Kuze kube manje, kunenqwaba yezidakamizwa ezisiza ukwehlisa i-cholesterol egazini lomuntu.
Zisetshenziswa ezimweni lapho ukudla nokudla okungezona izidakamizwa kunganikeli imiphumela emihle.
Enye yale mithi eyingxenye yezidakamizwa ezithile i-ciprofibrate.
I-ziprofibrate isidakamizwa esinciphisa i-lipid esinciphisa i-cholesterol ye-LDL ne-plasma triglycerides, kuyilapho i-lipoproteins ephezulu ("emihle" cholesterol), kunalokho, iyandisa.
Ukusetshenziswa kwesidakamizwa akunconywa hhayi njengethuluzi elizimele, kepha kuhlangene nokudla nezinye izindlela zokwelapha ezingezona ezokwelapha. Isenzo sincike emandleni okubopha kuma-cell nucleus receptors, lapho asebenze khona futhi andise noma anciphise umsebenzi wezakhi zofuzo obhekene nokushintshana kwama-lipoprotein emzimbeni.
Ukwelashwa okusebenza isikhathi eside okusebenzayo, lapho kunokwehla okukhulu kwe-serum cholesterol, kuholela ekunciphiseni noma ekushabalaleni ngokuphelele kwama-cholesterol deposits.
I-Ciprofibrate ivimbela ukuvela kweziqeshana zegazi, ikhuthaza ukuwohloka kwama-fibrins, futhi ithuthukise nokubekezelelana kwe-glucose, okuyinto ebalulekile ezigulini ezinesifo sikashukela.
Kuyasiza ukunciphisa inkambo yezifo zenhliziyo ezi-coronary, kepha akusona isizathu sokwehlisa ukushona kwabantu lapho kusetshenziswa ekuvinjelweni kwezifo zesistimu yenhliziyo. Amathebulethi athathwa ngomlomo, emva kwalokho ashesha futhi acishe amunca ngokuphelele. Inamandla okubopha kumaphrotheni e-plasma. Kukhululwa emchameni kungashintshiwe noma ngesimo sokuxutshwa ne-glucuronic acid.
Ngokuya kokubuyekezwa kweziguli ezithatha umuthi, kubonakaliswa ngasohlangothini oluhle.
Imiphumela emibi ayibonakaliswa, futhi umphumela wesidakamizwa unomphumela omuhle ku-cholesterol yegazi.
Isidakamizwa sisetshenziswa ngemuva kokubonisana nodokotela ohambayo, ozoqinisekisa isidingo sokusetshenziswa kwaso esimweni ngasinye ngawodwana. Izinkomba ezisetshenziswayo yilezi:
- Ukungezelelwa ekwelashweni kokudla kanye nezinye izindlela zokwelapha ezingezona izidakamizwa ze-cholesterol ephezulu;
- Ifomu elinamandla le-hypertriglyceridemia ene-cholesterol ephansi noma engenayo;
- I-hyperlipidemia exubekile ezimweni lapho ukusetshenziswa kwama-statins kuchazwe nganoma yisiphi isizathu.
Umuthi unqunywa u-100 mg kanye ngosuku. Uma kunesidingo, nyusa umthamo ube ngu-200 mg kanye ngosuku.
Ezinyangeni zokuqala eziyi-12 zokwelashwa nge-ciprofibrate, kuhleliwe uhlelo lokuhlola (isikhathi esingu-1 ezinyangeni eziningana) lomsebenzi we-planethi we-ALT.
Umuthi unohlu olubanzi kakhulu lwe-contraindication, phakathi kwako kukhona:
- Hypersensitivity kunoma yiziphi izingxenye zomuthi;
- Ukwehluleka kwangempela noma ezinye izifo zesitho;
- Ukwehluleka kwesibindi;
- Isikhathi sokukhulelwa kwabesifazane;
- Isikhathi sokuzala;
- Iminyaka yezingane.
Ngemuva kokusetshenziswa kwama-fibrate, kube nezimo zokulimazeka kwezicubu zemisipha, kufaka phakathi amacala e-rhabdomyolysis. Kulesi simo, ukwanda okumakwe kuzinga leengozi zale miphumela engemihle ezigulini ezinokwehluleka kwezinso. Imiphumela emibi ehambisana nokulimazeka kwemisipha imvamisa ibangelwa ukweqisa ngokweqile.
Ezigulini zokushoda kwama-hormone egilo, kungabonakala izinguquko zesisekelo se-pathological ekwakhekeni kwamafutha egazini. Kubalulekile ukulungisa inani labo ngaphambi kokuthatha umuthi. Ngesikhathi se-hypothyroidism, izifo zesifo sezinzwa ezingapheli zingakhula, zibonakaliswe ukulimala kwemisipha okuyisisekelo, okuthi esikhathini esizayo kungaholele ekwandeni komphumela onobuthi be-fibrate emzimbeni.
Imiphumela emibi yesidakamizwa:
- Ukuvela kwezihloko zekhanda lokuhlukahluka okungafani;
- Ukuvela kwenhliziyo;
- Ubuthakathaka obujwayelekile bomzimba, ukukhuphuka kokukhathala;
- I-Myositis;
- I-Myalgia;
- Ukwanda kwesikhashana emsebenzini we-ALT, CPK ne-LDH, okuqukethwe kwe-creatinine ku-plasma yegazi;
- Ukwanda kwe-cholelithiasis;
- Ukuvela kwesikhumba sokuqhuma kwendawo eyahlukahlukene;
- Ukuphazamiseka kwesisu - i-dyspepsia, isicanucanu, ukugabha, uhudo, ubuhlungu besisu, i-pancreatitis eqeda ukuqina kanye nesikhathi eside.
I-overdose ye-ciprofibrate ayibangeli zimpawu ezithile, noma kunjalo, lapho uthatha inani elikhulu lezinto, bonana nodokotela.
Akunconywa ukuthi usetshenziswe ngokubambisana namanye ama-fibrate, ngoba lokhu kukhulisa ubungozi be-rhabdomyolysis kanye ne-pharmacodynamic antagonism.
Uma isetshenziswa ndawonye ne-coagulants yomlomo, ikhulisa umphumela wayo emzimbeni, okwandisa ingozi yokopha.
Kwezinye izimo, kwandisa imiphumela yezidakamizwa zesifo sikashukela. Ngokuhambisana nama-statins namanye ama-fibrate, kungadala i-myopathy ngokweqile, kubonakaliswa ukubhujiswa kwamaseli we-izicubu zomzimba, ukwanda okukhulu komsebenzi we -ineine kinase, ukwanda kokuhlushwa kwe -ineineine kanye ne-myoglobinuria, okungaholela ekwehlulekeni kwe-renal yento enkulu.
Kwangathi kungadedelwa ezinye izidakamizwa kusuka kwizakhi zamaphrotheni ngokubopha kumaphrotheni e-plasma.
Uma, ngokumelene ingemuva lokwelashwa nge-ciprofibrate, ukwehla kokuxineka kwama-serum lipids akukaze kutholakale kungakapheli izinyanga ezi-3-6, khona-ke kufanele kunikezwe amanye ama-ejenti okwelapha noma amanye amaphilisi okwelapha.
Kwezinye iziguli, ukuthatha izidakamizwa zaleli qembu kubangela ukwanda kwesikhashana kokuqukethwe kwama-transaminases, okwenza ukuthi kudingekile ukunquma izinga labo izinyanga eziningana ngonyaka wokuqala wokwelashwa nomuthi.
Ngokwanda komsebenzi we-serum alanine transamylase ngaphezulu kwamayunithi ayi-100, ukwelashwa kufanele kuyekwe.
Ukusetshenziswa kwezinye izidakamizwa zeqembu le-fibrate ngokuhlangana ne-ciprofibrate akukhuthaziwe.
I-analogue yale nto kanye nomuthi owaziwa kakhulu, okuyingxenye yawo, yiLipanor. Kuyisidakamizwa esithengiswa ekhemisi ngokunikezwa umuthi. Kutholakala kumakhompiyutha aqukethe i-100 mg ye-ciprofibrate. Amakhandlela asemabhulashini, kwiphakheji - ama-3 amabhliki.
Eminye imithi, isakhi esisebenzayo sayo yi-Ciprofibrate, ayitholakali, noma kunjalo, kunezidakamizwa ezithengiswayo ezingabalingisi beqembu: Roxer, Lipantil, Lipantil 200 mg, Vitrum Cardio omega-3.
Intengo yale mithi ihluka kusuka ku-850.00 kuya kuma-ruble ayi-1300,00. Ukusetshenziswa kwabo kumele kuvunyelwane kakhulu nodokotela oholayo ukuze kungafakwa ukungabekezelelani komuntu ngamunye kanye nokuvela kokungaphenduki okuhle komzimba.
Ukwelashwa kwe-atherosclerosis kuchazwe kule vidiyo kule ndatshana.
