I-Lipoic acid yisakhi esisebenzayo esasiyilungu le-complements efana ne-vitamin. Okwamanje, iningi labacwaningi lithi leli khompiyutha linamavithamini anezokwelapha.
Ku-pharmacology, i-lipoic acid ibizwa nangokuthi i-lapamide, i-thioctic acid, i-para-aminobenzoic acid, i-alpha-lipoic acid, i-Vitamin N kanye ne-berlition.
Igama lomhlaba jikelele elaziwa ngaleli khompiyutha yi-thioctic acid.
Ngokusekelwe kuleli khompiyutha, imboni yezemithi ikhiqiza amalungiselelo wezokwelapha njenge, ngokwesibonelo, i-Berlition, Thioctacid neLipoic acid.
I-Lipoic acid yinto ebaluleke kakhulu ochungechungeni lwe-metabolism yamafutha emzimbeni. Ngenani elanele lale ngxenye emzimbeni womuntu, inani le-cholesterol liyancishiswa.
I-Thioctic acid, esiza ukwehlisa i-cholesterol yegazi, ivimbela ukuthuthukiswa kwezinkinga ezivela ekuthuthukisweni kwesifo sikashukela ngokumelene nesizinda somzimba esiningi.
Ukweqile kuvame ukuhambisana ne-cholesterol ephezulu. I-Lipoic acid ene-cholesterol iyasiza ekunciphiseni, okuvimbela ukuthuthukiswa kokuphazamiseka emsebenzini wenhliziyo, wamasosha nezinzwa.
Ukuba khona kwenani elanele laleli khompiyutha emzimbeni kusiza ukuvimba ukuthuthukiswa kwemivimbo kanye nokuhlaselwa yisifo senhliziyo, lapho kwenzeka, kubhebhethekisa imiphumela yezinkinga ezinjalo.
Ngenxa yokubamba okwengeziwe kwalesi simo esiphilayo, ukuvuselelwa ngokuphelele komzimba ngemuva kokuhlaselwa yisifo sohlangothi, futhi izinga le-paresis nokukhubazeka kokusebenza kwemisebenzi yalo yizicubu zemizwa yobuchopho kuncishiswa kakhulu.
Izici ezibonakalayo ze-lipoic acid
Ngokwezimpawu zomzimba, i-lipoic acid i-crystalline powder, enombala ophuzi. Leli khompiyutha linokunambitheka okumunyu nephunga elithile. Isakhiwo se-crystalline sinyibilika kancane emanzini futhi sinyibilika ngokuphelele kuma-alcohols. Usawoti we-sodium we-lipoic acid uncibilika kahle emanzini. Le mpahla kasawoti we-lipoic acid ibangela ukusetshenziswa kwaleli khompiyutha, hhayi i-pureic ye-lipoic acid.
Le khompiyutha isetshenziswa ekwenziweni kwemithi ehlukahlukene kanye nezithasiselo zokudla ezahlukahlukene.
Le khompiyutha inomphumela oqinile we-antioxidant emzimbeni. Ukudla lokhu kuhlanganiswa emzimbeni kukuvumela ukuthi ulondoloze amandla afanele omzimba.
Ngenxa yobukhona bezakhiwo ze-antioxidant, le khompiyutha ikhuthaza ukubopha nokuchithwa kwezinhlobo ezahlukahlukene zama-radicals wamahhala emzimbeni. IVitamin N inamandla amakhulu okubopha nokukhipha emzimbeni wezinto ezinobuthi kanye nama-ion ezinsimbi ezisindayo.
Ngaphezu kwalokho, i-lipoic acid isiza ukuguquguqula ukusebenza kwezicubu zesibindi. Inani elanele laleli khompiyutha emzimbeni livimbela ukukhula komonakalo kwezicubu zesibindi ngesikhathi sokwenzeka nokuthuthukiswa kwezifo ezingamahlalakhona, njenge-hepatitis kanye ne-cirrhosis.
Ukulungiselela nge-lipoic acid ekwakhiweni kwabo kukhulume izakhiwo ze-hepaprotective.
Izici ze-biochemical of lipoic acid
I-Lipoic acid iyakwazi ukuveza umphumela ofana ne-insulin, ovumela ukusetshenziswa kwamalungiselelo aqukethe le khompiyutha ukuze ungene esikhundleni se-insulin uma kwenzeka kunokushoda esimweni sikashukela emzimbeni.
Ngenxa yokuba khona kwale ndawo, amalungiselelo aqukethe amavithamini N enza sikwazi ukunikeza amaseli weglucous izicubu zomzimba ezigabeni zokuqala zokuthuthukiswa kwesifo sikashukela i-mellitus. Lokhu kuholela ekwehleni kokuqukethwe ushukela ku-plasma yegazi. Ukulungiselela, okubandakanya amavithamini, ayakwazi ukuthuthukisa isenzo se-insulin ngenxa yokuba khona kwezinto zawo futhi aqede indlala yeglucose engaba khona.
Lesi simo sivela kaningi ekwakhiweni kwesifo sikashukela sohlobo 2 emzimbeni.
Ngenxa yokwanda kokuthola kwamangqamuzana izicubu ze-glucose, zonke izinqubo ze-metabolic emangqamuzaneni ziqala ukuqhubeka ngokushesha nangaphezulu ngokugcwele. Lokhu kungenxa yokuthi ushukela esitokisini ungumthombo omkhulu wamandla.
Ngenxa yezakhiwo zayo ezithile, i-lipoic acid, amalungiselelo aqukethe le khompiyutha asetshenziswa kaningi ekwelapheni uhlobo lwe-non-insulin oluncike kwesifo sikashukela i-mellitus.
Ngenxa yokujwayelekile kokusebenza kwezitho ezahlukahlukene, kunokuthuthuka esimweni esejwayelekile somzimba.
Ngenxa yobukhona bezakhiwo ze-antioxidant, i-compact isiza ukubuyisela ukwakhiwa kanye nokusebenza kwezicubu zezinzwa.
Lapho usebenzisa le nsimbi, kuba ngcono emisebenzini eminingi yomzimba.
I-Vitamin yi-metabolite yemvelo eyakheka emzimbeni womuntu futhi isiza ukuguquguqula ukusebenza kwezitho nezinhlelo zazo.
Ukudla i-lipoic acid emzimbeni ngamanani anele kusiza ukwehlisa i-cholesterol emzimbeni.
Ukudonswa kwe-thioctic acid emzimbeni womuntu
Esimweni esijwayelekile, leli khompiyutha elisebenzayo lingena emzimbeni womuntu kusuka ekudleni okugcwele okuqukethwe yile ndawo.
Ngaphezu kwalokho, le nto esebenzayo iyakwazi ukuhlanganiswa ngumzimba ngokwayo, ngakho-ke i-lipoic acid akuyona enye yezakhi ezihlanganisiwe.
Kumele kuqashelwe ukuthi njengoba iminyaka yobudala, kanye nokwephulwa okuthile okunzima emzimbeni, ukwakheka kwalesi sakhi samakhemikhali kungancipha kakhulu emzimbeni. Lokhu kuholela ekutheni umuntu ohlushwa yizinhlobo ezithile zezifo aphoqeleke ukuthi athathe imishanguzo ekhethekile ukunxenxa ukuntuleka kwe-Vitamin N emzimbeni, ukuze enze lokhu kusweleka.
Inketho yesibili yokubuyiselwa kwemali yokusweleka kwevithamini ukulungiswa kokudla ukuze kudle ukudla okuningi okuqukethe i-lipoic acid ephezulu Ukwehlisa i-cholesterol emzimbeni onesifo sikashukela, kunconywa ukusebenzisa inani elikhulu lokudla okunothe i-lipoic acid. Lokhu kunciphisa amathuba okuthi kube nezinkinga futhi kwehlise izinga lokukhula kokukhuluphala, okuyi-complication ehambelana nohlobo 2 lwesifo sikashukela.
I-Lipoic acid itholakala ngesamba esikhulu kulokhu kudla okulandelayo:
- ubhanana
- i-legumes - uphizi, ubhontshisi;
- inyama yenkomo;
- isibindi senyama yenkomo;
- amakhowe;
- imvubelo
- noma yiziphi izinhlobo iklabishi;
- imifino - isipinashi, iparsley, dill, basil;
- anyanisi;
- ubisi nemikhiqizo yobisi;
- izinso
- irayisi
- upelepele;
- inhliziyo
- amaqanda.
Eminye imikhiqizo engafakwa kuhlu kulolu hlu ifaka ne-compio ye-bioactive, kepha okuqukethwe kwayo kuncane kakhulu.
Izinga lokusetshenziswa kokusebenza okujwayelekile komzimba womuntu libhekwa njenge-25-50 mg ye-compake ngosuku. Omama abakhulelwe futhi abancelile kufanele basebenzise i-alpha-lipoic acid mayelana ne-75 mg ngosuku, nezingane ezingaphansi kweminyaka engu-15 ubudala ukusuka ku-12,5 kuya ku-25 mg ngosuku.
Uma kwenzeka ukuba khona kwezifo zesibindi noma izinso zenhliziyo emzimbeni wesiguli ophazamisa ukusebenza kwazo, izinga lokusetshenziswa kwalesi sithangami lenyuka lifinyelela kuma-75 mg ngosuku kumuntu omdala. Lesi sikhombisi asincike eminyakeni yobudala.
Lokhu kungenxa yokuthi lapho kukhona ukugula kukhona ukusetshenziswa kwemali okusheshayo kwengxenye ye-bioactive emzimbeni.
Ukwedlula nokuntuleka kwe-Vitamin N emzimbeni
Kuze kube manje, izimpawu ezichazwe ngokucacile noma izimpawu ezithile zokuntuleka kwevithamini emzimbeni azikakhonjwa.
Lokhu kungenxa yokuthi le ngxenye yomzimba womzimba womzimba ingakheka ngokuzimele ngamaseli futhi ihlala ikhona okungenani ngamanani amancane.
Ngenani elinganele lale khompiyutha, ezinye izifo zingakhula emzimbeni womuntu.
Ukwephulwa okuyinhloko okutholakele lapho kunenkinga ye-lipoic acid yilezi ezilandelayo:
- Ukuvela kwezimpawu ze-neurological ezivame ukubonakala, ezibonakala njengesiyezi, izinhlungu ekhanda, ukuthuthukiswa kwe-polyneuritis kanye ne-neuropathy yesifo sikashukela.
- Ukuphazamiseka ekusebenzeni kwezicubu zesibindi, okuholela ekuthuthukisweni kwe-hepatosis enamafutha nezinqubo zokwenziwa kwe-bile.
- Ukuthuthukiswa kwezinqubo ze-atherosclerotic ohlelweni lwe-vascular.
- Ukuthuthukiswa kwe-metabolic acidosis.
- Ukuvela kokulimala kwemisipha.
- Ukuthuthukiswa kwe-myocardial dystrophy.
I-Vitamin N ethe xaxa emzimbeni ayenzeki. Lokhu kungenxa yokuthi noma yikuphi ukweqiwa kwaleli khompiyutha okungena emzimbeni ngemikhiqizo noma ngemikhiqizo yokudla ethathiwe ekudleni kususwa ngokushesha okukhulu kuyo. Ngaphezu kwalokho, uma kwenzeka kwehle uvithamini, akanaso isikhathi sokukhipha imiphumela emibi emzimbeni ngaphambi kokuqedwa.
Ezimweni ezingavamile, lapho kukhona ukwephulwa ezinqubweni ze-excretion, ukuthuthukiswa kwe-hypervitaminosis kuyabonakala. Lesi simo singase sibe ezejwayelekile kumacala wokusetshenziswa kwezidakamizwa isikhathi eside nokuqukethwe okuphezulu kwe-lipoic acid kumithamo edlula leyo enconyiwe.
Ukweqiwa kwe-vithamini emzimbeni kuboniswa ngokubonakala kwenhliziyo, ukwanda kwe-acidity yejusi esiswini, ukubonakala kobuhlungu esifundeni se-epigastric. I-Hypervitaminosis ingabonakala futhi ngesimo sokuqubuka komzimba esikhunjeni somzimba.
Ukulungiselela nezithasiselo zokudla ze-lipoic acid, izinkomba zokusebenzisa
Njengamanje, izidakamizwa nezithasiselo zokudla eziqukethe le vithamini ziyenziwa.
Imithi ihloselwe ukwelashwa kwezidakamizwa uma kwenzeka kunezifo ezahlukahlukene ezihambisana nokuntuleka kwe-lipoic acid.
Kunezelwa izithasiselo ukuze zisetshenziselwe ukuvikela ukuvela kokuphazamiseka emzimbeni.
Ukusetshenziswa kwezidakamizwa, okubandakanya i-lipoic acid, kuvame ukwenziwa lapho isiguli sikhomba lezi zifo ezilandelayo:
- izindlela ezahlukahlukene ze-neuropathy;
- ukuphazamiseka kwesibindi;
- ukuphazamiseka ohlelweni lwezinhliziyo.
Imithi iyatholakala ngesimo samaphilisi we-capsule nekhambi lomjovo.
Izithasiselo zitholakala kuphela ngesimo samaphilisi kanye namathebulethi.
Imithi ejwayelekile equkethe i-lipoic acid yile elandelayo:
- I-Berlition. Kutholakala ngesimo samathebulethi bese ugxila ngokulungiselela izixazululo zokulimala kwe-intravenous.
- Lipamide Umuthi uyatholakala ngesimo samathebulethi.
- I-Lipoic acid. Umuthi uthengiswa ngendlela yamathebulethi kanye nesisombululo somjovo we-intramuscular.
- I-Lipothioxone yindlela yokulungiselela izixazululo ezenzelwe umjovo we-intravenous.
- Neuroleipone. Umuthi wenziwa ngesimo samaphilisi okusetshenziswa komlomo nokugxiliswa lapho kulungiswa isisombululo somjovo we-intravenous.
- I-Thiogma - ekhiqizwa ngendlela yamathebulethi futhi igxile. Kuhloswe ukulungiswa kwekhambi.
- I-Thioctic acid - umuthi usesimweni sezibhebhe.
Njengengxenye, i-lipoic acid ifakiwe kulokhu okulandelayo kokudla:
- I-antioxidant evela ku-NSP;
- I-Alpha Lipoic Acid Evela DHC;
- I-Alpha Lipoic Acid kusuka ku-Solgar;
- I-Alpha D3 - Teva;
- IGastrofilin Plus;
- INutricoenzyme Q10 ene-alpha lipoic acid evela kuSolgar.
I-Lipoic acid iyingxenye yezakhiwo ze-multivitamin:
- Isifo Sikashukela Alphabet.
- Umphumela we-Alphabet.
- Kuhambisana nesifo sikashukela.
- Ihambisana nemisakazo.
I-Lipoic acid isetshenziselwa izinjongo ze-prophylactic noma njengengxenye ekwelapheni okuyinkimbinkimbi kwezifo ezahlukahlukene. Njengesinyathelo sokuvimbela, kunconywa ukusebenzisa izithasiselo zokudla kanye nama-multivitamin complexes. Ukudla nsuku zonke kwe-lipoic acid lapho usebenzisa izithasiselo zokudla kufanele kube ngu-25-50 mg. Lapho wenza ukwelashwa kwezifo okuyinkimbinkimbi, umthamo we-lipoic acid othathwe ungafinyelela ku-600 mg ngosuku.
Izinzuzo ze-lipoic acid zesifo sikashukela zizohlanganiswa ngevidiyo kuleli vidiyo.
