I-Atromide iyingxenye yeqembu elibizwa ngokuthi izidakamizwa ezisehlisa i-lipid. Izidakamizwa kuleli qembu zisiza ukwehlisa i-lipids yegazi. Lezi zingxube ze-organic zibamba iqhaza elibalulekile emzimbeni womuntu, kepha ukweqisa kwazo kungaholela ekubukekeni kwezifo ezahlukahlukene.
Ama-lipids aphakanyisiwe abangela i-atherosclerosis, isifo esidlangile namuhla. Phezu kwemithambo, kufakwa ama-atherosselotic plaque, akhula futhi asakazeke ngokuhamba kwesikhathi, anciphise ukukhanya kwemithambo bese kuphazamisa ukuhamba kwegazi. Lokhu kufaka ukuvela kwezifo eziningi zenhliziyo.
I-Hypolipidemia kungenzeka ingezi ngokwayo, ukuhlolwa kwegazi okune-biochemical kuyasiza ukuyikhomba. Imbangela yokuqala kwalesi sifo ingaba yindlela yokuphila engafanele, ukondleka nokudla izidakamizwa ezithile. Ukusetshenziswa kwe-Atromide kufakiwe kuyinkimbinkimbi yokwelashwa kwezifo ze-lipid metabolism futhi njalo kuthola ukubuyekezwa okuhle okuvela ezigulini, kepha ngaphambi kokuyisebenzisa, usadinga ukubonana nodokotela.
Izinkomba zokusetshenziswa nomphumela emzimbeni
Umphumela wokwelapha umuthi ukunciphisa okuqukethwe kwe-triglycerides ne-cholesterol ku-plasma yegazi kanye ne-lipoprotein ephansi futhi ephansi kakhulu.
I-Atromide ngasikhathi sinye iholela ekwandeni kwe-cholesterol kuma-lipoprotein aphezulu we-density, evimbela ukubonakala kwe-atherossteosis.
Ukwehla kwe-cholesterol kungenxa yokuthi umuthi uyakwazi ukuvimba i-enzyme, obandakanyeka ku-biosynthesis ye-cholesterol futhi ithuthukise ukuwohloka kwayo.
Futhi, umuthi uthinta izinga le-uric acid esegazini lapho uyehla, wehlise imbonakalo ye-plasma kanye ne-platelet.
Umuthi usetshenziswa ekwelapheni okuyinkimbinkimbi kwezifo ezilandelayo:
- i-angiopathy yesifo sikashukela (ukwephulwa kwethoni kanye nemvume yemithambo yegazi ye-fundus ngenxa yokwanda koshukela wegazi);
- i-retinopathy (ukulimala kwe-retic retina yemvelo engeyona yokuvuvukala);
- i-sclerosis yemithambo ye-peripheral kanye ne-coronary kanye nemithambo ye-cerebral;
- izifo ezibonakaliswa yi-lipidma lipids ephezulu.
Umuthi futhi ungasetshenziswa njengezinyathelo zokuvimbela ezimweni ze-hypercholesterolemia yomndeni - isakhi sofuzo sokunqunywa kwe-cholesterol emzimbeni, kanye nezinga le-lipids ne-triglycerides egazini, kanye nokwehla okungenangqondo kwezinga lama-lipoprotein aphansi. Ngazo zonke lezi zinkinga, i-Atromidine izosiza. Izici zayo ezinhle kakhulu zokuphulukisa zifakazelwa iziguli zokubonga.
Intengo yesidakamizwa ingasukela ku-850 kuya ku-1100 ruble ngephakethe ngalinye lama-milligram angama-500.
Imiyalo yokusebenzisa umuthi
Ngaphambi kokuthenga i-Atromid, udinga ukubheka ukuthi ngabe kukhona yini imiyalo yokusebenzisa ngaphakathi kwephakeji. Njengoba lesi sidakamizwa, njenganoma yisiphi esinye, kufanele sisetshenziswe ngokuqinile kwimithamo enqunyelwe. Umuthi uyatholakala ngesimo samaphilisi enomthamo ongama-0,25 amagremu kanye nama-0,500 amagremu. Ngabe umuthi kufanele usetshenziswe kanjani? Kunqunyelwe ngaphakathi, umthamo ojwayelekile ngu-0,2 amagremu. Thatha umuthi ngemuva kokudla, amaphilisi angama-2-3 kathathu ngosuku.
Ngokuvamile, ama-milligram angama-20-30 anqunyelwa ngekhilogremu eyodwa yobunzima bomzimba womuntu. Iziguli ezinesisindo somzimba esukela kumakhilogremu angama-50 kuye kwangama-65 zinqunywa ngamamayela ayi-1,500 nsuku zonke. Uma isisindo sesiguli sidlula uphawu lwamakhilogremu angama-65, kulokhu, amagremu we-0.500 womuthi kufanele aphuzwe kane ngosuku.
Inkambo yokwelashwa imvamisa isuka ku-20 iye ku-30 ​​ngeziphazamiso zesikhathi esifanayo nokuthatha umuthi. Kunconywa ukuphinda isifundo izikhathi eziyi-4-6, kuya ngesidingo.
Contraindication kanye nemiphumela emibi
Njenganoma yisiphi esinye isidakamizwa, i-Atromide lapho ithathwa ingaba nemiphumela emibi emzimbeni.
Ngaphezu kwalokho, umuthi unezinto eziningi eziphikisana nomkhawulo zokusetshenziswa kwawo ngezinjongo zokwelapha.
Ngaphambi kokusebenzisa umkhiqizo, kufanele uzijwayeze nohlu lwe-contraindication nemiphumela emibi engenzeka.
Lokhu kumele kwenziwe ukuvikela imiphumela emibi yokuphuza umuthi emzimbeni.
Imiyalo yokusebenzisa ikhombisa ukwenzeka kwezimpawu ezilandelayo:
- Ukuphazamiseka kwamathumbu emathunjini, kuhambisana nokucanuzelelwa kwenhliziyo nokuhlanza.
- I-Urticaria nokulunywa kwesikhumba.
- Ubuthakathaka bemisipha (ikakhulukazi emilenzeni).
- Ukulimala kwemisipha.
- Ukuqina kwesisindo ngenxa yokuqina kwamanzi emzimbeni.
Uma kwenzeka lezo zimpawu, kufanele uyeke ukuthatha umuthi bese zihamba zodwa. Ukusetshenziswa isikhathi eside kwe-Atromide kungavusa ukuthuthuka kokuqina kwe-bile nokubanga kwe-cholelithiasis. Kwamanye amazwe omhlaba, umuthi awusanconywa ukuthi usetshenziswe ngenxa yokubonakala kwamatshe emgodini. Iziguli ezinesifo sikashukela zidinga ukuthatha umuthi ngokucophelela, ngoba zinempahla yokunciphisa amazinga kashukela.
Izimpikiswano ze-atromid zifaka:
- ukukhulelwa nokuqunjelwa;
- isifo sesibindi
- umsebenzi wokuphazamiseka wezinso, kubandakanya isifo sikashukela.
Uma ukusetshenziswa komuthi kuhlangene nokusetshenziswa kwama-anticoagulants, umthamo wokugcina kufanele unqanyulwe. Ukwandisa umthamo, udinga ukuqapha i-prothrombin yegazi.
Izinhlu zomkhiqizo okwelapha
Lesi sidakamizwa sinama-analogues angabekwa ngudokotela esikhundleni se-Atromide. Lokhu kufaka phakathi i-Atoris noma i-Atorvastatin, Krestor, Tribestan.
Izici zomuthi ngamunye kufanele zixoxwe ngemininingwane eminingi.
I-Atoris ifana kakhulu ne-Atromide ezimeni zayo. Futhi kunciphisa kahle izinga le-cholesterol ephelele ne-LDL egazini. Isakhi esisebenzayo somuthi yi-atorvastatin, esiza ekunciphiseni umsebenzi we-enzyme GMK-CoA reductase. Futhi, le nto inomphumela we-anti-atherosulinotic, owakhiwa amandla we-atorvastatin athinta ukuhlangana, ukuqina kwegazi kanye ne-macrophage metabolism. Intengo yesidakamizwa ku-dosage ye-20 mg isukela kuma-ruble ayi-650-1000.
I-Tribestan nayo ingasetshenziswa esikhundleni se-Atromide. Umphumela wokusetshenziswa kwomuthi ungabonakala emavikini amabili ngemuva kokuqala kokwelashwa. Imiphumela emihle ibonakala ngemuva kwamasonto amathathu futhi iqhubeka phakathi nesikhathi sokwelashwa. Izindleko zale analogue zingaphezulu kune-Atromid, ukuthola amaphakheji angama-60 (250 mg), kuzodingeka ukhokhe kusuka kuma-ruble ayi-1200 kuye kwangama-1900.
Enye i-analogue yesidakamizwa esichazwe ngenhla yiKrestor. Kuzoba ngempumelelo ukuthi kusetshenziswe iziguli ezindala, kungakhathalekile ngobudala nangokobulili, abane-hypercholesterolemia (kufaka phakathi ifa), i-hypertriglyceridemia, kanye nesifo sikashukela sohlobo 2. Ngokwezibalo, kuma-80% eziguli ezinhlobo lwe-IIa ne-IIb hypercholesterolemia ngokusho kukaFrederickson (okune-average wastani yokuhlushwa kwe-cholesterol ye-LDL esifundeni sika-4,8 mmol / l) ngenxa yokuthatha umuthi ngomthamo we-10 mg, izinga lokuhlushwa kwe-cholesterol ye-LDL engaphansi kwama-3 mmol lungatholakala / l
Umphumela wokwelapha uyabonakala ngemuva kwesonto lokuqala lokuphuza umuthi, futhi ngemuva kwamasonto amabili ufinyelela kuma-90% womphumela ongaba khona. Lesi sidakamizwa sikhiqizwa e-UK, izintengo zokupakisha ze-10 mg zingasukela kuma-ruble angama-2600 ngezingcezu ezingama-28.
Ochwepheshe bazokhuluma ngama-statin kuvidiyo kule ndatshana.
