I-Autoimmune pancreatitis iyindlela yokuhleleka ehlelekile, okungahlangene nje kuphela namanyikwe, kepha nezinye izitho zangaphakathi ziyathinteka. Lesi sifo asijwayelekile, asiqondakali ngokuphelele, ngakho-ke, izimbangela zentuthuko azaziwa.
Imisebenzi yokuvikela umzimba womuntu iqala ukukhiqiza amasosha omzimba athile aphazamisa ukwakheka kwamaseli e-pancreatic, abe nomphumela onolaka emiseleni ye-bile, izinso, ama-lymph node, amaphaphu, kanye ne-gastrointestinal tract.
Lesi sifo senziwa ngama-pathologies abonakala ngenkambo engapheli. Bahlala ngaphezu kwezinyanga eziyisithupha. Izikhathi ezivame ukwanda ziyatholakala, ukukhishwa kuncane.
Ngesikhathi senqubo yokuvuvukala, okungukuthi, ngokwanda, kukhona ukwehla komsebenzi we-exocrine wesitho sangaphakathi. Cabanga ukuthi yiziphi izimpawu zomtholampilo ezihambisana nomonakalo we-autoimmune kuma-pancreas, yikuphi ukwelashwa okunqunyelwe.
Umtholampilo
I-etiology yenqubo ye-pathological emzimbeni ayicacisiwe. Ngenxa yokwephulwa, ukungasebenzi komzimba kuqala ukuhlasela amaseli awo. Uhlobo lwe-autoimmune lwe-pathology luvame ukuhlanganiswa nezifo - isifo se-Sjogren's, ukuphazamiseka kokuvuvukala kuphephabhuku lesisu.
Lesi sifo sihlala impilo yonke ngokwemvelo ngokushintshela kwifomu elingamahlalakhona, lapho ukuhlaselwa okuthe ngqo kulandelwa ngokuthethelelwa. Isiguli sithuthukisa izinkinga ku-70% wezithombe - i-mellitus yesifo sikashukela, ukubhujiswa kwezicubu ze-pancreatic, ifomu le-pseudocysts.
Kunzima ukusola i-pathology. Imvamisa, kuqhubeka ngokuhambisana nesizinda sokungabikho kwezimpawu zomtholampilo ezishiwo. Kwesinye isikhathi esigabeni esibuhlungu, izimpawu ezinzima azikho. Imvamisa iziguli zifunda ngokugula kwazo lapho izinkinga sezivele zikhula.
Isiguli singaba nezimpawu ezilandelayo:
- Ubuhlungu bukhula esiswini esingenhla, buhlala imizuzu eminingana noma amahora ambalwa. Ubulukhuni bezinhlungu bulungile.
- Ukuqondisisa kwengaphezulu lesikhumba nolwelwesi lwe-mucous, uketshezi lwebhayoloji - amathe noma izinyembezi. Kwenzeka ngenxa yokuphazamiseka kokuhamba kwe-bile ku-duodenum ngenxa yokuncipha kwama-ducts e-pancreatic. Izimpawu ezengeziwe zifaka umchamo omnyama, indle ecacisiwe, izimpawu zesikhumba - ukulunywa, ukuvutha.
- Izimpawu ze-dyspeptic. Iziguli zikhononda ngokulahlekelwa kwesifiso sokudla, ukuhlaselwa isicanucanu nokuhlanza, ukwanda kwerhasi, ubumunyu emgodini womlomo.
- Kukhona ukwephulwa komsebenzi we-intrasecretory of the gland, okuholela ekuthuthukisweni kwesifo sikashukela i-mellitus. Ubuntu balesi sifo nge-autoimmune pancreatitis ukuthi i-pathology ibonakala ngenkambo evumayo ngokululama okungenzeka ngokuphelele.
- Ukusebenza kwemizwelo, imizwa ecindezelekile, ukusebenza okunciphile, nezinye izibonakaliso ze-asthenic.
Izimpawu ezithile zingavela futhi ngenxa yomonakalo esithweni esithile. Isibonelo, ngomonakalo wamaphaphu, ukuphefumula okuncane kuyavela, kunomuzwa wokuntuleka kwe-oxygen.
Uma kunezinkinga ngezinso, khona-ke kutholakala ukwehluleka kwezinso, kuqhamuke iprotheni emchameni.
Izinhlobo ze-Autoimmune Gland Ukuvuvukala
Izifo ze-Autoimmune zama-pancreas zihlukaniswe izinhlobo ezahlukene. Ngokuya ngesithombe se-histological - ushintsho esakhiweni se-pancreatic esivezwa ukuxilongwa kwe-microscopic, izinhlobo ezimbili ze-pancreatitis ziyahlukaniswa.
Esokuqala yifomu le-scorposing lymphoplasmacytic. Uhlobo lwesibili luhlobo lwe-idiopathic ye-duct-concentric pancreatitis enezilonda ezikhona ze-granulocytic of izicubu ze-epithelial. Umehluko usezakhiweni zomlando kuphela. Ngamanye amagama, zinqunywa kuphela ezimweni zelebhu; azikho ezinye izindlela zokutholwa.
I-Pathology ibuye ihlukaniswe ngokuba khona kwe-autoimmune pathologies. Kunezinhlobo ezimbili:
- Uhlobo olulodwa lutholakala ezigulini lapho kutholakala khona amanye amaphutha e-autoimmune emzimbeni.
- I-Autoimmune pancreatitis syndrome yisifo esiphumela ngemuva kwesizinda sezinye i-autoimmune pathologies.
Ngokuya ngendawo yesilonda, i-pancreatitis ingaba ngefomu lokwehlukanisa - sonke isitho sangaphakathi kanye nohlobo lokugxila kuyathinteka - kukhona i-lesion yezindawo ngazinye ze-pancreatic, ezithombeni eziningi, ukuvuvukala kutholakala ekhanda.
Ukuxilongwa nokwelashwa
Lapho uthintana nodokotela, umlando wezokwelapha wesiguli uqoqwa, kwenziwa inhlolovo ngendaba yezikhalazo zabantu. Kuyahlolwa ukuhlolwa kwelabhoratri nezindlela zokuhlonza izinsizwa.
Ukuhlolwa kwelebhu kufaka ukuhlolwa kwegazi okujwayelekile, ukugcwala koshukela emzimbeni, ukuhlaziya i-glycosylated hemoglobin, ukuhlolwa kwegazi nge-biochemical, ukuhlolwa kwamamaki we-tumor nokuqukethwe kwe-immunoglobulin. Nikeza ukuxilongwa kwethambo - i-ultrasound of the esiswini, i-CT, i-MRI, ukuhlolwa kwe-biopsy, njll.
Ezimweni zokwelapha, kuye kwaba nezimo lapho lesi sifo sidluliselwa sodwa ngaphandle kwemithi. Kodwa-ke, imidwebo eminingi idinga ukwelashwa okulondolozayo kwe-autoimmune pancreatitis.
Iziguli zibekelwa inombolo yokudla 5. Ngokukhula kwesifo sikashukela, isincomo esiyinhloko kungukudla okufanelekile nokusetshenziswa okulinganiselwe ushukela obunjiwe. Ukwelashwa kokuqapha kubandakanya ukusetshenziswa kwale mithi elandelayo:
- Ama-corticosteroids ayizifanekiselo zokwenziwa zama-hormone e-adrenal cortex; ukusetshenziswa kwawo kungaphansi kwenkambo yokwelapha. Isikhathi sokwamukelwa cishe cishe amasonto amabili. Ezinye iziguli zidinga ukwelashwa isikhathi eside kumithamo emincane.
- Ama-Immunosuppressants - iqembu lezidakamizwa ezivimbela umsebenzi owedlulele wokugonywa. Ziyanconywa uma umphumela wokusetshenziswa kwama-glucocorticosteroids unganele noma uma kungenzeki ukuzisebenzisa.
- Ama-antispasmodics angaqeda izinhlungu, ezikhula ngenxa yokuncipha kweziqubu zepancreatic.
- Ukulungiswa kwe-enzyme kubekelwe ukuthuthukisa inqubo yokugaya yokudla okuchithiwe.
- Uma ukulimala kwesisu kukhona, khona-ke kunqunywe i-proton pump inhibitors. Basiza ukubuyisa izingqimba ze-mucous.
- I-insulin esebenza njengento emfushane isetshenziselwa ukwengeza amazinga kashukela egazini lapho kuvela isifo "esimnandi". Kwesinye isikhathi kusetshenziswa umphumela wesikhathi eside we-insulin.
Ukwelapha ngokuhlinzwa kuqukethe ukubuyisa i-lumenetic ejwayelekile ye-ducts ye-gland ne-bile ducts. Indlela yokusebenza iyadingeka ezimweni lapho kutholakala khona ukwehla okukhulu kobubanzi beziteshi, kuyilapho kungekho mphumela ovela ekusetshenzisweni kwe-glucocorticosteroids.
Ukwelashwa kwe-autoimmune yesifo kungenxa yezinkinga, i-autoimmune pathologies ebakhona kanye nokuba khona / ukungabi bikho kwesifo sikashukela. Ukuvimbela akukho, ngoba izinto eziholela ekuhlaselweni kokungazweli kwamaseli akho azaziwa kwezokwelapha.
Izimbangela nezindlela zokwelapha i-pancreatitis kuxoxwa ngazo kule vidiyo kulesi sihloko.
