YINI I-GLYCATED HEMOGLOBIN? - UKULAWULWA KWESIFO SIKASHUKELA

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I-Glycated hemoglobin (glycogemoglobin) indlela entsha yokuxilonga. Ikuvumela ukuba wahlulele izinga lokuthuthukiswa kwesifo sikashukela kanye nezinkinga zalo.

I-Glycohemoglobin ikhombisa ukuthi kungenzeka i-neuropathy, isifo se-coronary, unyawo lwesifo sikashukela, futhi ibuye ikhombise ukuthi ngabe umthamo we-insulin wohlobo 1 sikashukela ubalwa kahle yini. Ake sibheke ukuthi luyini lolu hlaziyo. Unganikela kanjani ngegazi nge-glycogemoglobin nokuthi uyiqonda kanjani imiphumela?

I-Glycated hemoglobin: i-biochemistry yenqubo yangaphakathi

Isikhathi sokuphila kwamangqamuzana abomvu egazi ahanjiswa yi-hemoglobin izinsuku ezingama-90-120. IHemoglobin inobuthi ngokwayo, kodwa iyadingeka ukuze kuthunyelwe i-oksijini ye-pulmonary alveoli yayo kumaseli wezitho ezahlukahlukene. Ngenxa yobuthi, i-molecule ye-hemoglobin ifakwe ngaphakathi kwengqamuzana legazi elibomvu, ingqamuzana elibomvu legazi.

Ehlelweni lokuphila, ukusabela kwamakhemikhali okungaphenduki kwenzeka phakathi kwengxenye yamaprotheni ye-hemoglobin (globin) neglucose yegazi. Njengomphumela walokhu kusabela, glycogemoglobin.

Igama elithi "alinakuguqulwa" lisho ukuthi ukusabela okuguqukayo akunakwenzeka. Uma i-globin yake yaphenduka ushukela, khona-ke into eyakhiwe izoba njalo kuze kube sekupheleni kwempilo yengqamuzana elibomvu legazi.

Le mpahla ibiyisisekelo sokuxilongwa kwesifo sikashukela, lapho kusetshenziswa ukuhlaziya kwe-hemoglobin ye-glycated ukuthola amazinga kashukela.

Yini umehluko phakathi kokuxilongwa okusha nokuhlolwa koshukela okujwayelekile?

Ukuhlaziywa kwe-Glycogemoglobin: izici nezinzuzo

Ukuhlola ushukela wegazi ngokwesiko kunquma inani lokuzila kweglue glucose.

Okubi ngalolu cwaningo ukuthi kukhombisa umphumela wesikhashana, izinga likashukela manje.

Kulokhu, isiguli esinohlobo lwesifo sikashukela sokuqala singaba noshukela omningi ngemuva kokudla (uma isilinganiso se-insulin sasingabalwa kahle).
Ngohlobo 2 sikashukela, ushukela ophezulu kungenzeka ngezikhathi ezithile uma ukudla kungalandelwa.
Mhlawumbe ukukhuphuka kweushukela ngokweqile. Kulokhu, ukutholakala kokuzila kwegazi lasekuseni kuzokhombisa umphumela ocishe ube yinto ejwayelekile, ukukhuphula kancane ushukela wegazi ekuseni. Futhi izinkinga zizokhula ngokushintshana okugcwele.

Ukuhlolwa kwe-hemoglobin ye-glycated kukhombisa amaphesenti amangqamuzana egazi egazi.

Ngaphezu kwalokho, konke ukweqa kweglucose phakathi nezinyanga ezintathu kuzobonakala kwisilinganiso esandisiwe se-glycogemoglobin. Ukuphakama kwale nkomba, kulapho inani le-glucose likhuphuka kakhulu emikhunjini. Lokhu kusho ukuthi izinkinga eziningi zesifo sikashukela zakha ezinye.

Kukhona enye indlela yokulawula ushukela wakho - imitha yeglucose yasekhaya nemichilo yokuhlola.

Ezigulini ezinesifo sikashukela, kunconywa ukuyisebenzisa kanye ngesonto. Kulolu vivinyo, iziguli ezinesifo sikashukela zilawula ushukela wegazi kaningana ngosuku:

ngaphambi kokudla konke
2 amahora emva kokudla ngakunye,
ngaphambi kokulala
nasebusuku, ngehora lesithathu.

Lokhu kukalwa kubizwa glycometric profile, yakha isithombe esiphelele kakhulu kunokuhlaziya okujwayelekile ushukela, kepha engaqedi ngokwanele ukuthola izinkinga nokulawula umthamo we-insulin.

Ungayiqonda kanjani imiphumela yokuhlaziywa?

Njengoba iseli elibomvu legazi lihlala izinsuku ezingama-120, imiphumela yokuqukethwe kwe-hemoglobin ye-glycated ikhombisa ubukhona bamazinga eglucose ezinyangeni ezintathu ezedlule.

Ngasikhathi sinye, ngaphezu kwengxenye yemizimba etholwe glycated ingeyanyanga edlule (ngaphambi kokuhlolwa). Okusho ukuthi, ukuhlaziya kukhombisa inani eliphelele loshukela wegazi ikakhulukazi esikhathini esiyinyanga eyodwa nesigamu kuya kwezimbili.

Kumuntu ophilile, ukuhlaziywa kwe-HbAIc (inkomba ye-glycated) kungu-4-6%.

Ezigulini ezinesifo sikashukela sanoma yiluphi uhlobo, okuqukethwe yi-glycohemoglobin (HbAIc) kuze kube ngu-6.5% kubhekwa njengesibonakaliso esihle, esibonisa ukuhambisana nokudla (okunesifo sikashukela sohlobo 2) nokubalwa okuyikho komthamo we-insulin (uhlobo 1 sikashukela).

Ukunyuka okwengeziwe kwesikhombi kukhombisa ukwakheka kwezinkinga zesifo sikashukela nesidingo sezinguquko.

Isiguli sohlobo 2 sikashukela sidinga ukulawula imenyu futhi sinikeze izinga lomsebenzi we-motor.
Isiguli esitholakala sinesifo sikashukela sohlobo 1 sidinga ukulungiswa komthamo womjovo we-insulin.

Uma inkomba ye-glycohemoglobin idlula okujwayelekile ngamaphesenti angaphezu kuka-7, ukulungiswa okuphuthumayo kokudla komsoco ne-insulin kuyadingeka.

Ngaphezu kwalokho, kukhona ukuxhumana okuningi kwamazinga kashukela kanye nama-glycogemoglobin. Bayakuvumela ukuthi uthole isifo sikashukela noma usikhansele. Sinikeza lezi zinkambiso:

Inkomba ye-glycated ye-4-5,5% ifana noshukela wegazi kuze kufike ku-4-5.3 mmol / l, asikho isifo sikashukela.
I-6.5% ihambelana no-7.2 mmol / l futhi ikhombisa ukuthi isiguli singasakha isifo sikashukela kungekudala (igama elithi ukwelashwa liqembu eliyingozi lesifo sikashukela).
I-7% nangaphezulu ihambelana nokungaphezulu kwe-8.2 mmol / l futhi kukhombisa ukuba khona kwesifo sikashukela.

Ungakudlulisa kanjani ukuhlaziya?

Ngokwezimiso zemibono, ukuhlolwa kwegazi kwe-glycated hemoglobin kungathathwa nganoma yisiphi isikhathi sosuku, kungakhathalekile ukuthi kudliwe (ngaphambi noma ngemuva). Kodwa-ke, ama-laboratri amaningi alawula ukwamukela izivivinyo ekuseni ngesisu esingenalutho. Akunconyelwe ukubhema ngaphambi kokuhlola.

Ingabe i-glycated hemoglobin ihlala isiza ukuthola isifo sikashukela? Kuyavela, cha.

Kunezimo lapho izinga lokuhlolwa lingahambelani nesigaba sangempela sesi sifo. Ungathembela nini kumphumela wokuhlaziywa?

Uma esikhathini sezinyanga ezintathu ngaphambi kokuhlolwa (futhi ikakhulukazi ngenyanga edlule) isiguli sathola ukulimala ngokulahlekelwa okukhulu kwegazi.
Uma kwenziwe ukumpontshelwa kwegazi.

Lezi zinto zinciphisa iphesenti lesikhombisi liye ezingeni elijwayelekile, ngenkathi lesi sifo uqobo singathuthuka.

IGlycated Hemoglobin - Ukuhlaziywa okubalulekile ekutholakaleni kwesifo sikashukela nokuthi kungenzeka ukuthi kuthuthukiswe izinkinga zako. Kusukela ngonyaka ka-2011, i-World Health Organisation yamukele inkomba njengekhombandlela eyinhloko yokuthola isifo sikashukela.

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