I-Diroton iyisidakamizwa esivame kahle ekwelapheni i-pathologies yenhliziyo, kubandakanya ne-hypertension ye-arterial kanye nokungakwaneli kwemisipha yenhliziyo. Ngokuvamile kusetshenziselwa ukwephula ukuhamba kwegazi emithanjeni.
I-ATX
C09AA03
I-Diroton iyisidakamizwa esivame kahle ekwelapheni i-pathologies yenhliziyo, kubandakanya ne-hypertension ye-arterial kanye nokungakwaneli kwemisipha yenhliziyo.
Khipha amafomu nokwakheka
Kutholakala kuphela ezibhebheni. Lapho uthenga, kufanele unake umthamo, kuya ngokuthi ijamo lephilisi lingase lihluke kanjani, yize wonke emhlophe. Kukalwe - 2,5 mg lilinye, liyisicaba (ngesimo sediski) - 5 mg lilinye, ama-convex amajiko angajwayelekile - 10 mg no-20 mg lilinye.
Isisekelo somuthi yi-lisinopril exhaswe nge-magnesium stearate, starch, talc ne-calcium hydrogen phosphate.
Ukuthengisa okufakwa emabhulokini akhethekile angu-14, afakwe kumakhadibhodi ezinqwaba zama-1-4 ama-PC.
Isenzo se-Pharmacological
Umuthi yi-ACE inhibitor (angiotensin eguqula i-enzyme). Lapho sithathwa ngomlomo, simunca ngokushesha futhi singene egazini. Isiza ngokwejwayelekile umfutho wegazi, ihambisa imithambo emikhulu, enomthelela ekugculisweni kwegazi okungcono kwezitho zangaphakathi. Amandla enhliziyo okumelana nokuzivocavoca ayanda.
Uma udla umuthi njalo, kungaholela ekunciphiseni kwezinqubo ze-hypertrophic ku-myocardium.
Uma udla umuthi njalo, kungaholela ekunciphiseni kwezinqubo ze-hypertrophic ku-myocardium. Imisipha yenhliziyo ethinteka yi-ischemia inikezela ukuhamba kahle kwegazi.
Ngosizo lwethuluzi, kungenzeka ukwelula impilo yabantu abanomlando okhombisile ukwehluleka kwenhliziyo. Isenzo somuthi siqala ngokwesilinganiso ngemuva kwehora, futhi umphumela wokwelapha uqhubeka ufike ngosuku.
Ngokuphazamiseka okubukhali ekwamukelweni, i-syndrome yokuhoxisa ingahle ivele, engadala inkinga yomfutho wegazi osheshayo.
I-Pharmacokinetics
Kukhishwe emgodini wokugaya ukudla. Ngemuva kwalokho, i-lisinopril ngqo kwi-plasma yegazi ibopha ezinhlakeni zamaprotheni. I-bioavailability yesidakamizwa icishe ibe ngama-30%. Izinga lokuncela aliguquki nganoma iyiphi indlela lapho kuguqulwa isidlo.
ILisinopril ayikho ngaphansi komzimba, ngakho-ke ichithwa ngemuva kwamahora ayi-12 nomchamo ungashintshiwe.
Okusizayo
Ngaphezu kokunciphisa ingcindezi, into iyasiza ukunqoba ezinye izifo:
- Umfutho wegazi ophezulu we-Arterial. Umuthi ubekwa njengengxenye yokwelashwa okuyinkimbinkimbi kanye neminye imithi.
- Ukwehluleka kwenhliziyo okungapheli. Isetjenziswa ihlanganiswe ne-digitalis decoctions, inkambo yokuhlwaya umzimba.
- Isifo sikashukela sikashukela. Kusetshenziswa uma isifo sikashukela sihambisana ne-arterial hypotension.
- I-Myocardial infarction. Kunqunyelwe ukuthi kugcinwe umfutho wegazi ojwayelekile futhi uvikele ukuthuthukiswa kokuhluleka kwenhliziyo ku-ventricle yangakwesobunxele.
Ukuzikhethela kokwelashwa kufanele kusondelwe ngokufanelekile.
Ngabe kunqunyelwe yiphi ingcindezi?
Umuntu ngamunye unezinkomba zokucindezela komuntu ngamunye. Emiyalweni yokusetshenziswa, akukho kukhomba ukuthi yiziphi izinkomba zokucindezela amaphilisi okufanele aphuzwe. Ngakho-ke, isidingo sokuthatha umuthi, kanye nomthamo kufanele unqunywe ngudokotela.
Contraindication
Umuthi unqunywa kuphela ngemuva kokuthola imiphumela yokuhlolwa ngokuphelele kwezokwelapha. Ngaphambi kokuqala ukwelashwa, kufanele utadishe ngokucophelela imiyalo, ngoba umuthi une-contraindication:
- ukungabekezeleli kwezinye izingxenye;
- iminyaka yengane ifinyelela eminyakeni eyi-6;
- ukungezwani komzimba (ukuthi kungenzeka i-edema kaQuincke ingabandakanywa);
- isikhathi sokukhulelwa nokuqunjelwa.
Ukuqapha kumele kusetshenziswe lapho kukhona ama-pathologies athile nezimo zomtholampilo:
- umsebenzi wezinso ongonakalisiwe;
- i-stenosis yemikhumbi emikhulu;
- ukomisa kakhulu;
- isikhathi emva kokufakwa kwezinso;
- izifo zenhliziyo ezingalapheki futhi ezinzima;
- ingcindezi encishisiwe kakhulu;
- inhliziyo ischemia;
- isifo sikashukela mellitus;
- izifo ezithinta izicubu ezithintekayo;
- i-potasium ephansi ne-sodium egazini.
Konke lokhu kuphambana kumele kubhekwe ngaphambi kokuqala ukuthatha.
Mhlawumbe ukuthuthukiswa kokuphikiswa okungahambi kahle kanye nezinkinga ezingafuneki ezithinta kabi ukusebenza kwezitho zesimo kanye nesimo esijwayelekile somzimba wesiguli.
Ungayithatha kanjani
Kunconywa isilinganiso esisodwa somuthi ngosuku. Ukugeza ngamanzi. Ukusetshenziswa kwomuthi akuxhomeki esikhathini sosuku noma ekudleni kokudla, kepha kungcono ukusiphuza ekuseni. Eqenjini ngalinye lezifo kukhona uhlobo lomuthi:
- Nge-hypertension ye-arterial, kubalwa i-10 mg ngosuku. Ngemuva kwalokho baphendukela kumthamo we-20 mg, obonwa njengowokusekelwa. Ezimweni ezinzima kakhulu, ukwanda okufika kuma-40 mg ngosuku kungenzeka. Umphumela omuhle wokusetshenziswa kwesikhathi eside kwenzeka ngemuva kwamaviki ama-2 wokwelashwa okuhlala njalo.
- Ngomfutho we-renovascular hypertension, umthamo ophelele nsuku zonke akufanele neze ube ngaphezulu kuka-5 mg. Lapho-ke umthamo uzoncika ekujuleni kwezimpawu zezimpawu zomfutho we-arterial.
Uma ngomthamo ojwayelekile wethamo eliphakeme awukho umphumela oyifunayo, khona-ke umuthi ubuyiselwa. Yonke imishanguzo ye-diuretic iyakhanselwa.
Uma kutholakala izimpawu zokuhluleka kwenhliziyo okungapheli, i-lisinopril kumele ihlanganiswe ne-diuretics. Kepha umthamo wokugcina wehliswa waba ubuncane.
Ngokungasebenzi kahle kwezinso, umthamo uzoncika ekuthini imvume ye-creatinine. Ukwehliswa kwenani lesamba, elingezansi lizoba yidosiosopril. Umthamo wokulungisa owengeziwe unqunywa izinkomba zokucindezela.
Ukuthatha umuthi wesifo sikashukela
Kunqunyelwe kumthamo osebenza okungenani okungenani. Kukho konke ukwelashwa, udinga ukulawula ukugcwala kweglucose egazini.
Imiphumela emibi
Ubuhlungu bekhanda nesiyezi, uhudo, isicanucanu, ubuthakathaka obujwayelekile, ubuhlungu besifuba, ukukhwehlela okuhlala isikhathi eside, ukuqubuka kwesikhumba komzimba.
Ezinye izimpawu zihlukaniswa zodwa, ngoba ukwenzeka kwabo kubangelwa ukuphazamiseka esimweni sezitho ezahlukene zomzimba.
Amapheshana wesisu
Ukuphazamiseka kwesistimu yokugaya ukudla kuyabonakala. Izimpawu eziphambili ukuhanjiswa yisisu, ukugabha, umlomo owomile, ubuhlungu besisu obukhulu, izimpawu ze-hepatitis, jaundice ne-pancreatitis.
Izitho zeHematopoietic
Uma umuthi ungathathwanga kahle, uhlelo lokujikeleza luyakwazi nokuhlupheka. Izimpawu ziyavela: i-neutro- kanye ne-leukopenia, i-anemia, kunciphile ukuqina kwe-hemoglobin egazini.
Isistimu yezinzwa ephakathi
Ukusuka ohlelweni lwezinzwa kunokuphazamiseka, ukugxilisa ingqondo kokuphazamiseka nokuxhumana kokunyakaza, ukuguquguquka kwemizwelo ebukhali, ukozela okwandayo nokunganaki. Kwezinye izimo, ukuvela kanye ne-paresthesias kungenzeka.
Engxenyeni yesistimu yezinzwa, imiphumela emibi yesidakamizwa ibonakala ngendlela yokuphazamiseka nokuxineka okungasebenzi kahle.
Kusuka ohlelweni lomchamo
Ukusabela kohlelo lokuchama kubonakaliswa yi-uremia, i-oliguria, ukwehluleka kwezinso kanye nokwehla okuthile kwe-potency emadodeni.
Kusuka ohlelweni lokuphefumula
Izimpawu zokungasebenzi kahle kokuphefumula: ukubukeka kokhwehlela owomile kanye nomsipha wemikhumbi ye-bronchial. Kwezinye izimo, i-dyspnea ne-apnea kuyaphawulwa.
Kusuka ohlelweni lwezinhliziyo
Ukuphazamiseka kwesistimu yenhliziyo kubonakaliswa ukwehla komfutho wegazi nokucindezela izinhlungu esifubeni. I-Tachycardia noma, ngakolunye uhlangothi, i-bradycardia kwesinye isikhathi iyaphawulwa. Mhlawumbe ukuthuthukiswa kwe-myocardial infarction.
Engxenyeni yesikhumba
Engxenyeni yesikhumba, kungavela ukuvela kwe-photosensitization. Ukulunywa nezinsimbi kungenzeka.
Kukhona ukujuluka okunzima nokuqothuka ngokweqile kwezinwele.
Allergies
Ukuvela kwe-allergic kungakhula (kuze kufike ku-angioedema Quincke edema).
Imiyalo ekhethekile
Kunemiyalo ekhethekile emiyalweni yomuthi. Kudingeka zifundwe ngokucophelela ukuze kugwenywe izinkinga ezingafuneki.
Ukuhambisana notshwala
Ukudla ndawonye neziphuzo eziqukethe utshwala akufanele kuvunyelwe, ngoba wonke umphumela wokwelapha umuthi ulahlekile.
Ukusetshenziswa okuhlangene kwesidakamizwa neziphuzo eziqukethe utshwala akufanele kuvunyelwe, ngoba wonke umphumela wokwelapha umuthi ulahlekile.
Umthelela ekhonweni lokulawula izindlela
Umuthi unomphumela wokuvimbela ohlelweni lwezinzwa, unciphisa ukugxilwa futhi ubangele ukukhathala okwandayo nobunzima, ngakho-ke kungcono ukuyeka ukushayela.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ayabelwe abesifazane ngesikhathi sokuzala ingane. ILisinopril yeqa i-placenta kahle futhi imvamisa ibangela ama-pathologies wokukhula kwengane. Ukusetshenziswa kwesidakamizwa ezigabeni zakamuva kungavusa ukushona kwe-fetus ngaphambi kokuzalwa kwayo noma ukukhula kokuhluleka kwe-renal enganeni ezelwe.
Uma umuthi uthathwe ngaphambi kokukhulelwa, udinga ukwazisa udokotela wezifo zabesifazane ngalokhu. Abesifazane abanjalo babhalisiwe, bahlala begadiwe ngaphambi kokuzalwa kwengane.
Akunconyelwe ukuphuza umuthi ngesikhathi sokuqunjelwa, ngoba akukho datha ethembekile yokuthi ingabe into esebenzayo ingena kubisi lwebele. Uma kunesidingo somuthi, kungcono ukuyeka ukondla.
Kunquma uDiroton ezinganeni
Ayikaze isetshenziswe ezinganeni.
Sebenzisa ebudaleni
Ngokuqapha ngokweqile.
Ukweqisa
Uma ungagcini umthamo odingekayo womuthi, ikakhulukazi ngokulawulwa isikhathi eside, kungaba nezimpawu ezingemnandi zokweqisa:
- ukwehla okukhulu kwengcindezi, ukuhamba kwegazi eliphansi emithanjeni, ukuwa;
- i-tachycardia;
- isiphazamiso, sinciphise ukunaka;
- umlomo owomile, ohambisana nokoma okungapheli;
- i-lethargy kanye nokwehla okungenzeka kokuphendula kwe-Reflex.
Uma ungahambisani nomthamo odingekayo womuthi, ikakhulukazi lapho uwuthatha isikhathi eside, umlomo owomile ungavela, uhambisane nokoma okungapheli.
Uma kwenzeka lezo zimpawu, isiguli kufanele siphuthunyiswe ngokuqondile esibhedlela. Ukuthatha umuthi kuyakhanselwa ngokushesha. I-overdose iphathwa nge-gastric lavage. Ngemuva kwalokho isiguli sinikezwa amaphilisi ambalwa we-carbon ocushiwe futhi nokwelashwa okubonakalayo, okufanele kuhlale kuze kube yilapho izibonakaliso zokweqisa zingasebenzi ngokuphelele.
Ukuxhumana nezinye izidakamizwa
Lapho usetshenziswa ngama-diuretics e-potassium, ubungozi be-hyperkalemia buyanda. Nge-infusions enjalo, umsebenzi wezinso nenhliziyo uvinjelwe.
Uma isetshenziswa ngama-alpha-blockers, ingcindezi iyehla, ngakho-ke ukulawula okuqinile kuyadingeka. Umphumela we-antihypertensive ukhuphuka ngokusetshenziswa kwawo okuhlanganyelanayo nabathile bokuncishiswa kwezidakamizwa.
Umphumela wokwelapha we-lisinopril uncishiswa yizidakamizwa ezithile ezilwa nokuvuvukala. Ukungena ezindongeni zamathumbu kukhubazeka ukwelashwa kwe-antacid.
Abesifazane abafuna ukuzivikela ekukhulelweni okungafuneki badinga ukwazi ukuthi umuthi unciphisa ukusebenza kwezindlela ezithile zokuvimbela inzalo ngomlomo.
Ungangena kanjani esikhundleni
Kunezindlela eziningi zokufana ezinomphumela ofanayo wokwelapha:
- Co Diroton;
- Vitopril;
- Ikhonsathi;
- I-Lysinocore;
- I-Lozap.
Ngaphambi kokukhetha okunye, kufanele uthintane nodokotela wakho mayelana nokufaneleka. Uchwepheshe kuphela ongasho ukuthi iliphi ithuluzi okungcono ukulisebenzisa.
Imibandela yekhefu lekhemisi
Ngokuyalelwa ngudokotela kuphela. Ayitholakali mahhala.
Kubiza malini uDiroton
Intengo ezitolo zezidakamizwa icishe ibe ngama-ruble angama-90.
Izimo zokugcina zomuthi i-Diroton
Gcina endaweni emnyama endaweni yokushisa yasekamelweni.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Ukubuyekezwa kwe-Diroton
Izazi zezenhliziyo
UZhikhareva O. A., eSt. Petersburg: "Kuyadingeka ukunquma kaningi ngenkambo efanayo kanye nemithi ye-antihypertensive. Ngokuqhubeka komfutho we-arterial hypertension, umuthi kufanele uphuzwe kuphela ngethebhulethi 1. Ngaphambi kokuqokwa, isimo sezinso kufanele sihlolwe."
UZubov V. L., Penza: "Umuthi muhle, cishe awuphethi lutho olubi. Lusebenza ngokushesha, kepha alulungele zonke iziguli. Kulabo abanomfutho wegazi ophakeme njalo, ukuphuza iphilisi elilodwa akusizi ukwehlisa umfutho wegazi. Angikucebisi ukuthatha umuthi ezigulini ezinegciwane. imithambo ye-varicose. "
Iziguli
U-Alexander, oneminyaka engama-43, uSaratov: "Umuthi awubi kangako. Kepha kube nezinkinga ezithile ezingezinhle. Ikhanda lami lalimala, kwavela ukukhwehlela okungabekezeleleki kanye nokuqhuma kwesikhumba. Konke kwahamba ngokushesha ngemuva kokuyeka ukuwusebenzisa. Bekumele ngikhethe omunye umuthi."
UValentina, oneminyaka engama-52, eMoscow: "Udokotela wancoma ukuyithatha njalo ekuseni. Ngiyayenza. Iba ngcono ngomthamo ngamunye. Ingcindezi ibuyele esimeni esejwayelekile, i-arrhythmia nayo yanyamalala. Ikhanda lami laqala ukulimala kancanyana. Isimo sami sempilo esithuthukile sesithuthuke kakhulu. Inkambo yokwelashwa ayikapheli okwamanje. Ngizoqhubeka. qhubeka nokwamukela. "
U-Irina, oneminyaka engama-48, uKursk: "Ngokusebenzisa njalo, umphumela uyabonakala. Kepha ngokuya ngokwami ngangiqiniseka ukuthi ngethamo elilodwa ukwehlisa ingcindezi, umuthi awusebenzi. Ingcindezi yahlala iphakeme, ngisho nomthamo owandisiwe nokusetshenziswa okuphindaphindiwe akuzange kusize. Bekumele ngiphuze esinye isidakamizwa. "