I-Lipanor iyisidakamizwa esiseqenjini le-fibrate - esuselwa ku-fibric acid. Inhloso eyinhloko yaleli qembu lezidakamizwa ukunciphisa inani lama-lipid egazini le-plasma yesiguli nokuvimbela ukuthuthukiswa kwezinguquko ze-atherosulinotic emzimbeni.
Isithako esiyisisekelo esisebenzayo sebhayoloji yi-ciprofibrate yamakhemikhali. I-Lipanor itholakala ngesimo samaphaphu, ikhebula ngalinye liqukethe i-100 mg yesakhi esisebenzayo ekwakhekeni kwayo.
Umenzi walesi sidakamizwa nguSanofi-Aventis. Izwe laseFrance.
Ukwakheka kwalo muthi nencazelo ejwayelekile
Isakhi esisebenzayo esiyisisekelo, njengoba kwashiwo, sisuselwa ku-fibric acid - ciprofibrate e-micronized.
Ngaphezu kwengxenye eyinhloko, amakhompiyutha aqukethe ezinye izingxube zamakhemikhali. Amakhemikhali angeziwe ekwakhiweni kwomuthi adlala indima yokusiza.
Izakhi ezisizayo yilezi zingxube ezilandelayo:
- i-lactose monohydrate;
- isitashi sommbila.
Igobolondo lamaphaphu wesidakamizwa liqukethe izinto ezilandelayo:
- IGelatin
- I-titanium dioxide
- Ama-iron iron oxides amnyama futhi aphuzi.
Amaphaphu wesidakamizwa aphakama, opaque abushelelezi onendawo ecwebezelayo. Umbala wamaphakethi uphuzi okhanyayo; isembozo se-capsule sinombala oluhlaza okotshani. Njengokuqukethwe, aqukethe i-powder enombala omhlophe noma ocishe ube mhlophe.
Umuthi ufakwa emaphaketheni okulimaza aqukethe amaphilisi ayi-10. Amathathu ala mapakeji agcwele ebhokisini lekhadibhodi futhi anikezwe nemiyalo enemininingwane yokusetshenziswa.
Ukusetshenziswa kwamaphilisi wezidakamizwa ngesikhathi sokwelashwa kukuvumela ukuthi ukhuphule izinga le-HDL egazini, kwenyusa ukusebenza kokudla kwamahhala kwe-cholesterol okuhlose ukunciphisa ukugcwala kwe-LDL, triglycerides kanye ne-lipoproteins ephansi kakhulu emzimbeni.
Izici ze-pharmacological zomuthi
Ukwehla kwe-lipasma lipids kutholakala. Uma usebenzisa i-ciprofibrate, ngokunciphisa inani lama-lipoprotein e-atherogenic - LDL ne-VLDL.
Ukwehla kwenani lala ma-lipoprotein kutholakala ngokucindezela izinqubo ze-cholesterol biosynthesis esibindini. Ngaphezu kwalokho, ukusetshenziswa kwalesi sidakamizwa kungakhuphula inani le-HDL kwi-serum yegazi, okuholela ekushintsheni kwesilinganiso phakathi kwe-lipoprotein ephansi nephezulu ukuvumela okwedlule.
Lezi zinqubo zinomthelela ekwenzeni ngcono ukwabiwa kwe-cholesterol equkethwe kuyi-plasma.
Lapho kukhona i-tendon kanye ne-xanthum enezinto eziningi kanye nokufakwa ngokweqile kwe-cholesterol emzimbeni wesiguli, bangena ekucindezelweni futhi kwezinye izimo bangaxazulula ngokuphelele. Izinqubo ezinjalo ziyaqashelwa emzimbeni phakathi nenkambo ende futhi ezinzile yokwelapha ngosizo lweLipanor.
Ukusetshenziswa kweLipanor kunomthelela wokuvimbela amapulatifomu egazi. Yini evimba ukwakheka kwezigaba zegazi ezindaweni zokubekwa kwe-cholesterol emithanjeni yegazi ngendlela yama-cholesterol plaques.
Umuthi uyakwazi ukukhipha umphumela we-fibrinolytic emzimbeni wesiguli.
I-Ciprofibrate ingena ngokushesha i-lumen ye-emathunjini emathunjini. Iqoqo eliphezulu lomuthi lifinyelelwa emahoreni angama-2 ngemuva kokuthatha umuthi.
Into esemqoka yokusebenza kwama-capsules iyakwazi ukwakha izakhi ezinzile ezinamaphrotheni enziwe ngeplasma yegazi. Le mpahla kufanele ibhekwe lapho kuthathwa i-Lipanorm namalungiselelo omlomo anezakhiwo ze-anticoagulant.
Ukuphila kwesidakamizwa kungamahora angama-17, okwenza sikwazi ukuphuza umuthi kanye ngosuku.
Ukwembiwa kwengxenye esebenzayo kwenziwa izinso ezinomchamo.
Ukwembiwa kwengxenye esebenzayo yenziwa kungashintshiwe futhi njengengxenye ye-glucuron - ifomu elihlangene.
Izinkomba kanye ne-contraindication yokusebenzisa umuthi
I-Lipanor isetshenziswa uma isiguli sinokuthayipha i-IIa hypercholesterolemia ne-endo native hypertriglyceridemia, yomabili esehlukanisiwe futhi ihlanganiswe (izinhlobo IV no-IIb no-III), lapho ukwelashwa okusetshenzisiwe nokubonakalayo kokudla kungavumeli ukuthola umphumela oyifunayo, ikakhulukazi ezimweni lapho izinga le-cholesterol le-serum Inamanani aphezulu kakhulu uma kwenzeka ulandela ukudla.
Isidakamizwa sinconywa ukuthi sisetshenziswe njenge-ejenti yokwelapha uma kunesidingo ukuvimbela ukubonakala kwe-cholesterol eyandayo emzimbeni, lapho kunezici zobungozi zokuthuthukiswa kwe-atherossteosis.
Futhi, umuthi unconyelwa ukuba unqunywe uma kungenzeka welashwa i-atherosulinosis.
Lapho usebenzisa umuthi, contraindication ekhona ukuze isetshenziswe kufanele icatshangwe.
Ukuphulwa okunjalo yile elandelayo:
- ukuba khona kokungabekezelelani komuntu ngamunye;
- ukutholwa kwama-pathologies emsebenzini wezinso nesibindi esigulini;
- ukugula komthambo;
- isifo se-yegilo;
- iqembu leziguli ezingaphansi kweminyaka engu-18;
- isiguli sinenkinga yokuzalwa kabusha ezinqubweni ze-carbohydrate metabolism;
- ukuba khona kwe-glucose ne-galactose ukungabekezeleleki kwesiguli;
- ukuba khona kokuntuleka kwe-lactase esigulini.
Lapho usebenzisa izidakamizwa ukwelapha amazinga aphezulu e-lipids emzimbeni wowesifazane okhulelwe, kudingeka ukuqapha okwengeziwe, okuhambisana nengozi yemiphumela emibi yama-fibrate kwi-fetus ekhulayo.
Imiyalo yokusebenzisa umuthi
ILipanor inconyelwa ukuba ithathwe ngomlomo. Umthamo onconywe ngumenzi ikhava elilodwa lomuthi ngosuku. Ngenkathi uthatha umuthi, kufanele ugezwe ngenani elanele lamanzi.
Kwenqatshelwe ukuthatha lesi sidakamizwa kanye neminye imithi eqenjini lama-fibrate, ngenxa yokuvela kwemiphumela emibi yezidakamizwa.
Indlela yokuncoma yokuphatha ihlanganiswa ne-HMG-CoA reductase kanye nama-inhibitors we-MAO ngenxa yokuthuthuka okungenzeka kwe-myopathy.
Lapho usebenzisa umuthi ngokuhambisana nemithi enciphisa ukuguquguquka kwegazi, kukhona ukwanda komthelela wokugcina kumuntu. Lesi senzo sidinga ukuqaphela lapho senza ukwelashwa okuhlangene.
Ngesikhathi sokwelashwa, imiphumela emibi ingavela.
Imiphumela ejwayelekile yilena elandelayo:
- Izifo zemisipha.
- Ukuzizwa unesicanucanu.
- Izifiso zokuhlanza.
- Ukwephulwa kwesitulo.
- Ukubonakala kwesiyezi.
- Ukuvela kokuzwa kwesizungu.
- Ukuthuthukiswa kwe-migraines.
- Isikhumba ukushesha nokulunywa.
Ngaphezu kwalokho, ukungakwazi amandla kanye nokwephulwa kwenqubo yokususa i-bile emzimbeni kungenzeka.
Uma kwenzeka i-overdose, kufanele uthintane nodokotela wakho ukuthola usizo lodokotela.
Izindleko zomuthi, ama-analogues nokubuyekezwa
Lesi sidakamizwa sithengiswa endaweni yezwe laseRussian Federation emakhemisi kuphela ngokuyalelwa kudokotela ohambelayo.
Ukugcinwa komuthi kufanele kwenziwe emazingeni okushisa angeqi ama-25 degrees Celsius. Endaweni engafinyeleleki ezinganeni futhi ivikelwe elangeni eliqondile.
Impilo yamashalofu yaseLipanor yiminyaka emithathu.
Intengo emaphakathi yomuthi e-Russian Federation icishe ibe ngama-ruble ayi-1400 ngamaphilisi angama-30.
Izifanekiso zomuthi zifaka imali elandelayo yeqembu lama-fibrate:
- I-Bezamidine;
- Bilignin;
- Cetamiphene;
- I-Diosponin;
- Hexopalum;
- IGavilon;
- IGipursol;
- Thuthukisa;
- I-Cholestenorm;
- I-Cholestide;
- I-Cholestyramine.
Ngaphambi kokusebenzisa i-Lipanor, isiguli sitshelwa ukuba sifunde ngokuningiliziwe imiyalo esetshenzisiwe, intengo yomuthi, ukubukeza ngayo nezithasiselo ezikhona, kanye nokubonisana nodokotela wakho ngokusetshenziswa kwomuthi.
Ukhetha izibuyekezo ezitholakalayo, lesi sidakamizwa sisebenza kakhulu ekulweni ne-high serum lipids.
Isazi sevidiyo esikulesi sihloko sikhuluma ngokwelashwa kwe-atherossteosis.
