Ngemuva kokufunda le ndatshana, uzofunda ukwelapha isifo sikashukela sohlobo 2 bese kuthi kwezinye izikhathi uthayiphe isifo sikashukela esingu-1 ngosizo lwezibhebhe. Uma unesifo sikashukela, khona-ke usuvele ubonile esikhunjeni sakho ukuthi odokotela abakwazi okwamanje ukuziqhenya ngempumelelo yangempela ekwelashweni kwesifo sikashukela ... ngaphandle kwalabo abaye bahlupheka ukuze batadishe indawo yethu. Ngemuva kokufunda leli khasi, uzokwazi okuningi ngemithi yesifo sikashukela kunokuya emtholampilo we-endocrinologist emtholampilo. Futhi okubaluleke kakhulu, ungawasebenzisa kahle, okungukuthi, ubuyisele ushukela wegazi kokujwayelekile futhi uthuthukise impilo yonke.
Ukwelashwa yizinga lesithathu lokwelashwa kwesifo sikashukela sohlobo 2. Kuyaqondakala ukuthi uma amazinga amabili okuqala - ukudla okune-carbohydrate ephansi kanye nemfundo yokomzimba ngentokozo - akusizi ukugcina ushukela ojwayelekile egazini, lapho-ke kuphela lapho sizoxhuma amaphilisi. Futhi uma izidakamizwa zingasizi ngokwanele, izinga lesine lokugcina imijovo ye-insulin. Funda kabanzi mayelana nokwelashwa kwesifo sikashukela sohlobo 2. Ngezansi uzothola ukuthi eminye yemithi yesifo sikashukela othanda ukuyinikeza iyingozi, futhi kungcono ukuyenza ngaphandle kwabo.
Ukuguqula ushukela wegazi ojwayelekile ngohlobo 1 bese uthayipha 2 isifo sikashukela, into esemqoka ukuthi udle ama-carbohydrate amancane. Funda uhlu lokudla okwenqatshelwe kanye nohlu lokudla okuvunyelwe kokudla okune-carbohydrate ephansi. Umuntu ojwayelekile udla isilinganiso sama-250-400 amagremu ama-carbohydrate nsuku zonke. Uzuze njengelifa into ephilayo engakwazi ukumelana nalokhu. Futhi nakhu umphumela - usuthole ushukela. Uma ungadli ngaphezu kwama-20-30 amagremu ama-carbohydrate ngosuku, ushukela wakho wegazi uzojwayelekile futhi uzozizwa ungcono. Kuzokwenzeka izikhathi eziningana ukunciphisa umthamo wezidakamizwa zesifo sikashukela ne-insulin ngemijovo. Ngoshukela, kuzoba wusizo kuwe ukuthi udle amaprotheni amaningi kanye namafutha, esikhundleni sama-carbohydrate, kufaka namafutha ezilwane, odokotela nabezindaba abathanda ukusesabisa ngawo.
Uma usuhlakulele i-neuropathy yesifo sikashukela, funda isihloko esithi Alpha Lipoic Acid for Diabetesic Neuropathy.
Ngemuva kokuba isiguli esinesifo sikashukela sishintshela ekudleni okuphansi kwe-carbohydrate, amaphilisi ne-insulin ngokuvamile kufanele kunikezwe kuphela labo abangamavila kakhulu ukuzivocavoca. Ngincoma ukuthi unake i-athikili yakho ngokuthi ungayithokozela kanjani imfundo yomzimba. Ngethuba le-90%, imfundo yenyama izokusiza ngesifo sikashukela sohlobo 2 ukuze ulondoloze ushukela wegazi ojwayelekile ngaphandle kwamatafula kanye nokunye ngaphandle kwemijovo ye-insulin.
Yikuphi ukwelapha isifo sikashukela?
Kusukela maphakathi no-2012, kunamaqembu alandelayo wezidakamizwa zesifo sikashukela (ngaphandle kwe-insulin):
- Amapilisi akhulisa ukuzwela kwamangqamuzana ukuya ku-insulin.
- Izidakamizwa ezivuselela ama-pancreas ukukhiqiza i-insulin eningi.
- Izidakamizwa ezintsha zesifo sikashukela maphakathi nawo-2000s. Lokhu kufaka phakathi izidakamizwa ezisebenza ngokuhlukile, futhi ngenxa yalokho kunzima ukuzihlanganisa kahle. Lawa ngamaqembu amabili izidakamizwa ezinomsebenzi we-incretin, futhi mhlawumbe ezinye eziningi zizovela ngokuhamba kwesikhathi.
Kukhona ne-glucobai (acarbose) amaphilisi avimba ukumuncwa kwe-glucose emgodini we-gastrointestinal. Zivame ukubangela ukukhuphuka kokugaya, futhi okubaluleke kakhulu, uma ulandela ukudla okune-carbohydrate eningi, khona-ke ukukuthatha akunangqondo nakancane. Uma ungakwazi ukunamathela ekudleni okune-carbohydrate ephansi, ngoba uhlangana nokudla ubukhazikhazi, bese usebenzisa imishanguzo yesifo sikashukela esiza ukulawula iphango lakho. Futhi kusuka ku-glucobaia ngeke kube nokusetshenziswa okuningi. Ngakho-ke, ingxoxo yakhe ekugcineni.
Sikukhumbuza futhi: Imithi yamaphilisi ingaba wusizo kuphela kusifo sikashukela sohlobo 2. Kuhlobo 1 sikashukela, azikho izidakamizwa, imijovo ye-insulin kuphela. Ukucaciswa. Amaphilisi we-Siofor noma we-Glucophage wohlobo 1 sikashukela angavivinya uma isiguli skhuluphele, inzwa yakhe yeseli ku-insulin incishisiwe, futhi ngenxa yalokho aphoqelekile ukuba afake imithamo ebalulekile ye-insulin. Ukuqokwa kukaSiofor noma iGlucofage ekulesi simo kufanele kuxoxwe nodokotela wakho.
Amaqembu ezidakamizwa enza ukuthi ushukela wegazi ube ngokwejwayelekile
Uhlu olunemininingwane yezidakamizwa zohlobo 2 lwesifo sikashukela ngaphandle kwe-insulin wethulwa kahle ngezansi. Ngokusobala, azikho eziningi zazo. Maduze nje, kuzovela imininingwane eningiliziwe mayelana naleso nalezi zidakamizwa kwiwebhusayithi yethu.
| Iqembu lezidakamizwa | Igama lomhlaba jikelele | Amagama wezohwebo (imithamo eyenziwe, mg) | Zingaki ngosuku okufanele uzithathe | Isikhathi sokusebenza, amahora |
|---|---|---|---|---|
| Sulfonylureas | I-Micronized Glibenclamide |
| 1-2 | 16-24 |
| I-glibenclamide enga-micronised |
| 1-2 | 16-24 | |
| I-Gliclazide |
| 1-2 | 16-24 | |
| I-Gliclazide ekhishwe modified (inwetshiwe) |
| 1 | 24 | |
| I-Glimepiride |
| 1 | 24 | |
| Glycidone | I-Glenrenorm (30) | 1-3 | 8-12 | |
| I-Glipizide | I-Movoglechen (5) | 1-2 | 16-24 | |
| Kukhishwe i-Glipizide (Inwetshiwe) | Ukubuyiselwa kwe-Glibens (5; 10) | 1 | 24 | |
| I-Glinids (meglitinides) | I-Repaglinide |
| 3-4 | 3-4 |
| I-Nateglinide | I-Starlix (60; 120; 180) | 3-4 | 3-4 | |
| IBiguanides | I-Metformin |
| 1-3 | 8-12 |
| I-metformin esebenza isikhathi eside |
| 1-2 | 12-24 | |
| I-Thiazolidinediones (glitazones) | I-Pioglitazone |
| 1 | 16-24 |
| I-Glucagon-like Peptide-1 Receptor Agonists | I-Exenatide | I-Baeta (5, 10 mcg) yomjovo ongaphansi | 2 | 12 |
| ILiraglutide | I-Victoza (0.6; 1.2; 1.8) yomjovo ongaphansi | 1 | 24 | |
| I-dipeptyl Peptidase-4 Inhibitors (ama-Gliptins) | I-Sitagliptin | UJanuvius (25; 50; 100) | 1 | 24 |
| I-Vildagliptin | UGalvus (50) | 1-2 | 16-24 | |
| I-Saxagliptin | U-Onglisa (2,5; 5) | 1 | 24 | |
| I-Linagliptin | I-Trazhenta (5) | 1 | 24 | |
| I-Alpha Glucosidase Inhibitors | I-Acarbose | I-Glucobay (50; 100) | 3 | 6-8 |
| Izidakamizwa zokuhlanganisa | I-Glibenclamide + Metformin |
| 1-2 | 16-24 |
| I-Glyclazide + Metformin | I-Glimecomb (40/500) | 1-2 | 16-24 | |
| I-Glimepiride + metformin | I-Amaryl M (1/250; 2/500) | 1 | 24 | |
| I-Glipizide + Metformin | I-Metglib (2.5 / 400) | 1-2 | 16-24 | |
| I-Vildagliptin + Metformin | UGalvus Met (50/500; 50/850; 50/1000) | 1-2 | 16-24 | |
| I-Sitagliptin + metformin | I-Yanumet (50/500; 50/850; 50/1000) | 1-2 | 24 | |
| I-Saxagliptin + Metformin | I-Combogliz Prolong (2,5 / 1000; 5/1000) | 1 | 24 |
Uma unesifiso se-insulin, khona-ke qala ngesihloko esithi “Ukwelashwa kwesifo sikashukela nge-insulin. Imuphi i-insulin okufanele uyikhethe. ” Uhlobo 2 lwesifo sikashukela, iziguli zesaba ize ngokwelashwa kwe-insulin. Ngoba imijovo ye-insulin inika amandla ama-pancreas akho ukuthi "aphumule" futhi awuvikele ekubhujisweni kwawo kokugcina. Ungafunda okuningi ngalokhu ngezansi.
Ithebula elilandelayo lizokusiza ukuthola ukuthi yimaphi amaqembu ahlukahlukene emithi anayo.
Ukusebenza ngokuqhathanisa, izinzuzo kanye nokubi kwezidakamizwa zesifo sikashukela sanamuhla
| Iqembu lezidakamizwa | Izinzuzo | Okubi | Contraindication |
|---|---|---|---|
| Izithako zokunciphisa i-insulin | |||
| I-Biguanides: i-metformin (i-siofor, i-glucophage) |
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| I-Thiazolidinediones (pioglitazone) |
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| Izidakamizwa ezikhuthaza ukuvikelwa kwe-insulin (onobhala) | |||
Ukulungiselela kweSulfonylurea:
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Meglitinides:
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| Izidakamizwa ezinomsebenzi we-incretin | |||
Okuvinjelayo kwe-DPP-4:
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I-Glucagon-like peptide-1 receptor agonists:
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| Izithako zokuvimba ukungena kwe-glucose | |||
| I-Alpha Glucosidase Inhibitor - i-Acarbose |
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| Insulin | |||
| Insulin |
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| Akukho okubangisana nemikhawulo yedosi kuze kube yilapho umphumela ufinyelelwa. |
Ukusetshenziswa okufanele kwemithi yesifo sikashukela sohlobo 2, okokuqala, ukugcina imigomo emibili eyisisekelo:
- yenqaba ukuthatha noma imaphi amaphilisi avuselela ukukhululeka kwe-insulin yi-pancreas (sulfonylureas, meglitinides);
- uma kunezinkomba zokwelashwa kwesifo sikashukela nge-insulin, lapho-ke kudingeka ukuthi uqale ngokujova i-insulin, futhi ungazami ukuyibuyisela ngeminye imishanguzo, izithasiselo, amakhambi noma amanye amakhambi abantu.
Sizocubungula lemigomo ngokuningiliziwe, ngoba ibaluleke kakhulu.
Uhlobo luni lwezidakamizwa zesifo sikashukela ezingazuzi, kepha zilimaza
Kukhona izidakamizwa zesifo sikashukela ezingalethi izinzuzo kwiziguli, kodwa ukulimala okuqhubekayo. Manje uzothola ukuthi le mithi iyini. Imithi yesifo sikashukela esiyingozi ngamaphilisi ashukumisa ama-pancreas ukukhiqiza i-insulin ethe xaxa. Banikele! Zenza umonakalo omkhulu empilweni yeziguli ezinesifo sikashukela. Amaphilisi akhuthaza ukukhiqizwa kwe-insulin ngama-pancreas afaka izidakamizwa ezivela kokuphuma kwe-sulfonylurea kanye namaqembu e-meglitinides. Odokotela basathanda ukubanikeza isifo sikashukela sohlobo 2, kodwa lokhu akulungile futhi kuyingozi ezigulini. Ake sibheke ukuthi kungani.
Kuhlobo lwesifo sikashukela sohlobo 2, iziguli, njengomthetho, nazo azakhiqizi i-insulin encane, futhi izikhathi eziphindwe izikhathi ezingama-2-3, kunabantu abanempilo ngaphandle kwalawa maphilisi. Ungaqinisekisa kalula lokhu kuhlolwa kwegazi kwe-C-peptide. Inkinga yeziguli ezinesifo sikashukela ukuthi zinokuzwa okuncishisiwe kwamangqamuzana esenzweni se-insulin. Lokhu kuphazamiseka kwe-metabolic kubizwa ngokuthi yi-insulin ukumelana. Esimweni esinjalo, ukuphuza amaphilisi agqugquzela ukukhululeka kwe-insulin yi-pancreas kuyafana nokushaya ngehhashi elihlushwayo, eliqhutshwa ngamandla alo wonke. Ihhashi elingeshwa lingafela khona lapho emashinini.
Indima yehhashi eliqhutshwa ama-pancreas akho. Inamaseli we-beta akhiqiza i-insulin. Zivele zisebenza ngomthwalo owengeziwe. Ngaphansi kwesenzo samathebulethi we-sulfonylurea derivatives noma ama-meglitinides “asha”, okungukuthi, afa kakhulu. Emva kwalokhu, ukukhiqizwa kwe-insulin kuyancipha, futhi uhlobo 2 lwesifo sikashukela eselapheka luphenduka uhlobo lwesifo sikashukela esiqine kakhulu futhi esingalapheki.
Okunye ukubuyisa okukhulu kwamaphilisi akhiqiza i-insulin ukuthi abangela i-hypoglycemia. Lokhu kwenzeka kaningi uma isiguli sithatha umthamo ongafanele wamaphilisi noma sikhohlwe ukudla ngesikhathi. Izindlela zokwelapha isifo sikashukela sohlobo 2 esizincomela ngempumelelo ushukela wegazi, kuyilapho ubungozi be-hypoglycemia buvele bube zero.
Ucwaningo olubanzi luye lwabonisa ukuthi okuphuma ku-sulfonylurea kukhulisa ukushona kuzo zonke izimbangela ezigulini ezizithathayo, kufaka phakathi ukubulawa yizifo zenhliziyo nomdlavuza. Ziphazamisa ukuhamba kwegazi emithanjeni nakweminye imithambo, zivimbe iziteshi ze-calcium ezinobuthakathaka be-ATP eziqabula imithambo yegazi. Lo mphumela awukafakazelwa kuphela izidakamizwa zakamuva zeqembu. Kepha futhi akufanele zithathwe, ngenxa yezizathu esizichaze ngenhla.
Uma isifo sikashukela sohlobo 2 sibhekwa ngokucophelela ngokudla okune-carbohydrate ephansi, ukuzivocavoca, kanye nemijovo ye-insulin uma kunesidingo, amangqamuzana e-beta alimele noma abuthaka angabuyisela umsebenzi wawo. Funda futhi ulandele uhlelo lokwelapha ngempumelelo isifo sikashukela sohlobo 2. Lokhu kungcono kakhulu kunokuphuza amaphilisi - ama-sulfonylurea derivatives noma ama-meglitinides, azobulala amaseli we-beta futhi andise izinkinga zesifo sikashukela. Ngeke siwabhale wonke amagama lawa mapilisi lapha, ngoba maningi kakhulu awo.
Okulandelayo kufanele kwenziwe. Funda imiyalo yamaphilisi kashukela owabelwe wona. Uma kuvela ukuthi bangabesigaba se-sulfonylurea derivatives noma meglitinides, ungazithathe. Esikhundleni salokho, funda futhi ulandele uhlelo lwe-2 sikashukela. Kukhona futhi amaphilisi okuhlanganisa aqukethe izithako ezimbili ezisebenzayo: a sulfonylurea derivative plus metformin. Uma unikezwe le nketho, bese usuka kukho uyi-metformin “pure” (Siofor noma Glyukofazh).
Indlela efanele yokwelapha isifo sikashukela sohlobo 2 ukuzama ukuthuthukisa ukuzwela kwamangqamuzana ukuya ku-insulin. Funda i-athikili yethu ngokumelana ne-insulin. Kukutshela ukuthi ukwenze kanjani. Emva kwalokho, awudingi ukukhuthaza ukukhiqizwa kwe-insulin. Uma icala likashukela lingathuthuki kakhulu, khona-ke i-insulin yomuntu uqobo izokwanela ukugcina ushukela wegazi ojwayelekile.
Ungazami ukufaka imijovo ye-insulin ngamaphilisi.
Yenza inani eliphelele lokulawula ushukela wegazi okungenani izinsuku ezintathu, futhi ikakhulukazi isonto lonke. Uma okungenani ushukela ngemuva kokudla kuphume kwaba ngu-9 mmol / L noma ngaphezulu, ngokushesha qala ukwelashwa nge-insulin, ngokuhambisana nokudla okune-carbohydrate ephansi kancane. Ngoba awukho umuthi ozosiza lapha. Okokuqala, ngosizo lomjovo we-insulin nokudla okufanele, qiniseka ukuthi ushukela wegazi lakho uphonsela kumanani okuhlosiwe. Futhi-ke lapho uzobe usucabanga ukuthi ungawasebenzisa kanjani amaphilisi ukunciphisa umthamo we-insulin noma uze uwushiye ngokuphelele.
Thayipha isifo sikashukela 2 sithande ukubambezeleka unomphela ukuqala kokwelashwa kwazo kwe-insulin. Ngokuqinisekile ngale njongo uye ekhasini lezidakamizwa zesifo sikashukela, akunjalo? Ngasizathu simbe, wonke umuntu ukholelwa ukuthi ukwelashwa kwe-insulin kunganakwa ngaphandle kokulimala, futhi izinkinga zesifo sikashukela zisongela omunye umuntu, kepha hhayi zona. Futhi lokhu kungukuziphatha okubuwula kakhulu kwabanesifo sikashukela. Uma "onethemba" enjalo efa ngokuhlaselwa yisifo senhliziyo, khona-ke ngiyasho ukuthi waba nenhlanhla. Ngoba kunezinketho ezimbi kakhulu:
- Ukuqunjelwa kwe-gangrene kanye nomlenze;
- Ubumpumputhe;
- Ukufa kabuhlungu ngenxa yokwehluleka kwezinso.
Lezi yizinkinga zesifo sikashukela isitha esibi kakhulu esingeke sazifuna. Uma uqhathanisa nabo, ukufa okusheshayo nokulula okuvela ekushayweni yinhliziyo kuyimpumelelo yangempela. Ngaphezu kwalokho, ezweni lethu, elingazisekeli izakhamuzi zalo ezikhubazekile kakhulu.
Ngakho-ke, i-insulin ikhambi elimangalisayo lesifo sikashukela sohlobo 2. Uma umthanda kakhulu, khona-ke ukusindisa kusuka kumjwayelana osondelene nalezi zinkinga ezingenhla. Uma kusobala ukuthi i-insulin ayikwazi ukusatshalaliswa ngayo, bese uqala ukuyifaka ngokushesha, ungachithi isikhathi. Uma ubumpumputhe benzeka noma ngemuva kokuqunjelwa imilenze, lowo onesifo sikashukela uvame ukuba neminye iminyaka embalwa yokukhubazeka. Ngalesi sikhathi, ukwazile ukucabangisisa kahle ukuthi wayengumuntu onjani lapho eqala ukujova i-insulin ngesikhathi ...
Kwezinye izimo, ukwenza ubungane ne-insulin kubalulekile, futhi ngokushesha:
- Kokudla okune-carbohydrate ephansi, ushukela wegazi lakho ngemuva kokudla uyaqhubeka ukweqa ku-9 mmol / L nangaphezulu.
- Ukuhlanganiswa kokudla okuphansi kwe-carbohydrate, ukuzivocavoca kanye namaphilisi "kwesokudla" akusizi ukwehlisa ushukela wakho ngemuva kokudla ngaphansi kuka-6.0 mmol / L.
Thanda i-insulin ngenhliziyo yakho yonke ngoba ungumngane wakho omkhulu, umsindisi kanye nomvikeli wakho ezinkingeni zesifo sikashukela. Kuyadingeka kahle inqubo yemijovo engenabuhlungu, ngenkani ngenkani i-insulin esimisweni futhi ngasikhathi sinye nenze imisebenzi ukuze umthamo wayo uncishiswe. Uma usebenzisa ngenkuthalo uhlelo lokuphuza isifo sikashukela (kubaluleke kakhulu ukuzivocavoca ngentokozo), ngakho-ke ungakwazi ukuphatha ngemithamo emincane ye-insulin. Ngokuthola okukhulu, uzokwazi ukwenqaba imijovo ngokuphelele. Kepha lokhu akunakwenziwa ngezindleko zokuthola ubunzima besifo sikashukela.
Amapilisi akhulisa ukuzwela kwamangqamuzana ukuya ku-insulin
Njengoba wazi, ezigulini eziningi ezinesifo sikashukela sohlobo 2, ama-pancreas akhiqiza i-insulin eyanele, noma izikhathi eziphindwe izikhathi ezi-2 kuya kwezijwayelekile. Inkinga ukuthi laba bantu banomuzwa ophansi wamaseli ezenzweni ze-insulin. Khumbula ukuthi le nkinga ibizwa ngokuthi yi-insulin ukumelana, i.e., ukumelana ne-insulin. Kunezinhlobo eziningi zemithi ezixazulula ingxenye. Emazweni akhuluma isiRussia, izidakamizwa ezimbili ezinjalo sezikhona manje - i-metformin (amaphilisi uSiofor noma uGlyukofazh) ne-pioglitazone (athengiswe ngaphansi kwamagama ama-Actos, uPioglar, iDiaglitazone).
Uhlelo lokwelapha olusebenzayo lwesifo sikashukela sohlobo 2 luqala ngokudla okune-carbohydrate ephansi, kanye nokuzivocavoca umzimba ngenjabulo. Lezi izindlela ezinamandla nezisebenzayo zokwenza ushukela wegazi ube ngokwejwayelekile. Kepha ezintweni eziyinkimbinkimbi, azisizi ngokwanele, njengokungathi onesifo sikashukela akazange awugcine ngokucophelela lo hlobo. Ngemuva kwalokho, ngaphezu kwabo, amaphilisi nawo anqunyelwe ukuthi andise ukuzwela kwamangqamuzana esenzweni se-insulin. Uma usebenzisa inhlanganisela yokudla okuphansi kwe-carbohydrate, ukuzivocavoca kanye namaphilisi okulwa ne-insulin, amathuba ukuthi uzokwazi ukulawula kahle isifo sikashukela ngaphandle kokujova i-insulin. Futhi uma kusadingeka ukuthi ufake i-insulin, khona-ke imithamo izoba yincane.
Khumbula ukuthi alikho iphilisi likashukela elingangena esikhundleni sokudla nokuzivocavoca. Isifundo somzimba ngenjabulo iyithuluzi eliphumelela ngempela lokukhulisa ukuzwela kwamangqamuzana ukungena ku-insulin nokulawula isifo sikashukela. Imithi ephumelelayo ayinakuqhathaniswa nayo. Futhi ngisho nangaphezulu, ngeke kwenzeke ukuthi ugweme izinkinga zesifo sikashukela uma ungalandeli ukudla okune-carbohydrate ephansi kakhulu.
I-Siofor (Glucophage) - umuthi odumile wesifo sikashukela sohlobo 2
Umuthi othandwayo wesifo sikashukela sohlobo 2 yi-metformin, othengiswa ngohlobo lwamaphilisi iSiofor ne-Glucofage emazweni akhuluma isiRussia. Funda indatshana yethu enemininingwane ngala mapilisi. I-Metformin ikhulisa ukuzwela kwamaseli esenzweni se-insulin, ngaleyo ndlela yehlise ushukela wegazi futhi isize ukwehlisa isisindo ngamakhilogremu ambalwa. Iphinde ivimbele isenzo se-ghrelin ye-hormone futhi ngaleyo ndlela kusiza ukwenqaba ukudla ngokweqile.
Ngaphansi kwethonya lalesi sidakamizwa, imiphumela yokuhlolwa kwegazi yezinto ezibeka engcupheni yenhliziyo iyathuthuka. Kuyafakazelwa nokuthi ukuthatha i-metformin kunciphisa ingozi yokufa ngenxa yomdlavuza nokuhlaselwa yisifo senhliziyo. Izinkinga zesifo sikashukela ziqhamuka ngoba ushukela ngokweqile okhona egazini ubopha amaprotheni ahlukene futhi uphazamisa umsebenzi wawo. Ngakho-ke, i-metformin ivimba lokhu kuzibopha, futhi lokhu kwenzeka noma ngabe kungamthelela muni omkhulu ekwehleni ushukela wegazi. Kuphinde kuthuthukise ukuhamba kwegazi emikhunjini, kunciphise ukuqina nokuqina kwe-capillaries, futhi kunciphise nengozi yokuphelelwa ngamandla emehlweni nge-retinopathy yesifo sikashukela.
Amathebhulethi kashukela weSifo seTiazolidinedione
Imithi yesifo sikashukela eqenjini le-thiazolidinedione ivimbela ukuthuthukiswa kokuhluleka kwezinso, ngaphezu komphumela wayo ekwehliseni ushukela wegazi. Kucatshangelwa ukuthi zivimba isenzo sezakhi zofuzo ezibhekene nokuqwabelana kwamafutha emzimbeni. Ngenxa yalokhu, ama-thiazolinediones asiza ukubambezeleka noma kuvimbela ngisho nokukhula kwesifo sikashukela sohlobo 2 kubantu abasengozini enkulu. Ngakolunye uhlangothi, kuye kwafakazelwa ukuthi le mishanguzo inyusa ingozi yokuba namathambo kwabesifazane ngemuva kokuya esikhathini.
I-Thiazolinediones nayo idala ukugcinwa kwamanzi emzimbeni. Lokhu akwamukeleki ezigulini ezinesifo sikashukela esinokuhluleka kwenhliziyo, ngoba imizimba yazo isivele igcwele uketshezi. Phambilini, bekukhona izidakamizwa ezimbili eqenjini le-thiazolidinedione: i-rosiglitazone ne-pioglitazone. Kodwa-ke, ukuthengiswa kwe-rosiglitazone kwavinjwa lapho kuvela ukuthi ukuyithatha kwandisa ingozi yokuhlaselwa yisifo senhliziyo, futhi manje sekuyi-pioglitazone kuphela ebekelwe iziguli.
Zenziwa kanjani izidakamizwa ezinciphisa ukumelana ne-insulin
Izidakamizwa zeMetformin neze-pioglitazone zandisa ukuzwela kwamangqamuzana ukuya ku-insulin. Futhi akunandaba ukuthi uluhlobo luni lwe-insulini - lona olwenziwe amanyikwe, noma lowo isiguli sikashukela esaluthola ngomjovo. Njengomphumela wesenzo samathebulethi ngokumelana ne-insulin, ushukela wegazi ezigulini ezinesifo sikashukela sohlobo 2 uyancipha, futhi ingxenye enhle kakhulu ukuthi ayikho imiphumela emibi eyingozi.
Kodwa-ke, imiphumela ezuzisayo ye-metformin ne-pioglitazone ayipheleli lapho. Khumbula ukuthi i-insulin yi-hormone eyinhloko ekhuthaza ukumiswa kwamafutha futhi ivimbele ukwehla kwesisindo. Lapho isiguli esinesifo sikashukela sohlobo 2 kanye / noma ukukhuluphala sithatha lawa maphilisi, khona-ke ukuqina kwe-insulin yakhe yegazi kuyancipha futhi kusondele ngendlela evamile. Ngenxa yalokhu, okungenani okunye ukuzuza kwesisindo kuyama, futhi kaningi kungenzeka ukulahlekelwa amakhilogremu ambalwa. Uma isifo sikashukela sohlobo 2 singakakhuli, futhi udinga kuphela ukulawula ukukhuluphala, lapho-ke i-metformin ivame ukunikezwa. Ngoba unengozi engacishe ibe yengozi yemiphumela emibi eyingozi, futhi i-pioglitazone inayo, yize incane.
Njengoba wazi, lapho umuntu enamafutha amaningi ngokweqile, umfutho wokuqina we-insulin kanye nemithamo ephezulu ye-insulin kufanele uwafake kushukela. Ukuthatha amaphilisi akhulisa ukuzwela kwamangqamuzana esenzweni se-insulin, kwenza ukuthi wehlise umthamo we-insulin. Ngaphezu kwalokho, lo mphumela uboniswa ezigulini hhayi kuphela ngesifo sikashukela sohlobo 2, kodwa futhi nesifo sikashukela sohlobo 1. Ukukhuluphala ngokweqile nokukhubazeka kwe-insulin kuyizinkomba lapho i-metformin (iSiofor noma i-Glucofage) futhi kuyelulekwa ukuthi iziguli ezinesifo sikashukela sohlobo 1 sinciphise imithamo ye-insulin. Bheka futhi: "Unganciphisa kanjani isisindo ngokudla okuphansi kwe-carb."
Sinikeza isibonelo ngokuvela kukaDkt Bernstein. Wayenesiguli esine-Type 2 sikashukela futhi nesisindo esikhulu ngokweqile. Lesi siguli sidinga ukujova amayunithi angama-27 we-insulin enwetshiwe ubusuku bonke, noma ngabe silandela ukudla okune-carbohydrate ephansi kancane. Ubuye walandela imiyalo echazwe esigabeni esithi “How to Poke Doses Large of Insulin”. Ngemuva kokuqala ukuthatha i-glucophage, umthamo we-insulin wehliswa waba amayunithi angama-20. Lokhu kuseyidosi ephezulu, kepha nokho kungcono kunamayunithi angama-27.
Ungawasebenzisa kanjani la maphilisi
Amathebulethi akhulisa ukuzwela kwamangqamuzana ukuya ku-insulin kufanele abekelwe iziguli ezinesifo sikashukela sohlobo 2 uma zingakwazi ukwehlisa isisindo ekudleni okune-carbohydrate ephansi, futhi kakhulu uma zingakwazi ukwehlisa ushukela wegazi wazo zibe ezijwayelekile. Funda ngokuthi yimiphi imigomo efanele yokunakekelwa kwesifo sikashukela. Ngaphambi kokwenza irejimeni yokuphuza izidakamizwa zesifo sikashukela, udinga ukwenza konke okulawulwa ushukela wegazi ngezinsuku ezingama-3-7 futhi urekhode imiphumela yako. Sikukhumbuza ukuthi uma ushukela wegazi okungenani kanye ngemuva kokudla ungama-9.0 mmol / L noma ngaphezulu, khona-ke udinga ukuqala ngokushesha ukujova i-insulin. Futhi-ke kuphela lapho ucabanga ukuthi ungayithoba kanjani imithamo yayo ngamathebulethi.
Uzothola ukuthi ushukela wegazi ukhuphuka ngaphezu kokujwayelekile ngasikhathi esithile, noma ugcina ephakeme njalo ngewashi. Ngokuya kwalokhu, thola ukuthi yisiphi isikhathi osidingayo ukuphuza amaphilisi kashukela. Isibonelo, ushukela wegazi lakho uhlala uphakanyiswa ekuseni. Lokhu kubizwa ngokuthi "yinto yokusa yokusa." Kulokhu, zama ukuthatha i-glucophage yobusuku obude. Qala ngomthamo omncane bese ukhulisa kancane kancane. Funda ngokuningiliziwe "Ungayilawula kanjani into yokusa yokusa".
Noma imitha kashukela wegazi izokhombisa ukuthi ushukela wegazi ukhuphuka ngemuva kokudla, ngokwesibonelo, ngemuva kwesidlo sakusihlwa. Kulokhu, thatha iSiofor esisebenza ngokushesha amahora amabili ngaphambi kokudla. Uma kunesifo sohudo esivela kulolu hlobo, thatha uSiofor ngokudla. Sebenzisa futhi amaphilisi kashukela ukusiza ukulawula iphango lakho. Uma ushukela wegazi ugcinwa unyuselwa kancane eceleni kwewashi, ungazama imithamo engama-500 noma ama-850 mg we-Siofor ngaso sonke isikhathi ngaphambi kokudla, kanye nasebusuku.
Kanjani futhi kungani uthatha i-metformin ne-pioglitazone ndawonye
I-Metformin (amaphilisi iSiofor ne-Glucofage) yenza isenzo sayo, yehlisa ukumelana kwe-insulin kumaseli wesibindi. Kubuye kuthinte kancane ukufakwa kwama-carbohydrate emathunjini. I-pioglitazone yenza ngendlela ehlukile. Kuthinta izicubu nezicubu ze-adipose, kuthinta isibindi ngezinga elincane. Lokhu kusho ukuthi uma i-metformin ingehlisi ushukela wegazi ngokwanele, khona-ke kunengqondo ukufaka i-pioglitazone kuyo, nokuphikisana nalokho.
Uyacelwa ukuthi uqaphele ukuthi i-pioglitazone ayikhombisi umphumela wayo ekwehliseni ushukela wegazi ngokushesha, kodwa emasontweni ambalwa ngemuva kokuqala kokuphatha. Ngenkathi uthatha i-metformin, umthamo wansuku zonke we-pioglitazone akufanele udlule i-30 mg.
Ububi bezidakamizwa ezinciphisa ukumelana ne-insulin
Amaphilisi akhulisa ukuzwela kwamangqamuzana ukuya ku-insulin angelinye lamathuluzi amahle kakhulu esinawo okulawula ushukela wegazi. Kodwa-ke, zibuye zibe nezingqinamba zazo.
Imiphumela Emibi yeMetformin
Ithebhulethi iSiofor ne-Glucofage (i-metformin esebenzayo yezinto) empeleni ayibangeli imiphumela emibi eyingozi. Kodwa-ke, kubantu abaziphuzayo, bavame ukubangela ukukhuphuka kokugaya - ukuqhakaza, isicanucanu, uhudo. Lokhu kwenzeka ngeziguli okungenani eziyi-⅓ ezisebenzisa umuthi osheshayo we-Siofor.
Abantu basheshe babone ukuthi uSiofor usiza ukwehlisa isisindo ngamakhilogremu amaningana, futhi ngesifo sikashukela sohlobo 2 sisondeza ushukela wegazi esijwayelekile. Ngenxa yale miphumela ezuzisayo, bakulungele ukubekezelela izinkinga ngepheshana lesisu. Lezi zinkinga ziba mbalwa kakhulu uma usuka ku-Siofor uye ku-Glucophage isenzo eside. Futhi, iningi leziguli lithola ukuthi ukuphazamiseka kokugaya ukudla ngokuthatha uSiofor kuya buthaka kanye nesikhathi, lapho umzimba usujwayela umuthi. Bambalwa kakhulu abantu abangakwazi ukubekezelela lo muthi nakancane.
Namuhla, iMetformin umuthi owuthandayo wamakhulu ezinkulungwane zabanesifo sikashukela emhlabeni wonke. Wayenanduleli - phenformin. Ngawo-1950s, bathola ukuthi kungadala i-lactic acidosis, isimo esiyingozi, nesingabulala. Ngenkathi ithatha i-phenformin, i-lactic acidosis yenzeka ezigulini ezikhubazekile ezazivele zinokuhluleka kwenhliziyo noma ukulimala kwezinso okunzima. UMnyango Wezempilo uxwayisa ngokuthi i-metformin nayo ingadala i-lactic acidosis uma unezinkinga zenhliziyo, isibindi noma izinso. Uma lezi zinkinga zingekho, khona-ke ubungozi be-lactic acidosis buyi-zero.
Imiphumela emibi ye-pioglitazone
Kwabanye abantu, i-pioglitazone (i-Actos, iPioglar, i-Diaglitazone) ibangela ukugcinwa kwamanzi. Lokhu kubonakala ngokuvuvukala kwemilenze kanye nokwehla kokuxinana kwamangqamuzana abomvu egazi ku-plasma. Futhi, ngenkathi uthatha i-pioglitazone, isiguli singathola isisindo esincane. Lokhu kungenxa yokuqongelela uketshezi, kepha hhayi amanoni. Ezigulini ezinesifo sikashukela ezithatha i-pioglitazone futhi ngesikhathi esifanayo zithole imijovo ye-insulin, ubungozi bokuhlaselwa yisifo senhliziyo luyanda. Kulabo abanesifo sikashukela, umthamo wansuku zonke we-pioglitazone akufanele udlule i-30 mg.Uma, ngokumelene ingemuva lokwelashwa kwe-insulin nokuthatha la maphilisi, ubona ukuthi imilenze yakho iqala ukuvuvukala, bese uyeka ukuthatha i-pioglitazone ngokushesha.
Kubikwe kumamagazini ukuthi ukuthatha i-pioglitazone kaningana kubangele ukulimala kwesibindi okubuye kubuye. Ngakolunye uhlangothi, lo muthi uthuthukisa iphrofayli ye-cholesterol, okungukuthi, wehlisa izinga le-cholesterol embi egazini futhi likhuphula izinga le-cholesterol enhle. Njengoba i-pioglitazone ingadala ukugcinwa kwamanzi, ayikwazi ukubekelwa iziguli ezinanoma yisiphi isigaba sokwehluleka kwenhliziyo, isifo sezinso noma samaphaphu.
Emzimbeni, i-pioglitazone ayihlanganisiwe yisibindi. Kulokhu, kusetshenziswa i-enzyme efanayo, ethatha izidakamizwa eziningi ezidumile. Uma uthatha izidakamizwa eziningana ngasikhathi sinye uncintisana ne-enzyme efanayo, khona-ke izinga lezidakamizwa egazini lingakhula ngengozi. Akusizi ukuthatha i-pioglitazone uma usuvele welashwa ngama-antidepressants, izidakamizwa ze-antifungal, noma ama-antibiotic athile. Emiyalweni ye-pioglitazone funda ngokucophelela isigaba esithi "Ukuxhumana nezinye izidakamizwa". Uma unemibuzo, xoxa ngayo nodokotela noma usokhemisi wakho ekhemisi.
Yini okufanele uyenze uma ushukela wegazi usuphezulu
Uma amaphilisi ezinshukela ehlisa ushukela wegazi, kodwa akwanele, khona-ke lokhu kungahle kube ngenxa yezinkinga ngokudla kwakho. Ngokunokwenzeka, udla ama-carbohydrate amaningi kunokuba ucabanga. Okokuqala, udinga ukuhlola ngokucophelela ukudla okudlayo ukuthola ukuthi ama-carbohydrate angeziwe angena kanjani kuwo. Funda ukuthi ukwelashwa kanjani ukulutha kwe-carbohydrate nokuthi imiphi imithi esiza ukulawula isifiso sakho sokudla ngokuphepha nangendlela efanele.
Ushukela wegazi ezigulini ezinesifo sikashukela nawo unyusa ukutheleleka noma ukuvuvukala okwenzeka kamuva. Izimbangela ezivame kakhulu zezinkinga i-caries yamazinyo, ukubanda, noma ukutheleleka ezinso. Ngemininingwane engaphezulu, funda isihloko esithi "Kungani ushukela eqhubeka nokudla okune-carbohydrate eningi nokuthi angakulungisa kanjani."
Sincoma ukwenza izivivinyo zomzimba ngokuthokozela uhlobo 2 sikashukela. Uma ukudla okune-carbohydrate ephansi namaphilisi kungasizi ngokwanele, khona-ke kusele ukukhetha - imfundo yokomzimba noma imijovo ye-insulin. Kodwa-ke, awukwazi ukwenza okukodwa noma okunye, kodwa-ke ungamangali ukuthi uzofuna ukwazi ngokusondelene nezinkinga zesifo sikashukela ... Uma isiguli sikashukela njalo futhi ngenkuthalo senza imfundo yezomzimba ngokuya ngezindlela esizincomayo, khona-ke ngethuba le-90% uzokwazi ukulawula kahle isifo sikashukela ngaphandle kwemijovo ye-insulin. Uma kusadingeka ukuthi ufake i-insulin, kusho ukuthi usuvele unesifo sikashukela sohlobo 1, hhayi uhlobo 2 sikashukela. Kunoma ikuphi, ukudla okuphansi kwe-carbohydrate nokuzivocavoca kusiza ukuthola ngemithamo emincane ye-insulin.
Izidakamizwa ezengeziwe ezandisa ukuzwela kwamangqamuzana ukuya ku-insulin
Ucwaningo luye lwabonisa ukuthi uvithamini A kwimithamo engaphezu kwe-25,000 IU ngosuku yehlisa ukumelana ne-insulin. Kulinganiselwa ukuthi uma kuthathwa i-vitamin A engaphezu kwe-5,000 IU ngosuku, lokhu kungadala ukuncipha kwezindawo ezigcina i-calcium emathanjeni. Futhi imithamo ephezulu ye-Vitamin A ibhekwa njengenobuthi kakhulu. Ngakho-ke, ungathatha i-beta-carotene ngemithamo elinganiselayo - lo "ngumanduleli", okuthi emzimbeni womuntu uphenduke uvithamini A njengoba kudingeka. Impela akayona ingozi.
Ukuntuleka kwe-Magnesium emzimbeni kuyimbangela evamile futhi enkulu yokuphikiswa kwe-insulin. E-United States, kubantu, izitolo ze-magnesium emzimbeni zihlolwa ngokuhlaziywa kwamazinga e-magnesium kumaseli abomvu egazi. Senza isivivinyo se-serum magnesium yegazi, kodwa asichanekanga futhi ngenxa yalokho asisebenzi. Ukuntuleka kwe-Magnesium kuthinta okungenani ama-80% abantu. Kuwo wonke umuntu onesifo sikashukela, sincoma ukuthi uzame ukuthatha amaphilisi e-magnesium ane-vithamini B6. Ngemuva kwamaviki ama-3, hlola umthelela abanawo enhlalakahleni yakho kanye nomthamo we-insulin. Uma umphumela ulungile, qhubeka. Qaphela Ngokuhluleka kwezinso, i-magnesium ayikwazi ukuthathwa.
Ukuntuleka kwe-Zinc emzimbeni kulimaza ukukhiqizwa kwe-leptin. Le yi-hormone evimbela umuntu ukuthi angadli futhi iphazamise inzuzo yesisindo. Ukushoda kwe-Zinc nakho kunomphumela omubi emgudwini we-thyroid. Incwadi yaseMelika ekwelashweni kwesifo sikashukela itusa ukuthi ihlolwe igazi nge-serum zinc, bese ithatha izithasiselo uma kutholakala ukuthi kukhona ukuntuleka. Emazweni akhuluma isiRussia, ukuthola ukuthi une-zinc eyanele emzimbeni wakho kuyinkinga. Ngakho-ke, sincoma ukuzama nje ukuthatha izithasiselo ze-zinc, njenge-magnesium.
Amaphilisi we-Zinc noma amaphilisi kufanele athathwe okungenani inyanga eyi-1 ukuze aqonde ukuthi uyini umphumela wazo. Nge-magnesium, ngalo mqondo kulula, ngoba umphumela wokuphatha kwawo ubonakala ngemuva kwamasonto ama-3. Ngokuthatha izithasiselo ze-zinc, iningi labantu liyabona ukuthi izipikili nezinwele zabo zaqala ukukhula kangcono. Uma unenhlanhla, khona-ke unganciphisa umthamo we-insulin ngaphandle kokulimaza ukulawulwa kwesifo sikashukela. Kuyini ukusetshenziswa kwe-zinc ngomzimba, kuchazwe ngokuningiliziwe encwadini ka-Atkins "Izithasiselo: enye indlela yemvelo yezidakamizwa."
I-Vanadium Sulfate
Kukhona into enjalo - i-vanadium. Lokhu kuyinsimbi esindayo. Usawoti wayo, ikakhulukazi i-vanadium sulfate, unomphumela olandelayo: banciphisa ukumelana ne-insulin, benza buthaka iphango futhi, mhlawumbe, basebenze njenge-insulin. Banamandla amakhulu okunciphisa ushukela wegazi kushukela. I-Vanadium ingaba yikhambi eliphumelelayo lesifo sikashukela, kodwa odokotela baselapha ngokukhulu ukucophelela, besaba imiphumela emibi.
Usawoti weVanadium unamandla okunciphisa ushukela wegazi ngokuvimbela i-enzyme ye-tyrosine phosphatase. Le enzyme idlala indima enkulu ezinqubweni eziningi ezahlukahlukene emzimbeni womuntu. Okwamanje akukafakazelwa ukuthi ukuvimbela umsebenzi wayo kuphephile futhi akunamphumela omubi wesikhathi eside. Izilingo ezihlelekile zokungezelelwa kwe-vanadium kubantu azikaze zihlale isikhathi esingaphezu kwamaviki ama-3. Futhi amavolontiya azimisele ukubamba iqhaza esivivinyweni eside awatholakali.
Kodwa-ke, i-vanadium sulfate iyisengezo sokudla esithengiswa kakhulu e-United States. Eminyakeni eminingi, azange kube khona izikhalazo zemiphumela emibi evela kwabayithatha. UDkt Bernstein namuhla utusa ukugwema ukwelapha isifo sikashukela ngaleli khambi kuze kufike lapho kufakazelwa ukuphepha kwalo. Lokhu kusebenza kuzo zonke izigaba zeziguli, ngaphandle kwabashayeli bezindiza bezentengiso. Abanakho okunye ukukhetha, ngoba ngandlela thile badinga ukulawula isifo sikashukela, futhi benqatshelwe ngokuphelele ukusebenzisa i-insulin, ngaphansi kokusongelwa kokulahlekelwa yilayisense lokundiza indiza.
Amanye amagama ambalwa abashayeli bezindiza abanesifo sikashukela, kodwa akufanele athathe i-insulin. Okokuqala, qhubeka nokudla okunama-carbohydrate angaphansi, futhi futhi ubandakanyeke ngokungathi sína emfundweni yomzimba ngenjabulo. Sebenzisa yonke imishanguzo yesifo sikashukela "engakwesokudla" esikubalile ngenhla ku-athikili, kanye nezithasiselo - amavithamini A, i-magnesium, i-zinc kanye ne-vanadium sulfate. Futhi kukhona elinye ithuluzi elaziwa kancane elingase libe lusizo kuwe.
Izitolo ezibalulekile zensimbi emzimbeni zikhonjiswe ukwehlisa ukuzwela kwezicubu ku-insulin. Lokhu kuyiqiniso ikakhulukazi kwabesilisa, ngoba abesifazane bakhipha insimbi eyeqile ngesikhathi sokuya esikhathini. Thatha ukuhlolwa kwegazi kwe-serum ferritin ukunquma izinga lakho lensimbi. Emazweni akhuluma isiRussia, lokhu kuhlaziya kungaphasiswa, ngokungafani nokuhlaziya okuqukethwe kwe-magnesium ne-zinc. Uma ukuqina kwakho kwensimbi emzimbeni kungaphezulu kwesilinganiso, kungakuhle-ke ukuthi ube ngumnikeli wegazi. Udinga ukunikela ngegazi elinikelwe kakhulu ukuze izitolo zakho zensimbi zisondele emkhawulweni ophansi owamukelekayo. Mhlawumbe ngenxa yalokhu, ukuzwela kwamangqamuzana akho ku-insulin kuzokhula kakhulu. Ungathathi ngaphezu kwama-250 mg we-Vitamin C ngosuku, ngoba le vithamini inyusa ukumuncwa kwensimbi ekudleni.
Ukwelashwa Okusha Kwesifo Sikashukela
Izidakamizwa ezintsha zesifo sikashukela zingama-dipeptyl peptidase-4 inhibitors nama-glucagon anjenge-peptide-1 receptor agonists. Ngokwe-theory, zenzelwe ukwehlisa ushukela wegazi ngemuva kokudla nohlobo 2 sikashukela. Ekusebenzeni, banomphumela obuthakathaka kakhulu kushukela wegazi, obuthakathaka kakhulu kune-metformin (iSiofor noma iGlucofage).
Kodwa-ke, imiphumela ye-dipeptyl peptidase-4 inhibitors (Galvus, Januvia kanye ne-Onglisa) ekwehliseni ushukela wegazi ngemuva kokudla ngohlobo lwesifo sikashukela 2 ingahambanisa imiphumela ye-metformin ne-pioglitazone. Ungasebenzisa omunye wale mishanguzo njengomuthi wakho wesithathu wesifo sikashukela uma udokotela wakho ekuyalela, uma i-metformin plus pioglitazone ingasizi ngokwanele.
Ama-agluists ama-geptcagon-like peptide-1 receptor amaVictoza kanye neBaeta. Ziyathandeka kithina hhayi ngoba zinciphisa ushukela kancane, kodwa ngoba zisiza ukulawula isifiso sokudla, ikakhulukazi iViktoza. Lezi izindlela zokwelapha ezisebenzayo zokulutha i-carbohydrate. Bobabili i-Baeta neViktoza abatholakali ngohlobo lwezibhebhe, kodwa kumashubhu wesirinji. Badinga ukushaywa njenge-insulin. Ngokubuka ingemuva lale mijovo, iziguli zingcono kakhulu ekudleni okune-carbohydrate ephansi, mancane kakhulu amathuba okuba nobukhazikhazi. Ukuthola eminye imininingwane, bheka isihloko esithi “Imithi Yesifo Sikashukela Yokulawula Iphango.”
IVictoza neBaeta yimithi emisha, ebizayo, yokuphathelene. Futhi udinga ukwenza imijovo, futhi lokhu akumjabulisi neze umuntu. Kepha le mishanguzo isheshisa ngempumelelo imizwa yokugcwala. Ungadla ngokulinganisela, futhi ngeke ube nesifiso sokudla ngokweqile. Ngenxa yalokhu, ukulawula ushukela kuzothuthukisa okuningi. Futhi okubaluleke kakhulu, konke lokhu kuphephile, ngaphandle kwemiphumela emibi ekhethekile. Izinzuzo zokusebenzisa iVictoza noma i-Baeta ukulawula ukuzidla zikhulu kakhulu. Ukhokhela konke ukuphazamiseka okuhambisana nokusetshenziswa kwalezi zimali.
Yini amaphilisi kashukela abangela i-hypoglycemia
Amaphilisi sikashukela akhuthaza ama-pancreas ukukhiqiza i-insulin eningi ngokuvamile abangela i-hypoglycemia. Isiguli kwesinye isikhathi kufanele sizwe izimpawu zayo ezingemnandi, futhi uma kwenzeka kuba ne-hypoglycemia enkulu lokhu kungaholela ekukhubazekeni noma ekufeni. Sincoma ukuthi uyeke ukuthatha amaphilisi agqugquzela amaseli e-beta ama-pancreas ukukhiqiza i-insulin. Ingozi ye-hypoglycemia ingenye yezizathu zalokhu, yize kungeyona eyinhloko; ngemininingwane, bheka i-athikili engenhla.
Ezidakamizweni ezandisa ukuzwela kwezicubu ezenzweni ze-insulin, ubungozi be-hypoglycemia cishe buyi-zero, ngokungafani namathebulethi avusa ama-pancreas. Imithi yokulwa ne-insulin ayithinti uhlelo lwe-pancreatic self-regulation system. Uma ushukela wegazi wehla, amanyikwe ayovele ayeke ukugcwalisa igazi nge-insulin, futhi ngeke kube ne-hypoglycemia. Inketho kuphela eyingozi uma uphuza amaphilisi okwehlisa i-insulin, kanye nemijovo ye-insulin. Kulokhu, i-hypoglycemia kungenzeka.
Imithi yesifo sikashukela ehlanganisiwe: ungayisebenzisi!
Izinkampani ezenza umuthi zidedela imishanguzo yesifo sikashukela emizamweni yokugwema amalungelo obunikazi abavikelwe izimbangi zabo, noma ukumane bandise umkhiqizo wabo futhi bathathe isikhala esithe xaxa emashalofini wezidakamizwa. Konke lokhu akuvamile ukwenziwa ngezinhloso zeziguli, kodwa kuphela ngenhloso yokwandisa ukuthengisa nezinzuzo. Ukusetshenziswa kwamaphilisi okuhlanganisa isifo sikashukela ngokuvamile akululeki. Esimweni esihle kakhulu, kuzobiza kakhulu, futhi okubi kakhulu - kuyalimaza futhi.
Inhlanganisela eyingozi yilena equkethe ama-sulfonylureas. Ekuqaleni kwendatshana sichaze kabanzi ukuthi kungani kubalulekile ukwenqaba ukuphuza amaphilisi aleli qembu. Qiniseka ukuthi ungathathi izinto eziyingozi kuma-pancreas wakho njengengxenye yemithi yokuhlanganisa yesifo sikashukela. Ukuhlanganiswa kwe-metformin enama-inhibitors we-DPP-4 nakho kuvamile. Akunangozi, kepha zingabiza ngokungenangqondo. Qhathanisa amanani. Kungavela ukuthi amaphilisi amabili ahlukene ashibhile kunelinye elihlanganisiwe.
Ungabuza imibuzo ngemithi yesifo sikashukela kumazwana. Abaphathi besayithi baphendula ngokushesha kubo.
