Njengamanje, kusetshenziswa imishanguzo eminingi ekwelapheni isiguli esithole uhlobo lwe-2 sikashukela mellitus. Omunye wale mishanguzo yiMetglib Force.
I-Metglib yisidakamizwa esitholakala kwifomu lethebhulethi. Ukwakheka kwalo muthi kufaka phakathi izakhi ezimbili ezisebenzayo - i-metformin ne-glibenclamide, okuvumela ukuthi kubhekiswe eqenjini lemikhiqizo yezokwelapha ehlangene esetshenziswa ekwelapheni isifo sikashukela i-mellitus. Ngenxa yalokhu kuhlanganiswa kwezakhi, i-Metglib ingesinye sezidakamizwa esisebenza ngempumelelo, njengoba kufakazelwa ukubuyekeza kweziguli nodokotela.
Ingxenye esebenzayo ye-metformin isiza ukunciphisa i-glucose yegazi emazingeni evamile omzimba. Ngaphezu kwalokho, izakhiwo zalo zifaka imiphumela ye-analgesic ne-antiviral, ukuncipha kwesisindo nokungasebenzi kahle kokudla.
I-glibenclamine ye-izidakamizwa esebenzayo isungulwe kahle njengesidakamizwa esinciphisa amazinga kashukela.
Umuthi usetshenziswa kabanzi ukwelapha isifo sikashukela sohlobo 2 uma ungekho umuthi we-insulin. Ngaphezu kwalokho, ukusetshenziswa kwayo kufanelekile ngemuva kokwelashwa okungasebenzi ngokusekelwe ekusetshenzisweni kwemikhiqizo emibili yezokwelapha - i-metformin ne-urea sulfonyl derivatives, inqobo nje uma isiguli sinezinga elizinzile le-glycemia.
Amacwecwe eMetglib aphakathi kwezidakamizwa ezingabizi. Intengo yazo ingahle ihambisane nezinto ezinjalo:
- inkampani yokukhiqiza yomkhiqizo okwelapha.
- umphakeli.
- indawo okuthengiswa kuyo umthengisi (ekhemisi).
Ngokwesilinganiso, izindleko zomuthi onjalo zingahluka kusuka kuma-ruble ayi-190 kuye kwangama-250 ngephakethe ngalinye (amaphilisi ayi-10).
Imiyalo yokusebenzisa umuthi
Iphakethe ngalinye lesidakamizwa liqukethe imiyalo yokusetshenziswa. Ngaphambi kokuqala inkambo yokwelapha, kufanele ufunde ngokucophelela okuqukethwe kuyo, imithamo enconyiwe, ukubonakaliswa okungenzeka kwemiphumela emibi kanye ne-contraindication.
Udokotela ovumayo kuphela onikezwe ukunquma ukwelashwa ngalo muthi.
Kuze kube manje, amaphilisi atholakala kumithamo ehlukahlukene, ekhethiwe esigulini ngasinye ngawodwana. Ngokuya ngobungako bezinto ezisebenzayo, umuthi ungasetshenziswa kwimithamo elandelayo:
- Ukwakheka kuqukethe i-500 mg ye-metformin ne-2,5 (5) mg ye-glibenclamine - ukuqala kokwelashwa kuqukethe ukuthatha ithebhulethi elilodwa ngosuku ekuseni. Uma kudingekile ukwandisa umthamo kuya kumathebhulethi amabili noma amane ngosuku, inani lemithamo liphindwe kabili futhi umuthi uyaphuzwa ekuseni nakusihlwa. Ngaphezu kwalokho, udokotela angakunquma ukuphuza umuthi okweqile kwezikhathi ezintathu (amaphilisi amathathu, amahlanu noma ayisithupha ngosuku).
- Kubantu asebekhulile, kuyadingeka ukukhetha ngokucophelela umthamo womuthi futhi ubheke ukubonakaliswa okungenzeka kwemiphumela emibi, ukusabela okuvela ezinso. Umthamo wokuqala kufanele ungabi ngaphezu kwethebhulethi elilodwa ngosuku.
Kumele kwaziwe ukuthi lesi sidakamizwa asenzelwe ukwelashwa kwesifo sikashukela ezinganeni.
Yikuphi ukuphambana kokusetshenziswa okukhona?
Ukwelashwa ngomuthi kufanele kube ngaphansi kokuqashwa okuphezulu kwesazi sezokwelapha.
Ngaphandle kwemiphumela eminingi emihle yesidakamizwa, kunohlu olubanzi lokuvela kwemiphumela emibi ehlukahlukene kanye nemikhawulo yokusetshenziswa kwayo.
Amantombazane nabesifazane abakhulelwe ngesikhathi sokuqunjelwa abakwazi ukusebenzisa lo muthi, ukuze kungalimazi ukukhula okujwayelekile kwengane.
Kuyenqatshelwa ukusebenzisa insiza yezokwelapha ezimweni ezilandelayo:
- ngokuthuthukiswa kwesiguli esinohlobo 1 sikashukela.
- uma kukhona ukuzwela okukhulayo noma ukungabekezelelani ngakunye kwengxenye eyodwa noma eziningi zomuthi.
- iziguli ezingaphezulu kweminyaka engamashumi ayisithupha, ikakhulukazi lapho kukhona ukuzikhandla okukhulu ngokomzimba.
- ekwelapheni izingane ezincane.
- phambi kwezifo zezinso, izitho zesistimu yezinhliziyo noma ukwehluleka kwesibindi, kwenqatshelwe ukuthatha amaphilisi wabantu abasanda kutholwa yi-myocardial infarction, aba nenhliziyo noma behluleka ukuphefumula.
- ngenkathi uthatha umuthi osuselwa ku-mycnalosis.
- okusanda kwenziwa ukungenelela kokulimala noma ukulimala nakho kungenye yezinto eziphambana nokuphuza lo muthi.
- ukudakwa kotshwala noma ukusebenzisa kanyekanye imithamo emincane yotshwala ngesikhathi sokwelashwa iMetglib.
- ukubonakaliswa kwe-lactic acidosis.
- ngenkathi unamathela ekudleni okuqinile okukhalori okuphansi, okungeqi i-kilocalories ayinkulungwane ngosuku.
Ngaphezu kwalokho, ukunakekelwa kufanele kuthathwe lapho welapha isiguli uma:
- isifo se-febrile.
- Izinkinga ngokusebenza okujwayelekile kwezindlala ze-adrenal.
- ukusebenza okunganele kwe-gust ye-anterior pituitary gland.
- i-pathology ye-gland yegilo.
Ukuqapha ekwelashweni kuyadingeka lapho usebenza neziguli ngemuva kweminyaka engama-70, ngoba i-hypoglycemia kungenzeka.
Yimiphi imiphumela emibi evela ekusebenziseni umuthi engenzeka?
Kwezinye izimo, odokotela bangabona ukubonakaliswa kwemiphumela emibi ehlukahlukene evela ngenxa yokuthatha umuthi nokukhethwa okungafanele komthamo womuthi.
Uma kunezimpawu noma ukungasebenzi kahle emzimbeni, kufanele wazise udokotela wakho ngokukhula kwabo.
Ngaphezu kwalokho, ukubuyekezwa kweziguli kukhombisa imiphumela emibi enjalo yesidakamizwa.
Ukubonakaliswa okungalungile okungabakhona kufaka phakathi:
- Ukuphazamiseka okuhlukahlukene okuvela ohlelweni lwe-lymphatic. Imiphumela emibi enjalo iyivelakancane futhi, njengomthetho, inyamalala ngokushesha emva kokuyekiswa komuthi.
- Ukuphazamiseka kwesistimu yomzimba kungaqhamuka. Ezimweni ezimbi kakhulu, ukushaqeka kwe-anaphylactic kuyabonakala. Ukuphendula kwe-Hypersensitivity kuma-sulfonamides noma kokunye okutholwayo nakho kutholakala.
- Ukuthuthukiswa kokuphazamiseka kwesistimu yokugaya ukudla nezitho zomgudu wegastrointestinal. Imiphumela emibi enjalo ibonakaliswa ngendlela yesicanucanu nokuhlanza, isifo sohudo nobuhlungu esiswini. Njengomthetho, lezi zibonakaliso ziwumphumela wokuqala komuthi futhi zidlule zodwa ezinsukwini ezimbalwa. Ukubekezelelwa okungcono kwezidakamizwa, odokotela batusa ukwehlukanisa umuthi emuthweni omningi ukuze umzimba ukwazi ukuzivumelanisa nawo ngokujwayelekile.
- Ukuthuthukiswa kwemiphumela emibi eboniswa izinqubo ze-metabolic emzimbeni. Enye yezimpawu zokubonakaliswa kwazo yi-hypoglycemia.
- Imiphumela emibi engenzeka engxenyeni yesistimu yezinzwa ivezwa ngendlela yokunambitheka kwensimbi emgodini womlomo.
- Izinkinga ngesikhumba zivele ngendlela yokulunywa, ubomvu, uritisaria nemisipha ehlukahlukene.
I-pharmacology yanamuhla inikezela ngamanani amakhulu wemishini ehlukene yezokwelapha, angama-Metglib analogue.
Ngabe umuthi ungafakwa esikhundleni somkhiqizo onezakhiwo ezifanayo?
Njengomthetho, izidakamizwa ezinjalo zinento efanayo esebenzayo ekwakhiweni kwazo, kepha zingahluka enanini lomthamo, uhlobo lokukhululwa, inkampani yokukhiqiza nenqubomgomo yamanani. Kumele kwaziwe ukuthi abathengi abaningi babheka izidakamizwa ezingeniswa njengezisebenza kakhulu, ezibizayo kakhulu, kepha zingahle zibe nokwakheka okufanayo kwesidakamizwa. Ukukhetha noma ukufaka umuthi esikhundleni somuthi kufanele kwenziwe kuphela ngudokotela ohambelayo.
Inani lemithi elifaka i-metformin esebenzayo yezithako ne-glibenclamine ifaka:
- I-Bagomet Plus ilungiselelo lethebhulethi olutholakala kumthamo we-500 mg we-metformin no-5 mg we-glibenclamine. Kuyi-analogue ephelele yamathebulethi akwaMetglib. Intengo ephakathi kumakhemisi asedolobheni cishe ama-ruble angama-215.
- I-Glibomet - amaphilisi aqukethe i-400 mg ye-metformin ne-2,5 mg ye-glibenclamine, evame ukusetshenziswa ukwelapha isifo sikashukela sohlobo 2. Ngokuqukethwe kwezakhi ezisebenzayo, zinobumnene ngokwengeziwe (zinomphumela ophansi) uma ziqhathaniswa ne-Metglib. Intengo ephakathi kumakhemisi iyahluka ngaphakathi kwama-ruble angama-315.
- I-Gluconorm - amaphilisi, okuthi ekubekweni kwawo nasezakhiweni zawo anezimpawu ezifanayo neMetglib. Intengo ephakathi imayelana nama-ruble angama-230.
Yonke le mishanguzo engenhla inezinto ezimbili ezisebenzayo ekwakhiweni kwayo futhi ifakwa eqenjini lemithi yokuhlanganisa esetshenziselwa ukwengeza ushukela wegazi.
Kuvidiyo ekulesi sihloko, udokotela uzonikeza izincomo zokwelashwa kwesifo sikashukela ngaphandle kwezidakamizwa.
