Umuthi i-Telzap 80: imiyalo esetshenzisiwe

I-Telzap 80 isidakamizwa esisebenzayo sehlisa umfutho wegazi. Ikuvumela ukuthi uzuze ngokushesha ukufundwa kwe-tonometer ejwayelekile ngaphandle kokubangela imiphumela emibi.

Igama Lezwe elingafanele

I-Telmisartan igama elejwayelekile lomhlaba wonke lesidakamizwa.

I-Telzap 80 isidakamizwa esisebenzayo sehlisa umfutho wegazi.

I-ATX

Ikhodi ye-ATX yesidakamizwa yi-C09CA07

Khipha amafomu nokwakheka

Kuyatholakala ngesimo sethebhulethi. Ithebhulethi ngayinye iqukethe i-0.04 noma i-0.08 g ye-telmisartan esebenzayo yezinto.

Ngaphezu kwalokho, ithuluzi lifaka izinto ezinjalo:

• i-meglumine;
• i-sorbitol;
• i-sodium hydroxide;
• i-povidone;
• usawoti we-stearic magnesium.

Amacwecwe ahlanganiswe emabhulini ezincezu eziyi-10.

Amacwecwe ahlanganiswe emabhulini ezincezu eziyi-10.

Isenzo se-Pharmacological

Umuthi ungowabaphikisi be-angiotensin receptors ΙΙ. Kusetshenziswa njengendlela yokuphatha ngomlomo. Ibonisa i-angiotensin ΙΙ, ayikuvumeli ukuxhumana kwayo nama-receptors. Ibopha kune-AT I angiotensin рецеп receptor, futhi lokhu kuxhuma kugcizelelwa ngokuqhubekayo.

Umuthi unciphisa ukugcwala kwe-aldosterone ku-plasma, ngaphandle kokwehlisa imiphumela ye-renin. Akuvimbi iziteshi ze-ion. Akuvimbeli inqubo ye-ACE synthesis. Izakhiwo ezinjalo zisiza ukugwema imiphumela engathandeki ekuphuzeni umuthi.

Ukuthatha umuthi ku-0,08 g ucisha umsebenzi we-angiotensin ΙΙ. Ngenxa yalokhu, umuthi ungathathwa ukwelapha i-arterial hypertension. Ngaphezu kwalokho, ukuqala kwesenzo esinjalo kuqala amahora ama-3 ngemuva kokuphathwa ngomlomo.

Umphumela wemithi uphikelela usuku ngemuva kokuphathwa, uhlala ubonakala nezinye izinsuku ezi-2.

Umphumela we-hypotensive unomphela uqhamuka emavikini ama-4 ngemuva kokuqala kokwelashwa.

Ngemuva kokuthi umuthi unqanyuliwe, izinkomba zokucindezela zibuyela kancane kwakwangaphambili ngaphandle kokubonakaliswa kwezimpawu zokuhoxa.

I-Pharmacokinetics

Ngemuva kokuphathwa ngomlomo, umuthi udonswa ngokushesha egazini. Cishe ingxenye ye-bioavava iyatholakala. Uma usebenzisa ithebhulethi ngokudla, lesi sibalo siphansi kakhulu. Ngemuva kwamahora ama-3, ukulinganiswa kancane kancane kwenani lemithi esegazini kuyabonakala. Kunomehluko phakathi kokuhlungwa kwe-plasma kwengxenye kweziguli zobulili obuhlukile: kwabesifazane, inkomba iphakeme kakhulu.

Ngemuva kokuphathwa ngomlomo, umuthi udonswa ngokushesha egazini.

Umuthi uboshelwe ngokuphelele kumaprotheni e-plasma. Ibola kanye ne-glucuronic acid. Izinto ezivelayo azinawo umsebenzi wezinto eziphilayo nokubaluleka kwezidakamizwa.

Isigamu sempilo cishe amahora angama-20. Cishe sonke isibalo somuthi sikhishwe singashintshiwe ngemithi.

I-Pharmacokinetics ezigulini esezikhulile ayihlukile kwiziguli ezikulesinye isigaba. Okufanayo kusebenza ezigulini ezinobumnene kuya ekulimazeni okulinganiselayo kwezinso, isibindi.

Izinkomba zokusetshenziswa

Kubekelwe ukwanda okumenyezelwe nokuhlala isikhathi eside komfutho wegazi kanye nokungatholakali komphumela wokwelapha ngesikhathi sokwelashwa neminye imithi.

Contraindication

Umuthi uvinjelwe ezimweni:

• ukuvimbela ipheshana lokuphilisana;
• ukwephulwa okuqhubekayo komsebenzi wesibindi weklasi C (kufaka phakathi i-cirrhosis);
• ukusetshenziswa kanyekanye kwe-Aliskiren ne-ACE inhibitors;
• ukungabekezelelani kwe-fructose (umuthi uqukethe inani elincane le-sorbitol);
• isikhathi sokulindela ingane;
• ukuncelisa;
• iminyaka yezingane (ukuya kufinyelela eminyakeni engu-18);
• ukuzwela okubukhali kwengxenye yomuthi.

Ukuphuza umuthi kwenqatshelwe i-cirrhosis.

Ukuphuza umuthi akuvunyelwe ngesikhathi sokukhulelwa.

Ukuthatha umuthi akuvunyelwe ngenkathi uncelisa ibele.

Ngokunakekela

Umuthi unikezwa ngokunakekelwa okukhethekile kumacala alandelayo:

• Ukuvalwa okumbili kwe-renal artery;
• ukuncishiswa kwe-artery yezinso evame ukusebenza;
• ukungasebenzi kahle kwezinso;
• ukuphazamiseka okukhulu kwesibindi;
• ukwehla kwenani eliphelele legazi ngenxa yokwelashwa kwe-diuretic, incl. futhi ukuze kwehliswe umfutho wegazi;
• ukusetshenziswa kosawoti okulinganiselwe;
• isicanucanu esedlule nokuhlanza, ukuthambekela kubo;
• ukuncipha kwe-calcium, potassium ne-sodium;
• isimo esaphawulwa ngemuva kokufakelwa kwezinso;
• ukwehluleka okukhulu kwenhliziyo nokuqhubeka isikhathi eside;
• ukwakheka kwama-valve namanye amaphutha;
• i-cardiomyopathy;
• inani elandisiwe le-aldosterone egazini.

Umuthi ubekwa ngokunakekelwa okukhethekile uma kwenzeka i-cardiomyopathy.

Umuthi ubekwa ngokunakekelwa okukhethekile uma kwenzeka ukwehluleka okukhulu kwenhliziyo.

Umuthi ubekwa ngokunakekelwa okukhethekile nge-renal dysfunction enzima.

Imikhawulo yokwamukelwa kufanele ibonwe ezigulini zomjaho weNegroid.

Ungayithatha kanjani i-telzap 80 mg?

Lo muthi uthathwa isikhathi esingu-1 ngosuku. Kungcono ukuyiphuza ngemuva kokudla noma ngaphambi kokudla. Amaphilisi ayagezwa ngamanzi ahlanzekile.

Umthamo wokuqala amaphilisi ½ we-80 mg. Ezinye izigaba zeziguli (ngokwesibonelo, ngokwehluleka kwe-renal) zidinga ukuncishiswa komthamo wesigamu. Uma kusukela ekuqaleni kokusetshenziswa komphumela wokwelapha akunakwenzeka ukufeza, bese ubhekisa ekunyuseni umthamo kuya ku-80 mg. Kepha lesi sinyathelo asihlali sithathwa, ngoba umphumela omkhulu we-hypotensive ubonwa emasontweni ama-4 kuphela ngemuva kokuqala kokwelashwa.

Ngokuvimbela ukufa kwesifo senhliziyo, umthamo onconywayo ngu-80 mg kanye. Ekuqaleni kokwelashwa, kunconywa ukuqapha okuqhubekayo kwe-tonometer.

Lo muthi uthathwa isikhathi esingu-1 ngosuku, ugezwe ngamanzi ahlanzekile.

Ukuthatha umuthi wesifo sikashukela

Njengoba umuthi ungadala i-hypoglycemia, i.e. ukwehla okukhulu kwezinga likashukela, isilinganiso esincane esisebenzayo kufanele sikhethwe ngesikhathi sokwelashwa, okuzoletha umphumela odingekile futhi ngasikhathi sinye singanikeli umphumela ongathandeki.

Ngesikhathi sokwelashwa, iziguli zidinga ukukala ngokucophelela i-glycemia yazo zisebenzisa i-glucometer ephathekayo.

Imiphumela emibi

Mayelana nokuhlukumeza amasosha omzimba, amathuba okukhula kwe-cystitis, sinusitis, pharyngitis ayanda.

Amapheshana wesisu

Kuyaqabukela, ukuphuza umuthi kuholela ekungaphatheki kahle esiswini namathumbu. Izimpawu ezinjengomuzwa wokudonsa esiswini, ukugabha, ukushisa kwenhliziyo, isifo sohudo futhi akuvamile ukuvela. Ukuvela kwalezi zimpawu akudingi ukusetshenziswa kwezidakamizwa ezikhethekile futhi kudlule ngokwakho.

Umphumela wecala ngenxa yesishayo senhliziyo uyivelakancane.

Izitho zeHematopoietic

Akuvamile, ukwehla kwenani lamangqamuzana egazi abomvu (anemia), ama-platelet, ama-eosinophils angakhula.

I-Telzap ibangela ukwephulwa emiphumeleni yokuhlaziywa kwethimba:

• ukwanda kwe-creatinine;
• ukukhuphuka kokuqina komchamo;
• umsebenzi owengeziwe wama-enzyme wesibindi.

Lezi zinguquko zitholakala ngenkathi kuhlaziywa amakhemikhali.

Isistimu yezinzwa ephakathi

Umuthi ungadala isiyezi, ukufiphala, ukungasebenzi kahle kwezinzwa. Ezinye iziguli ziba nokukhathala okwandayo futhi ukozela ngesikhathi sokusebenzisa umuthi. Ngaphezu kokuqwasha, ezinye iziguli zingathinteka ekukhathazekeni.

Akuvamile, ukulimaza okubukwayo. Kaningi, ukuphazamiseka kwemishini ye-vestibular kwenzeka.

I-Telzap ibanga ukuphazamiseka emiphumeleni yokuhlaziywa kwethambo.

Kusuka ohlelweni lomchamo

Kwesinye isikhathi kuyenzeka ukuthi kube nezinguquko ezimangazayo ekwakhekeni kwezicubu zezinso, okuholela ekwehlekeni okukhulu kwenani lomchamo ochithululiwe. Lokhu kuyingozi ikakhulukazi kwiziguli ezitholakala zisehlulekile izinso. Ukwehla kwenani lomchamo othunyelwe ku-0 (anuria) kuwuphawu olwesabekayo futhi kudinga ukulungiswa kokulashwa okuyisisekelo.

Impela kuyaqabukela, ukuthatha iTelzap kubangela ukuvela kokungcoliseka kwegazi kumchamo.

Kusuka ohlelweni lokuphefumula

Mhlawumbe ukuthuthukiswa kokuphefumula okusheshayo nomuzwa wokuntuleka komoya. Akuvamile ukuba kube nokukhwehlela futhi, ezimeni ezihlukile, isilonda sangaphakathi sezicubu zamaphaphu, i-sepsis.

Engxenyeni yesikhumba

Kuyaqabukela, ukusetshenziswa kwesidakamizwa kungadala ukulunywa kanye nokubomvu kwesikhumba, ukujuluka kokujuluka. Kwezinye iziguli, ngenxa ye-hypersensitivity kanye nokuthambekela kokungezwani komzimba, kuqhamuka isikhumba esincane. Kuyaqabukela, uhlobo lwe-edema ye-angioneurotic kwenzeka engaholela ekufeni.

Kuyaqabukela, ukusetshenziswa kwesidakamizwa kungadala ukulunywa kanye nokubomvu kwesikhumba.

Kusuka ohlelweni lwezitho zofuzo

Imvamisa, iTelzap ibangela ama-pathologies okuvuvukala wohlelo lokuzala lowesifazane kanye nokungahambi kahle kokuya esikhathini. Kumadoda, ukungasebenzi kwe-erectile kungahlakulela ngezikhathi ezithile.

Kusuka ohlelweni lwezinhliziyo

Kwesinye isikhathi izehlakalo ezinjengalezi zenzeka:

• ukwehla kwenhliziyo;
• ukwehla okubukhali kwengcindezi, okuholela ekudumeni;
• ukwehla komfutho wegazi ngesikhathi sokushintsha kwesikhundla somzimba;
• kuyaqabukela kakhulu kungenzeka kwenhliziyo.

Uhlelo lwe-Endocrine

Umuthi ungadala i-hypoglycemia, i.e. ukwehla kushukela wegazi. Metabolic acidosis kungenzeka. Ezigulini ezinesifo sikashukela, amathuba okuthola ukoma ayanda.

Engxenyeni yesibindi ne-biliary

Umuthi awuvame ukuholela ekulimaleni kwesibindi kanye nesinye.

Kwesinye isikhathi kuba nokwehla okukhulu kwengcindezi.

Allergies

Ukuphendula okulandelayo kungenzeka:

• ukuqubuka komzimba;
• I-edema kaQuincke;
• i-laryngeal edema;
• ubhejane.

Imiyalo ekhethekile

Ukwehla okwedlulele kwezinkomba zokucindezela kuvusa ukuthuthukiswa kokuhlaselwa yisifo senhliziyo, unhlangothi, kanye nokwanda kokushona kwezifo zalezi zifo.

Ukuhambisana notshwala

Umuthi awuhambisani ngokuphelele notshwala. Ukuphuza utshwala ngesikhathi sokwelashwa kungadala ukwehla komfutho wegazi, ukuwohloka komzimba.

I-edema ye-Laryngeal ingahle ivele.

Umthelela ekhonweni lokulawula izindlela

Ukuhlolwa okuyisipesheli kokuphepha kokuphuza umuthi ngenkathi ushayela futhi usebenza nezinqubo eziyinkimbinkimbi akukenziwa. Ukunakekelwa okukhethekile kufanele kuthathwe lapho kwenziwa lezo zenzo kanye nokusebenzisa kanyekanye kweTelzap.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Akukho mininingwane ethembekile ngokuphepha kwalo muthi ngesikhathi sokukhulelwa. Izifundo zezilwane zikhombisile imiphumela enobuthi yesidakamizwa esibelethweni. Uma isiguli sihlela ukukhulelwa, futhi sidinga ukuthatha umuthi ukwehlisa ingcindezi, kunconywa ukuthatha ezinye izindlela zokwelapha.

Ukusetshenziswa kwezidakamizwa eqenjini lama-inhibitors, ama-angiotensin antagonists ku-2nd kanye ne-3 trimesters kunomthelela ekuthuthukisweni komonakalo wezinso, isibindi, ukubambezeleka kwe-ossation yekhanda ku-fetus, i-oligohydramnion (ukwehla kwesilinganiso samanzi e-amniotic).

Umuthi awuhambisani ngokuphelele notshwala.

Izingane ezizalwa omama abathatha iTelzap zidinga ukubhekwa isikhathi eside.

Ukusetshenziswa kwesidakamizwa ngesikhathi sokuncelisa ibele kuyahlungwa.

Kunquma iTelzap 80 mg ezinganeni

Ukunquma umuthi kuphikisana ngokuphelele nezingane nasebusheni. Lokhu kungenxa yokushoda kwedatha ngokuphepha kwemithi kulezi zigaba zeziguli.

Sebenzisa ebudaleni

Iziguli esezikhulile (kufaka phakathi lezo ezingaphezulu kwama-70) azidingi ukulungisa umthamo.

Isicelo sokusebenza kokulimala kwezinso

Ukuphuza umuthi ezigulini ezingasebenzi kahle izinso kufundwe kabi. Akunasipiliyoni ngokusetshenziswa komuthi ezigulini dialysis. Kulezi zigaba zeziguli, umthamo wokuqala ngu-20 mg, futhi kufanele uhlale unjalo kuyo yonke inkambo yokwelapha.

Ukunquma umuthi kuphikisana ngokuphelele nezingane nasebusheni.

Sebenzisa umsebenzi wesibindi okhubazekile

Ngokuphathelene nomsebenzi wesibindi ongasebenzi kahle, kunconyelwa ukwenza ukulungiswa komthamo (inani eliphezulu - 0,04 g). Ekulimaleni okukhulu kwezinso, umuthi awusetshenziswa.

Ukweqisa

Izimpawu ze-overdose yilezi:

• Isiyezi
• ukwehla okukhulu kwengcindezi;
• ukwehla kwenhliziyo;
• ukwehluleka kwezinso okulimazayo.

Ukwelashwa kwalokhu kuphazamiseka kuyimpawu.

Ukuphuza umuthi ezigulini ezingasebenzi kahle izinso kufundwe kabi.

Ukuxhumana nezinye izidakamizwa

Umuthi unokuxhumana okuhlukile namaqembu athile wezidakamizwa.

Inhlanganisela ehlanganisiwe

Ngokwengxenye, inhlanganisela yeTelzap namanye ama-inhibitors wesifo sikashukela sohlobo 2 akavunyelwe, ngoba ukuhlanganiswa okunjalo kunomthelela ekuthuthukisweni kwe-hypoglycemia enzima.

Akuhlanganisiwe ukuhlanganisa

Ukusetshenziswa kweTelzap ngezithako ze-potassium kanye nezidakamizwa ze-potassium-sparing diuretic akunconyelwanga (i-hyperkalemia ingaqala).

Akunconyelwe futhi ukuthatha kanyekanye:

• anti-ukuvuvukala okungeyona i-steroidal;
• i-heparin;
• amalungiselelo nge-hydrochlorothiazide;
• ama-immunosuppressants.

Isibonakaliso esidaliwe se-overdose ukwehla kwenhliziyo.

Inhlanganisela edinga ukuqashelwa

Ngokuqapha, kufanele uthathe:

• digoxin;
• amalungiselelo e-lithium;
• i-aspirin;
• i-furosemide;
• ama-corticosteroids;
• ama-barbiturates.

Ama-Analog

Izindlela ezifanayo yilezi:

• UMikardis;
• I-Telpres
• I-Telzap Plus;
• Telsartan;
• I-Lozap 12 5.

I-analogue yesidakamizwa yiTelsartan.

I-analogue yesidakamizwa nguLozap.

Analogue yezidakamizwa uMikardis.

Imibandela yekhefu lekhemisi

Ikhishwa ngomuthi kuphela.

Ngingakwazi ukuthenga ngaphandle kadokotela?

Ukuthenga iTelzap ngaphandle kadokotela akunqunyelwe.

Intengo yeTelzap 80

Intengo emaphakathi ama-ruble angama-480.

Izimo zokugcina zomuthi

Ekushiseni kwegumbi.

Isikhathi sokuphelelwa yisikhathi

Kunconywa ukusebenzisa ngaphakathi kweminyaka eyi-2 kusukela ngosuku lokukhiqizwa.

Umkhiqizi

ITurkey (Zentiva Saglik Urunleri Sanai ve Tijaret).

Ukubuyekezwa mayelana ne-Telzap 80

Odokotela

U-Ana, oneminyaka engama-50 ubudala, udokotela wezifo zenhliziyo, eMoscow: "Nginikeza lesi sidakamizwa kwiziguli ezinomfutho wegazi ophakeme ophakeme. Uma sisetshenziswa, i-hypotension ye-arterial ayibhekwa. Iziguli ziyakubekezelela ukwelashwa kahle."

USergey, oneminyaka engama-55 ubudala, udokotela wezenhliziyo, eSt.

Ukusetshenziswa kweTelzap ngezithako ze-potassium kanye nezidakamizwa ze-potassium-sparing diuretic akunconyelwanga (i-hyperkalemia ingaqala).

Iziguli

U-Ana, oneminyaka engama-45, uSaratov: "Sekuphele izinyanga ezimbili ngithatha iTelzap. Ingcindezi ingaphansi kwemingcele ejwayelekile. Ngizwa kahle."

U-Irina, oneminyaka engama-50, eMoscow: "Ngosizo lweTelzap, ngakwazi ukunciphisa kakhulu ingcindezi futhi ngayiqeda ngokuphelele inkinga ye-hypertensive. Ngiphuza lo muthi ngezinjongo zokuphrinta."

U-Oleg, oneminyaka engama-59, uKazan: "Ngiphuza iTelzap kudosi yesondlo ukuze ngigweme ingozi yokuba nesifo senhliziyo. Amathebulethi asiza ukubhekana nomfutho wegazi ophakeme nazo zonke izimpawu zawo."