I-Atomax isho izidakamizwa-ama-statins zesizukulwane se-III, ezinomphumela ophansi we-lipid. Kuyinto blocker ekhethiwe yokuncintisana ye-HMG-CoA reductase, i-enzyme ebanga isilinganiselo sokuqala sokwehla kwe-cholesterol synthesis.
Ukusetshenziswa kwesidakamizwa kufanelekile ekwelapheni i-hypercholisterinemia kanye ne-thyroglobulin (TG) ephakeme. Ngenxa ye-Atomax, i-lipid metabolism ingahle yenziwe ibejwayelekile futhi imiphumela emibi ye-cholesterol ephezulu ingavinjelwa.
Kulesi sisetshenziswa ungathola imininingwane enemininingwane mayelana nomuthi i-Atomax, imiyalo yokusebenzisa, intengo, ukubuyekezwa kweziguli nezidakamizwa ezifanayo.
Khipha ifomu nokwakheka
I-Atomax isidakamizwa okuhloswe ngaso ukucindezela ukuncishiswa kwe-HMG-CoA, okuholela ekunciphiseni kokuhlanganiswa kwe-cholesterol kumaseli wesibindi. Ngokungafani nama-static esizukulwane sokuqala, i-Atomax ingumuthi wemvelaphi yokwenziwa.
Emakethe yamakhemikhali ungathola isidakamizwa esenziwa yinkampani yaseNdiya iHeteroDrags Limited nezitshalo ezifuywayo zeNizhpharm OJSC, Skopinsky Pharmaceutical Plant LLC.
I-Atomax iyatholakala ngesimo samathebulethi amhlophe ayindilinga ngesimo ezinhlangothini ze-convex. Ukusuka phezulu zimbozwe nge-membrane yefilimu. Iphakethe elilodwa liqukethe amaphilisi angama-30.
Ithebhulethi ifaka i-10 noma i-20 mg yento esebenzayo - i-atorvastatin calcium trihydrate.
Ngaphezu kwengxenye eyinhloko, ithebhulethi ngayinye negobolondo layo liqukethe inani elithile:
- i-croscarmellose sodium;
- i-talcum powder ehlanziwe;
- i-lactose mahhala;
- i-magnesium stearate;
- isitashi sommbila;
- i-calcium carbonate;
- i-povidone;
- i-silicon dioxide i-colloidal enamanzi;
- i-crospovidone;
- unxantin;
Ngaphezu kwalokho, inani elithile le-titanium dioxide lifakiwe kulungiselelo.
Umshini wokusebenza kwento esebenzayo
Njengoba kushiwo ngaphambili, umphumela wokuncipha kwe-lipid we-Atomax utholakala ngokuvimba ukuphindisela kwe-HMG-CoA. Umgomo oyinhloko wale enzyme ukuguqula i-methylglutarylcoenzyme A ibe i-mevalonic acid, okuyisandulelo se-cholesterol.
I-Atorvastatin isebenza kumaseli wesibindi, yehlisa inani lokukhiqizwa kwe-LDL ne-cholesterol. Isetshenziswa ngempumelelo yiziguli ezihlushwa i-homozygous hypercholesterolemia, engeke yelashwa nezinye izidakamizwa ezokwehlisa i-cholesterol. Amandla wokwehla kokuhlushwa kwe-cholesterol ngqo kuncike kumthamo wento esemqoka.
I-Atomax ayinconywa ukuba ithathwe ngesikhathi sokudla, njengoba ukudla kunciphisa isilinganiso sokumuncwa. Ingxenye esebenzayo igxilwe ngokuphelele emgodini wokugaya ukudla. Okuqukethwe okuphezulu kwe-atorvastatin kugcinwa amahora ama-2 ngemuva kwesicelo.
Ngaphansi kwethonya lama-enzymes CY ne-CYP3A4, i-metabolism iyenzeka esibindini, ngenxa yalokho kwakheka ama-metabolites e-parahydroxylated. Ngemuva kwalokho ama-metabolites asuswa emzimbeni kanye ne-bile.
Izinkomba kanye ne-contraindication yokusebenzisa umuthi
I-Atomax isetshenziselwa ukwehlisa i-cholesterol. Udokotela ubeka umuthi ohambisana nokondleka kokudla kokuxilongwa okunjenge-hypercholesterolemia eyisisekelo, ne-heterozygous.
Ukusetshenziswa kwamathebhulethi nakho kufanelekile ekugxileni kwe-serum ye-thyroglobulin (TG), lapho ukwelashwa kokudla kungalethi imiphumela oyifunayo.
I-Atorvastatin inciphisa ngempumelelo i-cholesterol ezigulini ezine-homozygous Famer hypercholesterolemia, lapho ukwelashwa nokudla okungeyona eyokwelapha kungazinzi umzimba we-lipid.
I-Atomax ayivunyelwe kwezinye izigaba zeziguli. Umyalo uqukethe uhlu lwe-contraindication kusetshenziswa umuthi:
- Izingane nentsha engaphansi kweminyaka engu-18.
- Isikhathi sokuzala nengane.
- Ukungasebenzi kwe-Hepatic kwemvelaphi engaziwa.
- Hypersensitivity kuzakhi zomkhiqizo.
Umuthi ubekwa ngokuqapha uma kwenzeka kune-arterial hypotension, ukungalingani kwama-electrolyte, ukungasebenzi kahle kohlelo lwe-endocrine, i-pathologies yesibindi, ukuluthwa utshwala okungapheli kanye nesithuthwane, okungeke kulawulwe.
Imiyalo yokusebenzisa umuthi
Iphuzu elibalulekile ekwelashweni kwe-Atomax ukugcinwa kokudla okukhethekile. Ukudla okunempilo kuhlose ukunciphisa ukunciphisa ukudla okuqukethe i-cholesterol ephezulu. Ngakho-ke, lokhu kudla akufaki ukusetshenziswa kwe-viscera (izinso, ubuchopho), izikhupha zamaqanda, ibhotela, fat yengulube, njll.
Umthamo we-atorvastatin uhluka kusuka ku-10 kuye ku-80 mg. Njengomthetho, udokotela oholayo unquma umthamo wokuqala we-10 mg ngosuku. Izici eziningana zithonya umthamo womuthi, njengezinga le-LDL ne-cholesterol ephelele, izinhloso zokwelashwa kanye nokusebenza kwawo ngempumelelo.
Ukungezelela umthamo kungenziwa ngemuva kwezinsuku eziyi-14-21. Kulokhu, ukugcotshwa kwama-lipids kwiplasma yegazi kuyimpoqo.
Ngemuva kwezinsuku eziyi-14 zokwelashwa, ukwehla kwamazinga e-cholesterol kuyabonakala, futhi emva kwezinsuku ezingama-28 umphumela omkhulu wokwelapha utholakala. Ngokulashwa isikhathi eside, i-lipid metabolism ibuyela kokujwayelekile.
Ukufakwa komuthi kufanele kugcinwe endaweni evikelwe elangeni eliqondile kude nezingane ezincane. Umbuso wokushisa wesitoreji uhluka kusuka ku-5 kuya ku-20 degrees Celsius.
Impilo yeshelf iyiminyaka emi-2, ngemuva kwalesi sikhathi umuthi owenqatshelwe ukuthatha.
Ukulimala Okungaba Kakhulu kanye Nehaba ngokweqile
Ukuzilawula kwomuthi wokwelapha izidakamizwa akuvunyelwe ngokuphelele.
Ngesinye isikhathi, umuthi ungadala ukusabela okungesihle esigulini.
Ngaphambi kokusebenzisa i-Atomax, kufanele uthintane nodokotela wakho.
Ishidi lokufundisa lisho ukuvela okungenzeka kwemiphumela emibi enjalo:
- Ukuphazamiseka kwesistimu yezinzwa esezingeni eliphakathi: i-asthenic syndrome, ukulala kabi noma ukozela, amaphupho amabi, i-amnesia, isiyezi, ikhanda, ukucindezeleka, i-tinnitus, izinkinga zokuhlala, i-paresthesia, i-peropheral neuropathy, ukuphazamiseka kokunambitha, umlomo owomile.
- Ukuphendula okuhambisana nezitho zokuzwa: ukuthuthukiswa kokungezwa, i-conjunctiva eyomile.
- Izinkinga zesistimu yenhliziyo ne-hematopoietic: i-phlebitis, i-anemia, i-angina pectoris, i-vasodilation, i-orthostatic hypotension, i-thrombocytopenia, ukukhuphuka kwenhliziyo, i-arrhythmia.
- Ukungasebenzi komgudu wokugaya ukudla kanye nohlelo lokuphilisana: ukuqunjelwa, isifo sohudo, isicanucanu nokuhlanza, Ubuhlungu besisu, i-hepatic colic, i-belching, ukushisa kwenhliziyo, ukwanda kwegesi, i-pancreatitis eyingozi.
- Ukuphendula kwesikhumba: ukulunywa, ukuqubuka, i-eczema, ukuvuvukala kobuso, i-photosensitivity.
- Izinkinga zesistimu ye-musculoskeletal: imisipha imincele yamaphethelo aphansi, izinhlungu ezithweni zokuhlangana kwamalunga nasemhlane, i-myositis, i-rhabdomyolysis, isifo samathambo, ukwanda kwe-gout.
- Ukusebenza kahle kokuchama: ukubambezeleka ukuchama, i-cystitis.
- Ukuwohloka kwamapharamitha okulebhu: i-hematuria (igazi emchameni), i-albhamuinuria (iprotheni emchameni).
- Okunye ukusabela: i-hyperthermia, ukuncipha kwesifiso sobulili, ukungasebenzi kahle kwe-erectile, i-alopecia, ukujuluka ngokweqile, i-seborrhea, i-stomatitis, izinsini ezopha igazi, umhluzi, ubufazi kanye nekhala.
Ukuthatha imithamo ephezulu ye-atorvastatin kwandisa ingozi yokuhluleka kwezinso, kanye ne-myopathy (isifo se-neuromuscular isifo) kanye ne-rhabdomyolysis (i-myopathy ebanga kakhulu).
Kuze kube manje, asikho isidakamizwa esikhethekile salo muthi.
Uma kuvela izimpawu zokweqisa, kufanele ziqedwe. Kulokhu, i-hemodialysis ayisebenzi.
Ukuxhumana nezinye izidakamizwa
Izinto ezisebenzayo zezidakamizwa zingasabela phakathi kwazo ngezindlela ezihlukile, ngenxa yalokho umphumela wokwelapha we-Atomax ungakhuphuka noma unciphe.
Amathuba okuxhumana phakathi kwezakhi zemithi ehlukahlukene kudinga ukuthi isiguli sazise udokotela oholayo ngokuthatha imithi ethinta umsebenzi we-Atomax.
Emiyalweni yokusetshenziswa komuthi we-hypolipidemic, kunemininingwane ephelele yokuxhumana nezinye izidakamizwa.
Ukufundiswa kwazisa:
- Ukwelashwa okuhlanganisiwe nge-cyclosporine, i-erythromycin, i-fibrate kanye nama-antifungal agents (iqembu lama-azoles) kwandisa ingozi ye-neuromuscular pathology - myopathy.
- Ngesikhathi sokucwaninga, ukuphathwa kanyekanye kwe-Antipyrine akubangeli ushintsho olukhulu kuma-pharmacokinetics. Ngakho-ke, ukuhlanganiswa kwezidakamizwa ezimbili kuvunyelwe.
- Ukusetshenziswa okuhambisanayo kokumiswa okuqukethe i-magnesium hydroxide noma i-aluminium hydroxide, kuholela ekwehleni kokuqukethwe kwe-atorvastatin ku-plasma.
- Ukuhlanganiswa kwe-Atomax ngemithi yokulawula ukuzala equkethe i-tinylestradiol ne-norethindrone kukhulisa i-AUC yalezi zingxenye.
- Ukusetshenziswa ngesikhathi esisodwa kwe-colestipol kunciphisa izinga le-atorvastatin. Lokhu-ke kuthuthukisa umphumela wokwehlisa i-lipid.
- I-Atomax inganyusa okuqukethwe kwe-digoxin egazini. Uma kunesidingo, ukwelashwa ngalesi sidakamizwa kufanele kube ngaphansi kokuqashwa okuqinile kwezokwelapha.
- Ukulawulwa okufanayo kwe-Azithromycin akukuthinti okuqukethwe kwengxenye esebenzayo ye-Atomax ku-plasma yegazi.
- Ukusetshenziswa kwe-erythromycin ne -cacithromycin kubangela ukwanda kwezinga le-atorvastatin egazini.
- Ngesikhathi sokuhlolwa kwemitholampilo, akukho ukutholwa kwamakhemikhali okutholakele phakathi kwe-Atomax neCimetidine, eWarfarin.
- Ukwanda kwezinga lezinto ezisebenzayo lubonwa lapho umuthi uhlanganiswa nama-proteinase blockers.
- Uma kunesidingo, udokotela ukuvumela ukuthi uhlanganise i-Atomax nemithi, efaka i-Amplodipine.
- Ucwaningo lokuthi umuthi uxhumana kanjani nezidakamizwa ze-antihypertensive awenziwanga.
Ngokuhlanganiswa kwe-Atomax ne-estrogen, akukho ukusabela okungekuhle okwabonwa.
Intengo, ukubuyekezwa kanye nama-analogues
Kunolwazi oluncane ngokusebenza kahle kokusebenzisa i-Atomax kwi-Intanethi. Iqiniso ngukuthi njengamanje, ama-statins ama-IV isizukulwane asetshenziswa kwezokwelapha. Le mishanguzo inomthamo omaphakathi futhi ayibangeli imiphumela emibi eminingi.
I-Atomax kunzima impela ukuyithenga emakhemisi akuleli ngenxa yokuthi manje cishe ayisetshenziswa. Ngokwesilinganiso, intengo yephakeji (amaphilisi angama-30 we-10 mg) isukela kuma-ruble angama-385 kuya kwangama-420. Uma kunesidingo, umuthi ungabhalwa ku-inthanethi kuwebhusayithi esemthethweni yabakhiqizi.
Kunokubuyekezwa okumbalwa ku-ejenti yokunciphisa i-lipid kwizithangami ezinezihloko. Esikhathini esiningi, bakhuluma ngokuvela kwemiphumela emibi ngenkathi bethatha umuthi. Noma kunjalo, kunemibono ehlukile.
Ngenxa yokuphambana okuhlukahlukene nokusabela okungekuhle, kwesinye isikhathi udokotela ubeka isichazamazwi (umuthi onento efanayo esebenzayo) noma i-analogue (equkethe izingxenye ezihlukile, kepha ukhiqiza umphumela ofanayo wonyango).
Izimpawu ezifanayo ze-Atomax zingathengwa emakethe yezokwelapha yaseRussia:
- I-Atovastatin (Cha. 30 ku-10 mg - ama-ruble ayi-125);
- I-Atorvastatin-Teva (Cha. 30 yama-10 mg - ama-ruble ayi-105);
- I-Atoris (Cha. 30 ye-10 mg - ama-ruble angama-330);
- I-Liprimar (No. 10 ku-10 mg - ama-ruble angama-198);
- INovostat (Cha. 30 ye-10 mg - ama-ruble angama-310);
- I-Tulip (Cha. 30 ye-10 mg - ama-ruble angama-235);
- I-Torvacard (Cha. 30 ku-10 mg - ama-ruble angama-270).
Phakathi kokufana okusebenzayo kwe-Atomax, kuyadingeka ukuhlukanisa izidakamizwa ezinjalo:
- I-Akorta (No. 30 ye-10 mg - ama-ruble ayi-510);
- I-Krestor (No. 7 ye-10 mg - ama-ruble ayi-670);
- I-Mertenil (Cha. 30 ye-10 mg - ama-ruble ayi-540);
- I-Rosuvastatin (No. 28 ku-10 mg - 405 ruble);
- I-Simvastatin (Cha. 30 ku-10 mg - ama-ruble ayi-155).
Ngemuva kokufunda ngokucophelela izidakamizwa ze-Atomax, imiyalo yokusebenzisa, intengo, i-analogues kanye nombono wabathengi, isiguli, kanye nochwepheshe ohambelayo, bazokwazi ukuhlola ngobuhlakani isidingo sokuphuza umuthi.
Imininingwane mayelana nama-statin inikezwe kuvidiyo kule ndatshana.
