I-Alanine aminotransferase ne-aspartate aminotransferase ngamaprotheni athize futhi atholakala kuphela ngaphakathi kwezicubu zezitho zezitho zomzimba ezahlukahlukene. Lezi zinkimbinkimbi ziza kuphela esimweni sokubhujiswa kwezakhi zamaseli.
Izitho ezahlukene ziqukethe amanani ahlukile alezi zingxenye. Ngakho-ke, ushintsho kwenye yalezi zingxube lungakhombisa ukuba khona kwezifo ezithweni ezithile zezitho.
I-ALaT iyi-enzyme etholakala ngokuyinhloko kwizicubu zesibindi, izicubu namanyikwe. Lapho kwenzeka umonakalo, izinga lale ngxenye lenyuka kakhulu, okukhombisa ukubhujiswa kwalezi izicubu.
I-ASaT iyi-enzyme equkethe ngezinga elikhulu:
- isibindi
- umsipha
- izicubu zezinzwa.
Njengengxenye yezicubu zamaphaphu, izinso namanyikwe, lo muthi uqukethe inani elincane.
Ukwanda kokuhlushwa kwe-ASaT kungakhombisa ukungasebenzi kahle esibindini sezakhiwo zemisipha nezicubu zezinzwa.
I-Alanine aminotransferase ne-aspartate aminotransferase ngama-enzyme aqukethe amangqamuzana futhi abandakanyeka ku-intracellular amino acid metabolism. Ukwanda kwalezi zingxenye kukhombisa ubukhona bokungasebenzi kahle kweziguli ekusebenzeni kwanoma isiphi isitho.
Isibonelo, ukwanda okukhulu kwe-ALT kungakhombisa ukuthuthukiswa kwe-pancreatitis ngezindlela ezingamahlalakhona noma ezinzima.
Endabeni yokuthola ukwehla kokuqoqwa kwalezi zinhlobo zokudluliselwa, singacabanga ukuthuthukiswa kwe-psychology yesibindi enzima, ngokwesibonelo, i-cirrhosis.
Ukuxhomekeka kokuhlushwa kwalokhu kudluliselwa esimweni sezitho zangaphakathi nokuba khona komzimba emzimbeni kuvumela le paramente ukuthi isetshenziswe ekuhlonzeni izifo.
I-ALT ejwayelekile ne-AST
Ukuzimisela kwalezi enzyme kwenziwa ukuhlaziywa kwe-biochemical.
Ukuthola imiphumela yokuhlaziywa enezinga eliphakeme lokuthembela, i-biomaterial yocwaningo lwelabhoratri kufanele ithathwe ekuseni nasesiswini esingenalutho. Kunconywa ukuthi ungadli ukudla ngaphambi kokunikeza igazi okungenani amahora angama-8.
Izinto zaselebhu zithathwa emthanjeni.
Esimweni esijwayelekile, okuqukethwe yilezi enzymene egazini lomuntu kuyahluka ngokuya ngobulili.
Kwabesifazane, izinga lithathwa njengejwayelekile, alwedluli kuzo zombili izinkomba inani le-31 IU / l. Engxenyeni yesilisa yabantu, izinkomba ezijwayelekile ze-alanine aminotransferase zithathwa njengezingekho ngaphezulu kwe-45 IU / L, futhi kuma-aspartate aminotransferase, izinga elijwayelekile emadodeni lingaphansi kwama-47 IU / L.
Ebuntwaneni, le nkomba ingahluka kusuka kuma-50 kuye ku-140 amayunithi / l
Izinkomba ezijwayelekile zokuqukethwe kwalezi enzymes zingahluka ngokuya ngemishini esetshenziselwa ukuhlaziya, ngakhoke udokotela kuphela owazi izakhi zelebhu lapho kwenziwa khona ucwaningo lwe-biochemical.
Izimbangela Zamazinga we-Alanine Aminotransferase
Okuqukethwe okuphezulu emgodini wegazi we-alanine aminotransferase kubonisa ubukhona bezifo zalezo zingxenye okuhlanganiswe kuzo lesi sakhi ngobukhulu obukhulu.
Ngokuya ngezinga lokuphambuka kusuka ekuhlushweni okujwayelekile, udokotela angaphakamisa hhayi kuphela ukuba khona kohlobo oluthile lwesifo, kodwa futhi nomsebenzi walo, kanye nezinga lokukhula.
Kungaba nezizathu eziningana zokwanda kwe-enzyme.
Lezi zizathu zingafaka:
- IHepatitis nezinye izifo, ezifana ne-cirrhosis, i-hepatosis enamafutha kanye nomdlavuza. Lapho kukhona noma yiluphi uhlobo lwe-hepatitis, ukubhujiswa kwezicubu kwenzeka, okucasulayo ukukhula kwe-ALT. Kanye nokukhula kwalesi sikhombisi, i-hepatitis ibonakala ngokwanda kwe-bilirubin. Imvamisa, ukwanda kwe-ALT egazini kuqala ngaphambi kokuvela kwezimpawu zokuqala zalesi sifo. Izinga lokukhuphuka kokuhlushwa kwe-alanine aminotransferase lilingana nobunzima besifo.
- I-Myocardial infarction iholela ekufeni nasekubhujisweni kwemisipha yenhliziyo, okucasulayo ukukhishwa kwe-alanine aminotransferase ne-AST. Ngokuhlaselwa yisifo senhliziyo, ukwanda ngasikhathi sinye kuzo zombili izinkomba kuyabonakala.
- Ukuthola ukulimala okuningana ngomonakalo wezakhiwo zemisipha.
- Ukuthola ukusha.
- Ukuthuthukiswa kwe-pancreatitis e-acute, okuwukuvuvukala kwezicubu ze-pancreatic.
Zonke izimbangela ze-ALT ezandayo zibonisa ubukhona bezinqubo ze-pathological ezithweni eziqukethe inani elikhulu lalesi enzyme futhi zihambisana nokubhujiswa kwezicubu.
Ukwanda kwe-alanine aminotransferase kwenzeka kakhulu ngaphambi kwezimpawu zokuqala zokuthuthuka kokukhula kwengqondo.
Izimbangela zokuphakama kwe-aspinate aminotransferase
Ukwanda kwe-AST emgodini wegazi kukhombisa ukwenzeka kwezifo zenhliziyo, isibindi kanye namanyikwe nokuthuthukiswa kwama-pathologies ekusebenzeni kwalezi zitho zomzimba.
Ukuqina okwandisiwe kwe-ASaT kungakhombisa ukubhujiswa kwezicubu zezitho eziqukethe inani elikhulu lalolu hlobo lokudluliswa.
Kunezici eziningana ezibangela ukwanda kokuhlushwa kwe-AST.
Izici ezisemqoka yilezi ezilandelayo:
- Ukuthuthukiswa kwe-myocardial infarction kuyimbangela evame kakhulu yokwanda kwenani le-aspartate aminotransferase. Ngokuhlaselwa yisifo senhliziyo, kunokwanda okukhulu kwe-AST ngenkathi kungakhuphi inani le-ALT ngokweqile.
- Ukuvela nokuthuthuka kwe-myocarditis kanye nesifo senhliziyo.
- I-pathologies yesibindi - i-hepatitis yegciwane kanye ne-hepatitis yemvelo yotshwala neyokwelapha, i-cirrhosis kanye nomdlavuza. Lezi zimo ziholela ekuphakameni kanyekanye kwe-AST ne-ALT.
- Ukuthola umuntu ukulimala kakhulu bese kuyashiswa.
- Ukuqhubekela phambili kwe-pancreatitis eqatha futhi engamahlalakhona.
Lapho uhumusha imininingwane etholwe ngesikhathi sokuhlaziywa kwe-biochemical kwegazi, kuyadingeka ukuthi unake umehluko wobulili.
I-ALT ne-AST yokuthola i-pancreatitis
Kwenziwa kanjani ukucaciswa kokuhlaziywa kwamakhemikhali ngesikhathi sokucwaninga nge-ALT ne-AST?
I-ALT ne-AST ye-pancreatitis ihlala inamanani anciphile kakhulu.
Uma kwenzeka ukuba khona kwe-aspartate aminotransferase egazini, kuyadingeka ukuthola ukuthi le pharamitha isuka kokujwayelekile kangakanani. Imvamisa, i-aspartate aminotransferase kowesifazane ayidluli ama-31 PIERES / l, futhi emadodeni - hhayi ngaphezulu kwama-37 PIERES.
Endabeni yokwanda kwalesi sifo, ukukhula kwe-ampartate aminotransferase kwenzeka kaningana, kuvame kakhulu ukwanda kokuhlushwa kwezikhathi ezi-2-5. Ngaphezu kwalokho, nge-pancreatitis, kanye nokukhula kwe-aspartate aminotransferase, ukuqala kwezimpawu zobuhlungu kuyabonakala endaweni yenkaba, isisindo somzimba silahlekile futhi isifo sohudo esivame ukusiphatha sihlasela umuntu. Ukuvela kokuhlanza nge-pancreatitis akunqunyelwe.
Inani le-ALT ku-pancreatitis nalo liyakhuphuka, futhi lokho kukhuphuka kungahambisana nokwanda kwe-alanine aminotransferase ngezikhathi ezi-6 ukuya kwezi-10.
Ngaphambi kokwenza ucwaningo lwe-biochemical for transferases, akunconywa ukuthi udle okungenani amahora angama-8.
Ngaphezu kwalokho, izidakamizwa ezingakhuphula okuqukethwe yilezi zinhlobo zama-enzyme akufanele zisetshenziswe. Musa ukwenza okungathi sína ngokomzimba ngaphambi kokunikela ngegazi ukuze lihlaziywe.
I-pancreatitis yisifo esihambisana nesiguli impilo yonke.
Ukuze inkambo ye-pancreatitis ingahambi nezikhathi zokuqhuma kakhulu, iziguli ziyelulekwa ukuthi zinikele njalo ngegazi ezifundweni ze-biochemical.
Ngaphezu kwalokho, iziguli kufanele njalo futhi ngokuhambisana nezincomo zikadokotela ozifundayo ziphuze umuthi wokumisa ukuqhubeka kwesifo nama-enzyme akhethekile aklanyelwe ukunciphisa umthwalo kumanyikwe.
Ngaphezu kwalokho, ohlelweni lokwelashwa, izidakamizwa kufanele zisetshenziswe, isenzo saso okuhloswe ngaso ukukhipha kanye nokususwa kwemikhiqizo evela ekubhujisweni kwezicubu ze-pancreatic.
Ukuhlolwa kwegazi kwe-ALT ne-AST kuchazwe kuvidiyo kule ndatshana.
