I-cholesterol ephakanyisiwe inomthelela ekuthuthukisweni kwe-pathologies ye-inhliziyo. Ngokwezibalo, izifo ezinjalo kaningi kunezinye ziholela ekushayweni noma ekushayweni yinhliziyo.
Ukuqongelela kwe-cholesterol embi egazini kungumphumela wokungasebenzi kahle kwe-lipid metabolism. Ezinye izimbangela ze-hypercholesterolemia azixhomekile kumuntu (ifa). Kepha kaningi lesi sifo senzeka ngenxa yendlela engafanele yokuphila - ukusetshenziswa kabi kokudla okunempilo, okunamafutha, ukubhema, ukudakwa, ukuntuleka komzimba.
I-hypercholesterolemia emnene ngokulinganayo iphathwa ngempumelelo ngokwelashwa kokudla. Kepha indlela enganakwa yesifo idinga ukusetshenziswa kwemithi.
I-Ursosan ivame ukusetshenziswa ukwehlisa i-cholesterol. Kepha ngaphambi kokusebenzisa umuthi, kufanele ufunde kabanzi ngezimpawu zawo.
Khipha ifomu nokwakheka
U-Ursosan ungoweqembu le-hepatoprotectors. Yenziwe ngesimo samaphilisi we-gelatin omnyama agcwaliswa nge-powder ecindezelwe.
Kwiphakheji elilodwa kungaba ngu-10,50 no-100 amakhompiyutha. Umuthi lo ukhiqizwa yinkampani yezokwelapha i-PRO.MED.CS Praha, a.s.
Into esebenzayo yesidakamizwa yi-ursodeoxycholic acid. I-capsule eyodwa iqukethe u-0.25 g noma u-0,50 g wesithako esisebenzayo.
Izinto ezengeziwe:
- titanium dioxide;
- i-gelatin;
- i-colloidal titanium dioxide;
- usawoti we-magnesium we-stearic acid;
- isitashi sommbila.
Izici ze-Pharmacological kanye nenqubo yokusebenza
Ngezifo ze-hepatobiliary, ulwelwesi nama-mitochondria amangqamuzana wesibindi ayalimala. Lokhu kuholela ekuwohlokeni kwe-metabolism yabo, ukuncipha kokukhiqizwa kwama-enzyme kanye nokuvinjezelwa kwamakhono okuvuselela.
I-Ursodechoxycholic acid ixhumana nama-phospholipids, ngenxa yalokho amafomu amangqamuzana ayinkimbinkimbi aba yingxenye yezindonga zeseli zesibindi, amathumbu, ne-bile ducts. Futhi, izinto ezakhiwe zandisa ukuvikelwa kwe-cytoprotective, ukukhulisa umphumela wama-asidi anobuthi.
Lokhu kuholela emiphumeleni eminingana emihle eyenzeka esibindini. Ngakho-ke, izakhiwo ze-antitoxic zesitho ziyakhula, ukukhula kwezicubu kwethambo kuyancipha, umehluko uyabonakala, bese umjikelezo weseli uzinze.
Ezinye izakhiwo zokwelapha e-Ursosan:
- Ibambezela ukumuncwa kwama-bile acid ku-mucosa yendlela yokugaya. Lokhu kwandisa ukukhiqizwa kanye nokuqhekeka kwe-bile, kusiza ukucindezela izakhiwo ze-lithogenic ze-bile futhi kwehlise ingcindezi emigudwini ye-biliary ducts.
- Ivimbela ukuhlanganiswa kwe-cholesterol yi-hepatocytes, okuholela ekunciphiseni kokuhlushwa kwe-lipid. I-Ursodeoxycholic acid iphula i-cholesterol futhi inciphise i-bilirubin ku-bile.
- Kwenyusa ukukhiqizwa kwama-enzymes e-pancreatic, okukuvumela ukuthi wenze izitho zokugaya ezijwayelekile namazinga weglucose aphansi.
I-Ursosan inethonya elizuzayo emasosheni omzimba. Umphumela ofanayo utholakala ngokuvimbela ama-immunoglobulins, ukunciphisa umthwalo we-antigenic kuma-ducts we-bile, amaseli wesibindi, ocindezela umsebenzi we-eosinophilic futhi wandise ukwakheka kwama-cytokines.
I-Ursosan ingamaphesenti angama-90 igxishwe ku-mucosa yesistimu yokugaya ukudla. Ibopha amaprotheni e-plasma ngo-97%.
Ngemuva kokufaka i-Ursosan, ukuqoqwa okuphezulu kakhulu kwengxenye eyinhloko egazini kutholakala ngemuva kwamahora ama-1-3. I-metabolism yayo yenzeka esibindini, ngenxa yalokho kwakheka ama-glycine ne-taurine conjugates, adalulwa ku-bile.
Kufika ku-70% we-ursodeoxycholic acid edalulwe ku-bile.
Insalela ihlukaniswe endaweni yokugaya ibe yi-lithocholic acid, edluliselwa esibindini. Lapho, iyagcotshwa, bese ikhishwa ku-bile.
Izinkomba kanye ne-contraindication
I-Ursosan isetshenziselwa i-hepatitis A, C no-B. Imiselwe isifo se-gallstone, ukudakwa kotshwala, i-cirrhosis.
Isidakamizwa sisetshenziswa uma kwenzeka i-dyskinesia ne-intrauterine anomaly ye-bile duct. Ngosizo lwe-Ursosan, cholangitis, cystic fibrosis, Reflux esophagitis noma gastritis ziphathwa ngempumelelo.
Umuthi usetshenziselwa ukungasebenzi kahle ohlelweni lokugaya ukudla okubangelwa ukungahambi kahle emthanjeni. Umuthi usetshenziselwa ukunciphisa imiphumela emibi esibindini ngemuva kokudla imishanguzo, izidakamizwa ezilwa nomdlavuza, izindlela zokuvimbela inzalo ngomlomo. I-Ursosan nayo ibekelwa i-jaundice ezinganeni nase hepatosis.
Kodwa ingabe i-Ursosan yehlise i-cholesterol? Ukubuyekezwa kodokotela abaningi kukhombisa ukuthi umuthi unganciphisa inani lama-lipoprotein aphansi egazini. Umphumela we-Hypocholesterolemic utholakala ngokuvimbela ukukhiqizwa kwe-cholesterol emzimbeni, unciphise ukuphuma kwawo ku-bile futhi kuvimbele ukumuncwa kwawo emathunjini.
I-Ursosan inganciphisa ngisho nengozi yokwakheka kwe-atherosselotic plaque odongeni lomkhumbi. Futhi, i-hepatoprotector iyakwazi ukususa amafutha kumaseli wesibindi. Ngakho-ke, kunqunyelwe ukukhuluphala okubangelwa ukuqokelelwa kwe-cholesterol ngama-hepatocytes.
I-Ursodeoxycholic acid ingakhulisa umphumela wokwelapha wabanye ama-ejenti onomphumela we-anticholesterolemic. Kulokhu, umuthi uvikela amaseli emiphumeleni eyingozi yemithi.
I-Ursosan ibekezelelwa kahle ngumzimba, kepha ezimweni eziningi ukusetshenziswa kwayo kuyaphikiswa. Umuthi awunqunyelwe emacaleni alandelayo:
- ukuba khona kwe-bistary fistulas;
- ukungasebenzi kahle kwezinso nezinso;
- ukwanda kwezifo zohlelo lwe-hepatobiliary;
- ukwehla kokusebenza kwe-gallbladder;
- ukungabekezeleli izingxenye zomkhiqizo;
- ukuphuma kwe-bile duct;
- ukuba khona ohlelweni lwe-urogenital lwamatshe aqukethe i-calcium;
- i-cirrhosis ebolile;
- ukuvuvukala kohlelo lokugaya;
- iminyaka efinyelela eminyakeni emi-4.
Ukwephula umthetho okuhlobene nokuthatha i-Ursosan ukukhulelwa. Kodwa uma kunesidingo, udokotela angabeka umuthi kowesifazane ku-trimester engu-2-3.
Imiyalo yokusebenzisa umuthi
I-Ursosan ithathwa ngomlomo ngaphandle kokuhlafuna i-capsule.
Ziyagezwa ngamanzi amaningi.
Kunconywa ukuphuza umuthi kusihlwa.
Umthamo nobude besifundo sezokwelapha sinqunywa ngobunzima kanye nohlobo lwesifo. Imvamisa umuthi uthathwa ezinyangeni eziyisithupha uye eminyakeni emi-2.
Ngokwesilinganiso, inani elifanele lomuthi likhethiwe ngokuya ngesisindo sesiguli:
- kuze kufike ku-60 kg - amaphilisi ama-2 ngosuku;
- 60-80 kg - amaphilisi ama-3 ngosuku;
- 80-100 kg - amaphilisi ama-4 ngosuku;
- ngaphezu kwe-100 - amaphilisi angama-5 ngosuku.
Lapho i-Ursosan ibekelwa injongo yokuqeda amatshe e-cholesterol, isimo esibalulekile ukuthi amatshe abe yi-X-ray engemihle, enobubanzi obufika ku-20 mm. Kulokhu, i-gallbladder kufanele isebenze ngokujwayelekile, futhi akunakwenzeka ukuthi inani lamatshe akulo lidlula isigamu umthamo wezitho.
Futhi, ukuthola kabusha ama-gallstones, kubalulekile ukuthi izindunduma ze-bile zibe nokuqina okuhle. Ngemuva kokuqeda amatshe e-cholesterol, udinga ukuphuza i-Ursosan ezinye izinsuku ezingama-90 njengesilinganiso sokuvimbela. Lokhu kukuvumela ukuthi uchithe izinsalela zamatshe amadala futhi uvikele ukwakheka kwamatshe amasha.
Ngaphambi kokuthatha i-Ursosan ukuze wehlise i-cholesterol ephezulu, kunconywa ukuthatha izivivinyo ze-AST, ALT futhi wenze ucwaningo lokuthola izinga le-cholesterol egazini. Imiphumela yokuhlola iqhathaniswa ngaphambi nangemuva kokwelashwa, okuvumela udokotela ukuthi aqonde ukuthi u-Ursosan usize kangakanani i-cholesterol ephansi.
Kuyaphawuleka ukuthi ezigulini ezingaphethwe yi-hypercholesterolemia kanye ne-atherosclerosis, ngemuva kokuthatha i-hepatoprotector, inani le-cholesterol emzimbeni lingaba ngaphansi kokujwayelekile.
Kodwa-ke, lesi simo asinabungozi empilweni futhi ekugcineni kokwelashwa kuyadlula.
Imiphumela emibi kanye ne-overdose
Imvamisa, ukusabela okungekuhle ngemuva kokuthatha i-Ursosan kwenzeka iziguli ezinganamatheli emiyalweni yezokwelashwa. Imiphumela eminingi emibi ihlobene nokuphazamiseka kwendlela yokugaya ukudla. Lokhu kuhlanza, isicanucanu, igesi ekhuphukayo, ubuhlungu besisu nokuphazamiseka emgodleni wamathumbu (ukuqunjelwa noma isifo sohudo).
Ukusetshenziswa isikhathi eside kwe-Ursosan kungaholela ekubalweni kwamatshe we-cholesterol. Ukwelashwa kwe-heepatoprotective kwesinye isikhathi kunomthelela ekuthuthukisweni komzimba futhi kuholele ekuqwashiseni, ebuhlungwini basemuva, kwi-alopecia, ekuphepheni komzimba, ekukhuliseni kwe-psoriasis.
Uma kwenzeka kwe-overdose ye-Ursosan, isifo sohudo sivame ukwenzeka, ukusabela okungekuhle okusetshenziswayo kuvame ukuvela lapho umthamo udlulwa. Kulokhu, into esebenzayo yesidakamizwa iqala ukungangeni kahle emathunjini futhi ishiye umzimba uhambisana nezindunduma.
Uma isifo se-stool siphawulwa ngemuva kokuthatha i-Ursosan, kufanele uthathe izinyathelo ezilandelayo:
- ukunciphisa umthamo wesidakamizwa noma ukuyeke ngokuphelele ukusetshenziswa kwawo;
- phuza amanzi amaningi ahlanzekile;
- buyisela ibhalansi ye-electrolyte.
Ukusebenzisana kwezidakamizwa kanye nama-analog
Umyalo wesidakamizwa uthi i-Ursosan ayinakuhlanganiswa ne-aluminium nama-antacid aqukethe ama-resin ion-exchange. Lokhu kunganciphisa ukumuncwa kwe-ursodeoxycholic acid.
Ukuphathwa kanyekanye kwezidakamizwa ngama-estrogens, i-Neomycyon, Clofibrate ne-Progestin kuzoholela ekwandeni kwe-cholesterol emzimbeni. Ukusetshenziswa kwe-Ursosan nge-cholestipol ne-cholestyramine, okuyi-antagonists, nakho akufiseleki.
IHepatoprotector ithuthukisa umphumela weRazuvastatin, ngakho-ke umthamo wokugcina kufanele wehliswe. I-Ursosan yehlisa ukusebenza kahle kwezokwelapha kwale mithi elandelayo:
- Dapson;
- Ama-cyclosporins;
- INifedipine;
- INitrendipine;
- Ama-Ciprofloxacins.
Ngesikhathi sokulashwa nge-Ursosan, akunakufiseleka ukuphuza utshwala kanye nama-tinctures nge-ethanol. Kunconywe futhi nokulandela inombolo yokudla engu-5, ngaphandle kokusebenzisa ukudla okunamafutha, inyama ebhemayo, ukudla okusemathinini neziphuzo zekhofi.
Izindleko ze-Ursosan zamakhompiyutha ayi-10 (250 mg) - kusuka kuma-ruble angama-180, ama-capsules angama-50 - kusuka kuma-ruble ayi-750, amaphilisi angama-100 - kusuka kuma-ruble ayi-1370. Uma ithebhulethi eyodwa iqukethe ama-500 mg ento esebenzayo, khona-ke inani lentengo lomuthi liyakhuphuka (izingcezu ezingama-50 - 1880 p., Izingcezu eziyikhulu - 3400 p.).
Ama-analogues adumile e-Ursosan yi-Aeshol, Ursokhol, Livodeksa, Holudexan, Ursofalk, Urso 100 ne-Ursomax. Futhi, umuthi ungashintshwa ngezindlela ezinjenge-Grinterol, Ursacline, Ursodez, Allohol ne-Ursofalk.
Ukubuyekezwa mayelana ne-Ursosan kulungile kakhulu. Iziguli ziqaphela ukuthi umuthi uchitha ngempela amatshe futhi uvimbele ukwakheka kwawo okulandelayo. Kodwa-ke, umphumela wokwelapha utholakala okungenani izinyanga ezi-3 ngemuva kokuqala kwemithi.
I-Ursosan inezibuyekezo ezingezinhle. Imvamisa zihambisana nokuthuthuka kwemiphumela emibi njengokucasuka kwesitulo kanye nenausea. Kepha ngaphandle kwalokhu, bobabili odokotela neziguli abaphiki ukusebenza kahle komuthi ekwelapheni izifo ze-gallstone kanye ne-hypercholesterolemia.
Ukubuyekezwa kwe-Ursosan kunikezwe kuvidiyo ekulesi sihloko.
