I-Zinc insulin inguhlobo loku-1 nohlobo 2 lwesifo sikashukela esiza ukumiswa. Lesi sidakamizwa i-insulin esebenza isikhathi eside okuhloselwe ukuphatha izicubu ezingezansi.
Isikhathi sokusebenza sokumiswa kwe-zinc-insulin cishe amahora angama-24. Njengawo wonke amalungiselelo e-insulin aqhubeka isikhathi eside, umphumela wawo emzimbeni awaveli ngokushesha, kodwa amahora angama-2-3 ngemuva komjovo. Isenzo esiphakeme se-zinc insulin senzeka phakathi kwamahora angama-7-14 ngemuva kokuphathwa.
Ukwakhiwa kokumiswa kwe-insulin kufaka phakathi i-purulin insulin ne-zinc chloride ehlanziwe kakhulu, evimbela umuthi ukuthi ungene egazini ngokushesha okukhulu futhi ngaleyo ndlela wandise isikhathi esisezingeni elifanele.
Isenzo
Ukumiswa kwe-insulin zinc ngokwejwayelekile i-carbohydrate, amaprotheni kanye ne-lipid metabolism. Lapho igxilwe, ithuthukisa ukuqina kwamaseli wokuqanjwa kwamangqamuzana kashukela, okusheshisa ukufakwa kweshukela yizicubu zomzimba. Lesi senzo somuthi sibaluleke kakhulu, ngoba sisiza ukunciphisa ushukela wegazi futhi sisiza ukugcina ungaphakathi kwemikhawulo ejwayelekile.
I-Zinc insulin inciphisa ukukhiqizwa kwe-glycogen ngamaseli wesibindi, futhi isheshise inqubo ye-glycogenogeneis, okungukuthi, ukuguqulwa kweglucose ibe yi-glycogen kanye nokuqongelela kwayo kwezicubu zesibindi. Ngaphezu kwalokho, lesi sidakamizwa sisheshisa kakhulu i-lipogenesis - inqubo lapho ushukela, amaprotheni namafutha abe ngama-acid acid.
Izinga lokufakwa egazini kanye nokuqala kwesenzo somuthi kuncike ekutheni i-insulin yayiphathwa kanjani - ngokungaziphathi kahle noma ngokuxinana.
Imithamo yesidakamizwa nayo ingathinta ukuqina kwesenzo se-zinc insulin.
Imiyalo yokusebenzisa umuthi
Ukusetshenziswa kwesidakamizwa Ukumiswa kwe-zinc insulin yokujova kuyanconywa ekwelapheni uhlobo 1 lwesifo sikashukela, kufaka phakathi izingane nabesifazane abasezikhundleni. Ngaphezu kwalokho, leli thuluzi lingasetshenziswa ekwelashweni kwezokwelapha uhlobo lwesifo sikashukela sohlobo 2, ikakhulukazi ngokungaphumeleli kwamathebhulethi anciphisa ushukela, ikakhulukazi okususelwa ku-sulfonylurea.
I-Zinc insulin isetshenziswa kabanzi ukwelapha izinkinga zesifo sikashukela, njengokulimazeka kwenhliziyo nemithambo yegazi, unyawo lwesifo sikashukela kanye nokukhubazeka okubukwayo. Ngaphezu kwalokho, kubaluleke kakhulu ezigulini ezinesifo sikashukela ezenza ukuhlinzwa okukhulu nangesikhathi sokululama ngemuva kwazo, kanye nokulimala okungathi sína noma okuhlangenwe nakho okuqinile ngokomzwelo.
I-insulin yokumisa izinsimbi ihloselwe umjovo ongama-subcutaneous, kepha ezimweni ezingavamile ungalawulwa nge-intramuscularly. Ukuphathwa okungaphakathi kwalesi sidakamizwa akuvunyelwe ngokuphelele, ngoba kungadala ukuhlaselwa kanzima kwe-hypoglycemia.
Umthamo wesidakamizwa i-Insulin Zinc ubalwa ngawodwa esigulini ngasinye. Njengamanye ama-insulin asebenza isikhathi eside, kufanele aphathwe izikhathi ezi-1 noma ezi-2 ngosuku, kuya ngezidingo zesiguli.
Lapho usebenzisa ukumiswa kwe-insulin zinc ngesikhathi sokukhulelwa, kubaluleke kakhulu ukukhumbula ukuthi ezinyangeni ezi-3 zokuqala zokuzala ingane owesifazane unganciphisa isidingo se-insulin, futhi ezinyangeni ezi-6 ezizayo, ngokuchasene nalokho, kuzokwanda. Lokhu kumele kubhekwe lapho kubalwa umthamo womuthi.
Ngemuva kokuzala i-mellitus yesifo sikashukela nangesikhathi sokuncelisa, kubalulekile ukubhekisisa izinga leshukela legazi futhi, uma kunesidingo, ulungise umthamo we-Insulin zinc.
Ukuqapha ngokucophelela okunjalo kokuhlushwa koshukela kufanele kuqhutshekwe kuze kube yilapho isimo sivele ngokuphelele
Intengo
Namuhla, ukumiswa kwe-insulin kuyivelakancane impela emakhemisi emadolobheni aseRussia. Lokhu kungenxa yokuvela kwezinhlobo zesimanje ze-insulin ezinde, okuyisusa lo muthi emashalofini ekhemisi.
Ngakho-ke, kunzima kunalokho ukubiza izindleko eziqondile ze-insulin zinc. Kumakhemisi, lesi sidakamizwa sithengiswa ngaphansi kwamagama okuhweba i-Insulin Semilent, Brinsulmidi MK, Iletin, Insulin Lente "HO-S", Insulin Lente SPP, Insulin Lt VO-S, Insulin-Long SMK, Insulong SPP neMonotard.
Ukubuyekezwa mayelana nalesi sidakamizwa ngokuvamile kuhle. Iziguli eziningi ezinesifo sikashukela bezisebenzisa ngempumelelo iminyaka eminingi. Yize eminyakeni yamuva nje bayijikisa esikhundleni sokufana okufana nokwamanje.
Ama-Analog
Njenge-analogues ye-zinc insulin, ungabiza noma imaphi amalungiselelo e-insulin asebenza isikhathi eside. Lokhu kufaka phakathi iLantus, Insulin Ultralente, Insulin Ultralong, Insulin Ultratard, Levemir, Levulin ne-Insulin Humulin NPH.
Lezi zidakamizwa izidakamizwa zesifo sikashukela sesizukulwane sakamuva. I-insulin efakwe ekwakhiweni kwayo i-analogue ye-insulin yabantu etholakala ngobunjiniyela bezakhi zofuzo. Ngakho-ke, empeleni akubangeli ukungezwani komzimba futhi kubekezelelwa kahle yisiguli.
Izici ezibaluleke kakhulu ze-insulin zichazwe kuvidiyo kule ndatshana.
