Inani elikhulu lemithi ehlukahlukene esetshenziselwa ukwelapha i-mellitus engaxineki ne-insulin, i-Gliclazide ingahlukaniswa.
Umkhiqizo uthole igama elinjalo ohlelweni lwe-INN. Ukusetshenziswa kwayo kungenzeka kuphela ngaphansi kokuqashwa okuqinile kodokotela ohambayo nangokuhambisana nazo zonke izincomo.
Kulokhu, ukusetshenziswa kweGliclazide kuzofeza umphumela omuhle.
Ukubonakaliswa kwalesi sifo nokwelashwa kwaso?
Uhlobo 2 sikashukela i-mellitus singabangelwa yi-pathologies eyikhulu yekhulu lamashumi amabili nanye. Indlela yokuphila yesimanje, ukushesha nokuxineka, umsebenzi ongasebenzi ndawonye ngokudla okungenampilo kube yizona zizathu eziphambili zokuthuthuka kwayo.
Ukwelashwa kwenqubo ye-pathological iqukethe ukusetshenziswa kwezinyathelo eziyinkimbinkimbi, phakathi kwayo lapho kunemithi ekhethekile nokudla okuqinile okuhlala ezindaweni ezibalulekile. Kumele kuqashelwe ukuthi umuntu angaphuza umuthi ngangokunokwenzeka, kepha ngaphandle kwendlela yokudla, ngeke akwazi ukufeza umphumela omuhle.
Imithi ekhethwe kahle izosiza umuntu onesifo sikashukela ukuba aphile impilo ephelele futhi agweme izinkinga ezingaba khona.
Yonke imithi esetshenziswa ekwelapheni okuyinkimbinkimbi ingahlukaniswa ngamaqembu alandelayo:
- Amaphilisi avusa amanyikwe.
- Izidakamizwa ezisusa ukumelana ne-insulin okubangelwa i-glucose. Isifo esinjalo kwesinye isikhathi senzeka kubantu abanesifo sikashukela sohlobo 2 futhi siyisibonakaliso sokunganakwa kwezicubu kwi-hormone ekhiqizwa yi-pancreas.
- Imithi ebandakanya i-acarbose. Ngenxa yalesi sakhi esisebenzayo, kunokuvinjwa kokufakwa kweglue emathunjini.
Phakathi kwemithi enomphumela omuhle ekuvumeni kwama-pancreas kukhona amaphilisi avela eqenjini le-sulfonylureas nama-glinides.
Umphumela ohlanganisiwe wenziwa ngaphansi kwethonya lama-incretins. Imithi evimbela ukuvela kokungamelana ne-insulin ngamathebulethi asuselwa ku-metformin noma i-thiazolinedione.
Okuhle esigulini ngasinye kunganqunywa kuphela ngudokotela ohambayo ngesisekelo sesithombe somtholampilo kanye nezimpawu zomuntu ngamunye.
Izici zamakhemikhali zomkhiqizo wezokwelapha
Umuthi i-Gliclazide kudala wasetshenziswa ukwelapha isifo sikashukela sohlobo 2 ngokubambisana nokwelashwa kokudla okunqunywe ngudokotela.
Umuthi awuvumeli kuphela ukwenza izinga leshukela egazini lijwayeze, kepha futhi liyasiza ekwehliseni isisindo ngokweqile, okubaluleke kakhulu kubantu abanalesi sifo.
Kuze kube manje, ezinye izici zalo muthi nazo sezihlonziwe.
Kusungulwe ngokwesayensi ukuthi umuntu angathatha i-Glyclazide 80 mg ukufeza izinhloso ezilandelayo:
- Isiza ukuvikela ubuchopho kusuka ku-obsolescence, ekuvumela ukuthi usebenzise izinhloso zayo ze-prophylactic zesifo se-Alzheimer's.
- Isithinta kahle isimo semikhumbi nemithambo yegazi. Ngakho-ke, ngosizo lomuthi, ukuthuthukiswa kwe-atherossteosis, ukungakwazi kwenhliziyo, umfutho wegazi ophakeme, kanye nokubalwa kwemithambo kungavinjelwa.
- Yehlisa amathuba womdlavuza
- Isebenza ngokugcwele ekuthuthukiseni amandla abantu besilisa abaphazamisekile ngenxa yezifo ezahlukahlukene zokuguga.
- Iphazamisa ukuthuthukiswa kwamathambo nesifo sikashukela. Ukulimala kwamathambo njalo kuthinta abesifazane ngemuva kokuqala kokunqamuka kokuya esikhathini, ngoba kukhona ukwehla okukhulu kwamahomoni - estrogen.
- Ithanda ukusebenza kahle kwe-yegilo yegilo.
- Kubonisa umsebenzi wokuzivikela maqondana nohlelo lokuphefumula.
Umuthi iGlyclazide usetshenziselwa ukwehlisa ushukela wegazi. Ngaso leso sikhathi, ukwehla kwezinkomba kwenzeka hhayi kuphela ngemuva kokudla okuyinhloko, kodwa futhi kukuvumela ukuthi wehlise izinga lesisekelo. Isakhi esisebenzayo samathebhulethi sikuvumela ukuthi ulawule ukukhiqizwa kwe-insulin ngama-pancreas, athinta umzimba kahle futhi ungavusi ukuthuthukiswa kwe-hypoglycemia. Ngaphezu kwalokho, phakathi kwemiphumela emihle ifaka:
- ukungathathi hlangothi kwe-hyperinsulinomy;
- umthelela omuhle kakhulu ekunciphiseni isisindo;
- kunciphisa ubungozi bokuthola izifo zohlelo lwethambo nenhliziyo;
- ithinta kahle i-lipid metabolism emzimbeni;
- kunciphisa inqubo ye-oxidation yamafutha;
- kunciphisa amazinga aphakeme e-cholesterol embi;
- kunciphisa ubungozi be-angiopathy yesifo sikashukela;
Isiza ukunciphisa i-triglycerides.
Imiyalo yokusebenzisa umuthi
I-gliclazide yezidakamizwa ichazwa kuphela ekwelashweni kwabantu abadala, futhi yithebhulethi ekhishwe modified.
Kuyadingeka ukuthatha umuthi onjalo kuphela ngaphansi kokuholwa kanye nokuqashwa kukadokotela oholayo. Imiyalo ye-Gliclazide yokusetshenziswa nayo inemininingwane efanele mayelana nemithamo nokuqapha.
Umuthi ungathengwa emakhemisi asedolobheni kule mithamo elandelayo:
- I-30 mg yento esebenzayo kwithebhulethi eyodwa;
- I-60 mg yesithako esisebenzayo;
- 80 mg
Kuya ngomthamo, imithetho yokuphuza umuthi izoncika. Inkambo yokwelashwa ichazwa kumthamo ophuma esithombeni esivamile somtholampilo walesi sifo kanye nezimpawu zomzimba womuntu ogulayo.
Isinkomba esikhulu okudingeka unake ngaso uma ukhetha umthamo yigazi le-glucose egazini kanye nesigaba sesisindo sesiguli. Umthamo wansuku zonke akufanele wedlule i-120 mg yento esemqoka.
Kulokhu, inkambo yokuqala yokwelapha kumele iqalwe ngemithamo engama-30 noma engama-60 mg. Amathebulethi kufanele aphuzwe kanye ngosuku, mhlawumbe ekuseni. Uma, ngenxa yezimo ezithile, umuthi uphuthelwe, asikho isidingo sokwandisa umthamo olandelayo. Ngaphezu kwalokho, imiyalo esemthethweni ithi ukwengeza umthamo kuyadingeka cishe inyanga ngemuva kokuqala kwemithi.
Okuhlukile ngaphandle kweziguli, ngemuva kwesifundo samasonto amabili, ezingabheki amandla amahle futhi nezinga le-glucose egazini lihlala lingaphezulu kwezinkomba ezijwayelekile. Ngemuva kwalokho, ukuthola umphumela omuhle kakhulu, udokotela anganquma ukwandisa umthamo.
Lapho uthatha lesi sidakamizwa, kuyadingeka ukusungula ukuqapha ushukela wegazi njalo ukuze i-hypoglycemia ingenzeki. Ukuze uthole umphumela ongcono kusuka ekuphuzeni umuthi, imvamisa inkambo yokwelapha ihambisana nale mithi elandelayo:
- izinto ezithathwe kuma-sulfonylurea;
- I-Gliclazide metformin;
- insulin;
- inhibitors;
- derizatives ze-thiazolidione.
Ngokuya enkampanini ekhiqiza izidakamizwa, intengo yeGliclazide ingahluka kancane. Izindleko zabo zingathinteka nomthamo womuthi (30 mg, 60 mg noma 80 mg).
Ukubuyekezwa kweziguli eziningi kukhombisa ukutholakala nokusebenza kahle kwamathebulethi.
Imiphi imiphumela emibi engahle ibe khona ngenkathi uphuza umuthi?
Ukwelashwa nokwelashwa nge-Glyclazide kufanele kwenzeke ngaphansi kokubhekwa kwezokwelashwa okusondele.
Akwamukelekile ukuthi uthathe lo muthi ngemithamo edlula izincomo zikadokotela, noma ngokuhlangana namanye amaphilisi akhethwe yisiguli.
Indlela yokusebenzisa nomthamo ikhonjiswe kwimiyalo evela kumenzi.
Ukuphathwa ngokungafanele komuthi kungadala imiphumela emibi eminingana, izindawo eziyingozi zomuthi womzimba womuntu zizovuleka.
Ukubonakaliswa okungekuhle kwesidakamizwa kubandakanya lokhu okulandelayo:
- Izinkinga zokugaya ukudla, ezingase zihambisane nokubumbana, izinhlungu esiswini noma uhudo.
- Imvamisa yensimbi engathandeki emlonyeni ingavela ngemuva kokungenisa.
- Umuzwa onamandla wendlala.
- Isicanucanu nokuhlanza.
- Ukubonakaliswa kokuphendula komzimba engxenyeni eyodwa noma eziningi zomuthi.
- Isiyezi nekhanda.
- Ukuqhekeka okuhlukahlukene esikhunjeni, amabala noma ukuvuvukala kwezicubu kungenzeka.
- Ukwephulwa kwezitho zombono.
- Ukuvela kwe-hypoglycemia.
- Ukuthuthukiswa kwe-lactic acidosis.
- I-anemopablastic anemia.
Njengomthetho, izimpawu ezinjalo ziyanyamalala ngemuva kokumisa umuthi. Kufanele futhi kuqashelwe ukuthi indlela engalungile nomthamo womuthi kungaholela ku-hypoglycemia enzima.
Kunqatshelwe nini ukwelashwa?
Umuthi unohlu olubalulekile lwe-contraindication ukusetshenziswa kwayo. Kungakho, ngaphambi kokuqala inkambo yokwelashwa, kufanele ufunde ngokucophelela imiyalo.
Uma kwenzeka kuba nemiphumela emibi, kufanele uthintane nodokotela wakho futhi nixoxe ngezinyathelo ezengeziwe maqondana nokuthatha umuthi.
Kuyenqatshelwa ukusebenzisa umuthi lapho kunezici nezifo ezilandelayo:
- Ukwelashwa kwesifo sikashukela sohlobo 1, iziguli ezithembela ku-insulin.
- Ukuthuthukiswa kwe-ketoacidosis, i-coma noma ukhokho wohlobo lwesifo sikashukela.
- Izinqubo ezibucayi ze-pathological ezinsweni noma esibindini, kanye nasebusweni bokungapheleli kwabo.
- Ezinye izifo zomgudu wokuphefumula, futhi uma kunzima ukuphefumula.
- Izifo zesistimu yezinhliziyo, ukuhluleka kwenhliziyo, noma ukufikelwa yi-myocardial infarction.
- Ukuthuthukiswa kwalesi sifo okubangelwa izifo ezahlukene.
- Ukuhlinzwa nokulimala kwakamuva.
- Ngobusuku nangemva kokuhlolwa okuthile kokuxilonga. Lokhu kufaka i-radiography, ngoba kusetshenziswa i-ejenti ehlukile enokuqukethwe kwe-iodine.
- I-Lactic acidosis;
- Ukungabekezeleli noma i-hypersensitivity engxenyeni eyodwa noma eziningi zomuthi;
- Ebusweni ukomisa;
- Ukusetshenziswa okufanayo kwe-miconazole.
Amantombazane nabesifazane abakhulelwe ngesikhathi sokuqunjelwa ayenqatshelwa ukuthatha i-metformin, njengoba kunezinkinga eziningi ngokukhula okuvamile kwesibeletho. Ngesidingo esiphuthumayo somuthi, owesifazane kufanele ayeke ukuncelisa ibele.
Ngaphezu kwalokho, izingane ezingaphansi kweminyaka eyishumi nesishiyagalombili zisengozini.
Kungenzeka yini ukuthi ungene esikhundleni somuthi nezinye izidakamizwa?
Umuthi i-Gliclazide, njengoba kufakazelwa ukubuyekezwa kweziguli, ibekezelelwa kalula futhi inomphumela omuhle okwehlisa ushukela.
Intengo ephakathi imayelana nama-ruble angama-135.
Kunezimo lapho kudingeka ukuthi kungene omunye esikhundleni salo muthi. Kulesi simo, ungakhetha ama-analogues we-Gliclazide noma umqondomqondo anikezwa yimakethe yemithi.
Kuze kube manje, kukhona okunjalo okufaka lesi sidakamizwa:
- Isifo sikashukela;
- I-Metformin;
- UGlidiab;
- I-Diabefarm;
- I-Glidiazinamide.
I-Diabeteson ingeqembu le-sulfonylureas yesizukulwane sesibili. Ukubuyekezwa kwezokwelapha kusikisela ukuthi uma uthatha i-Diabeteson iminyaka emibili, akukho ntuthuko yokumelana ne-insulin ezigulini.
Ngokwakheka kwayo, iDiabetes iyinhlangano egcwele yezibhebhe zeGliclazide. Indlela yokuphatha umuthi incike ezimweni eziqondene nesiguli. Njengomthetho, yithebhulethi elilodwa noma amabili ngosuku. Izindleko ezijwayelekile zesifo sikashukela ngama-ruble angama-330 kumathebulethi angama-30.
I-Metformin - umuthi ovela ekilasini lama-Biguanides, asetshenziswa ngenkuthalo ekwelapheni isifo sikashukela sohlobo 2. Into esemqoka esebenzayo yesidakamizwa yi-metformin hydrochloride. Intengo ephakathi kumakhemisi ingama-ruble angama-250.
IGlidiab umuthi we-hypoglycemic oqukethe i-80 mg yento esebenzayo. Inani lemakethe elijwayelekile ngama-ruble ayi-140 ngephakethe ngalinye (amaphilisi angama-60).
I-Diabefarm yisidakamizwa sethebhulethi esisetshenziswa ngenkuthalo ekwelapheni isifo sikashukela sohlobo 2. Intengo yalesi sidakamizwa iwalela ama-ruble ayi-120. Ividiyo ekulesi sihloko isitshela ukuthi ungaselapha kanjani isifo sikashukela nezidakamizwa.
