I-Metformin Sandoz ingenye yezidakamizwa ezaziwa kakhulu ezisetshenziswa zombili izinhlobo zikashukela ngokuhlanganiswa nemijovo ye-insulin kanye nesifo sohlobo II, lapho imfundo yezomzimba nokudla okunempilo kunganikezeli ukwehla kwamazinga eglucose.
Ngenxa yento esetshenziswayo, kwehla ukuqoqwa koshukela ku-serum yegazi, futhi inani eliyisisekelo le-glucose nalo liyancishiswa.
Njengoba wazi, umuthi ngamunye unezindlela eziningi zokuphikisana, imiphumela emibi nezinye izici ze-pharmacological. Ngakho-ke, kubalulekile ukwazi imininingwane eminingi ngangokunokwenzeka mayelana nomuthi ophuzwayo. Ungawusebenzisa kanjani umuthi?
Imininingwane ejwayelekile mayelana nomuthi we-hypoglycemic
Umenzeli we-hypoglycemic uqukethe isithako esisebenzayo, i-metformin hydrochloride, okuwukuphela kommeleli wesigaba se-Biguanide. Ngokuya ngefomu lomthamo, kukhiqizwa amaphilisi afaka i-500 noma i-850 mg yesithako esisebenzayo. Umphumela we-pharmacological wale nto uhlotshaniswa namandla okuvimbela ukwakheka kwe-glucose kusuka kumakhompiyutha angenayo i-carbohydrate (gluconeogeneis).
Ngaphezu kwe-metformin hydrochloride, ithebhulethi eyodwa yesidakamizwa iqukethe inani elincane lesitashi se-sodium, i-magnesium stearate, i-silicon dioxide, i-colloidal anhydrous, i-Copolyvidone Va64 ne-cellcrystalline cellulose.
Umuthi awukhubazi ukukhiqizwa kwehomoni enciphisa ushukela, ngakho-ke abantu abanempilo abaphuza lo muthi abazizwa izimpawu ze-hypoglycemia. Phakathi kwezici ezinhle zomuthi, okulandelayo kufanele kuqokonyiswe:
- Ukucindezelwa kwe-gluconeogeneis.
- Ukwanda kokucabanga kwamangqamuzana okuqondisa kwi-insulin.
- Ukugqugquzela ukuthathwa koshukela ngama-myocyte.
- Ukwehla kwesisindo, ikakhulukazi kubantu abakhuluphele.
- Yehlisa kokubili inani lesisekelo likashukela nokuqukethwe kwalo ngemuva kokudla.
- Umphumela othandekayo kumetabolism ye-lipid (ukwehla kwe-cholesterol, triglycerides ne-LDL).
- Yehlisa indlala.
- Ukuqinisa glycolysis ye-anaerobic.
- Ukubambezeleka kokufakwa kwe-carbohydrate emathunjini.
I-ejenti yokulwa nesifo sikashukela ithathwa ngaphakathi, ukugxila kwayo okuphezulu kubonwa ngemuva kwamahora we-2,5. Ukuqothuka kwengxenye eyinhloko kwenzeka emgodini wokugaya ukudla.
I-Metformin hydrochloride iyakhishwa ifomu elingashintshiwe nomchamo.
Imiyalo yokusebenzisa amaphilisi
Njengoba sekushiwo ekuqaleni, umuthi ungasetshenziselwa isifo sikashukela esingaxhomekeki ku-insulin. Udokotela kuphela ongabeka umthamo odingekayo wesidakamizwa, ngokususelwa ekuhlakazweni kwe-glucose kanye nezimpawu ezihlobene nesiguli.
Lapho uthenga umuthi, isiguli akufanele silandele izincomo zikadokotela kuphela, kodwa futhi sizijwayeze nokufakwa kwephakeji. Uma kuphakama imibuzo, kufanele ibuzwe uchwepheshe wakho wezempilo.
Ekuqaleni kokwelashwa, kuthathwa umthamo ophansi wansuku zonke - kuphela ama-500 noma ayi-1000 mg. Emavikini amabili kamuva, udokotela angayandisa umthamo womuthi, ecabanga ngokuqukethwe ushukela osegazini. Ukwelapha kokuqala ngalo muthi kungahambisana nokuphulwa kohlelo lokugaya ukudla. Izimpawu ezinjalo ezingemnandi zichazwa ngokuguqulwa komzimba kwento esebenzayo futhi ngemuva kwezinsuku eziyi-10-14 zidlule zodwa. Ukugcina izinga le-glucose ejwayelekile, kufanele udle ama-1,500-2,000 mg ngosuku. Umthamo omkhulu yi-3000 mg. Ukwehlisa umphumela ongemuhle wesidakamizwa emgodini wokugaya ukudla ekuqaleni kwekhambi, udinga ukuhlukanisa umthamo kaningana.
Ngokuhlanganisa iMetformin Sandoz ne-insulin, ukuncishiswa okuphumelela ngokwengeziwe ekubandakanyeni ushukela kungatholakala. Lesi sidakamizwa siphuzwa kabili noma kathathu ngosuku, singama-500 mg ngasinye. Ngokuphathelene nomthamo we-insulin, kuya ngezinga le-glucose esegazini.
Abantu abanesifo sikashukela asebekhulile abasebenzisa iMetformin Sandoz bafanelwe ukunakwa okukhethekile. Udokotela unquma umthamo womuthi, unikezwe isimo sezinso ukusebenza.
Lapho uthenga umuthi, umuntu akufanele akhohlwe ngokubheka isikhathi sokuphelelwa yisikhathi, esivame ukuba yiminyaka emi-5.
Umuthi ugcinwa endaweni eyomile emazingeni okushisa angabi ngaphezu kwama-25 degrees Celsius.
Contraindication kanye nemiphumela emibi
Lesi sidakamizwa asinconywa kwiziguli esezikhulile (ezingaphezu kweminyaka engama-60 ubudala), okuhlala kuzo kuhlotshaniswa nokuzivocavoca kanzima komzimba.
Ukuphuza umuthi ngomthwalo ophakeme ngokomzimba kwandisa amathuba okuba ne-lactic acid coma.
Imiyalo esetshenzisiwe ifaka izifo ezihambisanayo kanye nemibandela lapho i-ejenti yokulwa nesifo sikashukela ingenakusetshenziswa.
Phakathi kokuphikiswa okuyinhloko kukhona okulandelayo:
- isifo sikashukela sikashukela, i-ketoacidosis yesineke nesifo sikashukela;
- umsebenzi wokuphazamiseka wezinso, lapho imvume ye-creatinine (ijubane legazi ngokusebenzisa izinso) ingaphansi kuka-60 ml ngomzuzu;
- ukuthuthukiswa kwe-pathologies eyingozi engaholela ekungasebenzi kahle kwezinso. Kungaba ukomisa, umkhuhlane, i-hypoxia, izifo ezahlukahlukene;
- ukuhlinzwa kwakamuva kanye nokulimala kanzima;
- ukuthuthukiswa kwe-hyperlactatacidemia, ikakhulukazi ku-anamnesis;
- Izifo ezinzima noma ezingalapheki ezikhulisa amathuba okuba ne-izicubu hypoxia, kufaka phakathi i-myocardial infarction, ukuphefumula kanye nokwehluleka kwenhliziyo;
- uphuzo oludakayo, ubuthi obudakayo;
- ukwephulwa kwesibindi;
- ukusetshenziswa kwama-ejenti aqukethe iodine aqukethe izinsuku ezimbili ngaphambi nangemuva kwezivivinyo ze-radioisotope kanye ne-radiological;
- Ukudla kwe-hypocaloric, lapho kungathathi ngaphezu kwe-1000 kcal ngosuku;
- ukukhulelwa nokuncelisa ibele.
Njengomphumela we-overdose noma ukungahambisani nazo zonke izincomo zikadokotela, imiphumela engafuneki evela kumuthi kungenzeka. Lokhu kufaka phakathi:
- Ukuphazamiseka kwendlela yokugaya ukudla - ukunambitheka kwensimbi emlonyeni, isicanucanu, ukugabha, ukuncipha noma ukuntuleka kwesifiso sokudla, nobuhlungu besisu, ukwanda kwegesi, ishuda. Lezi zimpawu zenzeka ngenxa yokuthi umzimba ujwayela esenzweni somuthi.
- Ukuphazamiseka kweHepatobiliary - ukuvuvukala kwesibindi nokuqina kwesibindi.
- Ukuphazamiseka kwe-Metabolic - ukusweleka kwe-Vitamin B12 ne-lactic acid coma.
- Ukwephulwa kohlelo lwe-hematopoietic - i-megaloblastic anemia.
- Ukuphendula kwesikhumba ukuqwasha, i-erythema, ukuqubuka kanye ne-urticaria.
Ukusabela okubi okuyingozi kakhulu yi-lactic coma (lactic acidosis). Ngokukhula kwayo, isiguli sinenkinga yokugaya ukudla, izinhlungu emisipha nasesiswini, ukwanda kokushisa komzimba, isiyezi, ukudideka, ukuphefumula ngokushesha kanye nokukhula komzimba. Kulokhu, isiguli kufanele silaliswe esibhedlela ngokushesha.
Kaningi, udokotela wenza i-hemodialysis - indlela ephumelela kunazo zonke yokuqeda i-lactate ne-metformin.
I-Metformin Sandoz: Ukusebenzisana kwezidakamizwa
Kufanele kukhunjulwe ukuthi izidakamizwa ezithile zingakhuphula noma zinciphise umphumela we-hypoglycemic walesi sidakamizwa. Ezinye zazo zingadala i-lactic acid coma.
Kulokhu, uchwepheshe owelaphayo kufanele aqaphele zonke izifo ezihlangene zesiguli sakhe ukuze agweme imiphumela engathandeki. Isiguli, naso, akumele sigodlele udokotela amanye ama-pathologies ngaphandle kwesifo sikashukela.
Ngakho-ke, ngezansi amagama wezidakamizwa anciphisa ukusebenza komuthi, ngaleyo ndlela andise izinga le-glycemia ezigulini:
- UDanazole;
- I-Chlorpromazine;
- ama-antipsychotic;
- i-glucagon;
- ama-hormone egilo;
- i-thiazide diuretics;
- dericatives ye-nicotinic acid;
- i-sympathomimetics;
- ama-estrogen-progestogen agents;
- ama-beta-2-adrenergic receptors;
- ama-glucocorticosteroids wezenzo zasekhaya nezenqubo.
Kunezidakamizwa ezimbalwa, okuthi, kunalokho, zithuthukise umphumela we-hypoglycemic womenzeli wesifo sikashukela. Lokhu kufaka phakathi:
- I-Acarbose.
- Ukuthatha isikhathi eside kanye nokwenza insulin okufushane.
- Beta-2 abaphikisi be-adrenergic.
- I-Mao ne-ACE inhibitors.
- Okususelwa ku-sulfonylureas.
- Ama-salicylates.
- Okususelwa ku-clofibrate.
- Ama-NSAIDs.
- ICyclophosphamide, kanye nokuphuma kwayo.
- I-Oxetetracycline.
Kwandisa amathuba okuthi i-lactic acidosis iphuze umuthi ngotshwala nezidakamizwa eziqukethe i-ethanol, i-iodine equkethe izinto ezahlukile, i-cimetidine ne-diuretics.
Izindleko zomuthi, ukubuyekezwa kanye nama-analogues
Umuthi ungathengwa kunoma iyiphi ikhemisi ngemithi kadokotela. Ukonga imali, umuthi uyalelwa kuwebhusayithi esemthethweni yomthengisi.
Ngokwesilinganiso, intengo yesidakamizwa iyahlukahluka kusuka kuma-ruble angama-230 kuya kwangama-800, ngokuya ngesimo sokukhishwa. Ngakho-ke, i-ejenti yokulwa nesifo sikashukela iyatholakala kuzo zonke izingxenye zabantu, okuyiwona inzuzo yayo.
Kwi-Intanethi ungathola izibuyekezo eziningi ezinhle ezigulini ezidla umuthi. Kwehlisa ngempumelelo futhi kuzinze amazinga kashukela. Kuyasiza nokulahlekelwa ngamakhilogremu ambalwa angezekile kwishukela likashukela. I-ejenti ye-hypoglycemic ngendlela yamathebulethi kulula ukuyithatha. Ngaphezu kwalokho, empeleni akubangeli imiphumela emibi (ngaphezu kokuphazamiseka kwendlela yokugaya ukudla).
Kodwa-ke, kukhona ukubukeza okungekuhle mayelana nomuthi. Zihlotshaniswa nokuphazamiseka kokugaya okwenzeka ngesikhathi sokuguqulwa komzimba kwinto esebenzayo. Kwezinye iziguli, izimpawu ezinjalo ziphinyiselwa kakhulu kunezinye, ngakho-ke kufanele zingene esikhundleni sale nkampani ye-antidiabetesic kanye nezinye izidakamizwa.
Odokotela abancomi kakhulu ukuthatha umuthi kubantu abanempilo ukuze unciphise isisindo. Futhi kwenqatshelwe ngokuphelele ukusebenzisa iziphuzo ezinotshwala ngesikhathi sokwelashwa.
Kwesinye isikhathi odokotela kufanele balungise irejimeni yokwelashwa kweziguli. Lokhu kungahle kube ngenxa yokusabela okungemihle nokuphikisana. Ukushintsha umuthi ongafanele kungenziwa ngemikhiqizo equkethe into efanayo noma enomphumela ofanayo wokulapha.
I-Metformin hydrochloride iyisakhi esidumile emhlabeni wonke, ngenxa yalokho isetshenziswa ekwenziweni kwemithi eminingi ye-hypoglycemic. Akumangazi ukuthi iMetformin Sandoz inenombolo enkulu yama-analogues, phakathi kwawo kukhona:
- UGlatiniin (ama-ruble ayi-112).
- Metformin-Teva (ama-ruble ayi-136);
- IGlucophage (ama-ruble angama-223).
- Metformin Richter (ama-ruble ayi-183);
- I-Metfogamma 850 (ama-ruble ayi-134), iMetfogamma 1000 (i-168 ruble).
- I-Metformin Zentiva (ama-ruble ayi-134).
- I-Siofor (ama-ruble angama-245).
- I-Metformin Canon (ama-ruble ayi-172).
- IFommetin (ama-ruble ayi-100).
Njengoba ubona, iMetformin Sandoz iyisidakamizwa esisebenza ngempela esusa izimpawu ze-hyperglycemia nezimpawu zikashukela ezigulini zabantu abadala. Ngokusebenzisa kahle leli thuluzi, ungagcina i-glycemia ejwayelekile isikhathi eside.
Ochwepheshe bazotshela ngesenzo seMetformin entweni yesifo sikashukela esevidiyo kule vidiyo.
