Isifo sikashukela yisifo esibi kakhulu, ekwelapheni lapho kusetshenziswa khona imishanguzo ehlukahlukene, kubandakanya neNovoformin. Lo muthi ungoweqembu lama-Biguanides futhi uhloselwe ukuhlela amazinga kashukela ngokwejwayelekile.
Kunikezwa umuthi ezigulini ezinesifo sikashukela sohlobo 2 esikhuluphele uma ukwelashwa kokudla kunganele.
Ngaphezu kwalokho, i-Novoformin ivame ukunqunywa ngokuhlanganiswa nemijovo ye-insulin uma isiguli sinezinkinga zokukhuluphala nje kuphela, kepha futhi nokuqedwa kwe-insulin.
Ukwakheka kanye nesimo somuthi
INovoformin ingeyeqembu lezidakamizwa ze-hypoglycemic zokulawulwa komlomo.
Indlela eyinhloko yokukhishwa kwezidakamizwa ngamacwecwe amhlophe ayindilinga. Isimo biconvex; kukhona ubungozi ngakwelinye iphilisi.
Into esemqoka esebenzayo yesidakamizwa yi-metformin hydrochloride. Ngokuya ngokuhlushwa, kukhiqizwa izinhlobo ezimbili zamathebulethi: 500 mg wento esebenzayo kanye ne-850 mg. Abamele lesi sidakamizwa bafaka:
- polyethylene glycol,
- i-povidone
- i-sorbitol
- i-magnesium stearate.
Ukwahluka kwesidakamizwa nakho kuyahluka ngohlobo lwegobolondo: bakhipha amaphilisi ajwayelekile kanye namathebulethi wesenzo eside, kanye nefilimu noma ukumala okufakiwe.
Umuthi ungoweqembu lama-Biguanides. Umphumela omkhulu weNovoformin yi-hypoglycemic, i.e., kusiza ukwehlisa ukunqwabelana kwe-glucose kwiplasma yegazi. I-Metformin iyakwazi ukwehlisa ijubane ukwakheka kwe-glucose kuma-hepatocytes, yehlisa amandla okugaya i-glucose. Ngasikhathi sinye, umuthi uthuthukisa ukusetshenziswa koshukela okweqile kanye nokuzwela kwezicubu ukungena ku-insulin. Ngaphandle kwalomphumela, i-Novoformin ayikuthinti kabi ukukhiqizwa kwe-insulin futhi akubangeli ukusabela kwe-hypoglycemic.
Umphumela wokwelapha wesidakamizwa ubonakaliswa buthakathaka ngokungabikho kwe-insulin. Umphumela wemithi yesidakamizwa ihluke kancane ngokuya ngesimo sawo. Ngakho-ke, amaphilisi ajwayelekile abangela ukwehla kwe-cholesterol, IG ne-LDL. Umuthi osebenza isikhathi eside, ngokungafani nalokhu, awuthinti izinga le-cholesterol ne-LDL, kepha kwezinye izimo kungenzeka ukwenyuse izinga le-TG.
Ngaphezu kwalokho, lo muthi usiza ukuqinisa isisindo seziguli ezinesifo sikashukela, kanti kwezinye izimo kukhona ukwehla okuthe xaxa kwamafutha omzimba. Imvamisa isetshenziselwa ukwehla kwesisindo, noma ngabe kungekho ukutholakala kwesifo sikashukela.
Ukufakwa kwesidakamizwa kuvela emgodini wokugaya ukudla. I-bioavailability yomthamo weNovoformin ifinyelela ku-60%. Umuthi unamandla okuqongelela emzimbeni - ikakhulukazi ezicutshini, izinso, isibindi kanye nezindlala zesisu. Ukuhlushwa okuphezulu kakhulu kutholakala cishe amahora angama-2. Ukudonswa kwalo muthi kwenzeka kungashintshiwe ngezinso. Isikhathi sokuqedwa kwesigamu sezinto ezisebenzayo zesidakamizwa amahora angama-6.5
Ukubala kweNovoformin kungenzeka, kepha kuvame ukwenzeka ngomsebenzi wezinso ongasebenzi kahle. Ukusuka emzimbeni, umuthi ukhishwa emchameni.
Imiyalo yokusebenzisa umuthi
Ngaphambi kokuthatha umuthi, kubalulekile ukuthi uzijwayeze nemiyalo yokusetshenziswa kweNovoformin ukuze ngokuzayo kungabikho zimpawu ezingemnandi.
Uhlobo lomthamo kanye nomthamo kunqunywa ngokuhlukile kwisiguli ngasinye. Thatha amaphilisi we-500 mg wento esebenzayo kunconyelwa ukuqala ngamaphilisi angu-1-2 ngosuku, okungukuthi, kungabi ngaphezu kuka-500-1000 mg. Ngemuva kwamaviki angama-1.5-2 ekwelashwa, kungenzeka ukuthi kukhuphuke umthamo wezidakamizwa, yize lokhu kuncike kakhulu ezingeni likashukela egazini. Ukuze ulondoloze lesi simo, kunconywa umthamo wamaphilisi ama-3-4 we-Novoformin, ubuningi akufanele budlule amatafula ayi-6.
Amaphilisi we-Novoformin 850 mg aqala ukuthathwa ngethebhulethi eyi-1 nsuku zonke. Ngemuva kwamaviki awu-1.5-2, kususelwa kuzinga le-glucose egazini, kwenziwa isinqumo ngokwenyuka komthamo kancane kancane. Isilinganiso esiphezulu somuthi akufanele singeqi ku-2,5 g.
Izindinganiso ezinjalo ziyanconywa kubantu abadala. Kwabantu asebekhulile, kunconyelwa ukunciphisa umthamo kuya kumaphilisi ama-2 (hhayi ngaphezu kwe-1000 mg). Futhi, umthamo wehla ngokukhubazeka okungathi sína emzimbeni.
Kungcono ukuthatha umuthi ngokudla noma ngokushesha ngemuva kokudla. Amathebulethi angagezwa phansi, kepha inani lamanzi kufanele libe lincane. Njengoba kungenzeka imiphumela emibi yesidakamizwa iphelele, kunconywa yonke imithamo yansuku zonke ihlukaniswe izingxenye ezifanayo nezinezi-doses ezi-2-3.
Uma isiguli sinqunywa umuthi i-Novoformin kanye ne-insulin (umthamo wansuku zonke ongaphansi kwama-40 amayunithi), irejimeni liyafana. Kulokhu, kuvunyelwe ukwehlisa kancane kancane umthamo we-insulin, ngokungabi ngaphezu kwama-unit ayi-8, kanye njalo ezinsukwini ezi-2. Uma isiguli siphoqelelwa ukuthatha ngaphezu kwe-40 IU ye-insulin nsuku zonke, khona-ke ukuncishiswa komthamo nakho kuvumelekile, kepha akunconywa ukuwenza wedwa. Imvamisa, ukuncishiswa kwe-insulin kwenziwa esibhedlela, ngokuhambisana nazo zonke izindlela zokuqapha.
Umuthi unezindlela eziningi zokuphikisana okufanele zisetshenziswe:
- Izifo zesibindi, izinso.
- I-Myocardial infarction kushukela.
- Ukungabekezelelani komuntu ngamunye ku-metformin noma ezinye izinto zomuthi.
- I-Hyperglycemic coma.
- Ukudla okunama-calorie aphansi (ngokudla okungama-caloric ngaphansi kwe-1000 kcal / ngosuku).
Ngaphezu kwalokho, lesi sidakamizwa asinqunyelwe ezinsukwini ezi-2 ngaphambi kokungenelela kokuhlinzwa noma ukuhlolwa okuhlukile kokuqukethwe kwe-iodine.
Ukuphikisana nokuqokwa komuthi ukukhulelwa.
Ngesikhathi sokuhlela ukukhulelwa, kanye nangesikhathi sokukhulelwa ngemuva kokuqala komuthi, ukwelashwa ngeNovoformin kumele kuqedwe.
Ukubuyekezwa nezindleko zomuthi
Ukubuyekezwa mayelana nomuthi iNovoformin muhle kakhulu, kokubili phakathi kodokotela naphakathi kweziguli. Izazi ze-Endocrinologists ezishiyile izibuyekezo zazo zibika ukuthi sekuphele unyaka zinquma lesi sidakamizwa. Umuthi osebenza ngempumelelo ubhekelwa kakhulu kwiziguli ezinesisindo esikhulu ngokweqile (nge-BMI engaphezu kwama-35). Kunomthelela ekulahlekelweni kwamafutha ngokweqile, noma ukuze kufinyelelwe emiphumeleni kuyadingeka ukunamathela ekudleni futhi kunciphise ukusetshenziswa kokudla okuqukethe ushukela.
Ngokusho kokubuyekezwa, umuthi iNovoformin unesenzo esithambile kunazo zonke phakathi kwama-biguanides. Umuthi uyasebenza futhi ekwehliseni amazinga kashukela egazi. Ezigulini ezinokukhuluphala obukhulu, le nkomba yehle ngo-1.5% ngaphandle kokuthatha izidakamizwa ezengeziwe ne-insulin.
Izinzuzo zesidakamizwa zifaka intengo yaso: ngokuya ngedolobha nekhemisi, umuthi ungabiza kuhla lwama-ruble ayi-100-130.
Ngaphezu kwezibuyekezo ezinhle, umuthi uthole ezinye eziningi ezingezinhle. Ezinye iziguli azibonanga ukuthuthuka, noma kusetshenziswe isikhathi eside. Abanye odokotela bavumelana nabo: bakholelwa ukuthi iNovoformin "incane" kunama-analogues, njengeGlucofage noma iSiofor.
Ukwelashwa okusebenzayo, ama-endocrinologists ayelulekwa ukuba akhethe izifaniso zomuthi:
- I-Metformin (into esemqoka esebenzayo),
- I-Glucophage,
- Siofor
- Fomu Pliva,
- ISofamet
- I-Metfogamma.
Ezinye iziguli ezisebenzisa lo muthi zikhononda ngokuvela kwemiphumela emibi yomuthi:
- Ubuhlungu obukhulu besisu
- isicanucanu
- ukuntuleka kwesifiso sokudla
- ukuphazamiseka kwendlela yokugaya ukudla,
- ukungezwani komzimba
Umuthi ungathengwa kunoma iyiphi ikhemisi, kepha unikezwa ngomuthi kuphela.
Thatha umuthi ngokuqinile ngokwemiyalo, ugweme ukweqisa.
Ukudlula inani elidingakalayo lomuthi kungadala imiphumela emibi yezempilo. Ngakho-ke, ukuthatha noma yiziphi izidakamizwa zeqembu le-Biguanide (kufaka phakathi i-Novoformin) kungadala i-lactic acidosis - isimo se-pathological esingaholela ekufeni. Izimpawu ze-lactic acidosis Ubuhlungu bemisipha, ukunganaki, ukozela, ukushisa komzimba okuncishisiwe kanye nomcanuzelo.
Uma kuvela noma yiziphi izimpawu ze-lactic acidosis, kubalulekile ukuthi uyeke ukuthatha i-Novoformin futhi uphuthumise esibhedlela lowo ophethe ngokuphuthumayo.
Yiziphi izidakamizwa ezingasetshenziswa esikhundleni seNoformin yesifo sikashukela? Lokhu kuzoxoxwa ngakho kule vidiyo ekulesi sihloko.
