye nesikhathi sokwelashwa, kunqunywa kubhekisisa iminyaka yesiguli, ukuba khona kwezinye izifo kanye nesimo esijwayelekile somzimba.
Amacwecwe kufanele athathwe ngamanzi, ngaphandle kokuhlafuna.
Ukuthatha umuthi wesifo sikashukela
Kuvunyelwe ukusebenzisa umenzeli okukhulunywa ngakho ngokuxilongwa okunjalo, noma kunjalo, umthamo ungalandiswa, uma kunesidingo.
Imiphumela emibi ye-CardiASK
Okubi ngalo muthi yimiphumela emibi eminingana eyenzeka ngesikhathi sokwelashwa. Inani labo nobukhulu bayo buhlukile, okuthonywa uhlobo lwesifo nesimo sesiguli.
Amapheshana wesisu
Ukushaya kwenhliziyo, ukuhlanza ngokumelene nokucanuzelelwa kwenhliziyo, izilonda zokulimala kolwelwesi lwama-mucous wesistimu yokugaya ukudla, ukugcotshwa (ezimweni ezinzima), izinhlungu esiswini.
Imiphumela emibi I-CardiASK - Ubuhlungu esiswini.
Izitho zeHematopoietic
Ukopha kwe-GI, i-anemia.
Isistimu yezinzwa ephakathi
Ubuhlungu bekhanda nesiyezi, ukukhubazeka kwezindlebe.
Kusuka ohlelweni lokuphefumula
I-Bronchospasm.
Allergies
I-edema kaQuincke, izimpawu ze-urticaria (ukulunywa, ukuqunjelwa, ukucwazimula kwesikhumba), i-rhinitis, ukuvuvukala kwakhala, ukushaqeka kwe-anaphylactic.
Umthelela ekhonweni lokulawula izindlela
Ayikho imikhawulo, noma kunjalo, kungakuhle ukuthi usebenzise ukuqaphela ngenkathi ushayela.
Kuyelulekwa ukusebenzisa ukuqaphela ngenkathi ushayela.
Imiyalo ekhethekile
Uma umthamo womuthi udlulwa kaningi, amathuba okuba nezinkinga ezigulini ezinesifo sikashukela ayanda, ngokwesibonelo, i-hypoglycemia ingaqala ukwanda.
Ukudlula umthamo wesidakamizwa kwandisa ingozi yokopha.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokuzala ingane, kwenqatshelwe ukunikeza lesi sidakamizwa okukhulunywa ngaso ku-1st kanye ne-3 trimesters. Esigabeni sokuqala sokukhulelwa, ingozi yezinguquko ze-pathological ezicutshini ze-fetus iyanda. Ezinyangeni ezisanda kwedlula, kube nokuncipha kwezisebenzi.
Lapho uncelisa ibele, futhi awasebenzisi umuthi okukhulunywa ngawo. Lokhu kungenxa yokuthi ama-metabolites afaka ubisi lukamama.
Ukuqokwa kwe-CardiASK ezinganeni
Ayisetshenziswa ebuntwaneni.
Sebenzisa ebudaleni
Kuvunyelwe ukunquma umuthi. Inani lansuku zonke le-ASA alishintshi, kepha ukuqaphela kuyadingeka.
Kuvunyelwe ukunquma umuthi ekukhulelweni.
Isicelo sokusebenza kokulimala kwezinso
Ayisetshenziselwa ukusweleka kwalesi sitho. Umuthi unqunyelwe ukusebenza kwe-renal engasebenzi kahle, kuleli cala, imvume ye-renal iyahlolwa kanye nokuhlolwa kukadokotela kuyadingeka. Inani laleli pharamitha akufanele lidlule ku-30 ml / min.
Sebenzisa umsebenzi wesibindi okhubazekile
Ayibekelwe ukwehluleka kwalo mzimba. Umuthi ungasetshenziswa ngezinguquko ezincane nezilinganiselayo ekusebenzeni kwesibindi.
I-Cardiask Overdose
Ngokudakwa ngendlela efile, ukungazizwa kahle, isicanucanu, ukugabha, ukushintshwa kokungazi, isiyezi kungenzeka. Uma ingane iphuzile umuthi, i-metabolic acidosis ivame ukukhula. Ukwelapha ezimweni ezinjalo kuhlose ukuqeda ukweqisa kwento esebenzayo, etholakala ngokunciphisa kakhulu umthamo womuthi noma ukwesulwa kwawo, uthathe ikhabhoni esebenze kahle, yenza ibhalansi ye-electrolyte ibe sezingeni elifanayo.
Ngokudakwa ngokwefomu elincane, kungalimaza izindlebe.
Izimpawu zokudakwa kanzima:
- ukukhuphuka kokushisa komzimba kumanani amakhulu;
- umsebenzi wokuphefumula okhubazekile;
- ukwephulwa kwemali esele ye-electrolyte;
- ukwehla kwengcindezi, ukuvimbela ukusebenza kwenhliziyo;
- hyper- noma hypoglycemia;
- ukopha kwesisu;
- ukuthikamezwa kwezindlebe;
- i-encephalopathy enobuthi.
Ezimweni ezinjalo, ukulashwa kwesiguli kuyadingeka.
Ukuxhumana nezinye izidakamizwa
Ngokusebenzisa ngasikhathi sinye ngezindlela ezahlukahlukene, umphumela wazo ungathuthukiswa noma ucindezelwe:
- umphumela we-methotrexate uyathuthukiswa;
- ukuqina kwesenzo sama-anticoagulants kuyanda;
- kukhona ukwanda emiphumeleni ye-thrombolytic, izidakamizwa ze-antiplatelet;
- izinga le-digoxin egazini liyakhuphuka;
- umphumela wabenzeli be-hypoglycemic uyathuthukiswa;
- umsebenzi wezinto ezakhiweni zamalungiselelo we-uricosuric uyancipha;
- umphumela omuhle wokuthatha ama-salicylates wehliswa ngokuvezwa yi-GCS.
Ukuhambisana notshwala
Umuthi okukhulunywa ngawo ngenkathi uphuza iziphuzo eziqukethe utshwala unika ukubukeka kokuphuma kwegazi, ngenkathi kukhulisa isikhathi sabo.
Umuthi okukhulunywa ngawo, ngenkathi uphuza iziphuzo eziqukethe utshwala, unengxenye ekubonakaleni kokuphuma kwegazi.
Ama-Analog
Amakhambi aphumelelayo anganconywa:
- Acetylsalicylic acid;
- I-Thromboass;
- I-Cardiomagnyl;
- Aspirin;
- Aspirin Cardio;
- I-Thrombopol, njll.
Imibandela yekhefu lekhemisi
Ukuthenga umuthi, ayidingeki incwadi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Kukhona ithuba elinjalo.
Intengo ye-CardiSC
Izindleko ezijwayelekile eRussia ngama-ruble angama-70-90.
Izimo zokugcina zomuthi
Izinga lokushisa elisekamelweni akufanele lidlule + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Isikhathi esivumelekile sokusebenzisa umuthi kusukela ngosuku lokukhululwa yiminyaka emi-2.
Umkhiqizi
ICanonfarm Production, eRussia.
Ukubuyekezwa mayelana ne-Cardiask
UValeria Vasilievna, oneminyaka engama-55, uSamara
Ngiyasithanda lesi sidakamizwa, ngoba kufanelekile ukusiphuza. Ithebhulethi ayidingi ukuhlukaniswa, njengoba kunjalo ngo-Aspirin. Yebo, futhi intengo yinhle.
UVeronika, oneminyaka engama-33, u-Omsk
Nginemiphumela emibi ngenkathi ngithatha i-CardiASK: yenza umsindo ezindlebeni zami, ngizizwe nginesiyezi. Udokotela unikeze irejimeni - phuza umuthi zonke ezinye izinsuku. Kepha bekufanele nginciphise umthamo ngenxa yokusabela okungekuhle.
